Berkala Penelitian Hayati
Vol 21 No 2 (2016): June 2016

The effect of polysaccharides krestin bioactivity from coriolus versicolor to estradiol levels on Mus musculus estrous cycle

Sri Puji Astuti Wahyuningsih (Department of Biology, Faculty of Science and Technology, Airlangga University)

Article Info

Publish Date
10 May 2016


This study aimed to determine the activity of polysaccharide krestin (PSK) from Coriolus versicolor extract to the dura-tion of estrous cycle and estradiol levels. PSK was administrated for 24 days in female Mus musculus, strain Balb/C, 10 weeks old, weight about 25-30 grams. Polysaccharide krestin given in sub-chronic dose. There were 4 groups, i.e K0 (0 mg/kg BW), P1 (15 mg/kg BW), P2 (30 mg/kg BW), and P3 (60 mg/kg BW). Each treatment group contained 7 replica-tions. Data were analyzed using One Way ANOVA and Duncan test at α = 5%. The duration of estrous cycle was de-termined by vaginal smear methods. The estradiol levels were measured using ELISA kit. The results show that the administration of PSK decreased the duration of estrous cycle with an average of 4.4 days. Polysaccharide krestin dose of 15 and 60 mg/kg BW did not affect the estradiol levels. Decrease of estrous cycle duration was still in the range of normal estrous time between 4-6 days. PSK dose of 15 and 60 mg/kg BW can be used as a therapeutic dose.

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Journal Info





Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology


Berkala Penelitian Hayati is a half yearly international peer reviewed, an open access life science journal. The journal was published by The East Java Biological Society and formerly used the Indonesian language. The first edition of this journal is Vol 1 No 1 in June 1995. It was accredited by ...