Care : Jurnal Ilmiah Ilmu Kesehatan
Vol 9, No 2 (2021)

EFEKTIVITAS EKSTRAK DAUN SALAM (Eugenia polyantha) MENURUNKAN KADAR MALONDIALDEHYDE PADA KONDISI TIKUS HIPERLIPID

Putu Oky Ari Tania (Bagian Biomedik Penelitian Biomolekuler Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya)
I Kadek Angga Dwi Cahyadi (Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya)



Article Info

Publish Date
02 Jul 2021

Abstract

A high-fat diet leads to increasing intake of fatty acid in liver, making it susceptible to lipid peroxidation and free radical release. Malondialdehyde is a common biomarker for lipid peroxidation. Increasing free radicals should be balanced with the antioxidants in order to prevent oxidative stress. This study aim was to measured the effectiveness of bay leaf extract (Eugenia polyantha) in lowering MDA levels in hyperlipidemia rats. This study was an experimental study using 20 male rats divided into 4 groups. All rats were induced hyperlipidemia with high-fat diet for 12 days. KP was sacrificed in the next day after the feeding of high fat. KN administered by aquades 2 ml / day (peroral / po), P1 administered by bay leaves extract 1.08 g / day (p.0) and P2 received simvastatin treatment dose 0,0018 g / 150 g BB / day (p. 0). The results showed MDA levels in KP, KN, P1 and P2 were respectively 7.79; 7.07; 6.49; and 7.21 nmol / ml. One way ANOVA test showed p value was 0,073 (

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Journal Info

Abbrev

care

Publisher

Subject

Health Professions Nursing Public Health

Description

Care : Jurnal Ilmiah Ilmu Kesehatan ISSN 2527-8487(online), ISSN 2089-4503(cetak), adalah jurnal peer-review yang menerbitkan artikel tentang praktik, teori, dan penelitian di semua bidang kesehatan dan keperawatan.Scope jurnal terdiri dari keperawatan,kesehatan,kesehatan ...