Jurnal Respirologi Indonesia
Vol 42, No 2 (2022)

The Surfactant Protein D (SP-D) Serum Levels in Limestone Mining Worker

Sita Laksmi Andarini (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia)
Anna Yusrika (Universitas Indonesia)
Sri Wening Pamungkasningsih (Universitas Indonesia)
Farhan Hilmi Taufikulhakim (Universitas Indonesia)
Ahmad Hudoyo (Universitas Indonesia)
Widhy Yudistira Nalapraya (Universitas Islam Bandung)
Agus Dwi Susanto (Universitas Indonesia)

Article Info

Publish Date
27 Apr 2022


Background: Limestone is sedimentation rocks consist of minerals calcite and aragonite, often contains silica, and fossils, commonly used in building materials. Limestone mining workers are at high risk to pneumoconiosis. Surfactant protein D(SP-D) is part of collectin family, and served as innate immune system of pathogen recognition receptor (PRR). SP-D level were usually increased in fibrotic lung disease. In this study, we sought the serum level of SP-D as marker for early pneumoconiosis in limestone worker in Indonesia.Method: This study was cross-sectional observational study. Participant of the study were 65 limestone workers, willing to participate in this study by signing informed consent, were questionnaire, and blood sample were collected to measure SP-D level by ELISA.Results: This study found that characteristic subjects dominated by male with the median of age was 42 years old and last education mostly elementary school. Majority duration of working <6 years and time working in a day >8 hours per day. The limestone mining workers mostly did not wear mask and had normal weight group. Majority limestone mining workers ever smoker, mean SP-D level in limestone workers was (66.3±5.5ng/mL), slightly higher than normal subject. Smoking status, gender, working hour were correlated with higher SP-D level.Conclusion: Although not statistically significant, the SP-D serum levels in limestone mining workers might be used as monitoring for early screening for pneumoconiosis in limestone workers.

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Health Professions Medicine & Pharmacology


Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case ...