<![CDATA[Cancer patients experience the same general symptoms, but the prevalence and severity can be different. The prevalence and severity of symptoms within a cluster influence the better or worse the overall experience of signs and symptoms. This study aims to analyze the relationship between age, gender, and formal education on symptom clustering in head and neck cancer patients. The method of this study is analytic observational with a cross-sectional approach. Sample selection used inclusion criteria diagnosed with head and neck cancer without metastases to the brain, aged 18-70 years, able to cooperate and communicate well, and sampling used the consecutive sampling method on 111 patients treated at Dr. Central General Hospital. Kariadi Semarang. Statistical data analysis using the Spearman Rho method. The results of the study showed that there was a significant relationship between the gender variable and the cluster of gastrointestinal symptoms with a significance p<0.05. Age and formal education are not related to clustering of head and neck cancer symptoms. While the severity of the symptoms experienced differs based on gender, women experience more severity than men. Good identification of age, gender, and level of education can help treat head and neck cancer symptoms better.]]>
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