Jurnal Kedokteran Hewan
Vol 10, No 2 (2016): September

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus))

T. Armansyah TR (Laboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh)
Sudi Indriany (Program Studi Pendidikan Dokter Hewan Fakultas Kedokteran Hewan, Universitas Syiah Kuala, Banda Aceh)
Amalia Sutriana (Laboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh)
Rosmaidar Rosmaidar (Laboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda Aceh)
Nuzul Asmilia (Unknown)
Budianto Panjaitan (Unknown)
Dwinna Aliza (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Hamdan Hamdan (Laboratorium Reproduksi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)

Article Info

Publish Date
05 Sep 2016

Abstract

ABSTRACT The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each. All mice in group K1, K2, K3, and K4 were administered ethanolic extract of malaka leaves with the dose of 2, 4, 8, and 16 g/kg bw, respectively. Single dose of ethanolic extract of malaka leaves were given by oral gavage prior to clinical observation . The observation period was 14 days post administration, for sign of toxicity symptom, weight loss, and mortality. The result showed that no mortality was observed in the experimental animals during this study. Slight reduction of body weight was observed in group K2, K3, and K4, and no toxicity sign was found during fourteen days of observation. The LD50 of ethanolic extract of malaka leaves was higher than 16 g/kg body weight, thus, the substance was practically non toxic substance.

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Journal Info
Jurnal Kedokteran Hewan
Website

Abbrev

JKH

Publisher

Universitas Syiah Kuala

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Description

Jurnal Kedokteran Hewan (J. Kedokt. Hewan), or Indonesian Journal of Veterinary Sciences is a scientific journal field of veterinary sciences published since 2007, published FOUR times a year in March, June, September, and December by Universitas Syiah Kuala (Syiah Kuala University) and Indonesian ...