Universa Medicina
Vol 29, No 3 (2010)

Warfarin: do we need genotype-based dose prediction?

Yenny, Yenny (Unknown)

Article Info

Publish Date
25 Feb 2016


For the treatment and prevention of thrombo-embolic disease, the most frequently used anticoagulant drug worldwide is warfarin, an oral coumarin derivative, with more than 30 million prescriptions written for this drug in the United States in 2004.(1) The drug has a narrow therapeutic index and its metabolism varies by as much as a factor of 10 among individual patients, making warfarin therapy difficult to manage. Hemorrhagic complication rates of warfarin are estimated to be 5-7.9% for major (life threatening) hemorrhage and 14-36% for minor hemorrhage (e.g. nosebleeds, microscopic hematuria).(2) This condition makes it difficult to establish the appropriate dose of warfarin.

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Journal Info





Health Professions Immunology & microbiology Medicine & Pharmacology Public Health


Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through ...