Majalah Obat Tradisional
Vol 22, No 3 (2017)

Penares sp sponge from Menjangan Island-water West Bali National Park: Isolation of Cytotoxic Compounds

Erna Prawita Setyowati (Deprtment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta)
Sudarsono Sudarsono (Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta)
Retno Murwanti (Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta)

Article Info

Publish Date
21 Dec 2017

Abstract

Sponges are multicellular animals which have cytotoxic compounds. In this study, isolation and cytotoxic activity of Penares sp sponge from Menjangan island-water West Bali National Park have been carried out. The results showed that chloroform extract and GF V Penares sp fraction were toxic according to Brine Shrimp Lethality Test method (each 85% and 63.3% mortality at 25μg/mL concentration). The isolation result of GF V fraction was obtained a compound (Spot 4) that is active as cytotoxic agent against T47D cells (IC50 of 12.7 ug/mL). Spot 4 is a terpenoid compound which has conjugated double bonds.

Copyrights © 2017




Citation Download
RIS
EndNote, Reference Manager, ProCite
BibTex
Latex, Jabref
Full PDF
909.182 KB
Original Source
Download Original
Google Scholar
Check in Google Scholar
Journal Info
Majalah Obat Tradisional
Website

Abbrev

TradMedJ

Publisher

Universitas Gadjah Mada

Subject

Health Professions Medicine & Pharmacology Public Health

Description

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, ...