Health Notions
Vol 2 No 2 (2018): February 2018

The Improvement of TNF- α and Inflamation Cell on the Lungs Hypersensitivity Reaction becauses of Wood Dust Exposure

Marufi, Isa (Unknown)
Prahastuti, Anita Dewi (Unknown)
Hartanti, Ragil Ismi (Unknown)



Article Info

Publish Date
28 Feb 2018

Abstract

This research aimed to analyze the effect of wood dust on TNF-α on Mice blood (MusMusculus) BALB / C and to analyze the influence of wood dust on the number of inflammatory cells, ie macrophage, lymphocyte, neutrophil and mast cell in lung tissue of mice BALB / C, as well as explain the mechanism of lungs hypersensitivity reaction due to wood furniture dust exposure. The experimental laboratory research was conducted, and mice was become the animal experiment. The research design used was Randomized the post-test only control group design. Exposure was performed 4 hours a day with 2 hours length of exposure in the morning with 1 hour rest period in 6 times a week for 4 weeks at exposure space in a glass-shaped cube with a size of 20x20x20 cm3. Concentrations of wood furniture dust exposed were 0.50 mg / m3, 0.75 mg / m3, 1.00 mg / m3. The findings showed that: (1) wood furniture dust exposure increased between experimental group compared with control group in mice (Musmusculus) BALB / C; (2) wood furniture dust exposure increased TNF, in lung tissue between experimental group compared with control group in mice (Musmusculus) BALB / C; and (3) wood furniture dust exposure increased mast cells, neutrophils, lymphocytes, and macrophages in lung tissue between experimental group compared with control group in mice (Musmusculus) BALB / C.

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Journal Info

Abbrev

hn

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Description

"Health Notions" is a media for the publication of articles on research and review of the literature. We accept articles in the areas of health science and practice such as public health, medicine, pharmaceutical, environmental health, nursing, midwifery, nutrition, health technology, clinical ...