Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
Vol 10, No 2 (2015): August 2015

Effect of Agitation Speed and Cultivation Time on the Production of the Emestrin Produced by Emericella nidulans Marine Fungal

muhammad nursid nursid (Research and Development Center for Marine and Fisheries Product Processing and Biotechnology)
Martua Manulang (Unknown)
Joko Samiadji (Unknown)
Endar Marraskuranto (Unknown)

Article Info

Publish Date
23 Aug 2015

Abstract

Emestrin, an epipolythidioxopiperazine (EPT), is bioactive secondary metabolite produced by the marine fungus Emericella nidulans. Emestrin is potential to be developed as anticancer agent. Our present study investigated the effect of the agitation speed and cultivation time on the production of the mycelial biomass and emestrin in E. nidulans. The fungal was cultivated in malt extract broth (MEB) medium with varying agitation speeds of 0, 50, 100,150 rpm during 1,2,3 and 4 weeks of incubation at the temperature of 28 oC. Concentration of emestrin was determined by using high performed liquid chromatography (HPLC). The highest concentration of emestrin was found at static condition (0 rpm) cultivated for 1 week.

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Journal Info
Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
Website

Abbrev

squalen

Publisher

Pusat Litbang Daya Saing Produk dan Bioteknologi Kelautan dan Perikanan

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

Description

Squalen publishes original and innovative research to provide readers with the latest research, knowledge, emerging technologies, postharvest, processing and preservation, food safety and environment, biotechnology and bio-discovery of marine and fisheries. The key focus of the research should be ...