Indonesian Journal of Chemistry
Vol 15, No 2 (2015)

Characterization of Butanediol-Alginate Ester as Candidate of Hemodialysis Membrane

Choirul Amri (Department of Environmental Health, Poltekkes Kermenkes Yogyakarta, Jl. Tatabumi No. 3 Banyuraden, Yogyakarta 55293)
Mudasir Mudasir (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281)
Dwi Siswanta (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281)
Roto Roto (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281)



Article Info

Publish Date
13 Jul 2015

Abstract

An ester of butanediol-alginate has been studied as a possible hemodialysis membrane. With 1,4-butanediol molar ratio of 0.1, 0.5, and 1.0, it showed that the membrane mechanical properties, stability, protein adsorption, platelet adhesion and performance for urea and creatinine clearance are better than that of unmodified alginate. The increase in 1,4-butanediol molar ratio causes hemodialysis ratio to improve, and causes protein adsorption and platelet adhesion at the membrane surface to decrease. In the case of protein adsorption and platelet adhesion, the membrane with the molar ratio of 1.0 has better hemocompatibility properties. In the hemodialysis test for 4 h, using 2.742 mg cm-2 h-1 of urea and 0.058 mg cm-2 h-1 of creatinine flux, this membrane showed that 48.5% of urea and 44.2% of creatinine were cleaned.

Copyrights © 2015






Journal Info

Abbrev

ijc

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...