Pharmasipha
Vol 1, No 1 (2017): September

Uji Brine Shrimp Lethality Test (BSLT) Ekstrak Etil Asetat Spons Calthropella sp. Asal Zona Intertidal Pantai Krakal Gunung Kidul Yogyakarta

Fitria Susilowati (Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Darusssalam Gontor)



Article Info

Publish Date
12 Sep 2017

Abstract

Sponge is one of the most prolific sources in regard of their secondary metabolites as bioactive compounds. This study aimed to isolate and investigate the toxicity of ethyl acetate extract of sponge Calthropella sp. from intertidal zone of Krakal Beach, Gunungkidul. The isolation was done by maceration with methanol:dichloromethane (1:2) v/v. The dichloromethane extract was evaporated and then partitioned in ethyl acetate:water (3:2 v/v). The interesting layer of ethyl acetate was evaporated to yield a viscous extract. The toxicity test was assessed by Brine Shrimp Lethality Test (BSLT). The isolation resulted 7 fractions of ethyl acetate: 71,1; 86,4; 69,3; 88,8; 78,7; 97,5; and 100,2 mg. BSLT showed the LC50 value of the ethyl acetate fractions on toxic and very toxic category.

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Journal Info

Abbrev

pharmasipha

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of ...