<![CDATA[Objective: To analyze level of retinol deposit sufficiency in the
natural history of cervical cancer.
Methods: Serum retinol level was measured by ELISA from
peripheral blood of subjects with normal cervix, cleared and
persistent high risk human papilloma virus (HR-HPV) subclinical
infection, and cervical cancer who fulfilled the inclusion and
exclusion criteria. The study was held in Dr. Cipto Mangunkusumo
and Fatmawati Hospital, Jakarta, within 2 years (August 2013-
2015). Blood was taken twice, consisting of post-8-hour fasting
blood and 2 hours after 6000 IU retinyl palmitate oral
administration.
Results: Of 47 total samples, sufficient level of retinol deposit in
normal cervix, cleared and persistent HR-HPV subclinical infection,
and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89),
33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically,
there was no significant difference from sufficiency level of retinol
deposit between normal cervix and clearance HR-HPV subclinical
infection (p=0.628), normal cervix and persistent HR-HPV
subclinical infection (p=0.078), normal cervix and cervical cancer
(p=0.433), cervical cancer and clearance HR-HPV subclinical
infection (p=1.000), cervical cancer and persistent HR-HPV
subclinical infection (p=0.430), persistent and clearance HR-HPV
subclinical infection group (p=0.740).
Conclusion: This study proves that normal cervix group has the
highest level of retinol deposit sufficiency; however, it cannot
be stated that cervical cancer group has less sufficiency level.
Persistent HR-HPV subclinical infection group has the lowest
level of retinol deposit (OR 11.33). There is no association
between sufficient level of retinol deposit and clearance of
HR-HPV.
[Indones J Obstet Gynecol 2017; 5-1: 46-54]
Keywords: cervical cancer, HR-HPV clearance, retinol deposit]]>
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