eJurnal Kedokteran Indonesia
Vol 6, No 2 (2018): Vol 6, No. 2 (2018): Agustus

Influence of Mesenchymal Stem Cell Transplantation in Retaining Ganglion Cell of End Stage Glaucoma Patients

Widya Artini (Departemen Medik Mata, Fakultas Kedokteran Universitas Indonesia- RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia)

Article Info

Publish Date
14 Sep 2018


Mesenchymal stem cells transplantation enhances nerve growth factor synthesis, brain derived nerve factor, glial cell line-derived neurotropic factor, and neurotrophin-3.. We report four end-stage primary open angle glaucoma patients, consisting of three males and one female with a median age of 68 years old, treated at RSCM on September 2017. Visual acuity ranged between 1/300 to 2/60 and intraocular pressure (IOP) between 10-14 mmHg. All patients underwent allogeneic mesenchymal stem cells transplantation derived from umbilical cord by subtenon injection and evaluated the results of the potential evoked retinograph and average thickness of ganglion cell-inner plexiform layer (GC-IPL). Three months later, two patients admitted their vision was improved. with, no significant anatomical structure changes were observed. While two other patients did not report any significant effects.

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Journal Info





Medicine & Pharmacology


Elektronik Journal Kedokteran Indonesia (eJKI) is a peer-reviewed and open access journal that prioritize the publication manuscript of students (medical education program, magister/specialist, doctoral). This journal publishes editorial, research article, reviews, evidence-based case report, and ...