Jurnal Neuroanestesi Indonesia
Vol 2, No 2 (2013)

Peran Protease Calpains pada Neurotrauma

Prihatno, MM Rudi (Unknown)
Sudadi, Sudadi (Unknown)



Article Info

Publish Date
23 Jun 2013

Abstract

Cedera otak traumatik merupakan kejadian yang dapat berakibat fatal bila tidak mendapatkan penatalaksanaan yang adekuat. Penatalaksanaan tersebut dapat berupa terapi medikamentosa ataupun intervensional non-farmakologik seperti pemberian oksigen dengan ventilasi mekanik, tindakan pembedahan, dan lain sebagainya. Hal terpenting yang paling baik dilakukan adalah penatalaksanaan awal pasca kejadian, dimana proses-proses metabolik di otak sangat mempengaruhi hasil akhir dari kondisi seluler otak. Salah satu yang menjadi pertimbangan adalah penatalaksanaan pencegahan pemburukan dampak cedera otak traumatik dengan intervensi yang memanfaatkan jalur-jalur iskemik yang sudah diketahui, salah satunya adalah protease calpain The Role of Calpains Protease in Neurotrauma Traumatic brain injury is an event that can be fatal if not get an adequate management. Treatment may be either medical therapy or interventional non-pharmacological, such as providing oxygen with mechanical ventilation, surgery, and so forth. The most important thing is best done early post-incident management, in which metabolic processes in the brain greatly affect the outcome of the condition of the brain cell. One of the consideration is the impact of deterioration prevention treatment of traumatic brain injury with interventions that harness ischemic pathways already known, one of which is the protease calpain. 

Copyrights © 2013






Journal Info

Abbrev

jni

Publisher

Subject

Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

Description

Editor of the magazine Journal of Neuroanestesi Indonesia receives neuroscientific articles in the form of research reports, case reports, literature review, either clinically or to the biomolecular level, as well as letters to the editor. Manuscript under consideration that may be uploaded is a ...