Journal of Tropical Pharmacy and Chemistry
Vol. 4 No. 4 (2018): Journal of Tropical Pharmacy and Chemistry

Synthesis and Characterization of Methyl Amino Polystyrene as Resin Material of Chromatography

Herman Herman (Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Anni Anggraeni (Chemical Analysis and Separation Laboratory, Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, Indonesia)
Abdul Mutalib (Biomolecular Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Bandung, West Java, Indonesia)
Husein H. Bahti (Chemical Analysis and Separation Laboratory, Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor, West Java, 45363 Indonesia)



Article Info

Publish Date
31 Dec 2018

Abstract

Ion-exchange chromatography has been widely used in various separation process and purification. Commercial ion-exchange resin mostly uses polystyrene as stationer phase. This study reviewed the synthesis of cation-exchange resin with polystyrene as starting material. Polystyrene must be activated in order to make one of aromatic carbon chains being able to be binding with acetamide n-hidroxymethyl electrophilic. Polystyrene activation was conducted through two stages, i.e. (1) the formation of amidomethyl polystyrene (AMDP), and followed with (2) elimination of acyl group. The activation of polystyrene generated white methylamino polystyrene (MAP) resin, of which its characterization used spectrophotometry UV, Fourier Transform-Infrared (FTIR), and density of MAP resin confirmed by pycnometer. The results showed that the characterization of FTIR and spectrophotometer UV for AMP exhibited forming amino propyl group at 3374.52 cm-1 with ?max 230 nm due to N–H bond; and the average of density of AMP resin sample was 1.7158 g/mL.

Copyrights © 2018






Journal Info

Abbrev

jtpc

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

Description

Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: ...