<![CDATA[Background: Human Immunodeficiency Virus (HIV) is one of the important public health problems in the world which causes death of more than 35 million people annually. HIV infection is often associated with several comorbidities caused by the presence of endemic infectious diseases in certain regions, one of them is malaria. Analyzing the survival of HIV / AIDS patients malaria coinfection is based on risk factors for recurrence and death due to malaria. This study aimed to examine the determinants of recurrence and death in HIV-malaria co-infection patients in Jayapura, Papua, Indonesia.Subjects and Method: This was a retrospective cohort study conducted in the VCT room at Dok II Regional General Hospital, Jayapura, Papua Province, Indonesia, from May to June 2018. A sample of 183 people living with HIV/AIDS (PLWH) was selected by fixed disease sampling. The dependent variable was recurrence. The independent variables were drug taking adherence, nutritional status, economic status, use of mosquito nets, spraying residues in the house, healthy hygiene behavior, co-infection with malaria. The data were obtained from medical record. The other data were collected by questionnaire. The data were analyzed using path analysis.Results: The risk of recurrence in PLWH co-infected with malaria decreased with ARV treatment adherence (b= -2.17; 95% CI= -3.24 to -1.09; p<0.001) and compliance with Cotrimoxazole treatment (> 95 %) (b= -1.88; 95% CI= -2.58 to -1.19; p<0.001). The risk of recurrence in PLWHA co-infected with malaria increased with low income <Rp 2,000,000 (b= 3.06; 95% CI= 2.04 to 4.07; p <0.001), poor health behavior (mean <5) (b= 1.66;  95% CI= 0.92 to 2.40; p<0.001), poor nutritional status (b= 2.10; 95% CI= 1.44 to 2.76; p<0.001), and did not use bed nets (b= 0.73; 95% CI= 0.16 to 1.29; p= 0.011). The risk of death in PLWHA coinfected with malaria decreased with ARV treatment adherence (> 95%) (b= -2.08; 95% CI= -3.02 to -1.14; p<0.001) and healthy behavior (mean> 5) (b= -1.43; 95% CI= -2.15 to -0.70; p<0.001). The risk of death in PLWHA co-infected with malaria increased with low income (<Rp 2,000,000) (b = 3.06; 95% CI= 2.04 to 4.07; p <0.001), poor health behavior (mean <5) (b= 1.66; 95% CI= 0.92 to 2.40; p <0.001), and poor nutritional status (b = 2.10; 95% CI= 1.44 to 2.76; p <0.001).Conclusions: The risk of recurrence in PLWHA co-infected with malaria increases with low income, poor health behavior, and poor nutritional status, but decreases with adherence to ARV treatment and Cotrimoxazole treatment. The risk of death of PLWHA coinfected with malaria increases with low income, poor health behavior, and poor nutritional status, but decreases with adherence to ARV treatment.Keywords: recurrence, co-infection, HIV/AIDS, malaria, death, path analysis, people with HIV/AIDSCorrespondence: Dian Winiarti. Masters Program in Public Health. Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java 57126, Indonesia. Email: Dianwiniarti@gmail.com. Mobile: +6281344266960.Journal of Epidemiology and Public Health, 2019, 4(3): 138-155https://doi.org/10.26911/jepublichealth.2019.04.03.01]]>
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