Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Jurnal Farmasi Sains dan Komunitas (JFSK)

JFSK
Website

Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : -

Articles 166 Documents

1 2 3 4 5

THE SUB-CHRONIC TOXICITY TEST OF MENIRAN (Phyllanthus niruri L.) AND PEGAGAN (Centella asiatica) EXTRACT IN WISTAR STRAIN RATS ON LIVER AND KIDNEY FUNCTION Endang Darmawan; Iin Narwanti; Siti Fatmawati Fatimah; Ira Aprilia Wulandari; Ria Putri Salma; Dzulhaifa Dzulhaifa
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Meniran (Phyllantus niruri L.) and Pegagan (Centella asiatica L.) was proven had activity that considered as an antioxidant. However, the safety was not confirmed. This research is intended to evaluate sub-chronic toxicity of standardized combination extract of meniran and pegagan on liver and kidney function. This research used post-test-control design. Twenty female and twenty male Wistar strain rats divided into 4 groups. The first group was controlled in dosage of CMC Na 0.5%. The others were given a combination of meniran and pegagan extract in ratio with different dosage (50:50; 250:250; and 1250:1250 mg/KgBW). Sub-chronic toxicity test of meniran and pegagan combination was given orally once a day for 28 consecutive days. On the 29th day, all the rats were sacrificed and blood samples were analyzed using automatic analyzer. SGOT, SGPT, BUN, and creatinine value were statistically analyzed using one way ANOVA with post hoc LSD (p0.05). The results show that treatment of meniran and gotu kola combination had no significantly different of SGOT and creatinine value of male and female rats, and SGPT value of male rats (p0.05). The treatment of meniran and gotu kola combination had significantly different of BUN value of male and female rats, and SGPT value of female rats (p0.05) but still within normal range. Based on this study, it can be concluded that orally administered of meniran and gotu kola extract combination at doses 50:50 mg/KgBW; 250:250 mg/KgBW; and 1250:1250 mg/KgBW had no affected on SGOT, SGPT, BUN and creatinine value of Wistar strain rats on sub-chronic administration for 28 consecutive days.

FRAKSI ETIL ASETAT KULIT BATANG FALOAK (Sterculia quadrifida R.Br ) MENGINDUKSI APOPTOSIS DAN SIKLUS SEL PADA SEL KANKER PAYUDARA T47D Rollando Rollando; Kestrilia Rega Prilianti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Faloak (Sterculia quadrifida R.Br) is one source of bioactive compounds that could be developed as chemotherapeutic agent. Empirically East Nusa Tenggara people use boiled water of faloak bark as a cure for hepatitis (types A, B, and C), and gastroenteritis. This study was performed to test anticancer activity fraction of n-hexane, ethyl acetate, ethanol, and methanol of ethanolic extract from faloak stem bark for the type of breast cancer cell line T47D, and normal cell types Vero using cytotoxic 3- (4,5-dimetilazol- 2-yl) -2,5-difeniltetrazolium bromide (MTT) test method. Ethanolic extract was subjected to column chromatography using different solvents polarity level as n-hexane, ethyl acetate, ethanol, and methanol. Testing the cytotoxic effects using the MTT assay in T47D breast cancer cells and normal Vero cells with EC50 parameter. Ethyl acetate fraction in inducing apoptosis and cell cycle modulation was observed with flowcytometry method. The test results cytotoxic fraction indicating the fraction of ethyl acetate has the lowest activity with EC50 of 24.88 ?g/mL and selectivity index of 15.58. Ethyl acetate fraction effects an accumulation of cells in S phase (27.43%) in breast cancer cells T47D which is able to induce apoptosis. These results demonstrate that the ethyl acetate fraction can be developed as a chemotherapeutic agent in improving the effectiveness of breast cancer treatment.

FORMULASI MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP K30 DAN HIDROKSIPROPIL METILSELULOSA Beti Pudyastuti; Akhmad Kharis Nugroho; Sudibyo Martono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Transdermal delivery system is one of the delivery system for Pentagamavunon-0 (PGV-0) toavoid the high intensity of first pass metabolism of PGV-0 in peroral route. The purpose of this researchwas to optimize the formula of PGV-0 transdermal matrix with a combination of PVP K30 and HPMCpolymers.The simplex lattice optimization approach of the transdermal matrix formulas was performed byusing Design Expert 7.1.5 software. The visual appearance, weight, thickness, moisture content, moistureuptake, folding endurance, drug content, and dissolution efficiency of the release profil of PGV-0 from thematrix for 6 hours were evaluated as responses to determine optimum formula of matrix. The resultshowed that a combination of PVP K30 and HPMC polymers had a significant influence on the visualappearance, moisture content, and dissolution efficiency of PGV-0. Combination of 1.98% of PVP K30and 4.52% of HPMC as the optimum formula could produce homogeneous and flexible matrix withmoisture content of 3.21%. The dissolution efficiency was 9.11%, indicating that 101.93 g of PGV-0 wasreleased from the optimum formula during 6 hours.Keywords : Pentagamavunon-0, Transdermal matrix, PVP K30, HPMC

ANTIBACTERIAL ACTIVITY AND TLC-BIOAUTOGRAPHY ANALYSIS OF THE ACTIVE FRACTIONS OF Muntingia calabura L. LEAVES AGAINST Staphylococcus aureus Rizky H. Mawardi; Nanik Sulistyani; Nurkhasanah Nurkhasanah; Ricke Desyratnaputri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

This study aims to determine the antibacterial activity and TLC-bioautography profile of the active fractions of Muntingia calabura L. leaves against Staphylococcus aureus. Muntingia calabura L. leaves were macerated with ethanol 96% then fractionated with n-hexane, ethyl acetate, and methanol solvent, respectively. The antibacterial activity was tested by the Kirby-Bauer method to determine the most active fraction and the lowest concentration that inhibited the growth of Staphylococcus aureus. TLC-bioautography was tested using chloroform: ethyl acetate (2:8) as the mobile phase and silica gel F254 as the stationary phase. Antibacterial activity test of n-hexane and ethyl acetate fractions at a concentration of 10% w/v showed activities with inhibition zone diameter of 0.330.288 and 9.665.77 mm, respectively. At the same time, the methanol fraction showed no activity. The lowest concentration of ethyl acetate fraction which still showed the inhibition zone was 0.312% w/v. The TLC-bioautography profile showed active spots with an Rf value of 0.82 and had an inhibitory zone diameter of 4.0130.864 mm. It can be concluded that the ethyl acetate fraction was the most active fraction that inhibited the growth of Staphylococcus aureus and had one active spot on the bioautography test.

DAYA HAMBAT MINYAK ATSIRI DAN EKSTRAK LIMBAH SISA DESTILASI RIMPANG KUNIR PUTIH (Kaempferia rotunda L.) TERHADAP PERTUMBUHAN Candida albicans ATCC 10231 Christina Astutiningsih; Ratih Octaviani; Sri Suratiningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: White turmeric rhizome contains alkaloid, saponin, flavonoid, polifenol, and essentialoils. The purpose of this research is to determine the antifungal activity of essensial oil andresidual destillation of white turmeric rhizome against Candida albicans. Essential oils of whiteturmeric rhizome isolated by steam distillation method, the extraction of waste with soxhletasimethod. Antifungal activities were investigated by the paper disc method method. The test resultsshowed antifungal activity of essential oil of white turmeric rhizome in different concentrations(0.75, 1, 2, and 2.25%) were 0.0 ; 0.736 ; 0.894 ; 1.041 cm. The antifungal activities of theresidual distillation of extract (2.25, 2.5, 3, and 4%) were 0.0, 0.674, 0.743 and 0.874 cm. Therewas a difference of the zone of inhibition of Candida albicans growth between essential oils andresidual distillation of white turmeric rhizome.Keywords: White turmeric, Candida albicans, essential oils, extract of waste, inhibiton.

THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND OBESITY BASED ON BODY FAT PERCENTAGE IN BANJAROYO VILLAGE, KALIBAWANG, KULON PROGO, D.I. YOGYAKARTA Sesilia Effendy; Maria Felicia Gunawan; Daniel Lintang Adhi Argoputra; YB Abraham; Patricia Dian Anggraeni; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Obesity, a metabolic disorder characterized by the accumulation of excessive body fat, which is closely associated with metabolic derangement-related disease. Obesity can be caused by low physical activity that can be assessed using body fat percentage. The purpose of this study was to identify the relationship between physical activity and obesity based on body fat percentage in Banjaroyo village, Kalibawang, Kulon Progo, Special Region of Yogyakarta. This study was an observational-analytical study with cross sectional design and conducted in January-June 2017. Total samples were 243 people (86 males and 157 females) with age range between 18-65 years old. Physical activity data were collected using a structured interview based on International Physical Activity Questionnaire (IPAQ), while body fat percentage was taken using Bioelectrical Impedance Analysis (BIA). The data were analyzed using comparative Chi-square test with the level of significance of 95%. The prevalence of obesity based on body fat percentage was 78.2% and 21.8% in men and women, respectively. Results of the study showed that there is no significant relationship between physical activity and obesity based on body fat percentage (p=0.419; CI 95%: 0.66-2.689). In conclusion, there is no significant relationship between physical activity and incidence of obesity.

METODE PEMANASAN DAN SONIKASI MENGHASILKAN NANOLIPOSOM DARI FOSFOLIPID LESITIN KEDELAI (SOY LECITHIN) Rini Dwiastuti; Sri Noegrohati; Enade Perdana Istyastono; Marchaban Marchaban
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Liposomes in topical drug delivery preparation is developed because having a good penetration through the skin. The lecithin which is often used in liposome formulations is soy lecithin. Heating and sonication methods can be done to reduce the size of the particles. This study aims to produce nanoliposom dosage formulations of soy lecithin phospholipids by using a combination of heating and sonication methods to generate liposomes with size 150nm . The methods of nanoliposomes preparation in this study using a combination of heating 60?C and sonication methods for about 30 minutes in the manufacturing process . The results showed that the preparation of nanoliposomes formulation from soy lecithin can be done by using a combination of heating 60?C and sonication methods for about 30 minutes.

HUBUNGAN FAKTOR KOMORBIDITAS, INTENSIFIKASI TERAPI, DAN PENGENDALIAN TEKANAN DARAH Rita Suhadi; Jarir Atthobari; Bambang Irawan; Iwan Dwiprahasto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Background: Therapy intensification (TI) is the most important factor in bloodpressure control among the adherent patients. The TI is the physician prescription behavior toadd the item(s) and/or the dosage of hypertensive medicine when the patients' BP was ?10mmHgabove the target. Comorbid patients have 10mmHg lower BP target. Aims: to evaluate the effectof comorbidity on TI score and blood pressure control; and to correlate the variables of TI and BPcontrol. Method: retrospective cohort study done in 4 hospitals in Yogyakarta for 5 months. Thesubjects of age 18 years, hypertensive out-patient covered with Askes insurance, and ?1 visitwith uncontrolled BP were included. Hemodialysis subjects were excluded. Subjects weregrouped into with/without comorbid. The BP profile was analyzed with T-test, repeatedmeasurement Anova, and odds ratio. Results: subjects consisted of without (WO) (n=268) vs.with comorbid (W) (n=401) patients. Comorbid subjects had older age, more male proportionand more visits (p0.05). The profiles of final SBP/DBP in WO vs. W subjects were as follow:148.9/89.1 (WO) vs. 143.8/86.1mmHg (W) (p0.05); TI score (-) 0.360.26 (WO) vs. (-)0.380.24 (W) (p0.05); the final SBP: worse BP control 20.9 (WO) vs.16.2% (W), notcontrolled in all visits 38.1 vs. 45.9%, improved 17.5 vs. 23.9%, and good controlled in all visit23.5 vs.13.2%; proportion of subjects reached BP target 40.7% (WO) vs. 37.4% (W) (p0.05);the different of final minus target SBP: (-)9.018.5 vs. (-)13.917.4mmHg (p0.05); correlationbetween TI and variables of SBP (p0.05) with the coefficient (r) at 0.4-0.6 (medium).Conclusion: comorbidity had no effect on TI score; but subjects with comorbid had worse BPcontrol (p0.05); TI score correlated in medium level with SBP.Keywords: Comorbidity Factor, Therapy Intensification, Blood Pressure Control

EFEK PEMBERIAN JUS BUAH PISANG KEPOK (Musa paradisiaca forma typica) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG TERBEBANI GLUKOSA F. Eki Supra Bawati; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: This research aimed to determine the effects of administration of Musa paradisiacaforma typica juice on blood glucose levels and determine what dose of Musa paradisiaca formatypica juice which is most effective for lowering blood glucose levels in rats burdened glucose.This research was experimental with study with one way complete design using 25 male rats weredivided into five groups. Group I (negative control) was given CMC 1%, group II (positivecontrol) was given Glibenclamide dose of 0,64 mg/kgBW and group III, IV, V the rats were given5; 10; 20 mL/kgBW dose of Musa paradisiaca forma typica juice, all of the processes were giventhrough the oral method. Hypoglycemic effect of Musa paradisiaca forma typica juice was testedby following the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents weretaken, at the 0 minutes before the OGTT and also taken at minutes of 15, 30, 60, 90, 120, 180, and240 after the OGTT, from the tested animal that had been gotten the pre-treatment of the negativecontrol, positive control and Musa paradisiaca forma typica juice before. Data of blood glucoselevels was statistically analyzed using one way ANOVA and Scheffe test with 95% convidencelevel. The result of this research showed that Musa paradisiaca forma typica juice can loweringblood glucose levels on rats in burdened glucose. Dose Musa paradisiaca forma typica juice aremost effective in lowering blood glucose levels in a dose was 10 mL/kgBW.Key words: Musa paradisiaca forma typica, blood glucose levels, OGTT

STUDY OF PEAK EXPIRATORY FLOW RATE AMONG VEGETABLE FARMERS USING PESTICIDES IN BOYOLALI DISTRICT, CENTRAL JAVA, INDONESIA Manggala Sariputri; Ari Probandari; _ Hartono; Eti Poncorini Pamungkasari; Isna Qadrijati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Pesticides exposure affects respiratory system. The study of peak expiratory flow rate (PEFR) as a parameter of lung function changes due to limited pesticide among farmers. This cross-sectional study aims to analyze factors affecting PEFR and formulate a model for predicting PEFR among 76 vegetable farmers using pesticides in Tlogolele Village, Boyolali Regency. Data were collected through questionnaire-based interview and clinical examination. PEFR test was conducted using a peak flow meter while cholinesterase level was investigated using Deutsche Gessellschaftfur Klinische Chemie method. The data were analyzed using unpaired T-test and Pearson test continued by multivariate regression models. The examination showed 75% of subjects had abnormal PEFR. Cholinesterase, body mass index, smoking habits, personal protective equipment usage, pesticide dosage, length of work per day, and last time of spraying did not show a significant correlation with PEFR. On the other hand, age, height, weight, frequency of spraying, and spraying duration showed a significant correlation with PEFR and a prediction equation for PEFR model was obtained as R2=0.268 (p0.001). The developed model will be useful for early detection of abnormal lung function.

Page 1 of 17 | Total Record : 166

1 2 3 4 5

Filter by Year

2012 2023

Filter By Issues

All Issue Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2016) Vol 13, No 1 (2016) Vol 12, No 2 (2015) Vol 12, No 1 (2015) Vol 11, No 2 (2014) Vol 11, No 1 (2014) Vol 10, No 2 (2013) Vol 10, No 1 (2013) Vol 9, No 2 (2012) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA