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Jurnal Farmasi Sains dan Komunitas (JFSK)

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : -

Articles 166 Documents

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ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF AVOCADO SEED (Persea americana Mill.) Caecilia Desi Kristanti; Fransisca Puspa Jelita Simanjuntak; Ni Kadek Pramita Anggara Dewi; Skolastika Venita Tianri; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

The purpose of this research is to evaluate the anti-inflammatory and analgesic activities of infusion and methanolic extract from avocado seeds. The anti-inflammatory activity was determined using carrageenan-induced paw edema in mice. The analgesic activity was assessed using acetic acid stimuli to induce peripheral pain in mice. Results of this research showed that both all level doses of infusion and methanolic extract of avocado seeds have a significant reduction on the mice paw edema. All level doses of methanolic extract of avocado seeds have a significant reduction on the number of abdominal writhes induced by acetic acid, but only the lowest dose of infusion showed a significant reduction. Our findings suggest that avocado seeds contains potential anti-inflammatory and analgesic compounds which support its traditional use. Further phytochemical studies are required to determine the active compounds are actually responsible for such properties.

EFEK PROTEKSI DEKOKTA KULIT ALPUKAT PADA HEPAR TIKUS TERINDUKSI KARBON TETRAKLORIDA Phebe Hendra; Paramita Liong; Brigita Wina Rosari Putri; Angeline Syahputri Fransiskus; Fransisca Andriani; Asih Putriati; Theresia Eviani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

The decoction of avocado peels was tested for their hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rat. The rats were treated with the decoction of avocado peels at doses of 363; 762, 1600 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2 mL/kg) was given on the 7th day. Different groups of rats were given water decoction of avocado peels at a dose of 363; 762, 1600 mg/kg and after 6 hours received carbon tetrachloride (2 mL/kg), respectively. The degree of protection was measured by using biochemical parameters like serum transaminase, alkaline phosphatase and albumin. From these results it suggested that the decoction of avocado peels 762, 1600 mg/kg for 6 hours has a potent hepatoprotective action upon carbon tetrachloride-induced hepatic damage in rats.

HEPATOPROTECTIVE EFFECT OF FOREST HONEY ON CARBON TETRACHLORIDE INDUCED FEMALE WISTAR RATS Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Hepatoprotective effect study of forest honey had been conducted on a female rat induced with carbon tetrachloride (CCl4). The study aimed at obtaining the scientific data and the evidence of forest honey as hepatoprotective agent on the rat. The study was a true experimental study with a single factor completely randomized design. Thirty rats were randomly divided into six groups (n=5). Group I received carbon tetrachloride 2.0 mL/kgBW intraperitoneally, group II received olive oil 2.0 mL/kgBW intraperitoneally, group III received forest honey 8.1 mL/kgBW (6 days, peroral), groups IV, V, VI were given forest honey 3.6, 5.4, 8.1 mL/kgBW (6 days, peroral) and intraperitoneal induction of carbon tetrachloride 2 mL/kgBW on seventh day. The blood sample of all rats were taken for ALT-AST measurement and their liver were sampled for histological examination of the liver cell. Groups I and III on the seventh day, group II on the second day, groups IV,V,VI on the eighth day. The result showed that a forest honey can be used as a hepatoprotective agent on the female rat Wistar strain induced by carbon tetrachloride 2 mL/kgBW with doses 3.6, 5.4, 8.1 mL/kgBW.

ISOLASI SITRONELLAL DARI MINYAK SEREH WANGI (Cymbopogon winterianus Jowit) DENGAN DISTILASI FRAKSINASI PENGURANGAN TEKANAN Lucia Wiwid Wijayanti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: It has been carried out the isolation of citronellal from citronella oil by fractinational distillation under reduced pressure. From 500 g citronella oil, citronellal has been received at the amount of 10 g with the purity of 81.30%, 210 g with the purity of 99.14%. Keywords: isolation of citronellal, citronella oil, fractional distillation under reduced pressure

OPTIMASI FORMULA TABLET EFFERVESCENT EKSTRAK RIMPANG JAHE MERAH (Zingiber officinale Roxb. Var rubrum) Henny Dwi Arini; Lannie Hadisoewignyo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract:This study aims to determine the effect of sodium citrate and fumaric acid as a source ofacid in the tablet formula effervescent red ginger rhizome extract (Zingiber officinale Roxb. varrubrum) and obtain the optimum composition of the formula that has the physical properties oftablet effervescent red ginger rhizome extract (Zingiber officinale Roxb. var rubrum) that meetthe requirements. Optimization techniques used in research is a method of factorial design withtwo factors and two levels of sodium citrate and fumaric acid with low levels of 80 mg, and highlevels of 120 mg. Responses were observed to obtain optimum formula is hardness, friability, andthe soluble tablet (effervescent time). The result is the concentration of sodium citrate andfumaric acid did not significantly affect tablet hardness effervescent. Meanwhile, that issignificantly influences the friability and time effervescent soluble tablets. However, theinteraction between sodium citrate and fumaric acid did not significantly affect the hardness,friability, and the soluble tablet effervescent red giinger extract. Optimum formula tabletsobtained effervescent namely sodium citrate 80 mg and 80 mg of fumaric acid with 6,529 kgfresponse tablet hardness, tablet friability 0,1354%, and effervescent time of 5,98 minutes.Key words : Red ginger, effervescent tablet, factorial design

SIMPLE AND RAPID METHOD FOR ISOLATING ANTHOCYANIN FROM WILD MULBERRY (Morus nigra L.) Rollando Rollando; Christopher Daniel Kurniawan; Ririn Nurdiani; Sophia Yusnita Wahyu Timur; Paulina Genoveva Moza
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Wild mulberry (Morus nigra L.) is a kind of berries that has a high content of anthocyanin pigment. Anthocyanin is a natural pigment that has good biological activity so that widely be used as both food and drug ingredients. There are many studies conducted that have isolation anthocyanin from mulberry extract, but most of them used various expensive methods and the process included several steps that make them not cost-effective nor time-efficient. This research was conducted in order to do an isolation of anthocyanin from wild mulberry through a single step. The extraction of compounds was done by maceration and the isolation was done by thin layer chromatography method. The isolation product was identified with reagents, consisting of ferric chloride and sodium hydroxide, and with spectrophotometry methods, consisting of UV-Vis and infrared spectrophotometry. As result, this research was able to isolate anthocyanin from wild mulberry fruit by thin layer chromatography method. The identification with spectrophotometry methods indicated that the isolated compound hypothetically was anthocyanidin-3-O-rutinoside.

PEMANFAATAN EKSTRAK TERSTANDARDISASI DAUN SOM JAWA (Talinum paniculatum (Jacq.) Gaertn) DALAM SEDIAAN KRIM ANTIBAKTERI Staphylococcus aureus Wahyuning Setyani; Hanny Setyowati; Dewi Ayuningtyas
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Infectious diseases have been the leading cause of morbidity and mortality because of the widespread antibacterial resistance due to existing drugs. Thus, the discovery and development of new antimicrobial agents, especially from natural resources is important to promote the human health.This research aimed to examine the antibacterial activity of som jawa (Talinum paniculatum (Jacq.) Gaertn.) standardized extract thus their application into cream. Extraction was done by remaceration method, then followed by phytochemical investigation to obtain the active ingredients inside extract. The result of this research showed that both som jawa standardized extract and their formula cream had antibacterial activity towards Staphylococcus aureus. This formula cream was potential as alternative herbal medicine for skin infection caused by Staphylococcus aureus.

SINTESIS LAKTOGENIN DARI TETRAHIDROFURAN-3-KARBOKSALDEHIDA DAN 2-ASETIL-?-BUTIROLAKTON DENGAN KATALIS NATRIUM METOKSIDA Jeffy Julianus; Laurensius Widi Andhika Putra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Acetogenin compound known for its activity as anticancer by inhibited the NADHubiquinone reductase contained in the mitochondria. These compounds with high liphophilicityproperties have a weakness in solubility with log P 8.44, so modifications to improve thesolubility by maintaining a core group of tetrahydrofuran and ?-lactone as well as shortening thealkyl chain is needed. The modified compounds was lactogenin or 3-(3- (tetrahydrofuran-3-yl)acryloyl) dihydrofuran-2(3H)-one) that have a log P 0.90 and is expected to have a bettersolubility properties than acetogenin. Lactogenin synthesis was based on cross-aldolcondensation reaction by reacting tetrahyrdofuran-3-carbaldehyde and 2-acetyl-?-butyrolactone using sodium methoxide as catalyst. The synthesized compounds were red solutionwith specific smell. The TLC result showed the new products at Rf 0.314. The purity test by gaschromatography showed 74.07% purity. The structure elucidation by infrared and massspectroscopy showed that the synthesized compound was ?-hydroxy lactogenin or 3-(3-hydroxy-3-(tetrahydrofuran-3-yl) propanoyl) dihydrofuran-2(3H)-one.Keywords: NADH-ubiquinone oksidoreduktase, lactogenin, cross-aldol condensationreaction, ?-hydroxy lactogenin

HERBS USED AS ANALGESIC BY DAYAK TRIBE IN NORTH KALIMANTAN INDONESIA Irma Novrianti; Faizal Mustamin; Suharjono Suharjono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Traditional medicines produced from medicinal plants have played an important role in disease treatment in Dayak Tribe, North Kalimantan. Northern Kalimantan belongs to a remote area where health facilities like healthcare center (puskesmas pusat kesehatan masyarakat) and hospital are not easily accessible. This research aims to investigate herbs used by Dayak tribe in North Kalimantan for treating pain. It is a descriptive research applying two research methods i.e. observation and interview. We directly observed the research object and proposed questions to respondents that were traditional healers from each village. The research was conducted in nine villages within three regencies in North Kalimantan. Meanwhile, 38 herbs collected in this research were from 26 families and 34 species. Four species were still locally named. The highest proportion of the herb family used was Asteraceae. The most frequently used part of the herb for medicine was the leaf (60.53%). The main serving methods were by boiling the herb and drinking it (63.15%). Bone pain and stomachache were two main illnesses mostly treated by local herb therapy involving 11 herbs. In conclusion, Dayak tribe in North Kalimantan still used herbs to treat their pain.

THE EFFECTIVENESS OF CLOPIDOGREL AS AN ANTITHROMBOTIC COMPARED TO TICLOPIDINE AND ASPIRIN (META-ANALYSIS) Titien Siwi Hartayu; Dewi Setyaningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to treat Acute Coronary Syndrome (ACS). Aim of the study is to compare the effectiveness of Clopidogrel to aspirin and ticlopidine by meta-analysis of CLASSICS (The Clopidogrel Aspirin Stent International Cooperative Study), MATCH trial dan CAPRIE trial. Results of the study show that the effectiveness of Clopidogrel is significantly higher, however the risk of ischemic and bleeding is lower than aspirin and ticlopidine. Cost-effectiveness of Clopidogrel in avoiding secondary stroke in one episode is approximately US $ 33,000, and aspirin is only US $ 1400. In Indonesia the price of Clopidogrel is ranged from US $1.5 to US $3 each tablet, while the price of aspirin ranged from US $ 0.35 to US $ 0.72. However, in Indonesia Clopidogrel is now in the list of National Formulary, this fact might have contributed to the increasing use of Clopidogrel, which has reached around 1000 tablets per day in each hospital while aspirin has reached almost 1500 tablets per day.

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