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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 500 Documents
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2015: The beginning of the end of the war against malaria Richard Tjan
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.77-78

Abstract

In May 2015 the 62th World Health Assembly formulated a global malaria strategy for 2016-2030 aiming to “reduce the global disease burden by 40% by 2020, and by at least 90% by 2030. It also aims to eliminate malaria in at least 35 new countries by 2030”.(1) As a reminder, it was 60 years ago that the Eighth World Health Assembly decided in 1955 to shift from malaria control to malaria eradication, with the aim to make many areas of free of malaria “within 10 to 15 years”.(2) This has yet to be accomplished in many malaria endemic countries such as Indonesia, where the earliest program was the malaria eradication program of 1959, evolving into the malaria control program, the roll-back malaria program, and finally in 2012 into the malaria elimination program.(3) In view of the ever-present insecticideresistance
Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats Sunarti Sunarti; Edy Fachrial; Urip Harahap; Delyuzar Delyuzar; Tri Widyawati; Lokot Donna Lubis
Universa Medicina Vol. 36 No. 3 (2017)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.228-235

Abstract

BACKGROUNDNon-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.METHODSA study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.RESULTS    The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p<0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p>0.05).CONCLUSIONDeep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.
The specter of resurging communicable disease epidemics Richard Tjan
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.139-140

Abstract

In developing countries there still are differentials in immunization coverage between regions, such as in Indonesia for measles vaccination between urban and rural regions, as reported in 2007.(1) Therefore, it may not be surprising to hear about local or even national outbreaks of communicable disease in these countries. However, that an epidemic should occur in developed nations with relatively complete immunization coverage, comes somewhat as a surprise. The epidemic referred to is the whooping-cough epidemic occurring this year in the USA, and on a smaller scale in Europe, particularly in the UK.
Homocysteine and cognitive function in the elderly Pusparini, Pusparini
Universa Medicina Vol 28, No 2 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.106-116

Abstract

Dementia is prevalent among elderly people, and projections show that the number of affected might triple over the next 50 years, because of a large increase in the oldest segment of the population. The objective of this study was to investigate the relationship between cognitive function and serum homocysteine level. This study was a cross-sectional study carried out in Mampang district, South Jakarta. A total of 94 elderly people was recruited for this study consisting of 44 females and 50 males. In this study serum homocysteine level was assessed by fluorescent polarization immunoassay and cognitive function with the mini mental state examination (MMSE). In elderly women MMSE scores for plasma homocysteine concentrations of &lt;11.7 mmol/L, 11.7-14.9 mmol/L and &gt;14.9 mmol/L were 24.00 ± 3.68, 23.80 ± 6.51, and 20.80 ± 9.00 respectively, with p=0.000. In elderly men the MMSE scores for plasma homocysteine concentrations of &lt;11.7 mmol/L, 11.7-14.9 mmol/L and &gt;14.9 mmol/L were respectively 27.66 ± 2.06, 26.33 ± 3.79 and 24.03 ± 5.52 with p=0.008. Homocysteine concentrations of &gt;14.9 mmol/L were more commonly found in males (66%) than in females (22.70%). The results of a regression analysis indicated that the factors influencing cognitive function were level of education (p=0.001) and age (p=0.035), whereas gender and homocysteine concentration did not affect cognitive function (p=0.554 and p=0.714, respectively). Plasma homocysteine concentration was inversely related to cognitive function. The most important factors affecting cognitive function were level of education and age.
Prevalence of osteoporosis increased in postmenopausal women with postural scoliosis Rachmawati, Maria Regina; Sidarta, Nuryani; Bastian, Yefta D.
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.63-70

Abstract

BackgroundMenopause is an aging process of the female reproductive system characterized by reduced estrogen levels. This results in increased osteoclastic activity, causing increased bone resorption and thus reduced bone mineral density (BMD). In addition to being influenced by osteoclastic activity, BMD of the lumbar vertebrae is also affected by the erector spinae muscle. The purpose of this study was to determine an association between postural scoliosis and erector spinae muscle endurance and its relation to BMD in postmenopausal women. MethodsThis was a cross-sectional study conducted on postmenopausal women, who were selected by simple random sampling among residents of Mampang Prapatan subdistrict. The postural abnormality of scoliosis was determined by physical examnation, while erector spinae muscle endurance time was assessed using a modified Biering-Sorensen technique, and BMD was measured by bone mineral densitometry, to categorize into normal, osteopenia, and osteoporosis.ResultsA total of 213 postmenopausal women with mean age of 53.52 ± 3.64 years participated in the study. The prevalence of scoliosis was 54.0%, and osteoporosis was 38.1%. The prevalence of osteoporosis was higher in women with scoliosis (48.7%) in comparison with those without scoliosis (31.6%) (p=0.411). In postmenopausal women with strong erector spinae muscle endurance the risk of of scoliosis was lower (0.76;95% Confidence Interval = 0.58 - 0.99) ConclusionsIn post menopausal women with postural scoliosis found a higher incidence of osteoporosis. High endurance of erector spinae muscle lowers the risk of scoliosis. Exercise to improve posture and increase endurance of erector spinae muscle need to be done to prevent decline of BMD.
Age decreases quality of life in adolescents with intractable epilepsy Prastiya Indra Gunawan; Theresa Laura Limanto; Darto Suharso
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.104-111

Abstract

BackgroundIntractable epilepsy considerably affects both the private and social life of the patient. The objective of this study was to determine the quality of life of intractable epileptic adolescents and its correlated factors. Methods A cross sectional study was conducted in the Pediatric Neurology outpatient clinic of Dr. Soetomo Hospital. All intractable epileptic adolescents aged between 10 to 16 years were asked to complete a questionnaire on quality of life in epilepsy for adolescents (QOLIE-AD-48). A multiple linear regression was used to analyze the data through SPSS v17.0.ResultsThirty one patients with mean age of 12.41 ± 1.40 years were enrolled in the study. The mean duration of diagnosed intractable epilepsy was 6.12 ± 4.30 years. Mean score for impact of epilepsy was 57.11 ± 24.50, for memory and concentration 53.54 ± 26.66, physical functioning 65.56 ± 23.67, social stigma 52.23 ± 17.48, social support 52.64 ± 22.69, behavior at school 57.51 ± 26.50, attitude 53.40 ± 16.70 and health perception 61.51 ± 11.30. Multiple linear regression results showed that quality of life (QOL) was not significantly correlated with duration of epilepsy, sex and nutritional status (p>0.05), but increasing age was significantly decreases quality of life (p<0.05). ConclusionsIntractable epileptic adolescents have higher scores for physical functioning and health perception, but lower scores for social stigmatization. Social support has extremely low scores. Increasing age decreases quality of life in adolescents with intractable epilepsy.
Safety of bronchoscopic guided percutaneous dilatational tracheostomy in ICU patients in Tabriz City Hejazi, Mohammad Esmaeil; Rezazadehsaatlou, Mohammadamin; Namvar, Leila; Sadeghi, Armin; Hejazi, Veghar; Hejazi, Yasin; Aghazadeh, Katrin Buyuk
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.173-178

Abstract

BACKGROUNDTracheostomy is one of the most frequently performed procedures in intensive care units. The widespread attraction of percutaneous dilatational tracheostomy (PDT) is increasing in modern intensive care units (ICU). Bronchoscopic guidance seems to secure the safety of the technique. Multiple studies done to explain characterize differences in complications and cost-effectiveness of open and percutaneous tracheotomy. The objective of this study was to evaluate the benefits of percutaneous dilatational tracheostomy (PDT) using the Ciaglia technique with bronchoscopic guidance.METHODSA total of 100 elective percutaneous dilatational tracheostomies using the Ciaglia technique with a little modification were performed under flexible fiber optic bronchoscopic guide. The demographic variables were recorded, the underlying cause for patient’s referred to the center for PDT, and intraoperative as well as early postoperative complications. Patients followed for several days after tracheostomy for early complications.RESULTSNo severe complications related to percutaneous dilatational tracheostomy were noticed during and after the procedure. Three patients had bleeding during incision and two led to subcutaneus hematoma. There were no other complications such as infection, emphysema and puncture of  posterior wall.CONCLUSIONSWe recommended the use of endoscopic guidance bedside percutaneous tracheostomy using the Ciaglia technique with a little modification because it is safe and simple to do without significant complications. PDT with bronchoscopic guidance is a safe and easy procedure that can be done at the bedside setting.
Paclitaxel-carboplatin chemotherapy induced hematologic toxicities among epithelial ovarian cancer patients Charles, Afandi; Dewayani, Birgitta M.; Sahiratmadja, Edhyana; Winarno, Gatot N.A.; Susanto, Herman
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.165-170

Abstract

BackgroundEpithelial ovarian cancer (EOC) is one of the most common cancers diagnosed in Indonesian women. A combination of paclitaxel and carboplatin is used to treat EOC as standard chemotherapy which is known to have hematologic toxicities. This study aimed to investigate the effect of combined paclitaxel-carboplatin chemotherapy on hematologic status in EOC patients managed at Dr. Hasan Sadikin General Hospital, Bandung, West Java.MethodsAll patients with confirmed pathological diagnosis of EOC at Dr. Hasan Sadikin General Hospital in the period of 2013 to 2014 were registered. Only patients with complete hematologic data before and after chemotherapy were collected and compared using the paired non-parametric Wilcoxon and McNemar tests. ResultsIn total there were 147 patients with EOC (median age 46 ± 12 years), with the most dominant pathological diagnosis of mucinous (32.7%) and serous (29.3%) types. Only 33 patients had hematologic data before the initiation of chemotherapy. There was a significant decrease after chemotherapy including hemoglobin level (12.0 vs 10.9 g/dL, p=0.013), erythrocyte count (4.53 vs 3.74 million/mL, p&lt;0.001), leukocyte count (7,700 vs 4,000/mm3 p&lt;0.001) and platelet count (343,000 vs 215,000/mm3, p&lt;0.001). Interestingly, anemia cases after chemotherapy were predominant (87.9%) compared with erythopenia, leukopenia, thrombocytopenia i.e. 39.4%, 57.6%, and 27.3% respectively. ConclusionsThis study confirmed the hematologic toxicities after paclitaxel-carboplatin chemotherapy in EOC patients treated in Hasan Sadikin General Hospital, West Java. The hemoglobin concentration may serve as prognostic factor. Further studies directed to other factors such as genetic factor for polymorphisms may be encouraged to explore the decrease of the hematologic indices.
Factors influencing length of stay in the Emergency Department in a Private Hospital in North Jakarta Juss, Irwan
Universa Medicina Vol 27, No 4 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.165-173

Abstract

Length of stay (LOS) is a key measure of Emergency Department (ED) throughput and a marker of quality objectives. Time studies that assess ED services may help to clarify the causes of prolonged ED service to patients. The objective of this study was to analyse factors influencing LOS in the ED of Private Hospital X. This study was conducted at the ED of Private Hospital X in North Jakarta. One hundred and seventy one adult patients were admitted via the over a period of three weeks in March 2008. Data recorded included characteristics of patients, service time of nurses, service time of physicians, and overall ED LOS. Anova and independent t-test were performed to determine factors associated with ED LOS. Elderly patients, patients in emergency status, patients with letters of referral, electrocardiogram (ECG) training for physicians and advance cardiac life support (ACLS) training for nurses were significantly associated with duration of service in the ED. Mean ED LOS was 50 ± 20.7 minutes. Patient category and characteristics of physicians and nurses are important independent variables that influence the ED’s duration of service. Future research is necessary to determine how these and other factors can be incorporated into a model for predicting ED LOS.
Day-care patients and inpatients have similar visual acuity Kartadinata, Erlani
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.22-28

Abstract

Cataract is a cause of avoidable blindness and its prevalence increases with age. Cataract surgery is the only possible therapeutic modality for improving visual function in cataract patients. The rising numbers of cataract patients require a type of cataract surgery with minimal side effects and without hospitalization. In this connection the day care cataract surgery has been introduced, with excellent results. Therefore the aim of the present study was to compare the visual acuity of day-care patients and inpatients after extracapsular cataract extraction (ECCE). A comparative observational study was carried out on 30 mature senile cataract patients with regard to type of care after ECCE surgery. The study subjects were allocated to two groups of 15 subjects each, i.e. the day-care group and the in-patient group. The patients were observed postoperatively on the first day, first week, fourth week, and eighth week. They subsequently were corrected for best visual acuity. Hypothesis testing was done using independent t-test and the Mann-Whitney test. The study results indicated that the visual acuity of the subjects after the eighth postoperative week did not differ significantly between both groups (p&gt;0.05). There was no significant difference in outcome or risk of postoperative complications between day care and in-patient cataract surgery.This study therefore presents evidence that both post-ECCE day-care as well as post-ECCE inpatients had similar visual acuity levels.

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