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Jurnal Fitofarmaka Indonesia

fitofarmakaindo
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Published by Universitas Muslim Indonesia

ISSN : 23560398 EISSN : 25412329 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.

Arjuna Subject : -

Articles 125 Documents

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PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Aminah Aminah; Nurhayati Tomayahu; Zainal Abidin
Jurnal Fitofarmaka Indonesia Vol 4, No 2 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Avocado plant (Persea americana Mill.), belongs to Lauraceae family which have medicinal properties. Avocado peel contains flavonoid compounds that can be used to protect and reduce the skin damage against UV rays. This study aimed to determine the total flavonoids content of the ethanol extract of the avocado peel using UV-Vis spectrophotometry. The ethanol extract of avocado peel was obtained by maceration with ethanol. The qualitative analysis used FeCl3 by forming green complex. The determination of total flavonoids content is conducted based on AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at the maximum wavelength of 435 nm. The result showed that the average content of flavonoid total is 4.0122 mgQE/g extract.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL BUNGA BROKOLI (Brassica oleracea L. var. Italica) DENGAN METODE DPPH (2,2 diphenyl-1-picrylhydrazyl) dan METODE ABTS (2,2 azinobis (3-etilbenzotiazolin)-6-asam sulfonat) Fitriyanti Jumaetri Sami; Sitti Rahimah
Jurnal Fitofarmaka Indonesia Vol 2, No 2 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Telah dilakukan penelitian uji aktivitas antioksidan ekstrak metanol bunga brokoli (Brassica oleracea L. var. Italica) dengan menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) dan metode ABTS (2,2-Azinobis (3-etilbenzotiazolin)-6-asam sulfonat). Bunga brokoli diekstraksi secara maserasi dengan menggunakan pelarut metanol. Ekstrak bunga brokoli (Brassica oleracea L. var. Italica) dibuat dalam berbagai konsentrasi dan diuji aktivitas antioksidannya. Pada metode DPPH diperoleh nilai IC50 sebesar 123,698 ppm dan IC50 vitamin C murni sebesar 3 ppm sedangkan pada metode ABTS diperoleh nilai IC50 sebesar 32,1292 ppm dan nilai IC50 vitamin C murni sebesar 6 ppm.

STUDI KOMPARASI KADAR FLAVONOID TOTAL PADA BUNGA ROSELLA MERAH (Hibiscus sabdariffa L.) ASAL KABUPATEN LUWU UTARA PROVINSI SULAWESI SELATAN DAN KABUPATEN KEDIRI PROVINSI JAWA TIMUR Saida I. Suradji; Ahmad Najib; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Red Roselle (Hibiscus sabdariffa L.) is a medicinal plant used by the public as drugs. This plant is efficacious because one contains chemical constituents are flavonoids. Comparative Study of total Flavonoid content in red Roselle (Hibiscus sabdariffa L.) from North Luwu district of South Sulawesi province and the province of East Java Kediri district has done. The aim of study to determine of total flavonoid content in Kediri regency and district of North Luwu using a spectrophotometer. Extraction is done by maceration method using 96% ethanol. Phytochemical screening using the color reaction identification and determine content of Colorimetric method using UV-Vis spectrophotometry at the maximum wavelength of 417 nm. Meanwhile the yield extract red Rosellafrom Kediri (sample I) 12.703% and red Rosella from north Luwu (sample II) 10.44%. Test phytochemical to sample I and sample II positive containing Flavonoids. Test total Flavonoid content to sample I is 0.02816% and sample II is 0.2075%.

ANALISIS AKTIVITAS ANTIOKSIDAN PRODUK SIRUP BUAH MENGKUDU (Morinda citrifolia L.) DENGAN METODE DPPH Rahmawati Rahmawati; A. Muflihunna; Laode Muhammad Sarif
Jurnal Fitofarmaka Indonesia Vol 2, No 2 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

This research is about antioxidant activity analysis of Noni products syrup (Morinda citrifolia L.) using DPPH (1,1-diphenyl-2-picrylhydrazil) method. The research aimed to analysis of antioxidant activity of two different brands of Noni products syrup using spectrophotometer UV-Vis. This analysis using quarcetin as standard to determine antioxidant activity and DPPH reagen as radical sources. Quarcetin and Noni products syrup are made five series concentrations in metanol. One ml of each concentration added 4 ml DPPH 50 µM and then added metanol up to 10 ml in flask. Then incubated for 30 minutes at room temperature and protected from light. Measurement of absorbance using spectrophotometer UV-Vis at 514 nm. The IC50 values were 25.7 µg/mL for brand A, and 9.839 µg/mL for brand B.

SKRINING FITOKIMIA DAN PENETAPAN KANDUNGAN FLAVONOID TOTAL EKSTRAK METANOLIK HERBA BOROCO (Celosia argentea L.) Abd. Malik; Ferawati Edward; Risda Waris
Jurnal Fitofarmaka Indonesia Vol 1, No 1 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Phytochemical Screening and Determination of Total Flavonoids Content of Methanolic Extracts of Boroco Herbs (Celocia argentea L). Boroco plant is often used as a traditional medicine for anti inflammatory, diuretic, hypertension, dysentery. Chemical constituents in boroco herbs (Celocia argentea L.) are alkaloids and flavanoids, glycosides, tannin and saponin (2003) . Each sample extraction using 96 % methanol of maceration method. Then performed to determine the class of phytochemical screening of active compounds are contained in the sample. Determination of total flavanoids done by chang et al method (2002) of Boroco herbs. Result of the study showed the total flavanoids content of methanolic extract of boroco herbs calculated as a rutin for 2.57%.

IDENTIFIKASI GOLONGAN SENYAWA ANTIOKSIDAN DENGAN MENGGUNAKAN METODE PEREDAMAN RADIKAL DPPH EKSTRAK ETANOL DAUN Cordia myxa L. Rezki Amriati Syarif; Muhajir Muhajir; Aktsar Roskiana Ahmad; Abd. Malik
Jurnal Fitofarmaka Indonesia Vol 2, No 1 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Cordia myxa L .leaf is a plant from Boraginaceae family which is traditionally used as medicine of several skin diseases . The purpose of thid research is to know the chemical compound antioxidant activity of ethanolic extract of Cordia myxa L. leaf. The used extraction method was maceration method using 70% as solvent. Identification of coumpound group used color reaction and precipitation method respectively. While antioxidant activity test used free radical scavenging method of DPPH (1,1-dyphenyl-2 pycril Hydrazil). From the extraction result, that was found that %redamen of ethanolic extract of Cordia myxa L .leaf 2.76%. While the determination of chemical compound showed that ethanolic extcract of Cordia myxa L .leaf containing steroid, flavonoid, saponin, and phenol. The result antioxidant activity assay showed that ethanolic extract of Cordia myxa L .leaf has intermediate free antiradical activity with IC50 value 54.92 µg/mL. But it is potensial is lower than Quarcetin which has IC50 value 0.52 µg/mL.

EVALUASI STABILITAS FISIK DAN PROFIL DIFUSI SEDIAAN GEL (MINYAK ZAITUN) A. Mumtihanah Mursyid
Jurnal Fitofarmaka Indonesia Vol 4, No 1 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Olive oil contains vitamin E which is a natural antioxidant that is effective to prevent premature aging. The aims of the research was to obtained the most stable gel formulation of polyfloral honey phamaceutically.Physical stability evaluation carried out to in which the parameters were organoleptic, viscosity measurement, homogeneity, spreedability, pH, and flowing type, at 5oC and 35oC for 12 hours on each temperature for 10 cycles.Organoleptic assay showed that there was on change in color, odor, and concistency of all formula. Based on statistic analyses by Randomized design exhibited a significant change during storage. Homogeneity test showed that all formula posses even particle distribution. Spreedability test showed that all formula there were changes in viscosity. Based on rheogram exhibited thixotrophy-plastic flow type. From physical evaluation obtained formula B of gel was the must stable (Base gel of HEC). Based on release of active substances formula B of gel (Base gel of HEC) showed the highest release of active substances.

UJI AKTIVITAS LARVASIDA EKSTRAK DAUN JARAK KEPYAR (Ricinus communis L.) TERHADAP LARVA NYAMUK Aedes aegypti Wahyu Wira Utami; Aktsar Roskiana Ahmad; Abd. Malik
Jurnal Fitofarmaka Indonesia Vol 3, No 1 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Castor Plant (Ricinus communis L.) belongs to Euphorbiaceae family. In medicine has been used as antioxidant, antihistaminic, antifertility, antimicrobial, antidiabetic, antiinflammatory, antipyretic, and it has activities to larvacidal, molluscicidal and insecticidal. The aim of this study was to determine the level of mosquito larva (Aedes aegypti) mortality after giving of ethanolic extract showed with LC50. Extract obtained by maceration method, rendamen ethanolic extract obtained as much as 6.073%. This research uses 110 instar, III larvae of mosquito (Aedes aegypti), divided into test solution are made with 3 concentrations (10 µg/mL, 100 µg/mL, 1000 µg/mL), positive control using Abate and negative control using water. Observations were made after 24 hours of treatment. Toxicity test results shows ethanolic extract is an extract that is active as Larvacidal showed LC50 as much as 138,995 ± 1,5 µg/mL < 1000 µg/mL. Based on qualitative testing of the chemical component using TLC method known ethanolic extract of Castor Plant (Ricinus communis L.) leaves contain alcaloids, saponins and flavonoids.

UJI STABILITAS FORMULASI KRIM TABIR SURYA SERBUK RUMPUT LAUT (Eucheuma cottonii. Doty) Hamsinah Hamsinah; Sasanti D. Darijanto; Rachmat Mauluddin
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Over sunlight exposure in long periode may cause skin damage, premature aging, and skin cancer possibilitie. Sunsreen can protect the skin from negative effect of sunlight, it can reduce the negative effect of UV radiation. Seaweed powder Eucheuma cottonii. Doty is one of the sea plants that can be used as a sunscreen. The objective of this research was to evaluate the physical stability of cream seaweed powder (Eucheuma cotonii. Doty). Cream evaluation included organoleptic, pH, viscosity, freeze an thaw, and sentrifuge test. The organoleptic examination that has been done does not change the smell, color, fungal growth, and does not form a layer on the surface of the creams, and creams remain homogeneous. Emulsion type of preparation was the water in oil. The effect of storage time on viscosity creams are not significant changes. The result sentrifuge test at a speed of 3800 rpm for 5 hours showed the cream to remain stable, and there was no phase separation. Cream storage at two different temperatures or freeze thaw cycle was stable there were no phase separation until the cycle to six.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BAWANG MEKAH (Eleutherine Americana Merr.) TERHADAP KADAR MALONDIALDEHYDE TIKUS WISTAR (Rattus norvegicus) JANTAN PASCA PAPARAN ASAP ROKOK Melda Mery Andiriyani; Eka Kartika Untari; Sri Wahdaningsih
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Malondialdehyde (MDA) is a biomarker of lipid peroxidation that is closely correlated with level of oxidative stress. The aim of this study was to know ethanol extract activities from E. americana leaves against blood plasma MDA in male Wistar rats exposed by cigarette smoke using tiobarbituric acid test. The simplicia extracted by maseration using 70% ethanol. Twenty four rats were divided into six groups, i.e. : a normal group, an exposed cigarette smoke (negative) control group, a positive control group and three treatment groups. One normal group received carboxyl methyl cellulose and another groups exposed cigarette smoke during 14 days. Positive control group received vitamin E (18mg/kg BW), and another groups received ethanol extract of E. americana leaves doses 180; 90; 45mg/kg BW, respectively. The MDA level was analysed by spectrophotometer UV-Visible in 532,2 nm. The MDA level statically analysis by Kruskal-Wallis test and following by Mann-Whitney test. The mean MDA levels of normal group, negative control group, positive control group and groups received ethanol extract of E. americana leaves doses 180; 90; 45mg/kg BW were 0,11±0,09; 13,74±2,84; 0,06±0,03; 10,88±2,19; 0,13±0,03; 0,03±0,02 ppm. The mean MDA levels of groups received ethanol extract of E. americana leaves doses at 180; 90mg/kg BW significantly (p<0,05) lower than negative control group. These results show the beneficial effect of ethanol extract of E. americana leaves in the MDA level reducing on the rats that exposed by cigarette.

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