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Jurnal Fitofarmaka Indonesia

fitofarmakaindo
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Published by Universitas Muslim Indonesia

ISSN : 23560398 EISSN : 25412329 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.

Arjuna Subject : -

Articles 125 Documents

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PENGUJIAN AKTIVITAS ANTIOKIDAN EKSTRAK TERPURIFIKASI DAUN TEH HIJAU DAN JATI BELANDA Abd. Malik; Aktsar Roskiana Ahmad; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 4, No 2 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Teh hijau memiliki nama spesies Camellia sinensis (L.) Kuntze, family Theaceae dan Jati belanda (Guazuma ulmifolia Lam.) termasuk kedalam family sterculiaceae. Ekstrakse dengan metode maserasi termodifikasi microwave dengan pelarut air. Purifikasi ekstrak dengan menggunakan pelarut dengan tingkat kepolaran yang berbeda-beda dimulai dengan petroleum eter, kloroform, etil asetat dan metanol. Pengujian aktivitas antioksidan dengan metode peredaman radikal DPPH. Hasil penelitian dipeoleh rendamen ekstrak terpurifikasi ekstrak teh hijau 13,33 % dan jati belanda 46,66 %.Pengujian antioksidan menunjukkan nilai IC50 jati belanda yaitu 10,13 ppm, lebih besar dibandingkan teh hijau yaitu 31,13 %.

PENGUKURAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam.) MENGGUNAKAN METODE FRAP (Ferric Reducing Antioxidant Power) St Maryam; Muzakkir Baits; Ainun Nadia
Jurnal Fitofarmaka Indonesia Vol 2, No 2 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Measurement of antioxidant activity of ethanol extract of Marunggai leaves (Moringa oleifera Lam) was conducted. The aim research to obtain antioxidant activity using FRAP (Ferric Reducing Antioxidant Power). Marunggai leaves (Moringa oleifera Lam.) ware extracted using maceration method by ethanol 96 %. Free radical activity absorbance was measured with a spectrophotometer at a wavelength of 720 nm and the total value of antioxidant activity was calculated based on the data absorbance. The calculations showed that Marunggai leaves (Moringa oleifera Lam.) have the antioxidant activity with the value 7,923 mg AAE/g extract.

PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK DAUN CENGKEH (Syzygium aromaticum (L.) Merr & Perry) Wahyulianingsih Wahyulianingsih; Selpida Handayani; Abd. Malik
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Clove (Syzygium aromaticum (L.) Merr & Perry) is one of the plants used as medicine, society used leaves as anti-inflammatory drugs at the time of toothache, which at the leaf contained flavonoids. The aim of this study is to determine the content of total flavonoid of ethanol extract clove leaf (EECL). Clove leaf was extracted using maceration method with ethanol as a solvent during at 3 x 24 hours. Analysis qualitative of flavonoids compound using thin layer chromatography method. Determination of total flavonoids content of clove leaves using spectrophotometri UV-Vis method λ 418 nm. The result of the research with rendamen yield of EECL were 16,1134%, and total flavonoids content is 73,08 mgRE/g extract with persentation 7,308%.

UJI TOKSISITAS EKSTRAK DAUN PLETEKAN (Ruellia tuberosa L.) DENGAN MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Nurhawa Vitalia; Ahmad Najib; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 3, No 1 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Minnie root (Ruellia tuberosa L.) belongs to Acanthaceae family. In traditional medicine has been used as diuretic, antidiabetic, antipyretic and antihypertensive and it also recently been incorporated as a component in a herbal tea in Taiwan. This research is aim to determine LC50 value of Minnie root leaves extract (Ruellia tuberosa L.) to Artemia salina Leach shrimp larvae. Dryed samples extracted by graduate maceration with n-hexan, ethyl acetate and ethanol respectively. Rendamen n-hexane extract obtained as much as 1.158%, ethyl acetate extract as much as 2.017% and ethanol extract as much as 3.669 %. Based on qualitative screening used TLC method, ethyl acetate extracts and ethanol extracts of Minnie root (Ruellia tuberosa L.) leaves contain alkaloid, saponin, flavonoid and phenolic compounds. Toxicity assay Artemia salina Leach shrimp larvae have been conducted on leaves extracts of Minnie root (Ruellia tuberosa L.). Toxicity assay on sample extract of Minnie root (Ruellia tuberosa L.) leaves determine by counting the number died of larvae after 24 hours treatment. LC50 on sample calculated by probit analysis method. The toxicity assay showed LC50 of ethyl acetate extracts and ethanol extracts are toxic with LC50 266.07 ± 0.93 µg/mL and 142.160 ± 1.30 µg/mL.

PENETAPAN KADAR FLAVONOID TOTAL DARI EKSTRAK ETANOLIK DAUN BENALU MANGGA (Dendrophthoe pentandra L. Miq) Rizki Yulianti R; A. Amaliah Dahlia; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 1, No 1 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Mistletoes (Dendrophthoe pentandra L. Miq) is one of the medicine plant which used traditionally to remedy the various of disease. Empirically, communities used mistletoes leaves as cough, tonsillitis, measles, cancer, diuretic, and pain relievers. This research is aimed to determine total flavonoid content in extract of mistletoes leaves (Dendrophthoe pentandra L. Miq). Extraction has done with Thin Layer Cromathography (KLT) method to determine active content which in sample. Analysis of chemistry content in ethanolic extract of mistletoes leaves show are flavonoid content. Content of total flavonoid with Chang et al., 2002 method using UV-Vis spectrophotometry at a wavelength of 440 nm. From this research result 39.713 g ethanolic extract with percent of extract rendamen is 6.109% from 650 g dry powder of mistletoes leaves. The results of total flavonoid of ethanolic extract of mistletoes leaves is 2.48% calculated as quercetin.

PENGUJIAN AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI PENYEBAB JERAWAT Virsa Handayani
Jurnal Fitofarmaka Indonesia Vol 2, No 1 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Daun kersen (Muntingia calabura L) merupakan tanaman yang banyak tumbuh di Indonesia,tidak mengenal musim dan digunakan sebagai obat karena memiliki banyak khasiat salah satunya sebagai obat jerawat. Komponen senyawa kimia flavonoid, tannin dan saponin yang terdapat pada daun kersen diduga sebagai antibakteri. Tujuan penelitian ini untuk mengetahui apakah ekstrak etanol daun kersen mempunyai aktivitas antibakteri terhadap Staphylococcus epidermidis. Uji aktivitas antibakteri diakukan dengan metode difusi agar. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kersen memiliki kemampuan menghambat pertumbuhan Staphylococcus epidermidis pada konsentrasi 1ppm, 3ppm, 5ppm, 9ppm, ekstrak etanol daun kersen efektif menghambat pertumbuhan Staphylococcus epidermidis.

PENENTUAN KADAR FENOLIK TOTAL EKSTRAK ETANOL DAUN NILAM (Pogostemon cablin Benth.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Masdiana Tahir; A. Muflihunna; Syafrianti Syafrianti
Jurnal Fitofarmaka Indonesia Vol 4, No 1 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

One of the plants that is well known in the community and is used as a traditional medicine is patchouli (Pogostemon cablin Benth.). It contains essential oils, flavonoids, saponins, tannins, glycosides, terpenoids and steroids. The alcohol content, such as patchouli alcohol and its derivatives, phenol, and a group of terpenoids in patchouli oil has antibacterial activity. The aim at this research to determine the total phenolic condition the ethanol extract from the patchouli leaves. The extract obtained was analyzed ist content using UV-Vis spectrophotometer. The measurements were done at the maximum wavelength of 662,85 nm. The result showed that the total phenolic in patchouli leave is 327,84 mgGAE /gram of extract.

PENGEMBANGAN FORMULASI MIKROEMULSI MINYAK SEREH (Cymbopogon nardus) MENGGUNAKAN EMULGATOR SURFAKTAN NONIONIK A Hasrawati; Nursiah Hasyim; Nur Alif Irsyad
Jurnal Fitofarmaka Indonesia Vol 3, No 1 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Citronella oil (Cymbopogon nardus) is an essential oil which useful as an antibacterial that is usuallyprovided in the form of macroemulsion for topical use. absorption of macroemulsion through the skin relatively low, thermodynamically is not stable and can produce a separate phase in the storage period. The one of development emulsion system to get better characteristics is to form a microemulsion. Microemulsion is an oil and water dispersion stable thermodynamically stabilized by surfactants and in some cases a cosurfactant. The objective of this study was to formulatecitronella oil in the form of a stable microemulsion using nonionic surfactant. Optimization of the type and amount of emulsifier (surfactant) was required to formulate a stable microemulsion. In this study, microemulsion was evaluated during a month. Type and concentration of surfactant, cosurfactant, Citronella oil (Cymbopogon nardus) and water was optimized. A stable citronella oil microemulsion was successfully created with composition of 15% PEG 400 as cosurfactant, 15% tween 80 as surfactant, 2-4% Citronella oil as oil phase and 10% glycerin as humectant and distilled water as aqueous phase. From the observation, microemulsion formula has clear appearance but physically unstable during a month storage

UJI AKTIVITAS ANTIRADIKAL BEBAS EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.) DENGAN MENGGUNAKAN METODE DPPH Linda Erviana; Abd. Malik; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Basil leaves (Ocimum basilicum L.) the plant of the family Lamiaceae that can act as a free radical scavenger, flavonoid compounds. The aim of this research to determine and calculate the IC50 (Ocimum basilicum L.) that has activity as a free radical based on the binding free radical (1,1 diphenyl picryl-hydrazyl). Samplemasceration with ethanol, where in the amount of the extract obtained is 10.16 gr. At the free radical scavenging test ethanol extract has moderate activity with IC50 value is 52.68 μg/mL lower than quercetin with IC 50 value is 1.8 μg/mL.

UJI AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSAN KULIT BUAH NAGA MERAH (Hylocereus polyrhizus Britton & Rose) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 Sri Amalia; Sri Wahdaningsih; Eka Kartika Untari
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Inappropiate antibiotic use was one of the main reason that caused pathogenic microorganism resistance, leads to ineffective treatment. One of those resistance bacteria is Staphylococcus aureus. The research for discovering new antibiotics can help with this issue. The peel of red dragon fruit (Hylocereus polyrhizus) is one of the plants that has antibacterial compounds. The aim of this research is to prove and determine the minimum inhibitory concentration (MIC) value of n-hexane fraction of red dragon fruit’s peel againts Staphylococcus aureus ATCC 25923. The peel was maserated with chloroform, then fractinated by n-hexane. Futhermore, the antibacterial properties of the fraction was tested using Disc Diffusion (Kirby-Bauer) methode with 40, 20 dan 10 mg/mL concentrations. Ampisilin used as control positive. Based on the phytochemical screening of the fraction, the n-hexane fraction of the dragon fruit’s peel contain triterphenoid, steroid and alkaloid. Clear zones produced by 40 mg/mL is 12,80 mm and for 20 mg/mL is 11,17 mm. Wherea concentration 10 mg/mL didn’t show any inhibitory zone. According to this reasearch, the MIC value of the fraction is 20 mg/mL.

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