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INDONESIA
CHEMISTRY PROGRESS
Published by Universitas Sam Ratulangi
ISSN : 19795920     EISSN : 27158365     DOI : -
Core Subject : Science,
Chemistry
Majalah Ilmiah Chemistry Progress merupakan media untuk menyebarkan informasi ilmiah dan sarana komunikasi bagi para ilmuan dan cendekiawan melalui tulisan-tulisan ilmiah. Majalah Ilmiah Chemistry Progress terbit dua nomor dalam satu tahun (Mei dan November) berisi kajian penelitian dalam lingkup ilmu kimia (organik, anorganik, analitik, biokimia, fisika, bahan alam, lingkungan, pangan, kelautan, pertambangan, farmasi dan komputasi). Jumlah halaman pervolume adalah 55-65 halaman.
Arjuna Subject : -
Articles 246 Documents
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KARAKTERISASI METODE PAPER ANALYTICAL DEVICE BERBASIS PENCITRAAN DIGITAL UNTUK DETEKSI KADMIUM Rismiarti, Zuri; Indrawati, Renny
CHEMISTRY PROGRESS Vol 10, No 2 (2017)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.10.2.2017.27744

Abstract

ABSTRAK Logam kadmium merupakan logam yang bersifat toksik dan mencemari lingkungan serta mengalami proses biotransformasi dan bioakumulasi dalam organisme hidup (tumbuhan, hewan dan manusia). Ikan merupakan salah satu biota perairan yang dapat terpapar logam Cd sehingga merupakan sumber masuknya logam Cd ke dalam tubuh manusia. Telah banyak ditemukan keracunan bersifat kronis yang terjadi pada manusia seperti kanker disebabkan paparan logam kadmium. Paper analytical device telah dilaporkan sebagai metode yang efektif, sensitid dan telah banyak diaplikasikan dalam logam berat. Penentuan kadmium dengan metode paper analytical device berbasis kolometri dengan teknik pencitraan digital telah berhasil dikembangkan. Metode ini menggunakan kertas Whatmann yang telah dipreparasi, kemudian diteteskan dengan reagen alizarin red s yang berdifusi melewati kapiler kertas hingga membentuk warna kuning kehijauan. Intensitas warna yang terbentuk difoto dengan kamera kemudian dianalisis secara kolorimetri menggunakan program Image J untuk memperoleh absorbansi pada masing-masing warna komplementer merah, hijau, biru. Penelitian memfokuskan pada karakterisasi metode yang akan dikembangkan meliputi optimasi reagen (alizarin red S dan asam sulfat) serta waktu pengukuran. Hasil penelitian menunjukkan konsentrasi optimum dari Alizarin Red S dan H2SO4 masing- masing sebesar 750 ppm dan 0,05 M dengan waktu pengukuran sebesar 10 menit. Kata kunci: Kertas, analisis, kadmium, alizarin red S, pencitraan, digital     ABSTRACT Cadmium (Cd) in trace amounts as a toxicant and an environmental pollutant. The cadmium metal will undergo biotransformation and bioaccumulation processes in living organisms (plants, animals, and humans). Fish is one of the aquatic biotas that can be exposed to Cd metal which is the source of the Cd into the human body. Chronic poisoning that occurs in humans such as cancer caused by exposure to cadmium metal. Paper analytical device (PAD) has been reported as an attractive tool for analysis with good sensitivity and can apply for heavy metal detection. This research using Alizarin Red S reagent as a chelating agent with Cd metal to produce greenish yellow color complex on paper due to sample movement through the capillary paper. The greenish yellow color complex in a paper was photographed with the digital color camera. To produce absorbance data from each complementary color of Red, Green, Blue by colorimetry analysis using Image J software. This research focuses on optimization of the reagent such as alizarin red s, sulfuric acid, and time of measuring. The result showed that optimum concentration of Alizarin Red S is 750 ppm, sulfuric acid of 0.05 M with stability time for over 10 minutes. Keywords: Paper, analysis, cadmium, alizarin red S, digital color image
PERBANDINGAN KANDUNGAN MINYAK ATSIRI ANTARA JAHE SEGAR DAN JAHE KERING ., Supriyanto; Cahyono, Bambang
CHEMISTRY PROGRESS Vol 5, No 2 (2012)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.5.2.2012.771

Abstract

Jahe (Zingiber officinale var emprit) merupakan salah satu komoditas andalan ekspor Indonesia yang memberikan peranan cukup berarti dalam penerimaan devisa negara. Daya guna bahan ini sangat erat hubungannya dengan komponen bioaktif yang terkandung didalamnya. Kualitas dan kuantitas minyak atsiri jahe emprit segar dan simplisia jahe kering dilaporkan guna memberi informasi kepada masyarakat mengenai efek dari pasca panen. Total minyak atsiri diperoleh melalui destilasi Stahl selama ± 6 jam, sedangkan analisis komponen minyak atsiri dilakukan dengan GC-MS. Hasil penelitian menunjukkan bahwa kadar minyak atsiri jahe segar dan simplisianya masing-masing 3,71% (v/w) dan kadar 0,94 % (v/w). Data GC-MS memperlihatkan bahwa jahe segar memiliki jenis minyak atsiri lebih banyak daripada jahe kering, selain jumlah zingiberinenya lebih dominan. Hasil penelitian dapat memberikan informasi kepada masyarakat bahwa jahe segar lebih baik dibandingkan dengan simplisia jahe kering.Gingeris an important herbal commodities of Indonesia. The utilityof this ginger is related to itsbioactive components. The analysis of qualityandquantity ofessential oilof freshanddriedginger are necessary in order to informaboutpost-harvest to the public. Totalessential oilobtained byStahldistillation for ±6hours, and their components are performedbyGC-MS. The results showed that essential oil of fresh and dried ginger are 3.71% (v/w)and 0.94% (v/w), respectively. GC-MS spectra indicatethatfreshgingerhas many types of volatileessential oil and zingeberenethandriedginger. Therefore, the results of this research can explain the public understanding that the freshgingeris better thandriedginger.
PREDIKSI POTENSI ANTIKANKER SENYAWA TURUNAN XANTHON MENGGUNAKAN HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS (HKSA) Male, Yusthinus; Sutapa, I Wayan; Pusung, Yulian A. D.
CHEMISTRY PROGRESS Vol 11, No 1 (2018)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.11.1.2018.27907

Abstract

ABSTRAK Telah dilakukan penelitian untuk memprediksi potensi antikanker senyawa turunan xanthon menggunakan hubungan kuantitatif struktur dan aktivitas (HKSA) (Quantitative Structure Activity Relationship-QSAR) dengan deskriptor elektronik berupa muatan bersih atom, momen dipol, polarisabilitas, energi HOMO-LUMO, dan Log P yang dihitung menggunakan metode semi empirik PM3. Hasil analisis HKSA menunjukan bahwa model persamaan HKSA terbaik adalah Log IC50 = 18,730 + (-1,042.qC1) + (1,633.qC2) + (3,369.qC3) + (1,257.qC4) + (29,759.qC8) + (53,543.qC9) + (2,337.qC10) + (-0,161.momen dipol) + (1.550.Ehomo) + (-2,919.Elumo) +(0,140.Polarisabilitas) + (0.892. Log P) (n=27; r=0,997; r2=0,993; SE=0,08530; Fhitung/Ftabel=9,1588; PRESS= 50,04021). Penelitian ini menunjukkan bahwa pusat aktif senyawa turunan xanthon terletak pada atom karbon C1, C2, C3, C4 C8, C9 dan C10 sehingga modifikasi substituen pada posisi-posisi ini akan memberikan dampak signifikan terhadap aktifitas antikanker senyawa turunan xanthon  ABSTRACT The research has been done to predict anti cancer potential of xanthon derivative compounds using Quantitative Structure Activity Relationship (QSAR) with electronic descriptor such as : atomic net charge, dipole moment, polarizability, HOMO-LUMO energy and Log P were calculated by semi-empirical PM3 method. The best QSAR model equation were determined from analysis of multiple linear regression. The result of QSAR analysis shows that best QSAR model equation is Log IC50 = 18,730 + (-1,042.qC1) + (1,633.qC2) + (3,369.qC3) + (1,257.qC4) + (29,759.qC8) + (53,543.qC9) + (2,337.qC10) + (-0,161.momen dipol) + (1.550.Ehomo) + (-2,919.Elumo) +(0,140.Polarisabilitas) + (0.892. Log P) (n=27; r=0,997; r2=0,993; SE=0,08530; Fcal/Ftable=9,1588; PRESS= 50,04021). This research also shows that active site of the xanthon derivatives is located on carbon atom C1, C2, C3, C4 C8, C9 and C10 so that the modification of the substituents in these positions will have a significant impact on the anticancer activity of xanthon derivatives. 
AKTIVITAS ANTIOKSIDAN PADA BEBERAPA REMPAH-REMPAH MASAKAN KHAS MINAHASA Sangi, Meiske
CHEMISTRY PROGRESS Vol 4, No 2 (2011)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.4.2.2011.4976

Abstract

Telah dilakukan penelitian untuk menentukan aktivitas antioksidan dari beberapa rempah-rempah masakanMinahasa, yaitu batang sereh, daun kemangi dan daun pandan serta formula yang dibuat dengan kombinasirempah-rempah tersebut.Di dalam penelitian ditentukan kandungan total fenol, aktivitas penangkal radikal bebas dan kandungan totalantioksidan. Penentuan total fenol dilakukan menurut metode Folin-Ciocalteu, penentuan aktivitas penangkalradikal bebas menggunakan metode DPPH. Penentuan total antioksidan dilakukan menurut metode FRAP.Perubahan warna yang terjadi dalam setiap reaksi diukur dengan spektrofotometer Milton-Roy (visible).Berdasarkan hasil penelitian dapat diketahui bahwa sereh dan formula B (sereh + kemangi) memiliki aktivitasantioksidan paling tinggi. Sereh memiliki total fenol sebesar 42,959 mg/kg ekstrak, aktivitas penangkal radikalbebas sebesar 64,85 %, dan total antioksidan sebesar 104 µmol/L. Formula B (sereh + kemangi) memiliki totalfenol sebesar 169,082 mg/kg ekstrak, aktivitas penangkal radikal bebas sebesar 80,39 %, dan total antioksidansebesar 120,875 µmol/L. Dari hasil yang diperoleh dapat diketahui bahwa efek antioksidan akan lebih besar jikamenggunakan kombinasi dari rempah-rempah tersebut.Kata kunci : antioksidan, rempah, fenol, Minahasa
AKTIVITAS PENANGKAP RADIKAL BEBAS DARI EKSTRAK FENOLIK DAUN SUKUN (Artocarpus altilis F.) Suryanto, Edi; Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 2, No 1 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.1.2009.56

Abstract

The objectives of this study was to determine phytochemicals content and free radical scavengingactivities of bread fruit leaves. Bread fruit leaves were finely ground in a laboratory mill and samples wasextracted with methanol, ethanol and acetone under room temperature, respectively. Analyses ofphytochemicals based on total phenolic, flavonoid and condensed tannins. The radical scavengingactivities of extracts were determined by 1.1-diphenyl-2-picrylhydrazyl (DPPH) and the ferric reducingability plasma assay. The highest total phenolic content was in methanol extract (EM), followed byethanol extract (EE) and acetone extract are 179.89 ± 3.17; 152.55 ± 3.17 and 62.46 ± 1.31 mg/Kgrespectively. EM possessed highest contents of total flavonoid and condensed tannins compared with EEand EA. The addition of methanol extracts of in the reaction mixture showed the highest scavengingactivity in 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical 74.80% followed by EE 71.80% and 38.80%.These result suggested that contains phenolic compounds groups having free radical scavengingactivities.
AKTIVITAS ANTIOKSIDAN DARI FRAKSI TONGKOL JAGUNG (Zea mays L.) YANG DIINDUKSI OLEH Fe2+ DAN CAHAYA UV-B Mawardi, Rizky H.; Suryanto, Edi; Sudewi, Sri
CHEMISTRY PROGRESS Vol 9, No 1 (2016)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.9.1.2016.13906

Abstract

This research aims to study the anti UV-B activity from solvent fractions of corncobs. The study initiating by extracting the powder corn cobs using way reflux for two hours with 80% ethanol. Extract then partitioned using a series of solvent; n-hexane, ethyl acetate, butanol and distilled water. Then was determined the effect of fractions against lipid oxidation induced by UV-B light. The results showed that the ethyl acetate fraction showed the lowest content of conjugated diene followed fraction of butanol, n-hexane and distilled water. The content of conjugated diene was 21.89; 25.11; 42.94; and 46.08 mmol/kg, respectively. Based on this study, the fraction of ethyl acetate fraction could act as an antioxidant and anti UV-B better than the other fractionsPenelitian ini bertujuan untuk mempelajari aktivitas anti UV-B dari fraksi pelarut tongkol jagung. Penelitian dimulai dengan mengekstraksi serbuk tongkol jagung menggunakan cara refluks selama dua jam dengan pelarut etanol 80%. Ekstrak kemudian dipartisi berturut-turut menggunakan pelarut n-heksan, etil asetat, butanol, dan aquades. Kemudian ditentukan pengaruh fraksi terhadap oksidasi lipid yang diinduksi dengan cahaya UV-B. Hasilnya menunjukkan bahwa fraksi etil asetat memiliki kandungan diena terkonjugasi terendahdiikuti fraksi butanol, n-heksan dan aquades. Kandungan diena terkonjugasi berturut-turut adalah 21,89; 25,11; 42,94; dan 46,08 mmol/kg. Berdasarkan penelitian ini, dapat disimpulkan bahwa fraksi etil asetat dapat berperan sebagai antioksidan dan anti UV-B lebih baik dibandingkan dengan fraksi lainnya.
KONTAMINASI MERKURI DALAM SEDIMEN DI SUNGAI TALAWAAN Komalig, Rino
CHEMISTRY PROGRESS Vol 3, No 2 (2010)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.3.2.2010.18984

Abstract

ABSTRACTKomalig et al., 2010. Mercury contamination within Talawaan river sediment.Sediment plays an important role in controlling concentrations of heavy metals which accumulate in body tissues aquatic biota. Contamination of mercury in river sediments due to natural processes (weathering of mineralized rocks), the traditional processing of gold (amalgamation), or industrial processes that use raw materials containing mercury.This research is descriptive analytical that is describing the Hg content in the sediment. Sample preparation is done by following the instructions of JPHA, followed by analysis of sediment samples using AAS-CV. Then using Anova test to see the relationship of Hg distribution in the river from the mine based on the distance.Results showed that total Hg in sediment Hg concentrations found differences based on distance, where the farther from the mine, the smaller the concentration of Hg.Keywords : sediment, heavy metals, Hg, river
ANALISIS SENYAWA FITOSTEROL DALAM EKSTRAK BUAH BUNCIS (Phaseolus vulgaris L.) Jannah, Hilyatul; Sudarma, I Made; Andayani, Yayuk
CHEMISTRY PROGRESS Vol 6, No 2 (2013)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.6.2.2013.3497

Abstract

Fitosterol merupakan sterol nabati, termasuk dalam senyawa metabolit sekunder dan memiliki manfaat yang luas dalam bidang kesehatan. Sumber bahan alam yang mengandung senyawa fitosterol telah banyak digunakan sebagai bahan obat, salah satunya yaitu buncis (Phaseolus vulgaris L.). Penelitian ini merupakan penelitian eksplorasi, bertujuan untuk menganalisis kandungan senyawa fitosterol dalam ekstrak air, ekstrak etanol, dan hasil partisi dari ekstrak air buah buncis menggunakan teknik KLT dan KG-SM. Hasil uji fitokimia menunjukkan bahwa dari 13 ekstrak hasil partisi dengan pelarut n-heksan, DCM, etil asetat, dan metanol, hanya 5 ekstrak yang menunjukkan positif steroid, diantaranya ekstrak air, residu heksan, residu DCM, ekstrak metanol, dan residu metanol. Ekstrak etanol juga menunjukkan positif steroid. Hasil uji KLT pada residu heksan hasil partisi dari ekstrak air diduga merupakan senyawa stigmasterol karena memiliki harga Rf = 0,9 sama dengan harga Rf senyawa standar stigmasterol, sedangkan pada ekstrak etanol, senyawa fitosterol yang terdeteksi yaitu γ-sitosterol 6,01% dan stigmasterol 2,48%.
PRODUKSI DAN FRAKSINASI ASAP CAIR DARI LIMBAH TONGKOL JAGUNG UNTUK PENGHAMBATAN PEROKSIDASI LIPIDA IKAN LAYANG (Decapterus russelli) Mongan, Jemsi; Suryanto, Edi; Rumengan, Inneke
CHEMISTRY PROGRESS Vol 4, No 1 (2011)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.4.1.2011.26503

Abstract

ABSTRACTMongan et al., 2011. Production and fractionation of liquid smoke from corn cob to inhibit lipid peroxidation oflaying fish (Decapterus russelli).Corncob is a cellulose material and can be made to liquid smoke by pyrolysis. Liquid smoke from pyrolysis canbe purified using adsorbent. Chitin is an adsorbent produced by crustacea shell. Liquid smoke purified by chitincan act as antimicroba and antioxidant. Layang fish is very abundantly in Gorontalo Province, so preservativetechniques were needed to prevent lipids peroxidation in fish. The aims of this research was to determineantioxidative activity of liquid smoke from corncop to prevent lipids peroxidation on layang fish.This research using laboratory experiment methods to analyze total phenolic content, free radical scavengingactivity, total antioxidant and lipids peroxidation on layang fish by spectrophotometer UV-vis. This researchusing complete random design (rancangan acak lengkap, RAL), thus obtained data were analyzed usingstatistic. Significant difference between groups were analyzed using ANOVA with p<0,05. If there is significantdifference between groups, data were analyzed using Duncan’s multiple range test (DMRT).The results showed that liquid smoke can be produced using corncop by pyrolysis is 31,7 %. Fractioned liquidsmoke using chitin obtained 4 fractions were fraction I, II, III and IV. Liquid smoke and fractioned liquid smokecontain total phenolic content are 280, 273, 280, 286 and 301 mg/kg gallic acid, respectively. Free radicalscavenging activity from liquid smoke and fractioned liquid smoke are 87,39, 86,08, 89,29, 89,90 and 93,73%,respectively. Although, total antioxidant from liquid smoke and fractioned liquid smoke are 59, 35, 51,32, 51,57,52,74 and 53,58 ppm, respectively. Fraction IV of liquid smoke fractioned with chitin was used in antioxidativeactivity of laying fish test. Fraction IV with concentration 25% can inhibit lipid peroxidation on fresh layang fishby 19 mikromolar for two days. Although layang fish without liquid smoke shows high lipid peroxidation by 24,96mikromolar. Fraction IV with concentration 25% can inhibit lipid peroxidation on layang fish by 18,28 mikromolarfor two days. Antioxidative activity from liquid smoke caused by it phenolics compound that act as antioxidant.As conclusions of this research, liquid smoke can be produced from corncob and fractioned with chitin. Liquidsmoke contain phenolics and act as antioxidant. Liquid smoke can inhibit lipids peroxidation in layang fish. Thisresearch suggested that liquid smoke can be used to inhibit lipid peroxidation on layang fish..Keywords : liquid smoke, corn cob, peroxidation, layang fish
STUDI TENTANG PEMBUATAN 1-(3,4-METILENDIOKSIFENIL)- 2-PROPILALKOHOL Fatimah, Feti
CHEMISTRY PROGRESS Vol 2, No 2 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.2.2009.4967

Abstract

A study has been carried out to synthesis of 1-(3,4-methylenediooxyphenil)-2-propylalcohol from safrole. Thesynthesize was done using react the oxymercuration-demercuration by means of mercury of acetate andsodium of boronhydride, while identifying conducted with the liquid gas chromatography and spectrometer.The experimental result show that the percentage yield of 1-(3,4-methylenedioxyphenil)-2-propylalcohol was77,78%. Keywords: 1-(3,4-methylenedioxyphenil)-2-propylalcohol

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