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INDONESIA
Journal of Medicine and Health
Published by Universitas Kristen Maranatha
ISSN : 24425227     EISSN : -     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.
Arjuna Subject : -
Articles 255 Documents
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Karakteristik Klinis dan Tatalaksana Pasien Glaukoma Sudut Terbuka Primer di Pusat Mata Nasional, Rumah Sakit Mata Cicendo, Bandung, Indonesia Azmi I Salsabila; Andika P Gandasubrata; Maula Rifada
Journal of Medicine and Health Vol 5 No 1 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i1.4265

Abstract

Glaucoma is the largest cause of permanent blindness globally. Primary open-angle glaucoma (POAG) is one of chronic glaucoma and is asymptomatic in the early stage. This study was performed to identify the clinical characteristics and management of POAG patients at the Cicendo Eye Hospital, Bandung, Indonesia. This retrospective, descriptive study was conducted on medical records of POAG patients in Cicendo Eye Hospital in January-December 2020 using whole sampling method. Sociodemographic, clinical characteristics, and management data were collected. From 147 subjects obtained, the largest age group of POAG patients was 60-69 years old (30.6%), with most of the patients being male (68.0%). Most of the patients experienced blindness (37.6%) and had cup-to-disc ratio (CDR) 0.9-1.0 (36.8%). The mean of pre-treatment IOP was 29.1±13.1 mmHg, and the mean of post-treatment was 19.3±7.7 mmHg. The mean of anti-glaucoma medication in the first and the last control were 1.93±0.59 and 1.48±0.70, respectively. The most common treatments were medication only (69.8%), with combined surgery as the most performed surgery. In conclusion, most POAG patients were 60 years old or older and male, with most eyes being blind. The POAG treatments were mostly anti-glaucoma medication only to lower IOP as the goals of the treatment.
THE INHIBITION EFFECT OF MORINGA (Moringa oleifera L.) LEAVES AND RED GINGER RHIZOME (Zingiber officinale Rosc.) PT. "P" ETHANOL EXTRACT ON ENHANCEMENT SERUM CREATININE LEVELS OF MALE WISTAR RATS DYSLIPIDEMIA MODEL Juliana Wijaya; Penny S Martioso; Sugiarto Puradisastra
Journal of Medicine and Health Vol 5 No 1 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i1.4528

Abstract

Elevation of serum creatinine levels is a biomarker of decreased kidney function. Dyslipidemia can decrease kidney function. Long-term consuming statins can increase creatinine levels. Moringa leaves (Moringa oleifera L.) and red ginger rhizomes (Zingiber officinale Rosc.) have antioxidant effects. Aim of study is to determine the inhibitory effect on increasing serum creatinine levels of concoction Moringa Leaves and Red Ginger Rhizome ethanol extract (CML-RGRE). True laboratory experimental study with completely randomized design was conducted on 30 male Wistar rat dyslipidemia models, induced by high-fat feeding (HFF)-Propylthiouracil (PTU) 0.01% for 21 days. Subjects were divided into six groups (n=5), Group I, II, III were treated CML-RGRE 135, 202.5, 270 mg/kg BW, IV dyslipidemia control, V Rosuvastatin 1.8 mg/kg BW, and VI fenofibrate 5.4 mg/kg BW, all still given HFF-PTU for 21 days. Serum creatinine levels (mg/dL) were measured 3 times, after acclimatization, created dyslipidemia models, and treatment using spectrophotometer, colorimetric kinetic methods. Data were analysed with paired t-test, ANOVA test, and Fischer's LSD, α = 0.05. All doses of CML-RGRE have effectively inhibited the increase serum creatinine levels (p < 0.01). Conclusion, Moringa Leaves and Red Ginger Rhizome ethanol extract effectively inhibited the increased serum creatinine levels of animal dyslipidemia models.
Uji Validitas Eosinopenia Pada Pasien Sepsis Berdasarkan Kriteria Konsensus Sepsis-3 Adrian Suhendra; Ida Parwati; Adhi K Sugianli
Journal of Medicine and Health Vol 5 No 1 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i1.5351

Abstract

Sepsis remains a major global healthcare problem, indicate as most frequently cause of morbidity and mortality worldwide. The last consensus of sepsis in 2016 defined sepsis as life threatening organ dysfunction caused by a dysregulated host response to infection. Dysfunction of organs can be represented by Sequential [Sepsis-Related] Organ Failure Assessment (SOFA) score. Score2 points or more consequent to the infection. Nowadays, there is ideal biomarkers of sepsis such as procalcitonin (PCT). However, the use of that markers in developing countries are hardly accessible. Eosinopenia is an prepossess biomarker because eosinophil count is always measured in daily practice and considered as a forgotten marker. The study purpose is to determine the validity of absolute eosinopenia in bacterial sepsis patients. This study is a descriptive observational study, collecting 118 patient’s medical record data from the past, diagnosed as sepsis using consensus criteria of Sepsis-3 between January 1st 2018–December 31st 2019. Eosinopenia validity test in sepsis patients showed 92.7% specificity and 71.4% sensitivity. This study also showed significant differences of absolute eosinophil count between positive sepsis patients and negative group with p value <0.001. Eosinopenia had high specificity so it could be used as a marker of diagnostic in septic patients.
Hubungan antara Durasi Penggunaan Gawai Selama Masa Pandemi COVID-19 dengan Computer Vision Syndrome pada Mahasiswa FK Unika Atma Jaya Jakarta Julia R Tanjung; Cornelia T Tantra; Nelson Sudiyono
Journal of Medicine and Health Vol 5 No 1 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i1.5688

Abstract

Pandemi COVID-19 berimbas pada peningkatan durasi penggunaan gawai untuk kegiatan pendidikan daring yang berdampak buruk bagi kesehatan mata, salah satunya, Computer Vision Syndrome (CVS). Penelitian ini bertujuan untuk mengetahui hubungan durasi penggunaan gawai dengan CVS pada mahasiswa kedokteran Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya. Metode penelitian potong lintang dengan 98 responden (76 perempuan, 22 laki-laki) berusia 17-21 tahun, menggunakan Modified computer vision syndrome questionnaire dan aplikasi pengukur durasi penggunaan gawai. Rerata durasi penggunaan gawai adalah 610 menit per hari. Sebanyak 70% responden menggunakan gawai dengan rerata durasi >8,9 jam per hari. Prevalensi CVS ditemukan sebesar 47,9%, dimana 25,5% responden mengalami CVS derajat ringan dan 22,4% responden mengalami CVS derajat sedang hingga berat. Analisis Bivariat dengan uji Chi-square memperlihatkan hubungan yang bermakna antara durasi penggunaan gawai dengan derajat keparahan CVS (p<0,05). Simpulan penelitian ini, terdapat hubungan antara durasi penggunaan gawai dengan derajat keparahan Computer Vision Syndrome pada mahasiswa Fakultas Kedokteran Unika Atma Jaya Jakarta selama masa pandemi Covid-19.
Kontribusi Kepatuhan Konsumsi Obat Antihipertensi dan Terkendalinya Tekanan Darah Pasien Hipertensi di Puskesmas Cisauk, Kabupaten Tangerang, Banten Shirley I Moningkey; Iegreat Aprilyanri; I Gusti AN Hirania; Lidia Arita; Wahyuni L Atmodjo
Journal of Medicine and Health Vol 5 No 1 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i1.6097

Abstract

Hipertensi merupakan masalah kesehatan dengan tingkat prevalensi tertinggi di dunia. WHO mencatat bahwa terdapat 1 dalam 5 orang dengan hipertensi yang terkontrol disebabkan kepatuhan penderita hipertensi dalam mengonsumsi obat yang masih kurang. Walaupun beberapa penelitian melaporkan mengenai pengaruh kepatuhan mengonsumsi obat antihipertensi dengan terkendalinya tekanan darah tinggi, namun masih terdapat perbedaan pada kebermaknaan pada hasil penelitiannya. Tujuan penelitian ini adalah untuk membuktikan kontribusi kepatuhan konsumsi obat antihipertensi dengan terkendalinya tekanan darah pada penderita hipertensi. Penelitian ini menggunakan metode studi potong lintang terhadap 78 penderita tekanan darah tinggi di Puskesmas Cisauk yang memenuhi kriteria penelitian. Data kepatuhan meminum obat antihipertensi diamati dengan kuesioner Morrisky Medication Adherence Scale 8 (MMAS-8). Hasil penelitian menunjukkan 47 (60,3%) subyek hipertensi tidak patuh terhadap pengobatan hipertensi, sedangkan 56 (71,8%) subyek memiliki tekanan darah yang tidak terkendali yaitu >140/90. Hubungan antara kedua variabel pada penderita hipertensi di Puskesmas Cisauk yang dianalisa dengan metode chi-square menunjukkan kebermaknaan dengan p<0,0001 dan OR=5,35. Penelitian ini menyimpulkan apabila pasien tidak patuh minum obat antihipertensi maka kemungkinan akan mengalami hipertensi 5,35 kali lebih besar.
Potensi Teh Rosela (Hibiscus sabdariffa) dan Daun Sambung Nyawa (Gynura procumbens) Sebagai Diet Antiobesitas Putu ISL Dewi; Kadek MN Pamungkas; Erick K Tandiono
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.3835

Abstract

Menurut WHO pada tahun 2014, lebih dari 1,9 milyar populasi dunia mengalami overweight dan 600 juta di antaranya dengan obesitas. Kondisi ini disebabkan oleh asupan kalori yang melebihi pengeluaran energi disertai berbagai faktor. Modalitas terapi yang ada saat ini terbatas pada diet, farmakoterapi, dan operasi. Tujuan dibuatnya literature review ini yaitu menemukan tanaman obat yang berpotensi sebagai antiobesitas. Studi ini menggunakan metode tinjauan pustaka dengan mengumpulkan sumber dari literatur ilmiah seperti WHO, PubMed, dan Google Scholar. Ekstrak Hibiscus sabdariffa ditemukan dapat menurunkan oxysterols dan meningkatkan ekskresi asam palmitat di feses yang penting dalam mengontrol glukosa dan lemak. Ekstrak ini menginhibisi SREBP-1c, PPARγ, lipase pankreas, serta ekspresi PPARγ dan C/EBPα. Ekstrak Gynura procumbens mampu menurunkan pembentukan LDL sehingga berefek terhadap kolesterol dan lemak lain serta memiliki efek kardioprotektif. Ekstrak ini dapat meningkatkan ekspresi gen PPAR-α yang meningkatkan oksidasi asam lemak dan menginduksi aktivitas lipoprotein lipase. Teh rosela dibuat baik dengan metode infusi, decoction, maupun maserasi. Teh daun sambung nyawa dikonstruksi melalui deaktivasi enzim primer dan sekunder, rolling, pembekuan, serta vacuum freeze-drying. Kombinasi keduanya akan dibuat menjadi bentuk teh, kemudian diadministrasikan secara peroral. Disimpulkan bahwa, kombinasi teh rosela dan daun sambung nyawa mengandung senyawa antiobesitas yang berpotensi sebagai terapi untuk penderita obesitas.  
Pengaruh Penambahan Nanopartikel Seng Oksida (ZnO) terhadap Kekuatan Mekanik Semen Kedokteran Gigi: Telaah Sistematis Ardelina C Hartanto; Evi UM Situmorang; Mora Octavia
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.4896

Abstract

Semen gigi digunakan sebagai bahan pengisi, lapisan pelindung rongga, bahan luting untuk mahkota, jembatan, inlay dan peralatan ortodontik. Semen gigi memiliki kekuatan mekanik yang rendah sehingga memerlukan bahan tambahan untuk meningkatkan kekuatan mekaniknya, seperti dengan menambahkan nanopartikel Seng oksida (ZnO). Tujuan penelitian ini untuk mengetahui pengaruh penambahan massa nanopartikel ZnO terhadap kekuatan tekan dan kekerasan semen kedokteran gigi. Penelitian ini menggunakan metode penelitian menggunakan telaah sistematis dengan memasukkan kata kunci pada database Google Scholar, Pubmed, ProQuest dan Science Direct dengan rentang waktu 2012-2022. Telaah sistematis ini dibuat berdasarkan guideline PRISMA-P dan dievaluasi dengan kriteria JBI Critical Appraisal tools.  Kriteria inklusi pada review ini adalah seluruh studi eksperimental yang sesuai dengan topik penelitian. Hasil pencarian berdasarkan kata kunci didapatkan 3.972 jurnal. Setelah dilakukan inklusi dan eksklusi didapatkan lima jurnal yang relevan untuk studi ini. Dari lima jurnal tersebut didapatkan bahwa kekuatan tekan dan kekerasan semen gigi terus meningkat seiring penambahan massa nanopartikel ZnO. Hal ini disebabkan karena partikel berukuran nano dapat mengisi ruang kosong antar partikel semen yang berukuran besar saat berikatan, juga meningkatkan ikatan interlock menjadi lebih kuat dan lebih homogen. Dapat disimpulkan bahwa terdapat pengaruh penambahan massa nanopartikel ZnO terhadap kekerasan dan kekuatan tekan semen kedokteran gigi.
Successful Treatment of Relapse Cutaneous Tuberculosis on Pregnant Woman with Ethambutol Allergic Jahja T Widjaja; Dian Puspitasari; Evelyn Nathania
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.4985

Abstract

Tuberculosis infection among pregnant women often reveals unspecific clinical manifestations, and cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis. The aim of this case report is to manage well Extra-Pulmonary tuberculosis manifestation, especially in pregnant women. A Pregnant woman with a gestational age of 6-7 weeks complained of red spots on cheeks. One year ago, the patient suffered cutaneous tuberculosis and was only treated with Rifampicin, Isoniazid, and Levofloxacin; pyrazinamide and ethambutol were not given due to a strong suspicion of allergy. Physical examination revealed plaque with scales, and PCR examination revealed Mycobacterium tuberculosis. She suffered relapse of cutaneous tuberculosis and was given rifampicin, isoniazid, and pyrazinamide. After 2 weeks the skin lesion improved significantly, and ethambutol was added to the regimen. The patient suffered from drug eruption, ethambutol was discontinued, and the skin lesion disappeared after four months of treatment. The regiment was continued for one year; showed better condition and delivered a healthy baby boy. Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis (1-1.5%) and is hard to diagnose and treat, especially in pregnant women. Allergic to one of its drugs can increase its risk of being resistant and increase its mortality and morbidity. As conclusion, prompt treatment is needed for tuberculosis patients, especially pregnant women. Early detection and examinations are required to diagnose it properly.
Efek Andrographolide Oral Terhadap Biomarker Jantung pada Tikus yang Diinduksi Doxorubicin Silmi Hanifah; Wawaimuli Arozal; Vetnizah Juniantito
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Doxorubicin remains the most prescribed anticancer agent despite its unintended side effects on non-target organs. A limiting-dose strategy is used to lower incidence of cardiotoxicity. Andrographolide has therapeutic effects including antioxidant and anti-inflammatory. This study aimed to assess cardioprotective effects of andrographolide oral on lactate dehydrogenase (LDH), creatine kinase-myocardial band (CK-MB), and relative cardiac weight in doxorubicin-induced rats. Sixteen male rats Sprague Dawley randomized into four groups: receives saline i.p and vehicle orally (Normal), doxorubicin 16 mg/kgBW i.p and vehicle orally (Dox), doxorubicin 16 mg/kgBW i.p+andrographolide 30 mg/kgBW orally (Dox+And30), doxorubicin 16 mg/kgBW i.p+andrographolide 60 mg/kgBW orally (Dox+And60). Blood was collected via cardiac puncture and cardiac organs were weighed after four-weeks administration. Total LDH and CK-MB measured spectrophotometrically. LDH and CK-MB levels significantly elevated, and signs of acute toxicity in Dox group compared with Normal group. Co-treatment with andrographolide at 30 mg/kgBW and 60 mg/kgBW reduced signs of toxicity and significantly attenuated LDH and CK-MB levels compared with Dox group (P<0.05 and P<0.01). However, body weight and relative cardiac weight were not significantly different in all groups after co-treatment with andrographolide. In conclusion, andrographolide lowered LDH and CK-MB levels, therefore has a protective potency in alleviating toxic effects of doxorubicin.
Correlation between SREBP-1c and Prominent Nucleoli Hepatocytes of Type 2 Diabetic Rat Model Induced by Dietylnitrosamine Wahyuni L Atmadja; Erna Kristiani; Stella Marleen; Veli Sungono; Young Larasati; Kevin Feraldy
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.6076

Abstract

Type 2 Diabetes Mellitus (T2DM) demonstrates relative risk of cirrhosis towards livercancer. Although the relationship between of type 2 diabetic and cirrhotic toward HCC has beensuggested, the association between SREBP-1c and the number of prominent nucleoli hepatocyteshas not clearly explored. This study aims to prove the correlation between those variables byusing male Wistar rat model given fat diet continued with administration of Streptozotocininjections twice in low dosage and an injection of dietylnitrosamine once a week for 10 weeks. Atweek 16, they were sacrificed, the fresh liver tissue was processed for examining the expressionof SREBP-1c, while the fixative paraffin block was sliced and stained with Hematoxylin Eosin tocount the number of prominent nucleoli hepatocytes. The western blotting result demonstratedincreasing level of SREBP-1c in diabetic rat significantly. The liver sections showed nodulesconsisting of pleomorphic cells, inflammatory cells, and prominent nucleoli hepatocytes. Thecorrelation between level of SREBP-1c and total number of prominent nucleoli hepatocytes wasmeasured with non-parametric correlation method statistically. It demonstrated coefficientr=0,435 with p value=0,037. It is concluded that increasing number of prominent nucleolushepatocytes related to enhancing level of SREBP-1c in the process of T2DM towardsHepatocellular Carcinoma.

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