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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 349 Documents
 1   2   3   4   5 
EVALUASI ADVERSE DRUG REACTIONS DAN EFEKTIVITAS PENGGUNAAN KETOROLAK PADA PASIEN PASCA BEDAH SARAF DI RUMAH SAKIT UMUM PENDIDIKAN DR. WAHIDIN SUDIROHUSODO MAKASSAR Hendra Herman; Zullies Ikawati; Rina Handayani
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.837 KB) | DOI: 10.33096/jifa.v5i2.58

Abstract

Pain is often experienced by patients treated in the hospital and is the most frequently reported events in post-surgical patients. Ketorolac associated with the incidence of adverse reactions include, the incidence of acute renal failure and bleeding disorders. The purpose of the study was to observe and report on the profile of adverse reactions include the use of ketorolac on renal function and hemostasis as well as the effectiveness of the analgesic ketorolac. A total of 20 patients who received ketorolac compared to the value of the glomerular filtration rate (GFR), bleeding time (BT), Blood Clotting Time (CT), prothrombin time (PT) and International Normalized Ratio (INR) between before and after patients received ketorolac. Compared to the value of the Visual Analog Scale (VAS) ranging V day I to day administration of ketorolac. One of 20 patients (5%) who use ketorolac for 5 days had decreased GFR by 66.70%.. Whereas for hemostasis testing showed that ketorolac can influence hemostatic seen from increasing on BT  (0,04; p <0,05), CT (0,02; p <0,05), PT value (0,03, p <0,05), as well as an increase in INR value (0,03; p <0:05) but still in normal range. Comparison of the mean VAS score from day one to day five showed that administration of ketorolac can reduce pain and disappeared on day 4, where VAS values between days 4 and 5 showed no statistical difference (0,56; p> 0,05). Conclusion. incidence of renal damage incident occurred at 5%, and may affect hemostatic function in patients. Resolution of pain may occur at day 4 ketorolac administration.Key word : Evaluation, Adverse Effects, Effectiveness, Ketorolac, Post-Nerve Surgical Patient
OPTIMASI PRODUKSI ANTIBIOTIKA ISOLAT TERPILIH FUNGI ENDOFIT IKD FF-UMI 02 DARI KULIT BUAH DELIMA (Punica granatum L.) DENGAN VARIASI SUMBER KARBON Rusli Rusli; Nurul Vicky Syfriani; Sumarni Hatta; Muh. Wais
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.542 KB) | DOI: 10.33096/jifa.v9i1.262

Abstract

Research of endophytic fungi of pomegranate fruit peel (Punica granatum L.), as Anti-free radicals and antibiotic has been done with DIKTI-PKM funding at 2014. It is considered necessary to further research about optimization of antibiotic production from pomegranate fruit peel with variation of carbon source, first step is selection of isolates that have largest inhibition zone and has the most inhibit microbial test, that is endophytic fungi IKD FF-UMI 02 that has activity on Salmonella thypii, Staphylococcus epidermidis, Staphylococcus aureus and Shigella dysenteriae. Determination of growth curve from isolate by inoculating into Potato Dextrose Broth and incubated for 7x24 hours. Every 12 hours the mycelium is weighed to determine its stationary phase. Determination of optimum conditions of fermentation with carbon source such as glucose, galactose, and fructose. Endophytic fungi IKD FF-UMI 02 inoculated and fermented into production medium which is every 12 hours fermentate was taken. The activity was tested using agar diffusion method in Nutrient Agar (NA) against Salmonella thypii, Staphylococcus epidermidis, Staphylococcus aureus and Shigella dysenteriae. Resulted that growth curve of selected endophytic fungi IKD FF-UMI 02 from pomegranate fruit peel show that stationer phase starting on 192 hour and galactose carbon source is show optimum time of antibiotic production on 120 hours with inhibition zone 10,24 mm against Shigella dysenteriae.
EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) SEBAGAI ANTINEFROTOKSISITAS BERDASARKAN PENURUNAN KADAR KREATININ TIKUS Sukmawati Sukmawati; Ira Asmaliani
As-Syifaa Jurnal Farmasi Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.471 KB) | DOI: 10.33096/jifa.v11i2.540

Abstract

Nephrotoxicity is a disorder of the kidneys that occurs when exposed to drugs or toxins. Pandan wangi leaves have antioxidant activity expected to give antinephrotoxicity effect. This aim of study is to determine the antinephrotoxicity effect of the ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb.) based on the decline of rat creatinine level induced by gentamicin. Eighteen male Wistar rats were divided into 6 groups. That is naive, negative control by Na-CMC 1%, positive control by the suspension of keto acids, and treatment group with ethanol extract of pandan wangi leaves at 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW. Nephrotoxicity condition was induced by Gentamicin 80 mg/kgBW (ip) for seven days. The blood samples were taken and measured the serum creatinine levels on days 0, 8th and 22th by Human Analyzer. The results study showed that ethanol extract of pandan wangi leaves at 250 mg/kgBW and 500 mg/kgBW have the effect as antinephrotoxicity based on decreased creatinine levels.
ANALISIS KANDUNGAN POLIFENOL DALAM RUMPUT LAUT Sargassum sp DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Pirman AP; Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 1, No 1 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i1.90

Abstract

Seaweed are one of resource foreign exchange of state and earning source for coastal area society. Besides can be used direct upon which food, some result processing of seaweed like gelatinous, carrageenan and alginate represent the compound which important enough in industry. A lot of research proving that seaweedis substance of food which important, like some among other thing is anticancer, antioxidant, preventing kardiovaskular, and as diet food. As for content of chemistry compound anticipated by a sharing to cause the effect is compound polyphenol. Referring to above the mentioned, and to know furthermore hit the content polyphenol in Sargassum sp seaweed, is hence done by analysis research polyphenol in Sargassum sp seaweed. This research benefit is to give the erudite evidence and information about existence of content polyphenol of Sargassum sp seaweed. This research is done by using method of spectrofotometric UV-Visibel and as reagent used by Folin Ciocalteu and Na2CO3 yield the blue colour, then read by absorbance at 670 nm. As standard condensation used by tannat acid with the concentration 0,25; 0,5; 1,0; 2,0; 4,0; and 8,0 ppm. From research result indicate that the Sargassum sp seaweed contain the polyphenol with the rate polyphenol of Sargassum sp I as much 0,077 mg/100 g and Sargassum sp II as much 0,071mg/100 g.Key Words : Polifenol, Sargassum sp, Spectrofotometric UV-Vis
UJI AKTIVITAS LARVASIDA PERASAN HERBA SELEDRI (Apium graveolens L.) TERHADAP LARVA Aedes aegypti Dian Kartikasari; Mentari Novitasari
As-Syifaa Jurnal Farmasi Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (57.52 KB) | DOI: 10.33096/jifa.v10i2.346

Abstract

The people of West Kalimantan tend to store water in water reservoirs around their homes, so that the water reservoirs are preferred to be used as breeding sites for Aedes aegypti mosquitoes. Prevention of the development of mosquitoes is very important, one program to suppress mosquito transmission is by eradicating larvae. The many negative effects of synthetic larvicides make the use of cytetic larvicides restricted, thus encouraging the development of natural larvicides, which are safe for the human body, easily accessible and environmentally friendly. Celery is one of the vegetable larvicides that is being developed by several researchers, so the purpose of this study is to determine the larvicidal activity of celery herb infused and to determine the concentration that can kill the most larvae and determine the values of LC50, LC100 and LT50, LT100. This research was conducted with a concentration of 1%, 2%, 3%, 4% and 5%, positive control (abate 0.01%) and negative aquadest control tested on 25 larvae for 24 hours. The results of this study showed the highest Mortality Percentage of mortality of Aedes aegypti larvae obtained from the infused of celery herbs (Apium graveolens L.) at a concentration of 5% which was 98.64%. Lethal concentration (LC50) infused of celery (Apium graveolens L.) as larvacide was 1.88%, LC100 4.43%, and Lethal Time (LT50) at 12.39 hours, LT100 at 29.42 hours
VALIDASI METODE PENETAPAN KADAR GABAPENTIN TERDERIVATISASI SECARA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DAN APLIKASINYA DALAM SEDIAAN KAPSUL Nurmaya Effendi
As-Syifaa Jurnal Farmasi Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.122

Abstract

Gabapentine, is a new antiepileptic drug which has a structural analogue of neurotransmitter γ-aminobutyric acid (GABA). Gabapentine inhibits calcium uptake of gated calcium channels presinaps in the brain. This research aimed to develop and validate a new HPLC method with UV detection for determination of gabapentine in capsule. The method is based on the reaction of gabapentine with 1-fluoro-2,4-dinitrobenzen (FDNB) in acetonitrile which carried out in the presence of borate buffer (pH = 9,5) at 65oC for 20 minutes, which formed a yellow colored product with the absorption at 367 nm. The product was separated by HPLC using A Zorbax ODS (Agilent) column (250 x 4.6 mm, 5 µm) was utilized as stationary phase and 50 mM acetate buffer (pH 3.7) : methanol : acetonitril (25 : 30 : 45 v/v/v) as mobile phase, with flow rate 0.8 mL/min, and the detection at 367 nm.The purposed method was validated by means of accuracy, precision, linearity, selectivity, LOD and LOQ, and the complied with the requirement for validity. The method has been succesfully applied for the determination of gabapentine in capsule with LOD = 1.05 µg/mL and LOQ = 3.49, linear quantitative response curve was generated over a concentration range of 3.49 - 100 µg/mL with the correlation coefficient of 0.99996 and recovery range of 97.27 – 104.24% with RSD 2.63%.Keywords : gabapentin, FDNB, HPLC, validation
GAMBARAN PENGGUNAAN OBAT ANTIDIABETIK PADA PENGOBATAN PASIEN DIABETES MELITUS TIPE II RAWAT JALAN DI RSUP DR WAHIDIN SUDIROHUSODO MAKASSAR Hardianty Malinda; Rahmawati Rahmawati; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.68 KB) | DOI: 10.33096/jifa.v7i1.26

Abstract

Diabetes mellitus is a chronic disesase characterized by high blood sugar levels in the body. This research aims to present the use of antidiabetic medication for type 2 diabetes mellitus in outpatient at RSUP Dr. Wahidin Sudirohusodo Makassar. This is a descriptive survey in the form of retrospective search. The results showed that the use of drugs by drug class and type of antidiabetic drugs sulfonylurea (glibenclamide 12.4%, glimepiride 7.2%, gliclazide 3.9%), biguanide (metformin 43.8%0, inhibitor α-glucosidase (acarbose 3.3%), thiazolidinedione (pioglitazone 0.7%), the combination of OHO (gliburida-metformin 0.7%), vildagliptin-metformin 0.7%), rapid insulin 8.5%, insulin detemir 13.1%, insulin glargine 4.6%, and insulin premix 13.1%.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN WUNGU (Graptophyllum pictum (Linn) Griff) DENGAN METODE FRAP (FERRIC REDUCING ANTIOXIDANT POWER) Aminah Aminah; A. Muflihunna; Zainal Abidin
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.989 KB) | DOI: 10.33096/jifa.v8i1.156

Abstract

‘Wungu’ leaf is a plant known to contain flavonoids as the antioxidant. Thisresearch aimed to determine the antioxidant activit ethyl acetace fraction of ‘Wungu’ leaf (Graptophyllum pictum  (Linn) Griff) by Ferric Reducing Antioxidants Power (FRAP) method. Extraction by maceration method usingethanol 96 %. Extract partitioned with ethyl acetace and water. Thefiltrate was dried with rotary evaporator and produce ethyl acetace fraction.Fraction were analyzed quantitatively by FRAP method with potassium ferriccyanide reagent solution, phosphate buffer, ferricchloride and distillede water. The sampel solutions analyzed by UV-vis spectrophotometer at a maximum wavelength of 705 nm using kuarsetin solution as a standard. The result showed that the antioxidantactivity of ethyl acetate fraction of ‘wungu’(Graptophyllum pictum  (Linn) Griff) is3.984x10-6 g QE/g fraction.
AKTIVITAS ANTIBAKTERI EKSTRAK ISOLAT FUNGI ENDOFIT DARI AKAR MANGROVE (Rhizophora apiculata Blume) SECARA KLT BIOAUTOGRAFI Fitriana Fitriana; Eka Nurshitya
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.263 KB) | DOI: 10.33096/jifa.v9i1.234

Abstract

Endophytic fungi have the ability to produce bioactive compounds one of which is antibacterial. A search of bioactive compounds in this research are the first was isolated endophytic fungi on the roots of mangrove then be purified and macroscopic order to obtain pure 6 isolates endophytic fungi. Proceed with the screening test to test bacteria and endophytic fungal isolates obtained first by IJM 2 code  which provides activity against 5 test bacteria with the formation of the largest inhibition zone diameter. Then proceed with the fermentation of isolates IJM 2 for 21 days at room temperature using Potato Dextrose Broth medium after the separation to obtain a supernatant and mycelia. Then proceed with the solvent extraction using ethyl acetate and the extract obtained extract supernatant and mycelia. The extract obtained is then followed by TLC-Bioautografi testing using the eluent n-butanol: acetic acid: water (8: 1: 2). Results chromatogram profile with KLT-Bioutografi method showed antibacterial activity against bacteria Shigella dysentriae, Pseudomonas aeruginosa, Salmonella thypii, Vibrio cholerae, Stahpylococcus aureus.
STUDI ANTIDIABETES KOMBINASI EKSTRAK ETANOL KUBIS (Brassica oleracea L.) DAN TOMAT (Solanum lycopersicum L.) SECARA IN VITRO Devina Ingrid Anggraini; Dwi Damayanti
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.126 KB) | DOI: 10.33096/jifa.v11i1.503

Abstract

Diabetes mellitus is a health problem in the world including Indonesia. A lot of treatment efforts to control and lowering blood sugar levels done with drugs hypoglycemic of natural materials. This research was conduct to determine the combination of extract cabbage (Brassica oleracea L.) and tomato (Solanum lycopersicum L.) have activity antidiabetic and more effective than extract single. Study performed on four comparison concentration sample extract ethanol cabbage and tomato are 1: 0; 2: 1; 1: 2 and 0: 1. Method wich is use in this study the method of Nelson-Somogyi by using the instrument spectrophotometer UV-Vis. Decline glucose levels highest obtained in the concentration of extract cabbage and tomato with the ratio of 1: 2 is 4,5165 ppm and decrease in glucose levels lowest obtained in the concentration of extract cabbage and tomato with the ratio of 1: 0 is 5,1613 ppm.

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