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Profil PAsien Sindromik Kraniosinostosis selama 5 Tahun di dr.Soetomo Hospital Surabaya Adinda Widita; Magda Hutagalung; Indri Lakhsmi Putri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 02 (2017)
Publisher : Universitas Muhammadiyah Surabaya

Craniosynostosis is a premature cover of one or more sutures, which may occur as part of syndrome (syndromic) or as a separate defect / isolated defect (nonsyndromic). Cohen and Kreirborg state the incidence of Apert and Crouzon syndromes of 15.5: 1,000,000 and 16.5: 1,000,000 per birth. The incidence of craniosynostosis in Indonesia still not handled properly, as well as low recognition in this disorder. RSUD Dr. Soetomo as an eastern referral hospital, which has one of the centers of plastic surgery education in Indonesia, where craniosynostosis syndromic often occurs, so we have total cases handled in Indonesia. This is a retrospective descriptive study discusses more about the profile of patients syndromic craniosynostosis for 5 years in dr. Soetomo Surabaya, performed on twenty-four first syndromic craniosynostosis patients at Dr. Soetomo Surabaya period 1 January 2008 - 31 December 2013. Out of 24 total patients, 12 cases of apert (29%), 6 crouton cases (54%) and 3 cases of Pfeiffer (17%) were obtained. Based on sex, more commonly found in women (54%). With the most common age, the patient comes first is aged 5-10 years (37%). Each patient has an average of 2 surgeries, with a type of surgical action on cranial vault remodeling patients. Abnormalities of syndromic craniosinostosis found the most common in women and apert syndrome in RSUD dr.Sutomo. Where the most common age when the arrival of 5-10 years, caused by the late diagnosis of the disorder.

Kemampuan Konsentrasi Berhubungan dengan Waktu Reaksi tetapi Tidak Berhubungan dengan Pola Tidur di Pondok Pesantren Handayani -; Herdiantri Sufriyana; Abraham Ahmad Ali Firdaus
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Pesantren as dormitory-based educational institutions familiarize their students with sleep patterns and certain activities, including sports that increase reaction time. This study aims to prove the relationship between sleep patterns and reaction time with the ability of concentration in adolescent girls. This cross-sectional study was conducted on 27 Wachid Hasyim boarding school students whose average age was 17.49 years (IK 95% 17.33-17,66). Subjects filled out the Pittsburgh Sleep Quality Index (PSQI) and Krawietz Concentration Scale (KCS) questionnaires and underwent the Ruler Drop Test. All three consecutively measured sleep patterns, concentration ability and reaction time. The KCS questionnaire assessed four components: 1) Control of Focus (CF); 2) Uncontrolled Focus (UF); 3) Reading and Listening Focus (RLF); And 4) Control of Focus Before Sleep (CFBS). The results show that the subject has a PSQI score of 6.41 (95% IK 5.29-7.52) that exceeds the normal limit. However, subjects had a rapid reaction time (55.6%) and a KCS score of 216.78 (95% IO 958.06-225.49; p = 0.044) higher than their mean value. There was no relationship between sleep patterns with concentration ability (p = 0.487). There is a negative correlation trend between sleep patterns and CFBS (r = -322; p = 0.050) or with reaction time (r = -394; p = 0.069). There was a relationship between reaction time and overall concentration (p = 0.048) and partially on RLF + CFBS (p = 0.029). There is a positive correlation between the reaction time in the form of the catch distance response with CFBS (r = 0.326; p = 0.049). The effort of pesantren in maximizing the use of time that caused poor sleep pattern was found did not decrease the ability of student concentration. Exercise that increases reaction time is found to reduce their ability to start sleeping

Peran Jalur Phosphatidyl-Inositol-3-kinase (PI3K) dalam Resistensi Kemoterapi pada Kanker Zanuar Abidin
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Cancer has the ability to develop resistance to chemotherapy and increased prevalence of this drug-resistant cancer requires further research and development of treatment. There are several mechanisms that can stimulate chemotherapy resistance, such as drug inactivation, drug effectiveness mechanism, HER2 role, PI3K pathway, DNA damage repair, and apoptotic inhibition. The PI3K pathway is an important signal transduction pathway in the growth and development of cancer. This pathway plays a role in several functions, such as proliferation, cell growth, and tumor survival. PI3K activation has been identified in some cases of cancer, including breast cancer. This pathway undergoes excessive activation resulting in resistance to chemotherapy and increased metastasis.

Perbandingan Pengaruh Pemberian Ekstrak Zingiber officinale dengan Insulin terhadap Berat Plasenta pada Rattus norvegicus Model Diabetes Mellitus Pragestasional Sepfrita Katerine Aftabuddin
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Diabetes mellitus is a chronic disease that occurs in the community, with 1.9% prevalence of in the world is and the seventh leading cause of death in the world. It is estimated to increase up to 21.3 million by 2030 if the pattern of Diabetes management is not well developed. In 2007, the prevalence of Pregestational Diabetes Mellitus in Indonesia was 12% and had an impact on placental development that was important during pregnancy for fetal survival with placental weight as the indicator. Diabetes Mellitus pregestational therapy is insulin, however, it often causes complications. Oral hyperglycemic drugs with ginger dose extract of 500mg/kgBW significantly decreased serum glucose levels in diabetic-induced rats. Ginger extract is expected to decrease blood glucose levels so as to increase the weight of placenta. The purpose of this study was to determine the effect of insulin and ginger extract on the weight of placenta Rattus norvegicus model of diabetes mellitus. This research is an experimental research using post test only control group design. The population used in this study was pregnant Rattus norvegicus with simple random sampling. The independent variables are insulin and ginger extract and the dependent variable is the weight of placenta. Data analysis for placental weight using Kruskal Wallis was continued by Post Hoc Bonferroni test. Test results for placental weight p>α (0.63 > 0.05) mean that there is no difference in placental weight between negative control, positive control, and treatment group. The conclusion of this study is there is no significant difference between groups, however, based on mean data the weight of placenta Rattus norvegicus model of diabetes mellitus with insulin and ginger extract therapy are higher than the control group

Neurofibroma Type 1 with Intracranial Infiltration A Case Report Dinar Rahmania; Agus Santoso Budi
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 01 (2017)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/qm.v1i01.382

Neurofibromatosis (NF) is an AD dysplasi of mesoderm and ectoderm characterized by numerous neurofibromas and cafe-au-lait spot. It can develop on cranial and cavum orbita. Additional abnormalities such as episode of seizure, learning disabilities, and speech difficultie may present. Presented a rare case that has underwent surgery by multidisciplinary team consist of neuro surgeon, plastic surgeon, and ophthalmologist. A 31 years old female patient admitted to Dr.Soetomo Hospital with mass at left face since she was 3 years old. Clinical examination shows a large plexiform mass at left hemifacial, distopia left oculi, and facial deformity. Radiological examination shows a soft tissue mass destructing the left temporal and maxillary bone, a temporal lobe herniation to frontobasal, and a suppression on left optical nerve. In the present time, the patient is satisfied with her performance and vision. The result of surgery is satisfying. (QM 2017;01:44-47)

Rekomendasi Upaya Pemasaran dengan Model Value-Based Matrix pada Marketing 3.0 untuk Meningkatkan Hunian Unit Obsgyn RS ‘Aisyiyah Bojonegoro Fahtia Nur Rosyida
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTThe occupancy rate of obsgyn ward ‘Aisyiyah Bojonegoro Hospital is still very low (33,5%) compared to occupancy target (50.0%) in last five years. The purpose of this study was to identify the expectations of consumers to 4Ps (Product, Price, Place, Promotion) obsgyn inpatient services in mind, heart, spirit and the mission, vision, and values ‘Aisyiyah Bojonegoro hospital. Further arranged on marketing efforts with Value-Based Matrix models on marketing 3.0 for an alternative answer to the problems of dwelling of obsgyn ward ‘Aisyiyah Bojonegoro Hospital. This is a descriptive with cross-sectional approach study. The data was taken in January-August 2016. The data used are primary and secondary data. Primary data was taken with a questionnaire guidance to 152 patients respondent from obsgyn clinic specialist and 22 patients respondent from Maternal and Child Health (MCH) outpatient 'Aisyiyah Bojonegoro Hospital. The sampling method was accidental sampling. Secondary data such as mission, vision, and values are taken from the profile hospital hospital. Analysis of the respondents expectations and the hospitals mission, vision, and values are taken to be FGD material with hospital management to explore alternative marketing efforts that will be done. The researchers analysis from FGD results lead to the conclusion in the form of 19 marketing efforts recommendations based on value-based matrix in marketing 3.0 by identifying consumer expectations and the mission, vision, values hospital. These marketing efforts recommendations is expected to increase the occupancy rate of obsgyn ward ‘Aisyiyah Bojonegoro Hospital.Keywords:Marketing Efforts, Value Based Matrix, Marketing 3.0.

Perbedaan Pengaruh Pemberian Ekstrak Zingiber Officinale dengan Insulin terhadap Jumlah Anak Hidupa, Mati atau Resorbsi dan Cacat pada Rattus Norvegicus Model Diabetes Melitus Pragestasional yasinta siskaningtia
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Diabetes mellitus was metabolic disease which had chronic hyperglycemic characteristic .The risk of fetal death and malformation which were higher in pregestational diabetes. The complications could be suppressed through insulin therapy. The reasons about insulin side effect made herbal therapy began to develop, such as ginger (Zingiber officinale). This research aimed to prove the difference effect of Zingiber officinale extract and insulin on the number of fetal dead or resorbsion, and malformations in Rattus novergicus model of pregestational diabetes mellitus. Thirty rats were divided into 1 negative control group and 4 groups which were modeled with type 1 DM with streptozotocin (STZ) i.p dose 50mg/kgBB in citrate buffer 0,05M pH 4,5. Rat with blood glucose levels >200mg/dL after 2 days of induction, were sampled and bundled. The treatment groups were given 1IU insulin, ginger extract 500mg/kgBB, and 1IU insulin plus ginger extract 500mg / kgBB. The 17th day of pregnancy fetal sample was observed macroscopically. Analysis data with One Way ANOVA and Post Hoc with LSD. There were significant differences in fetal malformation with p value was 0,012 and death or resorbsion were 0,001. Ginger extract could be used as a single therapy or combination therapy to reduced the number of fetal death or malformation.

CD4 T-lymphocyte cell counts and pneumonia in HIV children Siti Habsyah Masri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 01 (2018)
Publisher : Universitas Muhammadiyah Surabaya

CD4 T-lymphocyte cell counts and pneumonia in HIV-infected childrenAbstractBackground Pneumonia is a major cause of morbidity and the most common cause of mortality in infants and children who are infected with Human Immunodeficiency Virus (HIV). For HIV-infected children, the risk for developing pneumonia has been closely related to an individual’s having a lower CD4 T-lymphocyte cell count.Objective To evaluate for an association between CD4 T-lymphocyte cell count and pneumonia in HIV-infected childrenMethods. A cross sectional study was conducted among all children diagnosed with and without pneumonia who had HIV at Adam Malik Hospital, Medan. Data were taken from patients’ medical records between January 2008 to December 2015. We studied demographic, clinical, radiological and CD4 T-lymphocyte cell counts on admission, as well as mortality outcomes.Results A total of 174 HIV-infected children were included in this study. Pneumonia was found in 47 children with 39 months as the median age of onset. The mean difference in CD4 levels was 0.912 cells/mm3 units (95% CI to -5.79 to 7.62) with higher mean in the pneumonia group than in the non-pneumonia group, but no significant difference. In addition, no significant association were found between nutritional status and incidence of pneumonia [OR 1,050; 95% CI 0,537 to 2,053); P = 0.886) or between immunodeficiency status and pneumonia, [OR 0.986;(95% CI 0,25 to 3.885);P= 0,984]. The common opportunistic infection in our subjects besides pneumonia were diarrhea, oral candidiasis and pulmonary TB, or some combination there of. Severe malnutrition was also present in some subjects.Conclusions There is no significant association between CD4 T-lymphocyte cell count and pneumonia in HIV-infected children Key words CD4, HIV, pneumonia, children

Prediksi Tinggi Badan Ditentukan dari Panjang Rentang Lengan dan Panjang Telapak Kaki Pada Mongoloid Feminina Khususnya Etnis Jawa Nur Mujaddidah Mochtar
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Background: There are various circumstances where measurements are not actually possible, replacement parameters can be used to estimate body height. Many characteristics of body height measurement and how to measure it. These include anthropometric measurements that can be used for the identification of medicolegal-forensic processes. Body height in clinical medicine and in the field of scientific research can be easily estimated using various anthropometric parameters such as arm span, knee height, foot length and foot breadth, and others. The arm span and foot length has proved to be one of the most reliable predictors. This study was conducted to estimate of body height from arm span and foot length using the regression equation and to determine the correlation between the body height and arm span and foot length.Methods: This study was conducted at Universitas Muhammadiyah Surabaya with 182 Javanese female students. Stature, arm span and foot length measured directly using anthropometric technique and measuring tape. The data obtained were then analyzed with SPSS version 16. The regression equation was derived for the estimate of body height and the relationship between stature, arm span and foot length determined by the Pearson correlation. Results: We found that the mean body height of Javanese women was 1534,45 ± 47,623 mm, mean of arm span 1543,25 ± 60,468 mm and the mean of foot length 226,14 ± 9,586 mm. The correlation between stature and arm span was positive and significant (r = 0,715 , p <0,05). The correlation between stature and foot length was positive and significant (r = 0,726 , p <0,05). The correlation between stature and arm span and foot length was positive and significant (r = 0,798, p <0,05). Conclusion: Body height correlates well with the arm span and foot length so that it can be used as a reliable marker for high estimates using regression equations.

Autopsi Verbal pada Kasus Kematian Mendadak di Instalasi Kedokteran Forensik RSUD Dr. Soetomo pada 1 November 2017 - 30 November 2017 Ambarini Isa Pratiwi
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRAKKematian mendadak biasanya terjadi pada orang-orang yang merasa sehat dan tidak memiliki keluhan sebelumnya. Sebab kematian pada kasus kematian mendadak perlu dikonfirmasi oleh dokter secara legal pada surat keterangan kematian. Dalam rangka menentukan sebab kematian kasus kematian mendadak harus melakukan autopsi. Namun, pelaksanaan autopsi pada kasus kematian mendadak sangat kecil. Berdasarkan data di Instalasi Kedokteran Forensik RSUD Dr. Soetomo periode 2014-2016, hanya sekitar 12% kasus kematian mendadak yang dilakukan autopsi. Autopsi verbal dikembangkan untuk menentukan sebab kematian jenazah tanpa autopsi. Penggunaan autopsi verbal diharapkan dapat digunakan untuk menentukan sebab kematian yang valid sehingga pencatatan kematian di rumah sakit akan semakin baik. Penelitian ini menggunakan desain deskriptif observasional berdasarkan data primer hasil wawancara kepada keluarga 20 sampel jenazah yang memenuhi kriteria inklusi dan eksklusi. Penelitian ini dilakukan pada jenazah kasus kematian mendadakdi Instalasi Kedokteran Forensik pada 1 November 2017 – 30 November 2017. Dari 20 jenazah kasus kematian mendadak, 75% jenazah merupakan jenazah laki-laki. Kejadian kematian mendadak didominasi kelompok usia 40-60 tahun (50%). Sebab kematian mendadak didominasi sebab kematian terkait sistem kardiovaskular (55%). Pada penelitian autopsi verbal pada kasus kematian mendadak, laki-laki mempunyai risiko lebih tinggi dibandingkan perempuan dan angka kejadian akan meningkat seiring bertambahnya usia. Penyebab kematian pada kasus kematian mendadak banyak ditemukan pada kematian terkait sistem kardiovaskular, sistem respiratori, sistem saraf pusat, sistem pencernaan dan SIDS.Kata kunci: Kematian mendadak, autopsi verbal, sebab kematian. ABSTRACTSudden death is common and usually happen to a people who are feeling healthy and having no symptom before. Any suspicions about the cause of sudden death are need to be confirmed by the doctor with the legal cause of death written in the letter of death. In order to confirm the cause of sudden death the doctor has to held an autopsy. Unluckily, there is only little number of an autopsy are held in the case of sudden death. Based on the data in Instalasi Kedokteran Forensik RSUD Dr. Soetomo, an autopsy are held only about 12% from all the case of sudden death in the periode 2014-2016. Autopsy verbal are developed in order to define the cause of death without an autopsy. The used of an autopsy verbal expected to define a valid cause of death therefore the death registration in the hospital will be good. This research used observasional descriptive study which use primary data collected from the interview records with the family of the dead body involving a sample of 20 dead body after considering the inclusion and exclusion criteria. The study was conducted in the dead body who were on sudden death case admitted to Instalasi Kedokteran Forensik from November, 1st 2017-November, 30st 2017. Out of 20 patients with sudden death case, 75% was male. The incidence of sudden death was dominated by 40-60 years age group (50%). The cause of the sudden death was dominated by the cardiovascular system (55%). In this study of the autopsy verbal on sudden death, males were more at risk than females where the incidence was increased by the increasing of the age. The cause of sudden death were mostly found in the cardiovascular system, followed by respiratory system, central nervous system, digestive system, and SIDS. Keywords: Sudden Death, Autopsy Verbal, Cause of death. Correspondence: Ambarini Isa Pratiwi, Jln. Serayu BH-12, Wisma Troposo, Waru, Sidoarjo Phone: 085785406614; E-mail: ambrnsprtw@gmail.com

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