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Journal of Islamic Medicine
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : -     EISSN : 25500074     DOI : https://doi.org/10.18860/jim
Core Subject : Health,
Medicine & Pharmacology
Journal of Islamic Medicine is a medical journal published twice a year in March and September by the School of Medicine, Faculty of Medicine and Medical Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang.
Arjuna Subject : -
Articles 92 Documents
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Antioxidant and Cytotoxic Effect of Water Extract of Ananas comosus in Human Breast Cancer Cell Line Widyanto, Rahma Micho; Halimah, Ririt Nafi'; Rahmi, Yosfi; Utomo, Budi; Proborini, Wahyu Diah; Yunimar, Yunimar
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10109

Abstract

Background: Breast cancer is the most common type of cancer and the second leading cause of death in the world. One of the supporting therapeutic efforts to overcome cancer is through food, mainly fruits. Ananas comosus has been investigated for its potential as an anti-cancer. It is a source of antioxidants from the content of Vitamin C and flavonoids that work by capturing free radicals, resulting in inhibition of cancer cell proliferation.Objective :This study was conducted to determine the antioxidant activity and cytotoxicity of water extract of Ananas comosus on T-47D breast cancer cell lines.Method: The process of extracting pineapple flesh is done using water as a solvent, then tested its antioxidant activity using DPPH and cytotoxicity using MTT assay on T-47D.Result: IC50 value for antioxidant activity was 463.369 μg / mL and the IC50 for the cytotoxicity assay was 488.003 μg / mL.Conclusion : The water extract of Ananas comosus have very weak antioxidant activity and moderate cytotoxicity properties that have potential as chemo preventive agents in T-47D breast cancer cell lines.
Perbandingan Uji Aktivitas Antibakteri Umbi Bawang Merah (Allium Cepa L) Dan Umbi Bawang Putih (Allium Sativum) Terhadap Pertumbuhan Bakteri Shigella Dysenteriae Purnomo S, Fahrurrozi Hari; Fitrianingsih, Avin Ainur; Rahmah, Zainabur; Milliana, Alvi
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10169

Abstract

Background :Diarrhea is one of the causes of morbidity and mortality in infants and children around the world. One of the causes of diarrhea is Shigella sp bacteria or shigellosis. Nowadays, many antibiotics resistant to the Shigella sp bacteria are one example of chloramphenicol, so it is necessary to have other alternatives such as natural ingredients. Objective: Determine the activity of the red onion (Allium cepa L) and garlic (Allium sativum), which is known to possess antibacterial phytochemical compounds against the Shigella dysenteriae bacteria. Method: This research is a laboratory experimental study to determine antibacterial activity using the Kirby-Bauer or diffusion method of discs and to determine the presence of Minimum Inhibitory Concentration (MIC) and Minimum Bacterial Concentration (MBC). The study uses five treatments i.e., onion extracts and garlic extracts with a concentration of 30%, 40%, 50%, 60%, 70%, control positive (Ciprofloxacin), and negative control (aquadest). Results: Red onion diffusion has the best antibacterial activity at concentrations 70% while garlic has the best antibacterial activity at a concentration of 70%. In this study, there were no MIC and MBC. The MIC data analyzed with the crucial test of Kruskal-Wallis (p 0.05) i.e., in onion extract p = 0.003 and in garlic P = 0.003, which means significant. The MBC Data is analyzed by crucial test (P 0.05) in the onion extract p = 0.003 and on garlic p = 0.04. Conclusion : the disc diffusion and the MBC can be concluded that garlic extract can inhibit the growth of S. dysenteriae compared to red onion extracts. onion extracts).
Potential Test Of Ethanol Extract From Onion (Allium Cepa L) Leaves As A Repellent To Aedes Aegypti Adnani, Basyar; Rahmah, Zainabur; Fitrianingsih, Avin Ainur; Setiawan, Abdul Malik
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10171

Abstract

Background : The most dangerous vector of mosquito-borne disease, namely Dengue Haemorrhagic Fever (DHF), is Aedes aegypti. One of the most commonly used prevention methods is using repellent.Objective: This study aims to know red onion (Allium cepa L) leaves ability as a repellent against mosquitoes bites, primarily Aedes aegypti. Onion leaves are known to have flavonoids and essential oil content that believed to have health benefits such as anti-inflammatory, insecticide, antifungal, and repellency effects.Method: This study design was a post test only control group of true experiment, with ± 300 mosquitoes in five treatment groups. The study design was a true experimental post-test only control group using ± 300 mosquitoes divided into five treatment groups. Positive control, negative control, and three groups with each extract containing 5%, 10%, and 20% content. The data taken is the number of mosquitoes alighted on attractants available, for five consecutive days. The analytical test used is the KruskalWalls and Spearman test with α coefficient 0.05.Results: the number of mosquitoes perching on each of the extract treatment plates decreased with increasing extract concentration. In the treatment control group, the negative control had the highest number of mosquitoes perching, while the positive control had the least number of perching mosquitoes. All concentrations of ethanol extract, either 10%, 15%, or 10%, all have the effect of repellent against Aedes aegypti.Conclusion : 20% of ethanol extract has the most repellency effect on Aedes aegypti mosquitoes.
Determinants Factors Affecting Stunting In Children 2-5 Years In The Working Area Of Tajinan Public Health Center Maulina, Rifzul
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10265

Abstract

Background: Malang Regency is included in the 100 priority districts for stunting with a stunting rate of 20% spread over 6 priority villages.Objective: The research was to analyze risk factors related to child, mother, and environmental factors for stunting under five years old.Method : The study used a case-control design population was all children aged 2 to 5 years at the Tajinan Public Health Center for six months in 2018. The case sample was 75 stunting toddlers and the control was 75 toddlers well-nourished. Data was collected by interview and measurement (anthropometry). Data was analyzed by chi square test and multiple logistic regression.Result : 80% of stunted children had infectious diseases, a history of length of birth 48 centimeters and low birth weight was 72% and 10%, a history of breastfeeding and complementary foods (59%). The risk factors for stunting were a history of low birth weight, a history of infectious diseases, maternal education, environment sanitation, and family income.Conclusion : The most influential factors are history of infectious diseases and environment sanitation. It is necessary to increase family empowerment related to the prevention of infectious diseases through improving dietary and health care patterns and improving environment sanitation.
Pendekatan Etnofarmasi Tumbuhan Obat Imunomodulator Suku Tengger Desa Ngadas, Kabupaten Malang, Indonesia Bhagawan, Weka Sidha; Aziz, Yaya Sulthon; Teguh Pamungkas, Rizki Putra
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10290

Abstract

Background: Ethnopharmaceutical is an approach that is emphasized to explore and inventory the local knowledge of an ethnic community or group about the use of a substance for treatment. The Tengger tribe is one of the tribes in Indonesia that still maintains knowledge of medicine from their ancestors.This study documents medicinal plant species and traditional knowledge related to the immunomodulators of the Tengger tribe who inhabit Ngadas village in TNBTS, Indonesia.Methods: This study uses the Snowball Sampling method which begins with the determination of the key sample with purposive sampling. Furthermore, the data were analyzed by UV, ICF, and FL.Results: This study documented 21 types of traditional medicinal plants belonging to 18 families used to treat 8 types of diseases of the human immune system. The data collection on the 10 selected immunomodulatory medicinal plants showed that the leaves, decoction, and oral use were the highest yields.Conclusion: Use Value, Informant Consensus Factor, and Fidelity Level value of recorded immunomodulatory medicinal plant species will provide a phytochemical basis reference in the discovery of new active compounds in the future and conservation practices In this regard, it is necessary to pay attention to the conservation of traditional medicinal plants and indigenous knowledge related to medicine in the Tengger tribe of Ngadas Village to preserve them in the future.
The Effect Of Beetroot Juice (Beta Vulgaris L) And Star Fruit (Averrhoa Carambola L) On The Reduction Of Blood Pressure In Second Trimester Pregnant Women With Gestational Hypertension Retnaningsih, Reny; Wijayanti, Tut Rayani Aksohini
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10373

Abstract

Background: Gestational hypertension is usually defined as high bloodpressure that develops after 20 weeks of gestation in the absence ofproteinuria. Beets and star fruit contain vitamins and minerals such as Bvitamins and calcium, potassium, phosphorus, and iron, which can safelylower blood pressure in pregnancy.Objective: Determine the effect ofbeetroot juice (Beta vulgaris L) and star fruit (Averrhoacarambola L) on reducing blood pressure in pregnant women in the second trimester with gestational hypertension.Method: This pre-experimental research was a one-group pretest-posttest design with 200 ml/day of beet and starfruit juiceintervention for two weeks. The samples taken were 15 second trimesterpregnant women with gestational hypertension.The data taken is bloodpressure before and after treatment—data analysis using paired t-test.Results: data onthe mean systolic blood pressure before treatment is 146.53mmHg and after treatment is 126.07 mmHg and the average diastolic blood pressure before treatment is 94.53 mmHg and after treatment is 91.13mmHg. There is an effect of beet and star fruit juice administration onsystolic and diastolic blood pressure in second-trimester pregnant womenwith gestational hypertension (p 0.05).Conclusion : pregnant women withgestational hypertension is to treat hypertension using beet and starfruit juice so that hypertension can be treated immediately.Keywords: Beetroot Juice, Beta vulgaris L , Star Fruit , Averrhoa carambola L, Gestational Hypertension
Aktivitas Antibakteri Ekstrak Etanol Biji Keluak (Pangium Edule) Terhadap Bakteri Salmonella Typhi Ricko Arie Jatmiko; Alvi Milliana; Christyaji Indradmojo
Journal of Islamic Medicine Vol 7, No 1 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i1.10546

Abstract

Background: Typhoid fever often occurs in various countries in the world and generally occurs in countries with low levels of cleanliness. Typhoid fever is a systemic disease caused by Salmonella typhi bacterial infection. The main therapy for typhoid fever is antibiotics. The challenge of using synthetic antibiotics nowadays is the emergence of side effects of resistance. One of the plants that can be used as an antibacterial is extract of keluak seed (Pangium edule). This study aims to determine the antibacterial activity of keluak seed (Pangium edule) antibacterial extract on the growth of Salmonella typhi. This research is a quantitative type of experimental research with true experimental post-test control design). Method: The method used in this study used a qualitative phytochemical test and dilution of the tube. This study uses 6 concentrations which are 5, 10, 15, 20, 25, and 30 mg/ml. Bacterial suspension was used as negative control and extract 100 mg/ml was used as positive control. Result: Based on the phytochemical test show that the seeds of the keluak seed (Pangium edule) contain alkaloids and terpenoids. The extract of keluak seed seed has a MIC at a concentration of 10 mg/ml and MKC 30 mg/ml. MKC data were analyzed by the KruskalWallis test (significance p = 0,000) with (coefficient correlation= -0,990) the relationship between the two variables is very strong. Conclusion: The extract keluak seed (Pangium edule) seeds can inhibit the growth of S. typhi bacteria.
Efektifitas Kombinasi Ekstrak Buah Pare Dan Sawo Manila Sebagai Antimikroba Bakteri Salmonella Typhi Isolasi Pada Carrier Tifoid Susanto, Awaluddin; Farhan, Antofani; Khanifah, Farach
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11091

Abstract

Latar belakang: Bakteri Salmonella typhi adalah penyebab penyakit demam tifoid. Kasus carrier demam tifoid merupakan faktor resiko terjadinya outbreak demam tifoid. Belum adanya penatalaksanaan pengobatan terhadap carrier inilah yang sekarang masih menjadi permasalahan. Buah pare dan sawo manila terkandung banyak sekali senyawa aktif dan berpotensi sebagai antimikroba alami, salah satunya bakteri Salmonella typhi penyebab demam tifoid. Tujuan: Penelitian ini bertujuan untuk mengetahui kombinasi ekstrak buah sawo manila dan pare yang efektif dalam menghambat pertumbuhan bakteri Salmonella typhi. Metode: Penelitian ini true eksperimental dengan pre-post test group desain control dengan populasi bakteri Salmonella typhi hasil isolasi dari mahasiswa Program Studi Analis Kesehatan STIKes ICMe Jombang yang terdiagnosa carrier demam tifoid. Teknik sampling menggunakan incidental sampling. Pengujian penghambatan pertumbuhan bakteri Salmonella typhi dari carier demam tifoid diberikan ekstrak buah pare dan sawo manila dengan konsentrasi 25%, 50%, 75% dan 100%. Pengukuran jumlah bakteri berasal dari sampel feces carier kemudian ditanam pada media SSA dan dilakukan uji antimikroba metode dilusi padat menggunakan media MHA. Analisa data dengan uji statistik ANOVA menggunakan program SPSS for tingkat kepercayaan p=0,05. Hasil: Hasil penelitian berdasarkan uji Kruskal Wallis menunjukkan perbedaan antar perlakuan secara signifikan (p= 0.018). Kemudian dilakukan uji Mann Withney dengan hasil kelompok perlakuan kontrol berbeda nyata dengan semua kelompok ekstrak, begitu juga antar kelompok perlakuan masing-masing berbeda nyata. Kesimpulan: Berbagai kombinasi konsentrasi ekstrak buah pare dan sawo manila efektif menghambat bakteri Salmonella typhi.Kata kunci : Buah pare , Carrier Tifoid , Ekstrak , Salmonella typhi, Sawo manila,
CHubungan Tingkat Beban Pekerjaan terhadap Kejadian Kifosis pada Buruh Panggul di Pasar Tradisional Tanjung Jember Periode Bulan Januari 2020 Totalenesya Reforrent Sutikno; Dion Krismashogi Dharmawan; Erfan Efendi
Journal of Islamic Medicine Vol 6, No 1 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i1.11261

Abstract

Background: Kyphosis is  vertebrae disorder characterized with increased of vertebrae curve in sagital line of 40o Cobb angle. Kyphosis is caused by degenerative proces,, neuromuscular disease, tumor, trauma, congenital abnormalities and unergonomic posture at the moment of carriying weights. One of kyphosis risk factor is excessive weights on the back in long duration. The complication of kyphosis such as vertebrae compression fracture could cause pain and deformities. Objective: Purpose of this research is to describe the correlation between workload level in carrier workers towards kyphosis at Tanjung Market, Jember. Methods: This research was observational analitic, cross sectional method, and total sampling. The respondents were 32 male carrier workers and 32 controls.. Data was obtained by interview and Cobb angle measurement on 1st and 12th thoracal vertebrae using inclinometer. Statistical test was done by Spearman correlation test. Results: The data analysis showed that p value for working time, work tenure, and transport weights toward kyphosis prevalence sequentially were 0,778; 0,326; and 0,739. Male carrier workers in Tanjung Traditional Market used to carry 50-100 Kg of weights once they start to transport. The working time of the carrier workers each day were seven hours and 15 years for work tenure in average. There were two carrier workers (6,2%) suffering of kyphosis (50 years old) with working time 8 hours per day, 10 years for work tenure, and 50 Kg for transport weights.. Conclusion: This research had proven that there is no any correlation between working time, work tenure, and carried load level towards kyphosis in carrier workers of Tanjung Market Jember.
Antioxidant And Antibacterial Activities Of Methanol Extract Of Fig Fruit And Leaves (Ficus Carica L.) Agustina, Eva; Lusiana, Nova; Purnamasari, Risa; Faidah, Nurul Ilmi; Agustin, Azlinda Mitha
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11376

Abstract

Background: Fig plants (Ficus carica L.) have phytochemical contents such as polyphenols, flavonoids, and anthocyanins which are relatively high. The content of this active compound can be used as an antioxidant and antibacterial. Objectif: The study aims to determine the antioxidant and antibacterial activity of methanol extracts fruit and leaves of fig (Ficus carica L.). Methods : DPPH method was carried out to determine the antioxidant fruit and leaves of fig (Ficus carica L.) by observing the change in colour of the test sample after incubation with DPPH solution using a UV-Vis spectrophotometer at a wavelength of 517 nm. The antibacterial test uses disc paper diffusion test to see the inhibition zone formed and continued with the MIC and MKC tests. Results : The antioxidant test results showed the IC50 values in methanol extracts of fig fruits were 13.402 ppm and 7.9875 ppm for fig leaves. From the IC50 value, both the fruit and fig leaves are classified into a solid antioxidant compound. The antibacterial test results showed that the highest inhibitory diameter was found at a 100% concentration of 28.5 mm. The quantitative antibacterial activity test showed that the methanol extract of fig fruit had a MIC value at a concentration of 80% and a MKC value at a concentration of 100%. The optimal strength as an antibacterial from fruit extracts and leaves is 100% concentration. Conclusion : The results showed the methanol extract of fig (Ficus carica L.) has potential as an antioxidant and antibacterial compound.Keyword : Antioxidant, Antibacterial , Fig Plants

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