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PROFIL KASUS TUBERKULOSIS RESISTEN OBAT DI RSUP Dr. SOERADJI TIRTONEGORO KLATEN PERIODE TAHUN 2012-2017 Lija Oktya Artanti, Alifia Rimadhani Yuwono, Surya Amal,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

DR TB (Drug Resistance Tuberculosis) is the resistance of Micobacterium tuberculosis to anti-tuberculosis drugs. These study aims are to observe and identify the case profile of drug-resistant tuberculosis, which includes patient characteristics and resistance patterns of Micobacterium tuberculosis against ATD at dr. Soeradji Tirtonegoro Klaten. The type of research is descriptive-retrospective based on secondary data from laboratory data and medical records in the period 2012-2017. Sampling was done by total sampling technique. Obtained a total population of TB patients resistant was 15 patients with 10 patients who met the inclusion criteria expressed in the study sample. Characteristics of patients with drug-resistant tuberculosis, mostly found were female (60%) with an age range of 60-70 years (40%). Mostly origins of Klaten (central region) (90%). The educational status was high school graduated (50%), not working (60%), comorbidities were bronchiectasis (15.4%), the nutritional status was underweight (60%), and suffering the pulmonary TB (70%). The result of this study showed the resistance patterns were primary resistance (50%) and secondary resistance (50%). Resistant to 1 ATD (60%), 2 ATD (30%), 3 ATD (10%). The highest resistance was monoresistant streptomycin (20%), ethambutol (20%), rifampicin (10%), Isoniazid(10%). Polyresistant found was the combination of ethambutol and streptomycin (30%). MDR TB incidence (10%) was the combination of rifampicin + ethambutol + streptomycin. The highest sensitivity was toward Isoniazid (22.5%). The highest resistance was toward ethambutol (15%) and streptomycin (15%).

PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfu'ah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

Formulasi Tablet Effervescent Daun Kersen (Muntingia calabura L.) dengan Variasi KonsentrasiEffervescent Mix Anggun Mahirotun Nur Sholikhah; Surya Amal; Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

Muntingia calabura L. is one of the type genus Muntingia which grows ever green and always has a lot of benefits but has not been used optimally. This study aims to utilize Muntingia calabura leaves take one form of pharmaceutical preparations namely effervescent tablet. Effervescent tablets are made using dry granulation of the metanol : water extract Muntingia calabura leaves. This study used variations of the concentration of effervescent mix to know the best concentration of the effervescent mix. Method to make it in relative humidity condition (RH) and appropriate temperature. Three of the formula that has made qualified evaluation of granules (time flow, angle of repose, and compresibility) and evaluation of effervescent tablets (weight variation, hardness test, time dissolved, assay test water, and pH level test). The results of analysis, showed that the three all formulas meet the requirement of test characteristics of granule and effervescent tablet. Based on the results of the research can be conclude that the formula with a concentration of 60% (formulation 2) effervescent mix is the best formula. This is due to the formula for concentration of 60% effervescent mix is the concentration that is ideal concentration for effervescent tablets.

Uji Efektivitas Air Perasan Jeruk Nipis (Citrus aurantifolia) dan Madu Randu dalam Menghambat Pertumbuhan Bakteri Propionibacterium acnes Nursalinda Kusumawati; Solikah Ana Estikomah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

Acne is one of the diseases that occurs in the skin due to inflammation caused by bacteria. Propionibacterium acnes is a main bacterium causes acne that forms part of the normal flora of the skin and only live in normal-alkaline pH. Lime juice and honey are the most commonly used by the community to overcome the problem of acne to avoid the side effects of acne medications in the form of antibiotics. Lime juice and honey have a low pH value so that it can be used as an antibacterial by inhibiting bacterial growth, even killing bacterial cells that are not acid resistant. The purpose of this study was to determine the effectiveness of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes bacteria. The study was conducted using the disk diffusion method with 4 variations of concentration; 25% v/v, 50% v/v, 75% v/v and 100% v/v in 4 repetitions incubated for 24 hours at 37 °C. The results of this study are in the form of clear zones around the disc paper which are considered as an inhibitory zones. The formation of inhibitory zones shows the potential of lime juice and honey randu (Randu honey) against the Propionibacterium acnes bacteria as antibacterial. Lime juice and Randu honey each with a concentration of 25% v/v, 50% v/v, 75% v/v and 100% v/v has the potential as an antibacterial against Propionibacterium acnes bacteria. It is concluded that the optimal concentration of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes were at a concentration of 100% v/v with a inhibition zone of 9.11 mm for lime juice and 28.10 mm for honey randu (Randu honey).

Profil Kasus Tuberkulosis Resisten Obat di RSUP Dr. Soeradji Tirtonegoro Klaten Periode Tahun 2012-2017 Alifia Rimadhani Yuwono; Surya Amal; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

DR TB (Drug Resistance Tuberculosis) is the resistance of Micobacterium tuberculosis to anti-tuberculosis drugs. These study aims are to observe and identify the case profile of drug-resistant tuberculosis, which includes patient characteristics and resistance patterns of Micobacterium tuberculosis against ATD at dr. Soeradji Tirtonegoro Klaten. The type of research is descriptive-retrospective based on secondary data from laboratory data and medical records in the period 2012-2017. Sampling was done by total sampling technique. Obtained a total population of TB patients resistant was 15 patients with 10 patients who met the inclusion criteria expressed in the study sample. Characteristics of patients with drug-resistant tuberculosis, mostly found were female (60%) with an age range of 60-70 years (40%). Mostly origins of Klaten (central region) (90%). The educational status was high school graduated (50%), not working (60%), comorbidities were bronchiectasis (15.4%), the nutritional status was underweight (60%), and suffering the pulmonary TB (70%). The result of this study showed the resistance patterns were primary resistance (50%) and secondary resistance (50%). Resistant to 1 ATD (60%), 2 ATD (30%), 3 ATD (10%). The highest resistance was monoresistant streptomycin (20%), ethambutol (20%), rifampicin (10%), Isoniazid(10%). Polyresistant found was the combination of ethambutol and streptomycin (30%). MDR TB incidence (10%) was the combination of rifampicin + ethambutol + streptomycin. The highest sensitivity

Pengaruh Puasa terhadap Jumlah dan Morfologi Spermatozoa Mencit (Mus musculus) Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using 5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

Efektvitas Kombinasi Getah Pelepah Pisang Ambon (Musa paradisiaca L.) dan Jarak Pagar (Jathropha curcas L.) untuk Menyembuhkan Luka pada Marmut (Cavia porcellus) Amal Fadholah; Salma Auliya Fatimah; Salma Cristy Syahidahalla
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Wounds are a condition of damage or loss of some body tissue. Wounds can be cured with various drugs but have side effects and long healing times, one of which is Oxytetracyclin 3%. Jatropha sap has tannin, saponin, curcain protease and banana midrib having saponin, lectin, anthraquinone, quinone, flavonoid, tannin compounds which can be used to accelerate the healing process, antibacterial, and stop bleeding. This study aims to determine the effectiveness of the combination of banana stem sap and jatropha curcas to heal wounds in guinea pigs. This study is an experimental type with a completely randomized design (CRD) design using 4 treatments and 2 replications. The treatment used was a combination of banana midrib and jatropha sap with a ratio of 4%: 4%, 8%: 8%, 16%: 16% and positive controls using Oxytetracyclin 3%. The sap of the banana midrib and the distance of the fence are made in the form of ointments. Data in the form of the number of days from the formation of wounds to guinea pigs until the wound heals. The results showed that the combination of jatropha resin and sap of Ambon banana stem can provide the best wound healing effect at a concentration of 16%: 16% with the fastest wound healing time in 6 days.

Uji Efektivitas Ekstrak Etanol Daun Bidara (Ziziphus spina- christi L.) terhadap Pertumbuhan Propionibacterium acne Nurul Marfu’ah; Chelsea Aulia Ramadhani; Aural Miftahul Hasanah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Traditional medicinal plants can prove the importance of natural ingredients for various processes of human medicine. In recent years, there has been an increase in researchers' interest in the use of natural materials as natural biological compounds in the manufacture of drugs. One of the plants used as medicine by the community is bidara plants. Plant bidara contains phenolics and flavonoids which are rich in antibacterial properties. One of the bacteria that causes acne is Propionibacterium acnes. Untrated pimples will cause serious illness. Therefore, this study was conducted to determine the antibacterial activity of the ethanol extract of bidara against Propionibacterium acnes. This is an experimental study with 3 concentrations of bidara leaf extract namely concentrations of 70%, 80%, 90% and using negative controls (aquadest) and positive control (clindamisin). Extract of bidara leaves is done by maceration using 70% ethanol solution. While the antibacterial test uses the agar diffusion method using a well. Data obtained in the form of inhibitory zone measurements were analyzed using Analysis of variants (ANOVA). The results of this study indicate that the ethanol extract of Bidara leaves with a concentration of 70%, 80%, and 90% is not effective in inhibiting the growth of Propionibacterium acnes bacteria.

Pengaruh Jenis Pelarut pada Ekstraksi Daun Kumis Kucing (Orthosiphon stamineus Benth) terhadap Kadar Kalium Janugraheni Prasetya Ningrum; Fitria Susilowati; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Indonesia has a variety of biological resources in various regions. One of the plants that can be used as medicine is Orthosiphon stamineus Benth. Orthosiphon stamineus Benth has several secondary metabolites, one of them is Potassium that has diuretic function. This study aims to know the effect of the solvent type to the level of Pottasium on the extraction of Orthosiphon stamineus Benth. The research method was done using atomic absorption spectrophotometry instrument. Samples were obtained and identified from UPT Materia Medica Batu Malang, East Java, sample was extracted by percolation method and infusion. The sample was the destructed then was destructied using HNO3 to transform organic metal into inorganic, then measured the absorbance using atomic absorption spectrophotometry at wavelength 766,5. The result showed that the concentration of potassium in Orthosiphon stamineus Benth in water solvent, ethanol 70%, ethanol 96%, and methanol were (29,256 ± 1,581) mg/L, (51,294 ± 5,028) mg/L, (31,406 ± 2.777) mg/L, (58.351 ± 2.925) mg/L. The method had in standard deviation value of each solvent is; water solvent 0,005, ethanol 70% 0,017, ethanol 96% 0,009, and methanol 0,001. Based on statistical test calculations using different test calculations over two samples there was a difference in average of Potassium level between each solvent, with the highest Potassium content found in methanol solvent.

Implementasi Standar Pelayanan Kefarmasian di Apotek M. Sidrotullah; Nur Radiah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Pharmaceutical work is always developing following the demands of the community so that the patients served understand about the pharmaceutical preparations they receive, and the monitoring system in patients can be carried out well. According to the Minister of Health of the Republic of Indonesia No.73 of 2016, regarding Pharmaceutical Service Standards at the Pharmacy which refers to Pharmaceutical Care, pharmacists are responsible for the quality of medicines given to patients, as well as information on how to use side effects to monitor drug use, to improve quality of life patient. This study aims to determine the description of the implementation of pharmaceutical service standards in pharmacies in the city of Mataram, as well as supporting and inhibiting factors on their implementation. This research is a descriptive study using 52 private pharmacies in 6 sub-districts in the city of Mataram. Data collection was carried out using a questionnaire, referring to Monitoring of Pharmaceutical Services at the Pharmacy, Ministry of Health of the Republic of Indonesia. Assessment includes six standards divided into thirty one parameters. While data on supporting and inhibiting factors are obtained from the results of interviews to respondents. Previously tested the validity and reliability of the questionnaire on 30 respondents using SPSS. The results showed that pharmaceutical service standards at pharmacies in Mataram had not been implemented well, with good categories (≥85) of 0%, medium (65-85) 27%, and less (≤65) 73%. Based on the results of the interview, it is known that the supporting factors for implementing standards are the pharmacist's motivation at work, PSA support and all staff at the pharmacy, support and commitment with relevant stakeholders namely policy makers and regulations, agencies that carry out socialization, monitoring and coaching, universities, professional organizations . While the inhibiting factor is the pharmacist has not played a role in the pharmacy, weak support and evaluation by the pharmacy management, including the procurement of facilities and infrastructure, lack of socialization, legislation, and weak regulatory control by the relevant authorities.

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Nurul Marfu'ah

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nurulmarfuah@unida.gontor.ac.id

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+6285336431175

Journal Mail Official
nurulmarfuah@unida.gontor.ac.id

Editorial Address
University Of Darussalam Gontor Gontor For Girls Campus 1, Sambirejo, Mantingan, Ngawi, East Java, Indonesia, 63257

Location
Kab. ponorogo,

Jawa timur

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Nurul Marfu'ah

Contact Email nurulmarfuah@unida.gontor.ac.id

Phone +6285336431175

Journal Mail Official nurulmarfuah@unida.gontor.ac.id

Editorial Address University Of Darussalam Gontor Gontor For Girls Campus 1, Sambirejo, Mantingan, Ngawi, East Java, Indonesia, 63257

Location Kab. ponorogo, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Nurul Marfu'ah

Contact Email
nurulmarfuah@unida.gontor.ac.id

Phone
+6285336431175

Journal Mail Official
nurulmarfuah@unida.gontor.ac.id

Editorial Address
University Of Darussalam Gontor Gontor For Girls Campus 1, Sambirejo, Mantingan, Ngawi, East Java, Indonesia, 63257

Location
Kab. ponorogo,

Jawa timur

INDONESIA