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Maturation of Vaginal Epithelium and Dyspareunia Symptoms in Equol Producing and Non-Producing Menopausal Women Tita Husnitawati Madjid; Nurlina Juniar; Dian Tjahyadi; Birgitta M. Dewayani; Wiryawan Permadi; Benny Hasan Purwara; Hadi Susiarno
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Introduction: Equol is a metabolite of soy isoflavon called daidzein which is produced by gastrointestinal tract bacteria. This research aims to analyze the maturation of vaginal epithelium and dyspareunia symptoms in producing and non-producing equol menopausal women.Method: This is a cross sectional research. Subject was a community of menopausal women who fulfilled inclusion criteria. Subjects were asked to sign a written informed consent. Subjects underwent vaginal epithelium maturation assessment and were asked whether she experienced dyspareunia. Research was conducted in January 2017.Result: There was a significant difference on the maturation of vaginal epithelium and dyspareunia symptoms between equol producing and non-producing women (p < 0.05). This research found that in equol producing menopausal women, there was a shift-to-the-right vaginal epithelium maturation with more superficial cells compared to parabasal cells produced and less dyspareunia. Meanwhile, in women who did not produce equol, there was a shift-to-the-left vaginal epithelium maturation with more parabasal cells compared to superficial cells produced and more dyspareunia.Conclusion: In equol producing menopausal women, vaginal epithelium will undergo a shift-to-the-right maturation, with more superficial cells produced compared to women who did not produce equol.Maturasi Epitel Vagina dan Gejala Dispareunia pada Wanita Menopause yang Menghasilkan Equol dan Wanita yang Tidak Menghasilkan EquolAbstrakPendahuluan: Equol adalah metabolit isoflavon kedelai yang disebut daidzein yang diproduksi oleh bakteri saluran pencernaan. Penelitian ini bertujuan untuk menganalisis maturasi epitel vagina dan gejala dispareunia pada wanita menopause yang memproduksi dan tidak memproduksi equol.Metode: Penelitian ini merupakan penelitian cross sectional. Subjek penelitian adalah sekelompok wanita menopause yang memenuhi kriteria inklusi. Subjek diminta untuk menandatangani persetujuan tertulis dan menjalani penilaian maturasi epitel vagina dan ditanya apakah mengalami dispareunia. Penelitian dilakukan pada Januari 2017.Hasil: Terdapat perbedaan yang signifikan pada maturasi epitel vagina dan gejala dispareunia antara wanita yang memproduksi equol dan yang tidak memproduksi (p <0,05). Pada wanita menopause yang memproduksi equol, terjadi pematangan epitel vagina shift-to-the-right disertai produksi sel superfisial yang lebih banyak dibandingkan sel parabasal dan lebih sedikit gejala dispareunia. Sementara itu, pada wanita yang tidak menghasilkan equol, terjadi pergeseran shift-to-the-left maturasi epitel vagina dengan produksi sel parabasal lebih banyak dibandingkan sel superfisial dan lebih sering gejala dispareunia.Kesimpulan: Wanita menopause yang memproduksi equol mengalami maturasi epitel vagina shift-to-the-right disertai produksi sel superfisial yang lebih banyak dibandingkan dengan wanita menopause yang tidak memproduksi equol.Kata kunci: Dyspareunia; equol; maturasi epitel vagina

Hubungan Penggunaan Antiretroviral (ARV) dengan Luaran Neonatal pada ibu terinfeksi Human Immunodeficiency Virus (HIV) Noor Aida Ariyani; M. Robyanoor Ahyadi Radam; Samuel L. Tobing; Renny Aditya; Ari Yunanto; Pudji Andayani
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Mengetahui hubungan penggunaan antiretroviral pada ibu terinfeksi HIV dengan luaran neonatal. Metode: Menggunakan metode analitik dengan pendekatan cross sectional. Pengambilan data dilakukan dari Poli Klinik VCT dan register VK RSUD Ulin Banjarmasin. Jumlah data dibagi berdasarkan penggunaan antiretroviral dan bukan pengguna antiretroviral di hubungkan dengan hasil luaran neonatal berupa berat badan lahir, prematur, IUGR, asfiksia dan kematian neonatal. Analisis menggunakan uji statistik chi square test bermakna bila p < 0.05 ,bila uji chi square tidak memenuhi kriteria maka dilakukan uji fisher.Hasil: Terdapat 73 kasus melahirkan terinfeksi HIV tahun 2015-2018. Ibu terinfeksi HIV yang menggunakan antiretroviral sebanyak 24 (33%) dan bukan menggunakan antiretroviral sebanyak 49 (67%). Dihubungan penggunaan antiretroviral dengan luaran neonatal berat badan lahir bayi, hasil uji square <0.05 signifikan yaitu p 0.019, hasil luaran neonatal prematur (p = 0.022). Hubungan penggunaan antiretroviral terhadap hasil luaran berupa IUGR, asfiksia dan kematian neonatal didapatakan p 0.166 ; 0.243 ; 0.649.Kesimpulan: Penggunaan antiretroviral pada ibu hamil terinfeksi HIV mengurangi kejadian bayi berat lahir rendah dan prematurRelationship between Antiretroviral Therapy (ARV) with Neonatal Outcome in Woman with HIV InfectionAbstractObjective: Assess the correlation of antiretroviral medication in HIV-infected pregnant women to the outcome of neonates. Method: Analytical method with a cross-sectional approach was used. Data were obtained from the VCT polyclinic and the register of the VK register of Ulin Banjarmasin Regional General Hospital (RSUD). The data are divided into antiretroviral user and non-antiretroviral users linked with the outcome of the neonate in birth weight, prematurity, IUGR, asphyxia, and neonatal death. Statistical analysis using the chi-square test will suggest a significant difference if the p-value is < 0.05. If the chi-square test can not be used, fisher test will be conducted.Result: There are 73 cases of HIV-infected births between 2015 and 2018. There are 24 (33%) of HIV-infected pregnant women on antiretrovirals compared to 49 (67%) non-users. There is a link between antiretroviral usage with the neonatal outcome of birth weight with a chi-square p-value of 0.019 (significant if p-value < 0.05). The outcome of prematurity is also significant, with a p-value of 0.022. The correlation of antiretroviral use to outcome in IUGR, asphyxia, and neonatal mortality are of p-value 0.166; 0.243, and 0.649, respectively.Conclusion: Antiretroviral use in HIV-infected pregnant women reduces the outcome of low birth weight and prematurity incidence in neonates.Key words: HIV, infected woman, outcome, antiretroviral, RSUD Ulin

Kanker Ovarium : “The Silent Killer” Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan artikel ini adalah untuk mereview sejarah dan implikasi kanker ovarium dengan bahasa metafora pembunuh diam-diam atau “Silent Killer” sehingga akan meningkatkan kesadaran tentang kanker ovarium. Pada abad kedua puluh, metafora pembunuh diam-diam sering dikaitkan dengan kata berbahaya yang menggambarkan kanker ovarium. Istilah "silent killer" sebetulnya sering digunakan untuk menggambarkan kanker lain dan juga diterapkan pada penyakit seperti hipertensi dan diabetes. Kanker ovarium sering disebut sebagai pembunuh diam-diam karena diyakini sebagian besar pasien didiagnosis pada stadium lanjut dan sering tidak ditemukan gejala yang jelas pada stadium awal

Faktor Risiko Kejadian Hipertensi dalam Kehamilan di Rumah Sakit Bhayangkara Denpasar Febyan Febyan; Ida Bagus Rumbawa Pemaron
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Meninjau sejumlah faktor risiko terjadinya penyakit hipertensi dalam kehamilan. Kejadian hipertensi dalam kehamilan dapat dipengaruhi oleh berbagai faktor, yaitu: Primigravida, nuliparitas, usia ibu dan Indeks Massa Tubuh, yang merupakan bagian dari faktor risiko terjadinya penyakit hipertensi dalam kehamilan. Metode: Penelitian ini merupakan studi observasional dengan metode potong lintang, variabel yang digunakan berupa usia maternal, graviditas, indeks massa tubuh terhadap kejadian hipertensi dalam kehamilan. Sampel penelitian ini adalah ibu hamil yang datang ke Poli Rawat Jalan Departemen Obstetri dan Ginekologi Rumah Sakit Bhayangkara, Denpasar, pada bulan Oktober – Desember 2018. Uji statistik menggunakan Chi Square/Fisher’s Exact Test.Hasil: Faktor risiko yang penting untuk terjadinya hipertensi dalam kehamilan antara lain, indeks massa tubuh (OR 2,60 95% IK 1,36-4,95 p = 0,005) dan usia maternal (OR 2,74 95% IK 1,41-5,43 p =0,004). Sementara itu graviditas (OR 1,58 95% IK 0,70-3,57 p=0,077) bukan merupakan faktor risiko yang bermakna. Kesimpulan: Terdapat hubungan antara indeks massa tubuh dan usia maternal dengan kejadian hipertensi dalam kehamilan, dan tidak ada hubungan yang bermakna antara graviditas dengan kejadian hipertensi dalam kehamilan.A Review on The Risk Factors of Hypertension in Pregnancy at Bhayangkara Hospital DenpasarAbstractObjective: To review some risk factors of the recurrence of hypertension in pregnancy disorder. The incidence of hypertension in pregnancy can be affected by several factors: Primigravida, nulliparitas, maternal age and increased body mass index are the risk factors for hypertension in pregnancy. Method: This study was an observational study with cross-sectional the variable used were maternal age, gravidity and body mass index (BMI) on the incidence of hypertension in pregnancy. The samples were pregnant women who came to Clinic of Obstetrics and Gynecology Departement, Bhayangkara Hospital Denpasar during October to December 2018. Statistical test used was chi square factor exact tes.Result: The most important risk factors for hypertension in pregnancy such as, body mass index (OR 2,60 95% CI 1,36-4,95 p = 0,005) and maternal age (OR 2,74 95% CI 1,41-5,43 p =0,004) mean while gravidity (OR 1,58 95% CI 0,70-3,57 p=0,077) is not a significant risk factor. Conclusion: There is a correlation between maternal age and body mass index with hypertension in pregnancy and no correlation between gravidity with hypertension in pregnancy.Key words: gravidity, hypertension in pregnancy, body mass index, maternal age.

Hubungan Kadar Vitamin D Serum dengan Konsentrasi, Motilitas dan Morfologi Sperma pada Pria Subfertil di Klinik Teknologi Reproduksi Berbantu Aster Rumah Sakit Dr. Hasan Sadikin Bandung Magnadi Yogi Rahma; Wiryawan Permadi; Anita Rachmawati; Jusuf Sulaeman Effendi; Tono Djuwantono; Budi Handono
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Untuk menganalisis hubungan kadar vitamin D dengan kualitas sperma pada pria subfertil, serta membandingkan kualitas sperma berdasarkan klasifikasi kadar vitamin D serum pada pria normospermia dan pria oligoasthenoteratospermia.Metode: Penelitian ini merupakan penelitian yang bersifat observasional analitik dengan rancangan studi potong lintang. Subjek penelitian adalah pria subfertil yang berusia 20-50 tahun, dibagi menjadi 2 kelompok, yaitu 30 pasien normospermia dan 16 pasien oligoasthenoteratospermia berdasarkan berdasarkan kriteria World Health Organization 2010. Penelitian dilakukan di Klinik Teknologi Reproduksi Berbantu Aster, RSUP Dr. Hasan Sadikin Bandung. Analisis data menggunakan analisis korelasi rank SpearmanHasil: Pada penelitian ini didapatkan korelasi positif antara kadar vitamin D dan motilitas sperma ( r = 0,639, p = < 0,001), tetapi tidak didapatkan korelasi pada konsentrasi dan morfologi sperma ( p>0,05). Perbedaan yang bermakna didapatkan antara kadar vitamin D pada kelompok normospermia dan oligoasthenoteratospermia dengan nilai p<0,05. Pada perbandingan kualitas sperma berdasarkan klasifikasi kadar vitamin D hanya motilitas sperma saja yang memiliki perbedaan bermakna dengan nilai p<0,05.Simpulan: Terdapat hubungan yang bermakna antara kadar vitamin D serum dan motilitas sperma.Correlation Of Vitamin D Serum Level With Concentration, Motility, And Morphology Of Spermatozoa Subfertil In Assisted Reproductive Technology Aster Clinic Hasan Sadikin Hospital BandungAbstractObjective: This study aims to analyze the relationship of vitamin D levels with sperm quality in subfertile men, as well as comparing sperm quality based on vitamin D serum levels classification in normospermic men and oligoasthenoteratospermia men.Method: This study is an analytic observasional with cross sectional design. Research subjects were subfertile men aged 20-50 years divided into 2 groups, consisting of 30 patients with normospermic and 16 patients with oligoasthenoteratospermia based on World Health Organization 2010 criteria. The research was conducted at Assisted Reproductive Technology Aster, RSUP Dr. Hasan Sadikin Bandung. Data analysis was using Spearman’s rank correlation analytic.Result: We found a positive correlation between vitamin D levels and sperm motility (r = 0.639, p = <0.001), but no correlation was found on sperm concentration and morphology (p> 0.05). There was a significant difference between vitamin D levels in normospermic and oligoasthenoteratospermia group with p <0,05. In the sperm quality comparison based on vitamin D serum classification, only sperm motility alone had a significant difference with the value of p <0.05. It was concluded that level of vitamin D serum has positive correlation with sperm motility.Key word: subfertile, vitamin D, sperm quality

Perbandingan Uji Hemostasis pada Preeklamsia antara Awitan Dini pada Awitan Lambat Aisah Djumadisstsaniah; Yusrawati Yusrawati; Andi Friadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Penelitian ini bertujuan untuk mengetahui perbandingan uji hemostasis pada preeklamsia antara awitan dini (PEAD) dengan awitan lambat (PEAL)Metode: Penelitian ini adalah penelitian analitik observasional dengan pendekatan potong lintang dengan menggunakan data rekam medis pasien preeklamsia yang dirawat dan atau melahirkan di RSUP DR M Djamil Padang. Analisis univariate disajikan dalam bentuk tabel distribusi frekuensi dan analisis univariate menggunakan uji T tidak berpasangan dan uji Mann-WhitneyHasil: PT (Prothrombine Time) dan APTT (Activated Partial Thromboplastin Time) lebih rendah pada PEAD daripada PEAL (p>0,05), D-dimer lebih tinggi PEAD daripada PEAL(p>0,05), dan jumlah trombosit lebih rendah PEAD daripada PEAL(p<0,05)Kesimpulan: Pada penelitian ini tidak terdapat perbedaan yang bermakna dari parameter faal pembekuan darah berupa PT, APTT, dan D-dimer, tetapi terdapat perbedaan yang bermakna pada jumlah trombosit antara PEAD dan PEAL dengan jumlah trombosit PEAD lebih rendah daripada PEALComparison of Hemostatic Test Result Between Cases of Early and Late Onset PreeclampsiaAbstractObjective: This study aimed to compare haemostatic test of early onset preeclampsia and late onset preeclampsiaMethod: This study was observational analytic study using cross-sectional design that collected data from medical records patients of preeclampsia who were hospitalized and/or giving birth in RSUP DR M Djamil Padang. Data were analized using Univariate analysis were presented in the form of frequency distribution table and Bivariate data were tested with Independent T-Test and Mann-Whitney TestResult: In this study, there was no differences in prothrombin time, activated partial thromboplastine time and D-dimer but thrombocyte count were different between early and late onset PreeclampsiaConclusion: On this research thrombocyte count is lower in early than late onset Preeclampsia and there is significantly different between early and late onset PreeclampsiaKey words: prothrombin time, activated partial thromboplastin time, D-dimer, thrombocyte count, early and late onset preeclampsia

Strategi Menurunkan Kematian Ibu Karena Preeklamsi dan Eklamsi Johanes C. Mose
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Menyimpulkan beberapa hasil penelitian tentang preeklamsi dan upaya menurunkan kematian ibu di negara maju maupun berkembang termasuk di Indonesia dan RSHS Bandung untuk menyusun strategi menurunkan kematian ibu karena preeklamsi.Metode: Dilakukan penelitian potong silang dengan rancangan observasional analitik dengan membandingkan data ibu hamil dengan preeklamsi/eklamsi yang melahirkan di RS Hasan sadikin Bandung periode Maret sampai September 2012 (sebelum JKN) dan 1 Januari 2016 sampai 31 Desember 2017(saat JKN dilaksanakan). Data dianalisis menggunakan uji statistik chi kuadrat untuk membandingkan perbedaan dengan kemaknaan nilai p< 0,05. Hasil: Terjadi kenaikan prevalensi preeklamsi dari 15,53% sebelum JKN, menjadi 25,04% saat JKN dilaksanakan. Terjadi peningkatan prevalensi preeklmasi menurut usia ibu, usia kehamilan, paritas, tingkat pendidikan, jumlah ANC, dan penyakit penyerta hipertensi dan kelainan jantung sebelum dan saat JKN dilaksanakan.Diskusi: Strategi menurunkan kematian ibu karena preeklamsi/eklamsi, adalah : mendukung program pemerintah untuk mengatasi kemiskinan, pendidikan dan kesulitan transportasi; melaksanakan program sosialisasi kepada masyarakat tentang tanda dan gejala preeklamsi; deteksi dini kelompok risiko dan diagnosis PE dengan pengukuran tekanan darah dan proteinuria serta pemberian pencegahan dengan aspirin dosis rendah dan kalsium; pelatihan pemeriksaan Doppler arteri uterina untuk SpOG serta sosialisasi protokol pengelolaan PE, dan pelatihan ‘preeclampsia special team’ di RS rujukan.Strategies for Reducing Maternal Mortality Due to Preeclampsia and EclampsiaAbstractObjective: To compile the result of studies on preeclampsia-eclampsia and strategies to reduce its maternal mortalities conducted in western and developing countries including Indonesia and Bandung aiming at developing strategies for reducing maternal mortality due to preeclampsia and eclampsia.Method: This is a cross sectional analytic survey by taking the data from medical record to compare and analyze data of mothers with preeclampsia-eclampsia who delivered at Dr. Hasan Sadikin General Hospital Bandung from March to September 2012 (before the implementation of National Health Insurance Program-NHIP) and from January 2016 to December 2017(during the implementation of NHIP). Data was analyzed by mean of Chi-square test and significant difference criteria of p<0.05. Result: There was a significant increase (p<0.05) in prevalence of preeclampsia before (15,53%) and during (25,04%) the implementation of NHIP. There was a significant increase (p<0.05) of incidence by maternal age, age of pregnancy, multiparity, low educational level, ANC of >4, and evidence of hypertension and cardiac complications before and during the implementation of NHIP. Discussion: The strategies for reducing maternal mortality due to preeclampsia are as follows : supporting the government programs to overcome poverty, education and transportation; socializing signs and symptoms of preeclampsia to the community; early detection of risk factors, blood pressure measurement and urine protein followed by administration of low dose aspirin and calcium tablets for prevention; training on Doppler examination of uterine arteries for OBGYN specialist and socializing standard guidelines and protocol for the management of preeclampsia; and training for a ‘preeclampsia special team’ in referral hospitals.Key words: Preeclampsia, maternal mortality, strategy for reducing maternal mortality.

Antley-Bixler Syndrome: A Case Report and Literature Review Hermanto Hermanto; Irwan Taufiqur Rachman
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Sindroma Antley-Bixler pertama kali dikemukakan oleh Ray Antley dan David Bixler tahun 1975. Sindroma ini jarang dan berhubungan dengan kelainan perkembangan tulang dan kartilago sehingga sering disebut multisynostotic osteodysgenesis syndrome. Craniosynostosis dan synostosis radiohumeral merupakan temuan yang paling konsisten. Penyebab sindroma ini belum jelas, diduga karena adanya mutasi genetik.Laporan kasus:Seorang ibu 22 tahun G2P1A0 dirujuk ke poliklinik obstetri dan ginekologi RSUP dr.Sardjito pada usia kehamilan 32-33 minggu untuk pemeriksaan antenatal dengan kecurigaan fetal craniosynostosis dan ventriculomegaly. Pada usia kehamilan 38 minggu, bayi lahir dengan craniosynostosis, ocular hypertelorism, disertai syndactily digiti II-IV pedis dextra et sinistra dengan diagnosis sementara sindroma Apert. Pemeriksaan penunjang yakni MSCT scan kranial dan foto rontgen regio artikulatio cubiti anteroposterior dan lateral menunjukan adanya craniosynostosis dan synostosis radioulna dan radiohumeral bilateral mengarahkan diagnosis sindroma Antley-Bixler. Bayi dipulangkan setelah 24 hari perawatan. Saat ini bayi masih menjalani perawatan berkala di instalasi rawat jalan ilmu kesehatan mata dan bedah saraf RSUP Dr. Sardjito Kesimpulan: Laporan kasus ini bertujuan untuk membahas penegakan diagnosis, tatalaksana yang telah dilakukan dan rencana tatalaksana yang akan datang. Kata kunci : Sindroma Antley-Bixler, craniosynostosis, synostosis radiohumeralAntley-Bixler Syndrome: A Case Report and Literature Review AbstractAntley-Bixler syndrome (ABS) was first described by Ray Antley and David Bixler in 1975. The syndrome is rare and characterized by abnormalities of bone and cartilage development (“syndrome of multisynostotic osteogenesis”). Craniosynostosis and radiohumeral synostosis are the most consistent findings. The cause of this syndrome is unclear, but genetic mutations are suspected.Case report: A 22-year-old female G2P1A0 was referred to the obstetrics and gynecology outpatient clinic at RSUP Dr. Sardjito at 32-33 weeks of gestation for antenatal care and further evaluation due to suspected fetal craniosynostosis and ventriculomegaly. At 38 weeks’ gestation, the baby was born with craniosynostosis, ocular hypertelorism, and syndactily digiti II-IV pedis dextra and sinistra, suspected Apert syndrome. Further investigation by using radiologic examination (cranial MSCT scan and X-ray at anteroposterior and lateral articulation cubital) revealed craniosynostosis, bilateral radioulna and radiohumeral synostosis, directed the diagnosis to Antley-Bixler syndrome. The baby was discharged after 24 days of hospitalization. Currently, the baby is still undergoing regular evaluation and treatment at the Ophthalmology and Neurosurgery outpatient departments at RSUP Dr. SardjitoConclusion: The aim of this case report is to discuss how to diagnose this syndrome and the management that had been done and further plans.

Maternal Obesity Increases Risk for Adverse Maternal Outcome at RSUP Dr. Mohammad Hoesin Palembang Syifa Alkaf; Optima Fitra Ilhami; Mutiara Budi Azhar; Nuswil Bernolian; Ardesy Melizah
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Objective: To find the relationship between level of obesity and adverse maternal outcomes in pregnant women Method: An observational analytic study with a cross sectional design with secondary data from medical record. Subjects were pregnant women who gave birth at RSUP Dr. Mohammad Hoesin Palembang in January 2015-December 2017. Samples were taken by purposive sampling technique. BMIs were divided into 5 categories based on WHO criteria, normoweight, overweight, obese level I, II, and III. Underweight was excluded from the study.Result: Of 252 research subjects, 94 (37.3%) were subjects with normal BMI, 102 (40.5%) were overweight, 44 (17.5%) were obese level I, 6 (2.4%) were level II, and 6 (2.4%) were level III. The maternal outcome consisted of 135 cases (53.6%) of preeclampsia, 6 cases of gestational diabetes mellitus (2.4%), 41 cases of uterine inertia (16.3%), 56 cases of preterm labor (22.2%), assisted delivery 111 cases (44%), and healthcare associated infections (HAIs) 6 cases (2.4%). Further analysis showed that increased level of maternal obesity is related significantly with preeclampsia, gestational diabetes mellitus, uterine inertia, and assisted delivery.Conclusion: There are statistically significant association between obesity level and the incidence of preeclamsia, gestational diabetes, uterine inertia and assisted delivery.Obesitas Pada Wanita Hamil Meningkatkan Morbiditas Maternal Di RSUP Dr. Mohammad Hoesin PalembangAbstrakTujuan: Untuk menemukan hubungan antara tingkat obesitas dengan luaran maternal pada wanita hamil. Metode: Studi analitik observasional dengan desain potong lintang menggunakan data sekunder rekam medis. Subjek adalah wanita hamil yang melahirkan di RSUP Dr.Mohammad Hoesin Palembang pada Januari 2015 - Desember 2017. Sampel diambil secara purposive sampling. Indeks massa tubuh (IMT) dibagi menjadi 5 sesuai kriteria WHO, yaitu normal, berat badan lebih, obesitas level I, II, dan III. Berat badan kurang diekslusi dari penelitian. Hasil: Subjek penelitian dari 252 orang, 94 (37.3%) subjek dengan IMT normal, 102 (40.5%) subjek berat badan berlebih, 44 (17.5%) obesitas level I, 6 (2.4%) obesitas level II, dan 6 (2.4%) obesitas level III. Luaran maternal terdiri dari 135 kasus (53.6%) of preeklampsia, 6 kasus diabetes mellitus gestasional, 41 kasus inertia uteri (16.3%), 56 kasus persalinan preterm (22.2%), 111 kasus (44%) persalinan pervaginam berbantu, dan infeksi luka 6 kasus (2.4%). Analisis menunjukkan adanya tingkatan obesitas maternal berkaitan secara signifikan dengan kejadian preeklampsia, diabetes mellitus gestasional, inertia uteri, dan persalinan pervaginam berbantu. Kesimpulan: Terdapat hubungan antara tingkat obesitas pada ibu hamil dengan preeklampsia, diabetes mellitus gestasional, dan persalinan pervaginam berbantu. Kata kunci: Indeks Massa Tubuh, Obesitas, Luaran Maternal, Morbiditas.

Hubungan Kadar Asam Urat, Laktat Dehidrogenase, Aspartat Aminotransferase Serum Penderita Preeklamsi Berat Disertai Komplikasi dan tanpa Komplikasi Galih Apriadi; Budi Handono; Akhmad Yogi Pramatirta; Jusuf S. Effendi; Tita Husnitawati Madjid; Adhi Pribadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: penelitian ini untuk mencari perbedaan kadar asam urat, laktat dehydrogenase (LDH) dan aspartat aminotransferase (AST) pada serum penderita preeklamsi berat disertai komplikasi dan tanpa komplikasi dan mengukur kuatnya hubungan peningkatan kadar asam urat, LDH dan AST dengan peningkatan risiko terjadinya komplikasi pada pasien preeklamsi berat. Metode: Rancangan penelitian ini adalah penelitian comparative cross sectional dengan metode consecutive sampling. Subjek penelitian adalah penderita preeklamsi berat disertai komplikasi dan tanpa komplikasi (n=68). Hasil: Hasil penelitian didapatkan perbedaan kadar asam urat, LDH dan AST pada kedua kelompok secara bermakna dengan nilai p ≤ 0,05. Peningkatan kadar asam urat, LDH dan AST berhubungan dengan peningkatan risiko terjadinya komplikasi dengan nilai cut off kadar asam urat > 6,5 mg/dL sebesar 33 kali, LDH > 573 U/L sebesar 8,95 kali dan AST > 30 U/L sebesar 5,19 kali. Jika terjadi peningkatan seluruh kadar asam urat, LDH dan AST diatas nilai cut off maka risiko terjadinya komplikasi sebesar 98,1%.Kesimpulan: Penelitian ini menyimpulkan kadar asam urat, LDH, AST pada preeklamsi berat disertai komplikasi lebih tinggi dibandingkan preeklamsi berat tanpa komplikasi dan peningkatan kadar asam urat, LDH, AST berhubungan dengan peningkatan risiko terjadinya komplikasi pada preeklamsi berat. Relations of Uric Acid, Lactat Dehydrogenase, and Aspartat Aminotransferase Serum LevelIn Severe Preeclampsia with and Without ComplicationsAbstractObjective: This study compared level of uric acid, LDH, and AST level between severe preeclampsia patients with complication and without complication, and measured correlation between the rise level of uric acid, LDH and AST towards the increased risk of complication in patient with severe preeclampsia.Method: The study design was comparative cross sectional study with consecutive sampling method that compare the results of laboratorium uric acid, LDH, AST between complications and without complications group. Subjects of this study were severe preeclampsia patients with and without complication that fulfilled study criteria (n=68). Result: It is revealed that the differences level of uric acid, LDH, and AST in both groups were significant with p value ≤ 0.05. Increase level of uric acid, LDH, and AST were related to inreased risk of complication in severe preeclampsia occurence with cut off point of uric acid level of > 6.5 mg/dL by 33 times, LDH level of > 573 U/L by 8.95 times, and AST level of > 30 U/L by 5.19 times. If all uric acid, LDH, and AST level rise above the cut off value so the risk of complication of severe preeclampsia will rise by 98.1%. Conclusion: It is concluded that level of uric acid, LDH, and AST in severe preeclampsia with complication were higher than severe preeclampsia without complication and the rise of uric acid, LDH, and AST were related with the rise of complication risk on severe preeclampsia. Key word: Severe preeclampsia, complication, uric acid, LDH, AST

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Wiryawan Permadi

Contact Email obgyniajurnal@gmail.com

Phone -

Journal Mail Official obgyniajurnal@gmail.com

Editorial Address -

Location Kab. sumedang, Jawa barat INDONESIA

Abstract

Abstract

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Abstract

Contact Name
Wiryawan Permadi

Contact Email
obgyniajurnal@gmail.com

Phone
-

Journal Mail Official
obgyniajurnal@gmail.com

Editorial Address
-

Location
Kab. sumedang,

Jawa barat

INDONESIA