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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 178 Documents
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Patogenesa Dan Pemilihan Terapi Hemorrhoid Taufik Sudirman
Medicinus Vol 5, No 3 (2016): June 2016 - September 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i3.1174

Abstract

Therapy of hemorrhoids ranges from dietary and lifestyle modification to  surgery, depending on degree and severity of symtoms. While debate continues as to which is the best surgical method for the therapy of hemorrhoids, none of the currently available surgical methods approach the ideal surgical option, which is one that effective while being safe and painless. In reality, the less painful the procedure, the more likely it is to be associated with recurrence post-op. A fuller understanding of the pathophysiology will help to make choices.Keywords: hemorrhoids, pathophysiology, therapy.
Comparing The Who 1997 / Who Searo 2011 And Who 2009 Dengue Classification In Diagnosing Dengue Infection In Out-Patient Settings In Tangerang District, Banten Province, Indonesia Cucunawangsih Cucunawangsih
Medicinus Vol 5, No 1 (2015): October 2015 - January 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i1.1180

Abstract

The World Health Organization (WHO) 1997 / WHO (Regional Office of South-East Asia) SEARO 2011 and WHO 2009 dengue guideline emphasized different aspects. Indonesia as a limited resources hyperendemic area will a large number of patients hopitalized using the WHO 2009. This study compared the adult non severe dengue cases in out-patient settings using both classification. This retrospective cohort study on 85 patients found 48 dengue cases confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) on the period of August 2011 – January 2012, in 5 out-patient settings health facilities. The sensitivity and spesificity of WHO 1997 / WHO SEARO 2011 were 48.93% and 23.68%, while the WHO 2009 were 78.72% and 68.42%. Out of 8 secondary infection patients, 25% in WHO 1997 / WHO SEARO 2011 and 0% in WHO 2009 were classified as the more severe form. The WHO 2009 shown higher sensitivity and specificity, but the WHO 1997 / WHO SEARO 2011 could diagnose more patient that would have suffered severe forms of dengue and also more secondary infection who have the probability of severe forms compared to WHO 2009.Keywords: dengue, out-patient setting, world health organization
EFEK ANTIBAKTERI VIRGIN COCONUT OIL TERHADAP METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS Tirta Darmawan Susanto; Muchtan Sujatno; Hendro Sudjono Yuwono
Medicinus Vol 4, No 8 (2015): February 2015 - May 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i8.1186

Abstract

Kejadian infeksi, baik di lingkungan rumah sakit yang disebut infeksi nosokomial maupun di luar rumah sakit, cukup besar. Infeksi mempertinggi angka kematian dan kesakitan, serta memperlama waktu perawatan di rumah sakit. Saat ini banyak tanaman yang terbukti secara empiris memiliki efek antibakteri, diantaranya adalah minyak kelapa murni (Virgin Coconut Oil / VCO), oleh karena itu perlu dilakukan penelitian ini guna mengetahui efek anti bakteri VCO pada luka yang telah diinfeksi dengan Methicillin Resistant Staphylococcus aureus (MRSA).Telah dilakukan penelitian eksperimental laboratorium dengan desain penelitian Rancangan Acak Lengkap. Hewan coba yang digunakan adalah marmut jantan galur albino sebanyak 15 ekor . Dermis hewan coba diinsisi hingga diperoleh luka berukuran 9cm2 dasar otot, luka diinfeksi dengan suspensi bakteri MRSA, kemudian diberi 3 macam perlakuan yaitu dibiarkan saja tanpa pengobatan untuk control negatif, terapi VCO per oral 3 cc / hari dan terapi VCO topikal 0,4 cc / hari. Data yang diperoleh dianalisis dengan analysis of variance (ANOVA) dan two sample – T test.Hasil penelitian menunjukkan bahwa pemberian VCO topikal dengan dosis 0,4 cc / hari mampu mengobati infeksi dan mempercepat penyembuhan luka hewan coba secara bermakna (p = 0,043 < α = 0,05), tetapi pemberian VCO peroral 3 cc / hari menunjukkan hasil yang tidak bermakna (p = 0,376 > α = 0,05). Pemberian VCO per oral 3 cc / hari dan topikal 0,4 cc / hari mampu menurunkan jumlah lekosit darah pada hewan coba. Pemberian VCO topikal 0,4 cc / hari mampu membunuh bakteri sehingga dapat mengurangi jumlah bakteri pada luka secara bermakna (p = 0,0092 < α = 0,05), namun pemberian VCO per oral tidak mampu mengurangi jumlah bakteri pada luka secara bermakna (p = 0,17 > α = 0,05). Pada hasil penelitian di atas, dapat disimpulkan bahwa pemberian VCO topikal menunjukkan efek antibakteri yang bermakna untuk mengatasiinfeksi MRSA.
EMBOLI PARU Fidelia Octaviani; Andree Kurniawan
Medicinus Vol 4, No 9 (2015): June 2015 - September 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i9.1191

Abstract

Emboli paru merupakan salah satu kegawatdaruratan pada bidang kardiovaskular yang cukup sering terjadi dengan berbagai manifestasi klinis dari keadaan yang asimptomatik hingga keadaan yang mengancam nyawa. Insidensi terjadinya emboli paru pada populasi mencapai 23 per 100,000 penduduk dengan tingkat mortalitas mecapai 15%. Emboli paru dapat disebabkan oleh tromboemboli vena, emboli udara, lemak, cairan amnion, fragmen tumor, dan sepsis. Pemeriksaan ventilation-perfusion scintigraphy masih menjadi baku emas untuk menegakkan diagnosis emboli paru. Sedangkan pemeriksaan lain dapat dilakukan untuk membantu klinisi mendiagnosis kejadian emboli paru. Tatalaksana pada emboli paru akut harus dilakukan dengan segera dengan menggunakan antikoagulan seperti unfractioned heparin, LMWH atau vitamin K antagonis, dilanjutkan dengan trombolitik atau embolektomi apabila trombolitik tidak dapat dilakukan. 
Poor Sleep Quality of Hospitalized Geriatric Patients in General Hospital in Karawaci, Tangerang, Banten Province, Indonesia Nata Pratama Hardjo Lugito; Theo Audi Yanto; Andree Kurniawan; Indra Wijaya; Margaret Merlyn Tjiang; Resa Setiadinata; Stevent Sumantri; Euphemia Seto
Medicinus Vol 6, No 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1136

Abstract

Background: In Indonesia, geriatric population in the year 2005 was 15.8 million (7.2 % population), and expected to reach 11.34% in the year 2020. There was growing evidence for poor sleep as an independent risk factor for poor physical and mental health. Geriatric population may be particularly vulnerable to effects of sleep disturbance due to significant age-related changes in both sleep and inflammatory regulationObjective: To study the epidemiological (gender, age group) and health status (co-morbidities), sleep quality according to Pittsburgh Sleep Quality Index (PSQI) and its associations in geriatric population hospitalized in General Hospital in Karawaci, Tangerang, Banten Province, Indonesia.Materials and Methods: A hospital based cross sectional study was conducted from January to June 2014. A total of 92 subjects aged 60 years and above were selected consecutively from hospitalized geriatric patients for this study. The data was analyzed by means and proportions.Results: The male and female subjects were 51.1% and 48.9%. Mean age was 66.79 + 5.448 years. The age group of 60 – 75 years and above 75 years was 92.4% and 7.6% consecutively. Subjects with diabetes, hypertension, allergy, asthma, cardiac failure and chronic kidney disease were 30.4%, 62.0%, 18.5%, 21.7%, 21.7%, 20.7% consecutively and 63.0% with more than 2 co-morbidities. According to PSQI 72.8% subjects have poor sleep quality. Associations between poor sleep quality to epidemiological and health status were not significant except for diabetes (RR= 3.208 [95% CI: 1.045 – 9.848], p = 0.022) and chronic kidney disease (RR= 6.247 [95% CI: 0.902 – 43.279], p = 0.017)Conclusions: Seventy two percents of subjects have poor sleep quality, and associations between poor sleep quality to epidemiological and health status were not significant except for diabetes.
Characteristic of Central Nervous System Tumours from 2011-2015: A Single Institution Study Febrihardita Dwinovitch; Nadya Aisyah Widowati; Erna Kristiani
Medicinus Vol 6, No 2 (2017): February 2017 - May 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i2.1142

Abstract

Background: Central nervous system (CNS) tumours affect the quality of life of patients since its neurological deficits. Data from Globocan 2012 reveals that there are 256,000 cases of CNS tumour. Epidemiology of the CNS tumours is very important for diagnosis and treatment, but data in Indonesia is still not fully reported.Objective: The aim of this study was to determine the exact amount of the incidence, histologic type of the tumour and the characteristic of patient in our institution.Methods: This is an observational study, all pathology report of CNS tumours that underwent surgery at Siloam Hospitals Lippo Village from 2011 until 2015. We classified based on gender, age, location of the tumour, and the histologic type according to WHO Classification of CNS tumour 2007.Results and Discussion: There were 913 patients of CNS tumours from 2011 until 2015. The most common tumours were meningioma (32.96%) followed by glioma (21.35%) and pituitary adenoma (16.10%). In meningioma, most occur in women, 41 - 50 years old, located in the frontal region and the most common subtype is transitional meningioma. In glioma, most occur in men, 31 - 40 years old, located in the frontal region and the most common subtype is glioblastoma. In adenoma hipofisis, most occur in men, 41 - 50 years old.Conclusion: The result of this study was accordance with the literature so this data could be a reference for further research.
Karakteristik Histopatologik dan Imunofenotipik Kanker Payudara di Rumah Sakit Cipto Mangunkusumo Jakarta, Indonesia Primariadewi Rustamadji; Stephanie Marisca
Medicinus Vol 6, No 3 (2017): June 2017 - September 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i3.1147

Abstract

Introduction: Breast cancer can be classified into luminal A, luminal B, Her2+, dan basal-like molecular subtype according to genetic profile and immunophenotype. The aim of this study is to assess histopathologic and immunophenotype characteristics of breast cancer in Cipto Mangunkusumo Hospital Jakarta, Indonesia.Material and methods: This study is a cross-sectional retrospective study. The sample was 2632 breast cancer case in Department of Anatomical Pathology Cipto Mangunkusumo Hospital from the year 2011 until 2015. ER, PR, Her2, Top2 α, and Ki67 immunohistochemical stain was then grouped into luminal A (ER+/PR+/Her2-/Ki67<20%) subtype, luminal B (ER+/PR+/Her2-/Ki67≥20%) subtype, Her2+ (ER-/PR-/Her2+) subtype, and basal-like (ER-/PR-/Her2-) subtype. Kendall’s Tau analysis was done to assess association between sample characteristics and molecular subtype, association between top2α positive and molecular subtype.Result: The most prevalent to the less prevalent breast cancer molecular subtype was luminal B (43,9%), Her2+ (14,6%), luminal A (14,0%), and basal-like (11,3%). There was a significant association between the tumor stage and breast cancer subtype (p=0,0001). There is also a significant association between Top2α expression and molecular subtype (p=0,0001).Conclusion: The most prevalent breast cancer molecular subtype was luminal B. There was an association between breast cancer molecular subtype and a higher degree and Top2α expression.
Prevalensi Infeksi Clostridium difficile Pada Pasien Neutropenia dengan Kanker Andree Kurniawan
Medicinus Vol 5, No 2 (2016): February 2016 - May 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i2.1164

Abstract

Clostridium difficile (C. difficile) infection mostly found in immunocompromised patient. Most of the patients with neutropenia had hematologic malignancy and come with multiple risk factors for C. difficile infection. The aim of this study is to know the prevalence and characteristic of C. difficile infections in cancer neutropenia patients. This cross-sectional study was done in secondary referral hospital in suburban Karawaci, Tangerang, Banten, Indonesia from June 2014 until Mei 2015. Adult cancer patients hospitalized with neutrophil count less than 1500 106 cell/L were included. All patients were checked for antigen and toxin C. difficile in faeces. From 25 patients were evaluated for C. difficile infection in neutropenia. C. difficile antigen only found in one patient or 4% sample.Key words: C. difficile, cancer, neutropenia
Hubungan Antara Panjangnya Waktu Kuliah dengan Tanggung Jawab, Kemandirian, dan Kekuatan Ego mahasiswa di Fakultas Kedokteran Engelberta Pardamean
Medicinus Vol 5, No 3 (2016): June 2016 - September 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i3.1170

Abstract

Introduction: Previous studies showed that personality have significant association with the outcome of performance of the students in clerkship. There are three dominance factors of personality such as Ego strength (Es), Responsibility (Re), and Dominance (Do) associated with the length of study of students. This three personality factors will be measured by using MMPI-2 Test. Aim: This study wants to find the mean difference of three factors of personality among the length of study in Faculty of Medicine of University of Pelita Harapan.Methods: This was a cross-sectional study by using the secondary data of MMPI-2 test of student from batch 2005-2006. Personality factors of Ego Strength, Responsibility, and Dominance are measure by mean and standard deviation.Results: Eighty one students were 27 males and 54 female.  From 81 students, 79 persent has finished their medical study within 5.5 years (on time) and 21 persent more than 5.5 years (not on time).Corellation by using spearman test show the significant association of Es with Do (p=0.001 and r=0.357); Es with Re (p=0.001 and r=0.3589). However the Do has no show the significant correlation with Re (p=0.525; r=0.0716). Analysis of t-test show that students who has graduate on time has higher Es (mean=44.12 ± 9.71) than student graduate not on time (mean 42.82 ± 7.97). Score of Do of students has graduate on time (mean 45.85 ± 10)  also higher than late graduate group (mean 41.05 ± 8.45) with p=0.0738. However the Responsibility of graduate on time (mean 48.06 ± 11.21) is lower than late graduated students (mean 49.7 ± 9.66).Conclusion: Ego strength and Dominance has positive association with the length of study.Keywords: ego strength, responsibility, dominance, MMPI-2, medical education
A Planned Cesarean Section-Hysterectomy For Placenta Previa Totalis Percreta In Patient With History Of Two Cesarean Sections Julita Nainggolan
Medicinus Vol 5, No 1 (2015): October 2015 - January 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i1.1176

Abstract

The presence of placenta previa may be associated with placenta accreta[1].  Maternal and fetal morbidity and mortality from placenta previa accreta are considerable and are associated with high demands on health resources. With the rising incidence of caesarean sections combined with increasing maternal age, the number of cases of placenta praevia and its complications, including placenta accreta, will continue to increase[2]. Here, we present a case of  placenta previa totalis percreta in previous cesarean section twice. In this case, patient with placenta previa totalis-percreta we diagnosed and prepared  proper management with the involvement of multidisciplinary team. We reduced blood loss by performing total abdominal hysterectomy immediately after delivered the baby and the postoperative course was uneventful.Keywords: Cesarean Section-Hysterectomy, placenta accreta, placenta percreta, placenta previa

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