cover
Contact Name
Mohammad Rizki Fadhil Pratama
Contact Email
mohammadrizkifadhilpratama@gmail.com
Phone
+6287815093560
Journal Mail Official
lp2m@umpalangkaraya.ac.id
Editorial Address
Jl. RTA Milono Km.1,5 Komplek Perguruan Tinggi Muhammadiyah Palangka Raya Kalimantan Tengah Indonesia 73111 Palangka Raya, Indonesia
Location
Kota palangkaraya,
Kalimantan tengah
INDONESIA
Borneo Journal of Pharmacy
ISSN : -     EISSN : 26214814     DOI : http://doi.org/10.33084/bjop
Core Subject : Health,
The publication of Borneo Journal of Pharmacy certainly participates in disseminating the results of research and review of science and technology development conducted by lecturers and researchers especially from UM Palangkaraya and other universities. This edition contains 12 articles consisting of Pharmacognosy-Phytochemistry, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy.
Arjuna Subject : -
Articles 211 Documents
The Rationality of Antibiotics Use on Inpatient Department of Pediatric in One of the Hospital in Cimahi Vina Septiani; Pudjiastuti Kartidjo; Fenny Asri Nurdiani
Borneo Journal of Pharmacy Vol 2 No 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.586 KB) | DOI: 10.33084/bjop.v2i2.1044

Abstract

The purpose of this study is to assess the rationality of the use of antibiotics from inpatients in one hospital in Cimahi, West Java. The research about rationality analysis of antibiotics at pediatric inpatient in one of the hospitals in Cimahi was done retrospectively use descriptive analysis design. The data source was the medical record of a patient who treated at the children's inpatient ward from January through March 2017. The result shows that 39% of infected patients were children under one-year-old. Three significant cases of diseases that occurred in the period were bronchopneumonia, typhoid fever, and typhoid fever+bronchopneumonia. Antibiotics therapy was given as single therapy as well as combination, where cefotaxime (51%) and ceftriaxone (42%) were the most antibiotics widely used as single therapy. Antibiotic use at children inpatient ward during the period January – March 2017 on bronchopneumonia, typhoid fever, and typhoid fever + bronchopneumonia patients was not 100% rational referring to criteria: correct diagnosis, correct indication, the correct drug of choice, correct dosage, correct method, and correct time interval of drug administration.
Antioxidant Activity of Ethanolic Extract from Tandui Leaves (Mangifera rufocostata Kosterm.) by DPPH Radical Scavenging Method Revita Saputri; Tia Mariati Risma Melati; Fitriyanti Fitriyanti
Borneo Journal of Pharmacy Vol 2 No 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.441 KB) | DOI: 10.33084/bjop.v2i2.1070

Abstract

Tandui (Mangifera rufocostata Kosterm.) is a typical plant from South Kalimantan which belongs to the genus of Mangifera. Several species of Mangifera are known to have antioxidant activity. This study aimed to determine the antioxidant activity of ethanol extract of Tandui leaves. Tandui leaves that were obtained from the maceration method used 70% ethanol. Antioxidant activity was conducted quantitative using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The result of the antioxidant activity of Ethanol extract of Tandui leaves quantitatively obtained IC50 value was 60.7042 µg/mL. The ethanol extract of Tandui leaves has strong antioxidant activity
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 2 No. 2 November 2019 Chief Editor of Borneo J Pharm
Borneo Journal of Pharmacy Vol 2 No 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1327.991 KB) | DOI: 10.33084/bjop.v2i2.1083

Abstract

Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published at November 2019. Starting from this edition, Borneo J Pharm make changes to the template in the article that will be published. The amendment aims to make it easier for readers to observe essential parts of each page of the article. The aim of this journal is to publish high-quality articles dedicated to all aspects of the latest outstanding developments in the field but not limited to Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Clinical-Community Pharmacy, Management Pharmacy, and other Pharmacy aspects. This edition contains 13 articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, and Clinical-Community Pharmacy topics. Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank the University, all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors of the articles, could re-participate for the success of the publication in the next edition on May 2020
Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking Natalya Mykolaivna Chalenko; Anna Olegovna Syrovaya; Natalya P Kobzar; Maryna V Rakhimova; Irina A Sych; Igor Vladimirovich Sych
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.578 KB) | DOI: 10.33084/bjop.v3i1.1082

Abstract

The strategy of rational approaches to the search for selective COX-2 inhibitors as potential antiinflammatory agents has been proposed and elaborated. It is based on the use of PASS-prediction and molecular docking. The choice of the basic structure of 4-amino-3-thio-1,2,4-triazole as a promising object of chemical modification has been substantiated. Using a modification of the primary molecule, a virtual library of S-derivatives of 5-substituted 4-amino(pyrrol)3-thio-4H-1,2,4-triazoles in the amount of 100 compounds (ten groups) has been obtained by introducing various pharmacophore fragments. Based on the analysis of the results of the PASS-prediction and molecular docking, six of the ten planned groups of compounds have been selected for the synthesis as promising selective COX-2 inhibitors. The reliability of the prediction results has already been confirmed for one of the promising group 4-amino-5-(pyridine-4-yl)-1,2,4-triazole (4Н)-3-yl-thioacetamides.
Design of Experiments Assessment for the Determination of Moisture Content in Five Herbal Raw Materials Contained in Tea Products Luis Castillo; Eleaneth Baltodano; Nils Ramírez; Rolando Vargas; Georgia Hanley
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (774.282 KB) | DOI: 10.33084/bjop.v3i1.1236

Abstract

Research interest in natural raw materials is rapidly growing due to the high demand for natural products like herbal teas. Their quality control has a direct impact on safety and efficacy. The aim of this study was to evaluate the impact of sample’s mass and temperature on moisture content in Camellia sinensis (Black tea), Cassia fistula (Senna), Chamaemelum nobile (Chamomille), Lippia alba (Juanilama) and Tilia platyphyllos (Linden) with a gravimetric method developed through a full factorial 32 DoE. A response optimizer was executed in order to establish the test conditions that allow obtaining a response according to a target value from a certified method. DoE’s ANOVA shows reproducibility for Camellia sinensis, Cassia fistula, and Lippia alba. Also, the method’s model is able to explain the response variability for all samples based on the R2 (adj). The composite desirability for the proposed conditions of analysis for the five herbal materials is satisfactory according to each target value. However, the lack of reproducibility in Chamaemelum nobile and Tilia platyphyllos and also, the response prediction problems according to the R2 (pred) for Cassia fistula and Chamaemelum nobile, suggest the execution of further studies for them. Therefore, the present method is considered to be adequate for the analysis of moisture content in Camellia sinensis and Lippia alba raw herbs.
Test on the Antioxidant Activities of Methanol Extract of Bidara Leaves (Ziziphus spina-christi L.) using the DPPH Radical Immersion Method Dwi Bagus Pambudi; Nuniek Nizmah Fajriyah; Vidiah Rizka Shalekhah
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.143 KB) | DOI: 10.33084/bjop.v3i1.1242

Abstract

Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant. It is capable of inhibiting any cell damages caused by free radicals. This study aimed to measure the activities of the free radicals in methanol extracts of Z. spina-christi leaves. The process of extracting the Z. spina-christi leaves was carried out through the maceration method using methanol as a solvent. The qualitative analysis of chemical compounds with certain eluents using thin-layer chromatography (TLC) was purposely to determine the groups of active compounds in extracts. The measurement of antioxidant activities was carried out using the 1,1-Diphenyl-2-picryl Hidrazyl (DPPH) immersion method in which absorption was measured at a maximum wavelength of 513 nm. The results showed that the methanol extract of Z. spina-christi leaves had a very weak antioxidant activity with the IC50 value of 466.804 μg/ml. The results of the bioautographic profile showed the presence of flavonoid compounds, phenols, saponins, and tannins.
Phytochemical Screening and Antioxidant Activity of Ethanolic Extract of Cawat Hanoman Stem (Bauhinia aculeata L.) using DPPH Method Rahmi Muthia; Muhammad Hidayatullah; Rahmi Hidayati
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.934 KB) | DOI: 10.33084/bjop.v3i1.1245

Abstract

The free radical is an unstable molecule because contains one or two unpaired electrons. The antioxidant substance is a simple way to decrease the illness caused by free radicals. Cawat hanoman (Bauhinia aculeata L.) was known to contain tannin components one of the benefits as an antioxidant. This research aims to determine the antioxidant activity of the B. aculeata stem tested by qualitatively used thin-layer chromatography (TLC) and quantitatively using the DPPH method. Bauhinia aculeata stem was extracted using a maceration extract method with 96% ethanol. Antioxidant activity test was done qualitatively by eluent of ethyl acetate : methanol : purified water (6 : 2 : 1) using TLC and quantitatively using the DPPH method. The result of antioxidant activity from 96% ethanol extract of B. aculeata stem qualitatively showed the presence of yellow spots on a purple background at TLC after syringed DPPH 0.5 mM and quantitative test that resulted in an IC50 of 21.862 μg/mL. These results indicate that 96% ethanol extract of B. aculeata has very strong antioxidant activity.
Effect of Broccoli (Brassica oleracea L. var. italica) Extract on Bleeding Time in Male White Mice (Mus musculus L.) Suci Fitriani Sammulia; Almahdy Almahdy; Aldo Wahyu Rezky
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.023 KB) | DOI: 10.33084/bjop.v3i1.1246

Abstract

Cessation of bleeding is influenced by many factors including the type of medication used. The use of drugs to stop bleeding can be done in various ways, one of which is the use of traditional medicine. One of the traditional plants that can be used as a stop bleeding is broccoli (Brassica oleracea L. var. italica) which has a fairly high vitamin K content, where is efficacious as hemostatic. This study aims to determine the effect of broccoli on the bleeding time of mice tail cuts. The first group was negative control (Na-CMC), the second group was positive control (tranexamic acid), while groups three, four, and five were broccoli extract dose of 20, 40, and 60 mg/kg BW, respectively. All treatments were given orally for seven days. Bleeding time was calculated from the initial blood loss until the blood stopped (tail bleeding I method) and the data were analyzed with the ANOVA one way test and the post hoc Least Significant Difference (LSD) statistical test. The results showed that there were differences in the time to stop bleeding in the treatment control group at a dose of 20 mg/kg BW (122.60 ± 29.535 seconds), 40 mg/kg BW (102.40 ± 9.607 seconds) and 60 mg/kg BW (90.40 ± 3.845 seconds). From these results, it can be concluded that the extract of broccoli at a dose of 60 mg/kg BW gives the best results as hemostatic, while the effect is almost similar to the positive control group.
Preliminary Phytochemical Analysis and Antioxidants Activities of Ethanolic Extract from Gomphrena serrata Whole Plant Kodukothanahalli Naganna Nandini; Mekerahalli Narayanappa Palaksha; Belakavadi Shivalingu Mamatha; Anasosalu Ramesh Lekhana
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.433 KB) | DOI: 10.33084/bjop.v3i1.1250

Abstract

The present study was designed to investigate the phytochemical analysis and antioxidant activities of the whole plant of Gomphrena serrata. Gomphrena serrata widely distributed in South America, North America, and India. These plant parts are used as traditional medicine for the treatment of several ailments. This study aims to assess the phytochemical and free radical scavenging of ethanolic extract of G. serrata present in the plant. The preliminary phytochemical study was performed by standard method. The whole plant of G. serrata proved the presence of bioactive constituents such as carbohydrates, alkaloids, steroids, glycosides, triterpenoids, protein and amino acids, saponins, as well as flavonoids. The in-vitro antioxidant study was performed on the ethanolic extract of shade-dried of the whole plant, which determined by hydrogen peroxide, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) 100 µg/ml assay and was compared to ascorbic acid. The ethanolic extract of the whole plant of G. serrata shows the strong free radical scavenging activity. The present study was the proof for ethanol extract of G. serrata which have medicinally significant and bioactive compounds since these plant species are used as traditional medicine for the treatment of various diseases.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 3 No. 1 February 2020 Chief Editor of Borneo J Pharm
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1323.161 KB) | DOI: 10.33084/bjop.v3i1.1269

Abstract

Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published in February 2020. Starting from this edition, Borneo J Pharm increases the frequency of publishing four times a year. This change aims to improve the circulation of the best articles published by Borneo J Pharm. Also, starting from this edition, Borneo J Pharm applying the publish-as-you-go issue to present the title of the article that has been received as early as possible in order to increase the chances of readability and quotation of articles in Borneo J Pharm.Starting in the 2019 edition, Borneo J Pharm has been accepted for indexing in EMBASE by Elsevier. This is an acknowledgment of the quality of the publications presented by Borneo J Pharm. In addition, Borneo J Pharm has also been accredited at SINTA in rank 3. In the future, Borneo J Pharm will try to improve the accreditation rank and register with other indexers such as ESCI and ASEAN Citation Index.This edition contains six articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, and Natural Product Development. This edition includes writings from four countries including Indonesia, India, Ukraine, and Costa Rica. The authors come from several institutions, including Sekolah Tinggi Ilmu Kesehatan Mitra Bunda Persada Batam, Bharathi College of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Borneo Lestari, Universidad de Costa Rica, Kharkiv National Medical University, National University of Pharmacy, Hon. Prof. M. S. Bokarius Kharkiv Research Institute of Forensic Examinations, and Universitas Muhammadiyah Pekajangan Pekalongan.

Page 5 of 22 | Total Record : 211