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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 303 Documents

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Penetapan Kadar Berberin dari Ekstrak Etanol Akar dan Batang Sekunyit (Fibraurea Tinctoria Lour) dengan Metode KCKT Rahayu Utami; Armon Fernando; Indah Puspita Sari; Mustika Furi
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Determination of berberine content of ethanol extract of root and stem of “sekunyit” (Fibraurea tinctoria Lour) has been conducted. “Sekunyit” is one of medicinal plant that has been used to treat several diseases traditionally. Its root and stem could relieve jaundice, diarrhea, conjunctivitis as well as antidiabetic agent. Based on previous study, it is known that Fibraurea tinctoria contains isoquinoline alkaloid, berberine. This present study aims to determine berberine content which was done by HPLC (High Performance Liquid Chromatography) method using C-18 reverse phase column, methanol : phosphate buffer (pH 6,8) as its mobile phase with flow rate of 1 ml/min and UV detector. The analysis was performed at wavelength 346 nm. The result showed that the ethanol extract contains 25.8% of berberine

Senyawa Antioksidan Ekstrak Metanol Glycine max (L.) Merr Varietas Detam 1 Hasil Estraksi Ultrasonik Rika Yulia; Ivon Sindu Wijaya
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Penelitian ini bertujuan untuk mengetahui kandungan senyawa antioksidan yang terkandung dalam ekstrak metanol Glycine max varietas Detam 1 hasil dari ekstraksi dengan metode ultrasonik. Ekstraksi dilakukan dengan 2 pelarut yaitu pelarut n-heksan untuk menghilangkan lemak yang mungkin dapat mempengaruhi hasil selama analisis dan metanol 80% untuk mengambil senyawa aktif dalam kedelai. Hasil ekstraksi kemudian dipekatkan dengan Rotary evaporator (BUCHI Rotavapor R-114) dan BUCHI Waterbath B-480. Analisis dilakukan secara kualitatif dengan menggunakan Gas Chromatography-Mass Spectra (GS-MS). Analisis terhadap senyawa antioksidan menggunakan GC-MS menunjukkan terdapat tiga senyawa antioksidan yaitu Methyl-10-trans,12-cis-octadecadienoate, Methyl 9-cis,11-trans-octadecadienoate, dan 9,12-Octadecadinoic acid.

Uji Efek Teratogenik dari Yoghurt Terhadap Fetus Mencit Putih (Mus musculus) Dwisari Dillasamola; Almahdy A; Amirah Desri; Skunda Diliarosta
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Yogurt is one of the dairy products made from lactic acid fermentation by using Lactobacillus bulgaricus and Streptococcus thermophilus. A study on teratogenic effects of yogurt on the white female mice fetus (Mus musculus) has been carried out. Pregnant mice used were 20 which divided into 4 groups : the control group, D1, D2, and D3. The treatments giveThe mice were Distidelled water (control), 0.52 yogurt (D1), 1.04 yogurt (D2), and 2.08 g yogurt (D3). Data were analyzed using one-way ANOVA followed by Duncan multiple range test. Results showed that administration of yogurt during pregnancy could affect mother body weight of mice (P < 0,05).The administration of yogurt during pregnancy did not affect the number of fetuses and fetal body weight significantly (P > 0,05). Observations with Alizarin solution did not show skeletal defects in comparison to the control group. Observations with Bouin’s solution showed defective visceral cleft palate in fetal mice yogurt group D3. This study conclude that yogurt is safe to consume in groups D1 and D2. Yogurt has the potential to cause fetal teratogenic in group D3

Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) Terhadap Fungsi Ginjal Tikus Yori Yuliandra; Armenia Armenia; Annisa Nur Salasa; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Sub-chronic toxicity test of the deffated ethanolic extract of tali putri (Cassytha filiformis L.) on the rat renal function has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and 5 mg/kg extract administrated intraperitoneally once a day for 14 days. The creatinine clearance, renal function, and the ratio of renal were calculated and analyzed by two-way ANOVA followed by Duncan’s test. The study showed that the creatinine clearance and renal function decreased significantly during treatment (p<0.05). The kidney weight ratio of groups treated with extract, especially with greater doses, showed a very significant increase as compared with control (p<0,01). These indicated that the ethanolic extract of C. filiformis on the doses of 1.25 – 5 mg/kg might decrease the renal function, althought it seemed to be relatively safe when used for 14 days.

Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations Lili Fitriani; Rudi Abdillah; Elfi Sahlan Ben
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Floating tablet is one of the most suitable dosage forms that used for delivering long term drug release. The objective of this study was to evaluate Hydroxypropyl cellulose (HPC), Hydroxypropyl Methyl Cellulose (HPMC) K100M, and the combination as matrix in manufacturing floating tablets. Metformin HCl, an anti-diabetic, was used as a drug model. Metformin HCl floating tablet was manufactured by wet granulation method in three formulas using variation of matrix, which were 40% of HPC (F1), 40% of HPMC K100M (F2), combination of 20% HPC and 20% HPMC K100M (F3). Prior to tablet compaction, evaluation for granules were done which included moisture content, angle of repose using, bulk and tapped density, Hausner ratio, and compressibility. The evaluations of floating tablet were physical properties, floating ability, and in vitro drug release. The average of floating lag time for F1, F2, F3, were 7 minutes 13 seconds; 5 minutes 27 seconds; and 14 minutes 5 seconds, respectively. In addition, the floating time for F1 was 3 hours 16 minutes whereas F2, F3 were more than 48 hours. F2 showed the best floating ability to retain the drug release, which was 84.68% over 8 hours, while F1 and F3 were completely dissolved less than 6 hours.

Formulasi Pasta Gigi Gel Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Husnul Warnida; Ade Juliannor; Yullia Sukawaty
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Dental caries is a disease of tooth decay that starts from the surface and evolve in the direction of the tooth, beginning with the process of tooth demineralization. Tooth decay is usually caused by the bacterium Streptococcus mutans. Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) has antibacterial activity due to its compound i.e. flavonoid, fenol, triterpenoid, dan antrakuinon. This study aims to formulate the bawang dayak ethanol extract into a stable gel toothpaste. Bawang dayak ethanol extract 2,5% was formulated in 5 formulas with varying degree of sorbitol (5 - 50%) and carboxymethyl cellulose (3 - 7%). Physical stability of bawang dayak ethanol extract gel toothpastes were evaluated including organoleptic and homogeneity test, pH measurement, viscosity measurement, spreading test, and freeze-thaw cycling test. The result showed bawang dayak ethanol extract gel toothpastes have pH range of 5.50 - 5.80, spreading area 4.61 - 5.82, viscosity value 17066 - 99877 mPas. Organoleptic and homogeneity in 7 days showed two layers color of gel toothpaste. Consistency test and Freeze-thaw cycling test results showed no change in organoleptic, homogeneity, pH, and viscosity of gel toothpastes.

Optimasi Tablet Levofloksasin yang Mengandung Bahan Pengikat PVP K-30 dan Disintegran Vivasol Dina Ayu Fatmawati; Bambang Widjaja; Dwi Setyawan
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

The aim of this research was to get optimal formula of levofloxacin tablet prepared with variation of PVP K-30 as binder and vivasol as disintegrant. The making of levofloxacin tablets was done by wet granulation. Tablet was prepared with various levels of PVP K-30 and disintegrant vivasol, compressed using a hydraulic press with 12 mm punch diameter, for 3 seconds. Physical quality (hardness, friability, and disintegration time) and dissolution rate of tablet was evaluated. The optimization of the formula was done by factorial design of 22 factorial experiments with 2 factors (PVP K-30 and vivasol) and 2 levels (2% and 4%). Optimization results showed that elevated levels of PVP K-30 increased tablet hardness, reduced friability of tablet, decreased disintegrating time, and increased dissolution rate of levofloxacin tablets. Meanwhile, elevated levels of vivasol increased the hardness of tablets, decreased the disintegrating time of tablets, decreased the dissolution rate of levofloxacin tablets, but did not affect the friability of tablets. In conclusion, the optimal tablet that meet the specifications of physical quality (hardness, friability, and disintegrating time) and dissolution rate was made by 2.4 to 3.7% of PVP K-30 and 2.0 to 3.2% vivasol as shown in the feasible area of design space.

Efektivitas Sistem Penghantaran Liposom pada Katekin Sebagai Antioksidan Verawaty Verawaty; Auzal Halim; Febriyenti Febriyenti
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

A study on the effectiveness of liposome delivery system of catechin as an antioxidant has been done. Liposome was derived from phosphatidylcholine of egg and cholesterol. The method used to prepared liposome in this research was thin layer hydration method by using rotary evaporator. Liposome was made in 3 formulas with different comparison between phosphatidylcholine and cholesterol. The first formula with ratio of 1:1; second formula with ratio of 1:2 and third formula with a ratio of 2:1. The result found that the observation with SEM seen sperical liposome and some oval liposomes. The level of entrapment efficiency (%EP) obtained on Formula I, II, and III were 24.49%, 24.67%, and 20.06%, respectively. We can conclude that the increase of cholesterol will increase the efficiency of drug entrapment. Test of the effectiveness of antioxidant found formula II was better than formula I and formula III. It can be concluded that the increase of cholesterol was able to improve the formulation and stability of liposome.

Pengembangan Instrumen Penilaian Kepuasan Pasien terhadap Pelayanan Kefarmasian di Rumah Sakit Dedy Almasdy; Yulihasri Yulihasri; Dila Deria Putri
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Instrument to assessing patient satisfaction to hospital pharmacy services has developed. The instrument consists of two dimensions which are friendly explanation and managing theraphy. The result of instrument developing are a instrument which have fair to good of the level of agreement (ĸ = 0.53), fair to good validity (r > 0.632) and good reliability (cronbach alpha = 0.97).

Pengetahuan Pasien dan Rasionalitas Swamedikasi di Tiga Apotek Kota Panyabungan Nur Aini Harahap; Khairunnisa Khairunnisa; Juanita Tanuwijaya
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Self-medication is a part of community effort to preserve their health. In practice, the self-medication can be a source of drug related problem because of lack of knowledge about drugs and their use. The aim of this study was to determine the level of knowledge and rationality of medicinal use self-medication. This study was using survey cross-sectional method. Total respondents (n=342) were involved this study of three pharmacies. Respondents were 18-60 years old and selected by consecutive sampling method. Data was collected by using a validated questionnaire. Data were analyzed by Chi-square test and Fisher test using Statistical Product and Servicer Solution (SPSS) version 17. The research showed that level knowledge of patients 20.5 % were good, 41.8% were medium, and 37.7% were low. Drug use self-medication was 59.4% rational and 40.6% irrational used. Based the result of Chi-square and Fisher test, educated and jobs can influence the level of knowledge, meanwhile rationality of self-medication use was not influenced by sociodemographic factor. Based on the research results obtained that majority level knowledge of patient was good classified. Irrational drug use on self medication reached 40.6%.

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Home Page

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Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
-

Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA