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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : -
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
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Skrining Farmakognosi Tanaman Etnofarmasi Asal Kabupaten Bulukumba yang Berpotensi sebagai Antikanker Amin, Asni
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.278 KB) | DOI: 10.25026/jtpc.v1i4.36

Abstract

The use of traditional medicine has long been known and used by the people of South Sulawesi and recorded since the 15th century in lontara 'pabbura. Bulukumba as one of the areas of south Sulawesi inhabited by ethnic of Kajang and ethnic of Makassar has also been used plants to treat several of diseases including. Screening studies pharmacognostic origin Bulukumba conducted to identify medicinal plants used by the community Bulukumba to treat cancer. The research location is the village of Bahari Bonto Lembanna District Bulukumba, The research location is the village Lembana of Bonto Bahari District Regency of Bulukumba, the surveys plants etnofarmasi through sanro (traditional healers), public figures and society who have knowledge of traditional medicine with purposive sampling method. Pharmacognosy screening includes determination etnofarmasi plants that have been collected, organoleptic examination, morphology, anatomy and identification of chemical constituents using color reagent and precipitation reactions. The results obtained five plants etnofarmasi potential for the treatment of cancer, leaf of landep (Barleria prionitis L.) Family Acanthaceae, gewor (Basella rubra L) Famili Acanhtaceae, pecut kuda (Stachytarpheta jamaicensis) Family Loranthaceae, rumput mutiara (Hedyotis corymbosa L.) family Rubiaceae dan gondola (Commelina benghalensis L.) Family Commelinaceae, with chemical ingredients contain flavonoids, saponins, alkaloids, and tannins. The content of flavonoids and alkaloids in plants has the potential to be used as a cancer treatment. Keywords : Etnopharmacy, anticancer, Pharmacognosy screening. Abstrak Penggunaan obat tradisional telah lama dikenal dan digunakan oleh masyarakat Sulawesi Selatan dan dibukukan sejak abad ke-15 dalam lontara’ pabbura. Bulukumba sebagai salah satu wilayah Sulawesi Selatan dihuni oleh etnis Makassar dan etnis Kajang juga telah menggunakan tanaman termasuk untuk mengobati berbagai penyakit. Penelitian skrining farmakognostik asal Kabupaten Bulukumba dilakukan dengan tujuan untuk mengidentifikasi tanaman obat yang digunakan oleh masyarakat Bulukumba untuk mengobati penyakit kanker. Lokasi penelitian adalah desa Lembanna Kecamatan Bonto Bahari Kabupaten Bulukumba, dengan mensurvei tanaman etnofarmasi melalui sanro (pengobat tradisional), tokoh masyarakat dan masyarakat yang memiliki pengetahuan tentang obat tradisional dengan metode purposive sampling. Skrining farmakognosi meliputi determinasi tanaman etnofarmasi yang telah dikumpulkan, pemeriksaan organoleptik, morfologi, anatomi dan identifikasi kandungan kimia menggunakan pereaksi warna dan reaksi pengendapan. Hasil penelitian didapatkan lima tanaman etnofarmasi yang potensial untuk pengobatan kanker yaitu daun landep (Barleria prionitis L.) Famili Acanthaceae, gewor (Basella rubra L) Famili Acanhtaceae, pecut kuda (Stachytarpheta jamaicensis) Famili Loranthaceae, rumput mutiara (Hedyotis corymbosa L.) family Rubiaceae dan gondola (Commelina benghalensis L.) famili Commelinaceae, dengan kandungan kimia mengandung flavanoid, saponin, alkaloid, dan tanin. Kandungan flavonoid, dan alkaloid dalam tanaman berpotensi untuk digunakan sebagai obat kanker. Kata Kunci : Etnofarmasi, Antikanker, Skrining farmakognosi.
Potensi Antimikroba Fraksi Aktif Ekstrak n-Heksan Daun Rami (B.virgata F.) Guill terhadap Beberapa Mikroba Uji Ibrahim, Arsyik
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.858 KB) | DOI: 10.25026/jtpc.v1i4.37

Abstract

This study aims to determine the potential antimicrobial activity of extracts soluble, insoluble n-hexane and fractions of n-hexane extract of leaves of B. virgata, some microbial testing with solid dilution method. Test material used was n-hexane-soluble extract (A) and hexane-insoluble (B), two extract was monitored by Thin Layer Chromatography method (TLC) chemical components, then tested its activity by solid dilution method. Test results of the antimicrobial activity of both types of extracts showed better activity than the methanol extract of soluble fraction of n-hexane and methanol extract of insoluble, because it can inhibit the growth of the bacterium E. coli, V. cholerae and S. thyposa, while the methanol extract of n-hexane soluble not only able to inhibit the bacteria V. cholerae, at a concentration of 1000 μg/ml medium. Fraction of methanol extract of n-hexane soluble (A) is then fractionated by the method of three funel system using eluent hexane: methanol: water (20: 6: 0.5), obtained three kinds of fractions ie fraction A, fraction B and fraction C. The antibacterial activity tes result of fraction A is active against bacteria V. chilerae, B fraction active against bacteria V.cholerae, S. thyposa and E. coli, and the active fractions of the yeast C.albicans C respectively each active at a concentration of 750 μg/ml medium. Key word: leaf B. virgata, antimicrobial, fraction soluble extracts of n-hexane, solid dilution Abstrak Penelitian ini bertujuan untuk mengetahui potensi dan menguji aktivitas antimikroba ekstrak larut dan tidak larut n-heksan dan fraksi-fraksi ekstrak n-heksan daun B. virgata, dengan metode dilusi padat terhadap beberapa mikroba uji. Bahan uji yang digunakan adalah ekstrak larut n-heksan (A) dan tidak larut heksan (B), kedua ekstrak ini dimonitoring komponen kimianya dengan metode Kromatografi Lapis Tipis (KLT), kemudian diuji aktivitasnya dengan metode dilusi padat. Hasil uji aktivitas antimikroba dari kedua jenis ekstrak yang diuji, menunjukkan bahwa fraksi ekstrak metanol larut n-heksan memiliki aktivitas yang lebih baik dibandingkan dengan fraksi ekstrak metanol tidak larut n-heksan, karena dapat menghambat pertumbuhan bakteri E. coli, V. cholerae dan S. thyposa, sedangkan ekstrak metanol tidak larut n-heksan hanya menghambat bakteri V. cholerae, pada konsentrasi 1000 μg/ml medium. Fraksi ekstrak metanol larut n-heksan (A) difraksinasi dengan metode three funel system menggunakan eluen Heksan : metanol : air (20 : 6 : 0,5), diperoleh 3 macam fraksi yaitu fraksi A, fraksi B dan fraksi C. Hasil uji aktivitas antibakteri menunjukkan fraksi A aktif terhadap bakteri V. chilerae, fraksi B aktif terhadap bakteri V.cholerae, S. thyposa dan E. coli, dan fraksi C aktif terhadap khamir C.albicans masing-masing aktif pada konsentrasi 750 μg/ml medium. Kata Kunci: daun B. virgata, antimikroba, fraksi ekstrak larut n-heksan, dilusi padat
Analisis Kandungan Garam Gunung Asal Krayan Kabupaten Nunukan Kalimantan Timur Herman, Herman; Rusli, Rolan
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.012 KB) | DOI: 10.25026/jtpc.v1i4.38

Abstract

Has been studied composition of mountain salt from Krayan, Nunukan, East Kalimantan. This study aims to determine the composition of the minerals contained in the mountain salt. Mountain salt is obtained from wells Krayan District residents were further prepared for analysis using a technique using Atomic Absorption Spectrometer (AAS), further by looking at the pattern of X-ray Diffraction (XRD) and Scanning electron microscopic (SEM). Based on the results obtained AAS has identified mineral deposits include: Na, K, Mg, Al, Cu, Zn, Fe, Ba, and Sr. From the results of XRD shows that the main peak of the salt Krayan shows major peaks for NaCl crystals with impurities such as KCl, CaCl2, MgCl2, and AlCl3. SEM observation showed that morphology of Krayan salt have cube shape which is the shape of NaCl crystals with space group Fm3m and lattice parameter (a) 5.620 Ã… Keywords : Mountain Salt, krayan, AAS, XRD, SEM Abstrak Telah dilakukan penelitian analisis kandungan garam gunung asal Krayan Kabupaten Nunukan Kalimantan Timur. Penelitian ini bertujuan untuk mengetahui komposisi mineral yang terkandung dalam garam gunung. Garam gunung diperoleh dari sumur warga Kecamatan Krayan yang selanjutnya dipreparasi untuk dianalisis dengan menggunakan menggunakan teknik Spektrometer Serapan Atom (SSA), selanjutnya dengan melihat pola Difraksi Sinar X (XRD), dan Scanning Elektron Microscopy (SEM). Berdasarkan hasil SSA telah diidentifikasi diperoleh kandungan mineral antara lain: Na, K, Mg, Al, Cu, Zn, Fe, Ba, dan Sr. Dari hasil XRD terlihat bahwa puncak utama dari garam krayan tersebut menunjukkan puncak utama untuk Kristal NaCl, dengan impurities antara lain KCl, CaCl2, MgCl2, dan AlCl3. Selain itu hal ini didukung pula oleh pengamatan SEM, bahwa morfologi SEM garam krayan memperlihatkan bentuk kristal kubus yang merupakan bentuk dari Kristal NaCl dengan grup ruang Fm3m dengan panjang kisi kristal 5,620 Ã…. Kata Kunci : Garam Gunung, Krayan, SSA, XRD,SEM
Aktivitas Hepatoprotektor Batang Fibraure tinctoria Lour Secara In Vivo Fikriah, Ika
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.031 KB) | DOI: 10.25026/jtpc.v1i4.39

Abstract

Study on Fibraurea tinctoria Lour (FT) stems gives information about its traditional utility as yellow fever treatment. Research of antecedent of FT stem proved that inhibited lipid peroxidation more effective than tocopherol acetate. These study was intended to prove hepatoprotector activity of ethanolic FT stem extract by in vivo. FT stem extract was macerated using absolute ethanol during 5 days that was repeated 3 times . FT stem extract hepatoprotector activity by in vivo was tested using carbon tetrachloride induced hepatotoxicity on Wistar rat. They were given FT stem extract orally once a day at dose 50, 100, and 200 mg/kgBW and Curcumin at dose 50 mg/KgBW as positive control. After 10 days, all groups were examined liver function (SGOT, SGPT, ALP), liver Malonedialdehide (MDA) level by Thiobarbituric acid method, and liver histopathology by Haemotoxylin-Eosin staining. Group that induced by CCl4 showed significant elevation of SGOT, SGPT and ALT also Liver MDA than group control. FT stem extract treatment inhibited elevation of SGOT, SGPT, ALT and Liver MDA significantly.Qualitative histopathological examination on Group 2 showed extensive fibrosis and necrosis, along with periportal PMN and lymphocyte infiltration. FT stem extract treatment inhibited pathological change that was induced by CCl4. Dose elevation showed tendency of stronger inhibition on liver cell tissue destruction and inflammation. Key words: Fibraurea tinctoria, hepatoprotector, in vivo Abstrak Penelusuran secara etnobotani, batang Fibraurea tinctoria Lour (FT) digunakan untuk obat sakit kuning. Penelitian pendahuluan batang FT berkemampuan meredam peningkatan lipid peroksidasi secara in vitro yang lebih kuat dibandingkan dengan tokoferol asetat. Membuktikan khasiat ekstrak etanol batang FT sebagai hepatoprotektor secara in vivo. Batang FT dimaserasi dengan etanol absolut selama 3 x 5 hari. Uji hambatan kerusakan hati secara in vivo digunakan model tikus yang diinduksi karbon tetraklorida (CCL4), ekstrak etanol FT diberikan dengan dosis 50, 100, 200 mg/KgBB sekali sehari dan curcumin dosis 50 mg/KgBB sebagai kontrol positif selama 10 hari lalu diperiksa fungsi hati (serum SGOT, SGPT dan ALP), kadar malondialdehida hati (MDA-hati), serta pemeriksaan patologi anatomi hati dengan pewarnaan Hematoksilin Eosin (HE). Kelompok tikus yang diinduksi CCl4 memperlihatkan peningkatan nilai SGOT, SGPT dan ALT dan MDA-Hati secara bermakna dibandingkan dengan kontrol. Pemberian ekstrak etanol batang FT secara oral dapat melemahkan peningkatkan nilai SGOT, SGPT dan ALT serta dapat menghambat peningkatkan nilai MDA-Hati pada tikus yang diinduksi CCl4 secara bermakna. Hasil pemeriksaan PA menunjukkan fibrosis dan nekrosis yang luas disertai infiltrasi sel-sel PMN dan limfosit di daerah periportal pada kelompok tikus yang diinduksi CCl4 > Curcumin > FT 50 > FT 100 > FT 200 mg/KgBB. Kata Kunci: Fibraurea tinctoria, Hepatoprotektor, in vivo
Beberapa Tumbuhan Obat Asal Kalimantan Timur sebagai Sumber Saponin Potensial Rijai, Laode
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (44.503 KB) | DOI: 10.25026/jtpc.v1i4.40

Abstract

Saponin is a class of natural compounds that have activity that is strongly associated with utilization in pharmacy. Exploration has been carried out against a number of secondary metabolite content of medicinal plants in East Kalimantan and some of them found to contain saponins. Plants were found to contain saponins and are considered potential Kokang leaf (Lepisanthes amoena), Kesumbakeling leaf (Bixa orellana, L), Belimbing Wuluh leaf (Averrhoa bilimbi L.), Sugi Gadjah leaf (Hyptis capitata), Karamunting leaf (Melastoma malabathricum L), Cempedak bark (Artocarpus champeden), Wijaya Kusuma leaf (Epiphyllum oxipetalum), Langsat seeds (Lansium domesticum), ekor kucing leaf (Acalypha hispida), Kelor bark (Moringa oleifera), Jarong leaf (Stachytarpheta mutabilis), Miana leaf (Coleus atropureus), Jengger Ayam leaf (Celosia cristata), and fruit of Libo (Ficus vargelata). Key words : East borneo medicinal plants, saponins Abstrak Saponin adalah golongan senyawa alami yang memiliki aktivitas yang sangat terkait dengan pemanfaatan dalam bidang farmasi. Telah dilakukan eksplorasi kandungan metabolit sekunder terhadap sejumlah tumbuhan obat yang ada di Kalimantan Timur dan beberapa diantaranya terbukti mengandung saponin. Tumbuhan-tumbuhan yang terbukti mengandung sponin dan dianggap potensial adalah daun Kokang (Lepisanthes amoena), daun Kesumbakeling (Bixa orellana, L), daun Belimbing Wuluh (Averrhoa bilimbi L.), daun Sugi Gadjah (Hyptis capitata), daun Karamunting (Melastoma malabathricum L), kulit batang Cempedak (Artocarpus champeden), daun Wijaya Kusuma (Epiphyllum oxipetalum), biji Langsat (Lansium domesticum), daun ekor kucing (Acalypha hispida), Kulit Batang Kelor (Moringa oleifera), daun Jarong (Stachytarpheta mutabilis), daun Miana (Coleus atropureus), daun Jengger Ayam (Celosia cristata), buah Libo (Ficus vargelata). Kata Kunci: Tumbuhan Obat Kaltim; Saponin
Analisis Fitokimia Senyawa Metabolit Sekunder Ekstrak Kasar Etanol Daun Meranti Merah (Shorea leprosula Miq.) dan Sifat Antibakterinya terhadap Staphylococcus aureus dan Eschericia coli Sudrajat, Sudrajat; Sadani, Sadani; Sudiastuti, Sudiastuti
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.931 KB) | DOI: 10.25026/jtpc.v1i4.41

Abstract

This study aims to determine the content of secondary metabolites and antibacterial power crude extract copper leaf meranti (Shorea leprosula Miq.) against Staphylococcus aureus and Escherichia coli. Antibacterial power is determined by the size of inhibition zone formed using paper disc diffusion method of Kirby-Bauer. The research design using a completely randomized design (CRD), with a concentration of 6 treatments and 4 replication for each type of bacteria. Variations in the concentration of a given treatment consisting of 0%, 3.75%, 7.5%, 11.25%, 15%, and chloramphenicol (positive control). The results shown that crude extract copper leaf meranti (Shorea leprosula Miq.) contain secondary metabolites such as alkaloids, saponins, triterpenoids, flavonoids, phenols and antibacterial power against Staphylococcus aureus and Escherichia coli, with the relatively strong antibacterial category. Anova analysis showed that the value of F count = 41,190 with sig = 0.000 <0.05, which means that H0 is rejected, in other words, treatment factors meranti copper leaf crude extract with various concentrations of 3.75%, 7.5%, 11, 25%, and 15%. different significantly affect the bacterial inhibition zone for S. aureus. The result same effect shown onE. coli demonstrated the value Fcount = 81, 236 with sig = 0.000 <0.05. These results demonstrate the influence of crude extract of leaf meranticopper very significantly to the growth of bacteria S. aureus and E. coli. At S.aureus, treatment concentration of 3.75%, 7.5%, 11.25%, and 15%yielding different significant of inhibition zone. In the E.colibacterial, treatment concentration of 3.75%, 7.5%, 11.25%, and 15% yielding different significant of inhibition zone.Best concentration as antibacterial S.aureus and E.coli have been shown on providing the lowest treatment concentration (3.75%), which shows the power antibacterial properties not significantly different from the concentration on it. Keywords: Leaf of Shorea leprosula Miq, secondary metabolite substance, antibacterial, Staphylococcusaureus, Escherichia coli Abstrak Penelitian ini bertujuan untuk mengetahui kandungan senyawa metabolit sekunder dan daya antibakteri ekstrak kasar daun meranti tembaga (Shorea leprosula Miq.) terhadap bakteri Staphylococcus aureus danEscherichia coli.Ukuran daya antibakteri ditentukan oleh zona hambat yang terbentuk menggunakan metode difusi kertas cakram Kirby-Bauer.Rancangan penelitian menggunakan Rancangan Acak Lengkap (RAL), dengan konsentrasi dari 6 perlakuan dan 4 replikasi untuk setiap jenis bakteri.Variasi konsentrasi perlakuan yang diberikan terdiri atas 0%, 3.75%, 7.5%, 11.25%, 15% dan kloramfenikol (kontrol positif). Hasil penelitian menunujukkan bahwa ekstrak kasar daun meranti tembaga (Shorea leprosula Miq.) mengandung senyawa metabolit sekunder seperti alkaloid, saponin, triterpenoid, flavonoid, fenol dan daya antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli, dengan kategori antibakteri tergolong kuat.Analisis anava menunjukkan bahwa nilai F hitung = 41.190 dengannilai sig = 0,000 < 0,05, yang berarti bahwa H0ditolak, dengan kata lain faktor perlakuan ekstrak kasar daun meranti tembaga dengan variasi konsentrasi 3,75%, 7,5%, 11,25%, dan 15 %. berpengaruhberbeda secara sangat signifikan terhadap zona hambat untuk bakteri S. aureus.Hal yang sama ditunjukkan pengaruhnya terhadap E.coli dengan nilai Fhitung = 81.236 dengannilai sig = 0,000 < 0,05. Hasil ini menunjukkan adanya pengaruh ekstrak kasar daun meranti termbaga secara sangatsignifikan terhadap pertumbuhan bakteri S. aureus dan E. coli. Pada bakteri Staphylococcus aureus,perlakuan konsentrasi 3.75%, 7.5%, 11.25%, dan 15% menghasilkan zona hambat yangberbeda signifikan. Pada bakteri Escherichia coli, perlakuan konsentrasi 3.75%, 7,5%, 11.25%, dan 15% menghasilkan zona hambat yang berbeda signifikan. Konsentrasi terbaik sebagai antibakteri S.aureus dan E.coli telah ditunjukkan pada pemberian konsentrasi perlakuan terendah (3,75 %), yang menunjukkan sifat daya antibakterinya tidak berbeda nyata dengan konsentrasi di atasnya. Kata Kunci : Daun meranti tembaga (Shorea leprosula Miq.), zat bioaktif, antibakteri, Staphylococcus aureus, Escherichia coli
Team, Front cover, Editorial information, Table of Content, Back Cover
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.332 KB)

Abstract

J. Trop. Pharm. Chem. 2012. Volume 1 Nomor 4 Team, Front cover, Editorial information, Table of Content, Back Cover

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