cover
Contact Name
Hadi kuncoro
Contact Email
kuncoro_hadi82@yahoo.com
Phone
-
Journal Mail Official
kuncoro_hadi82@yahoo.com
Editorial Address
-
Location
Kota samarinda,
Kalimantan timur
INDONESIA
Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : -
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
Arjuna Subject : -
Articles 10 Documents
Search results for , issue "Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry" : 10 Documents clear
Sintesis 2,6-bis(2?-hidroksibenzilidin)sikloheksanon dari Hidroksibenzaldehid dan Sikloheksanon dengan Katalis Natrium Hidroksida Ramadhan, Adam M.; Utami, Dwi; Sardjiman, Sardjiman
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.132 KB) | DOI: 10.25026/jtpc.v3i1.82

Abstract

The synthesis of ciklovalon (HGV-0) analogue was done by substituent modification on aromatic ring. One of the ciklovalon analogues is 2,6-bis(2′-hydroxybenzylidene)cyclohexanone. The objective of this study was obtaining the amount of mol NaOH catalyst in order to find the highest rendement. The synthesis of 2,6-bis(2′-hydroxybenzylidene)cyclohexanone has been done using aldol condentation reaction from 2′-hydroxybenzaldehyde and cyclohexanone. The variation of mol catalyst NaOH used in this research were 0.2 mole; 0.4 mole and 0.8 mole. The synthesized product was purified by recrystalization with ethanol and cold water. The structure of the synthesized compound was determined by UV-Vis, IR, 1H-NMR, and GC-MS. The result showed that the average rendement the variation of mol catalyst NaOH 0.2 mole; 0.4 mol and 0.8 mole were (25.12±0.86)%, (11.23±0.40)% and (9.50±0.56)%. The highest rendement was obtained when the 0.2 mole NaOH used. Statistical analysis using tukey test resulted significant differences. The spectroscopic analysis using UV-Vis, IR spectrometry, 1H-NMR spectrometry, and GC-MS showed that synthesized compound was 2,6-bis(2′-hydroxybenzylidene)cyclohexanone. Keywords: 2,6-bis(2′-hydroxybenzylidene)cyclohexanone, synthesis, catalyst, rendement ABSTRAK Sintesis analog siklovalon (HGV-0) dilakukan melalui modifikasi substituen pada cincin aromatiknya. Salah satu analog siklovalon tersebut adalah 2,6-bis(2′-hidroksibenzilidin)sikloheksanon. Tujuan penelitian adalah untuk mengetahui jumlah mol katalis NaOH yang menghasilkan rendemen paling besar. Sintesis 2,6-bis(2′-hidroksibenzilidin)sikloheksanon dilakukan melalui reaksi kondensasi aldol dari 2-hidroksibenzaldehid dan sikloheksanon dengan menggunakan katalis natrium hidroksida. Variasi jumlah mol katalis NaOH yang digunakan dalam penelitian ini adalah 0,2 mol; 0,4 mol dan 0,8 mol. Pemurnian hasil sintesis dilakukan dengan rekristalisasi menggunakan etanol dan aquades dingin. Struktur senyawa hasil sintesis ditentukan dengan cara spektrofotometri UV-Vis, spektrometri Inframerah, spektrometri Resonansi Magnetik Inti (1H-RMI), dan GC-MS. Dari hasil penelitian menunjukkan bahwa rerata rendemen dari variasi jumlah mol NaOH 0,2 mol; 0,4 mol dan 0,8 mol berturut-turut adalah (25,12±0,86)%, (11,23±0,40)% dan (9,50±0,56)%. Rendemen paling optimal diperoleh pada jumlah mol katalis NaOH 0,2 mol. Hasil uji Tukey menunjukkan adanya perbedaan yang signifikan pada masing-masing kelompok. Berdasarkan data spektrofotometri UV-Vis, spektrometri Inframerah, spektrometri 1H-RMI, dan GC-MS menunjukkan bahwa senyawa yang dihasilkan adalah 2,6-bis(2′-hidroksibenzilidin) sikloheksanon. Kata kunci: 2,6-bis(2′-hydroxybenzylidene)cyclohexanone, sintesis, katalis, rendemen
Formulasi Krim dari Kulit Buah Kakao (Theobroma cacao L.) Berkhasiat Antioksidan Mita, Nur
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.312 KB) | DOI: 10.25026/jtpc.v3i1.83

Abstract

A research about the antioxidant cream formulation from cocoa (Theobroma cacao L.) pod husk extract have been done. The research was aimed to formulate cream from extract of cocoa pod husk with high antioxidant activity and physically stable. Fresh cocoa pod husk was extracted with both of ethanol-water (7:3) and acetone-water (7:3), then both of extracts was tested their antioxidant activities by DPPH (2,2-diphenyl-1-picrylhidrazyl) method. The acetone-water (7:3) extract which have the higher antioxidant activity (IC50 = 0,08 mg/ml toward DPPH free radical) was formulated become cream preparation with variated emulsifying agents, i.e. anionic emulsifier (stearic-triethanolamine (TEA) with vary concentrations of TEA i.e. 1%, 2% and 3%) and nonionic emulsifier (Span 60-Tween 60 3%, 4% and 5%). The result of research indicated that antioxidant cream with Span 60-Tween 60 3% as emulsifying agent was the most physically stable cream. Keywords: cocoa pod husk, antioxidant, cream, physics stability, Span 60- Tween 60 ABSTRAK Penelitian tentang formulasi krim antioksidan dari ekstrak kulit buah kakao (Theobroma cacao L.) telah dilakukan. Penelitian ini bertujuan untuk memformulasi krim dari ekstrak kulit buah kakao dengan aktivitas antioksidan tinggi dan stabil secara fisika. Kulit buah kakao segar diekstraksi dengan penyari etanol-air (7:3) dan penyari aseton-air (7:3) kemudian diuji aktivitas antioksidannya dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Ekstrak aseton-air (7:3) yang memiliki aktivitas antioksidan tertinggi (IC50 = 0,08 mg/mL terhadap radikal bebas DPPH) diformulasi menjadi sediaan krim dengan bahan pengemulsi yang bervariasi yaitu emulgator anionik (trietanolamin (TEA)-stearat dengan variasi konsentrasi TEA 1%, 2% dan 3%) dan emulgator nonionik (Tween 60-Span 60 3%, 4% dan 5%). Hasil penelitian menunjukkan bahwa krim dengan emulgator Tween 60-Span 60 3 % adalah krim yang paling stabil secara fisika. Kata kunci: kulit buah kakao, antioksidan, krim, stabilitas fisika, Tween 60-Span 60
Pengaruh Waktu Pengambilan Sampel Darah terhadap Pemeriksaan Testosteron Ardana, Mirhansyah
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.139 KB) | DOI: 10.25026/jtpc.v3i1.84

Abstract

The research about “The Influence of Sampling Time to Testosterone for Medical Check Up” had been develoved to 19 man aged 19 – 25 years old. Sample was collected at 8 a.m. and 12 a.m. to determine testosterone serum level. Determining of testosteron serum level was done using Electrochemiluminescence Immunoassay(ECLIA). The result show that testosterone serum level mean at 8 a.m. (608.90 ng/dL) is slightly lower than testosterone serum level at 12 a.m. (647.95 ng/dL). The analysis of t test (α=0.05) show that there was not significantly difference between testosteron level mean at 8 a.m. and 12 a.m. So the sampling time to determine testosteron serum level to men can be done until 12.00 a.m. Keywords: Testosterone, Electrochemiluminescence, Immunoassay ABSTRAK Telah dilakukan penelitian mengenai “Pengaruh Waktu Pengambilan Sampel Darah Terhadap Pemeriksaan Testosteron”. Sampel darah diambil dari 19 pria berumur 19 – 25 tahun. Sampel darah dikumpulkan pada pukul 08.00 dan pukul 12.00 untuk pemeriksaan kadar testosteron. Penentuan kadar testosteron dilakukan menggunakan metode Electrochemiluminescence Immunoassay (ECLIA). Hasil penelitian menunjukan bahwa kadar testosteron rata-rata pada pukul 08.00 (608,90 ng/dL) sedikit lebih rendahdaripada kadar testosteron rata-rata pada pukul 12.00 (647,95 ng/dL). Hasil analisis uji t (α = 0,05) menunjukan bahwa tidak terdapat perbedaan yang signifikan antara kadar testosteron rata-rata pada pengambilan pukul 08.00 dan pukul 12.00. Sehingga pengambilan sampel darah untuk pemeriksaan kadar testosteron pada pria dewasa dapat dilakukan hingga pukul 12.00. Kata kunci: Testosteron, Electrochemiluminescence Immunoassay
Aktivitas Antibakteri dari Fraksi Daun Bandotan (Ageratum conyzoides L.) secara Kromatografi Lapis Tipis Bioautografi Ahmad, Islamudin
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.272 KB) | DOI: 10.25026/jtpc.v3i1.85

Abstract

Screening Ageratum conyzoides L. fraction for antibacterial activity using thin layer chromatography bioautography have been done. The method is based on thin-layer chromatography–direct bioautography of Ageratum conyzoides chloroform fraction. The aim of study to determine the antibacterial activity of chloroform Ageratum conyzoides L. fraction in TLC bioautography. Extraction was done by maceration using methanol solvent, followed by partition using chloroform solvent using liquid-liquid extraction method is done by chromatographic profile of each eluent comparison is then performed further fractionated using vacuum liquid chromatography method. Screening activity of the compound was done qualitatively raction results are antibacterial activity test using thin layer chromatography bioautography The results showed that the eluent to separate the components of a compound based on the chomatography profile is eluent n-hexane: ethyl acetate (2: 1), the results obtained by fractionation of the active fraction (51-53) Rf value of 0.59. Results of screening activity held chloroform fraction Ageratum conyzoides leaves are antibacterial activity which can be seen from the formation of inhibition zones in the region stain spot on the TLC plate were grown in glucose medium Nutrient. The results were analyzed descriptively, that is to describe the characteristics of the research which is obtained. Keywords: TLC bioauttography, Ageratum conyzoides L., TLC profiles, antibacterial ABSTRAK Telah dilakukan penelitian dengan judul skrining aktivitas dari fraksi daun bandotan (Ageratum conyzoides L.) secara kromatografi lapis tipis bioautografi. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri fraksi kloroform daun bandotan secara KLT bioautografi. Ekstraksi dilakukan secara maserasi dengan menggunakan pelarut metanol yang dilanjutkan dengan partisi menggunakan pelarut kloroform dengan menggunakan metode ekstraksi cair-cair yang dilakukan dengan melihat profil kromatografi dari setiap perbandingan eluen selanjutnya dilakukan fraksinasi lebih lanjut dengan menggunakan metode kromatografi cair vakum. Skrining aktivitas senyawa hasil hasil fraksi dilakukan secara kualitatif yaitu uji aktivitas antibakteri menggunakan metode kromatografi lapis tipis (KLT) Bioautografi. Hasil penelitian menunjukkan bahwa eluen yang dapat memisahkan komponen senyawa dengan baik berdasarkan profil kromatografinya adalah eluen n-heksana : etil asetat (2 : 1), hasil fraksinasi diperoleh fraksi aktif pada (vial fraksi 51-53) nilai Rf sebesar 0,59. Hasil skrining aktivitas yang dimiliki fraksi kloroform daun bandotan yaitu aktivitas antibakteriyang dapat dilihat dari terbentuknya zona hambat pada daerah spot noda pada plat KLT yang ditanam di dalam medium Glukosa Nutrient Agar. Hasil penelitian yang diperoleh dianalisis secara deskriptif, yaitu dengan menjabarkan karakteristik hasil penelitian yang diperoleh. Kata Kunci: KLT bioautografi, Ageratum conyzoides L., profil KLT, antibakteri
Efek Imunostimulan Infus Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Asal Kab. Sidrab Sulawesi Selatan terhadap Sekresi Antibodi Tikus Putih (Rattus norvegicus) Jantan dengan Teknik Hemaglutinasi Emelda, Andi; Rahman, Safriani; Hardianti, Hardianti
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.175 KB) | DOI: 10.25026/jtpc.v3i1.86

Abstract

Phaleria macrocarpa has chemical constituents that are flavonoids. Flavonoids may act as antioxidants and modulate the immune system. This study aimed to determine the effect of immunostimulatory infusion Phaleria macrocarpa using hemagglutination method. The animals were white rats (Rattus norvegicus) male. The animals were divided into 5 groups. Group I (control), group II (SDMD 5%), group III, IV and V are the groups given Phaleria macrocarpa infusion at the dose of 7.5 %, 15 % and 30 % respectively for 7 days. The animals were induced SDMD 5% intraperitoneally. Observations were made with a view the agglutination titer blood serum of the mice with SDMD. The results showed that infusion of Phaleria macrocarpaprovide the highest concentration at the 7.5% for titer antibody. Keywords: Phaleria macrocarpa, Imunostimulant, Immunoglobulin, Hemagglutination ABSTRAK Buah mahkota dewa mempunyai kandungan kimia yaitu flavanoid. Flavanoid dapat berfungsi sebaigai antioksidan dan memodulasi sistim imun. Penelitian ini bertujuan untuk menentukan efek imunostimulan infus buah mahkota dewa menggunakanmetode hemaglutinasi. Hewan uji yang digunakan pada penelitian ini adalah tikus putih (Rattus norvegicus) jantan. Hewan uji dibagi menjadi 5 kelompok. Kelompok kontrol, kelompok II (SDMD 5%), kelompok III, IV dan V adalah kelompok yang diberi infus buah mahkota dewa dengan dosis berturut-turut 7,5%, 15% dan 30% selama 7 hari.Hewan uji diinduksi dengan SDMD 5% secara intraperitonial. Pengamatan dilakukan dengan melihat titer aglutinasi serum darah tikus dengan SDMD. Hasil pengamatan menunjukkan bahwa infus buah mahkota memberikan titer antibodi tertinggi pada konsentrasi 7,5%. Kata Kunci: Imunostimulan, Mahkota Dewa, Imunoglobulin, Hemaglutinasi
Pengaruh Penambahan Kulit Jeruk Bali (Citrus maxima) terhadap Kualitas Minyak Goreng yang Mengalami Pemanasan Fadraersada, Jaka
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.331 KB) | DOI: 10.25026/jtpc.v3i1.87

Abstract

Cooking oil is used to fry foods. The longer and more frequent the cooking oil being used, more its quality is getting lower. The goal of this research is to know if there is an effect of adding grapefruit peels due to the quality of cooking oil that has been used several times. Grapefruit peel contains lycopene which can reduce oxidation process. By adding grapefruit peel, we hope its can reduce the lowering quality. The orientation shows that 3% grapefruit peel weight/weight is the most efficient concentration to be used. And with 3% grapefruit peel weight/weight, the results shows a big difference between cooking oil with no grapefruit peel addition and cooking oil with grapefruit peel addition. Keywords: Cooking oil, frying, grapefruit peel, quality of cooking oil ABSTRAK Minyak goreng digunakan untuk memasak bahan makanan. Semakin lama dan semakin sering minyak goreng digunakan, kualitasnya akan semakin menurun. Tujuan dari penelitian ini adalah untuk mengetahui efek dari penambahan kulit Jeruk Bali pada kualitas minyak goreng yang mengalami pemanasan berulang. Kulit Jeruk Bali merupakan produk waste (buangan) yang mengandung likopen yang dapat mengurangi proses oksidasi. Dengan menambahkan kulit Jeruk Bali, diharapkan dapat mencegah penurunan kualitas minyak goreng. Dari penelitian didapatkan hasil bahwa 3% B/B kulit Jeruk Bali merupakan konsentrasi terbaik yang dapat digunakan. Pada studi ini minyak goreng yang diberi tambahan kulit Jeruk Bali dengan konsentrasi 3% B/B menunjukkan perbedaan yg besar pada beberapa parameter SNI dibandingkan dengan minyak goreng tanpa pemberian kulit Jeruk Bali setelah dipanaskan. Kata Kunci: Spirulina platensis, reaktor tubular vertikal, pengurangan kadar CO2
Bioassay-Guided Fractination of Antimitotic Compound from Ongkea Cortex (Mezzettia parviflora Becc) Towards Sea Urchin Eggs Bahar, Muh. Akbar; Alam, Gemini; Manggau, Marianti A.; Mufidah, Mufidah; Suparman, Suparman
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.227 KB) | DOI: 10.25026/jtpc.v3i1.88

Abstract

Ongkea cortex, the wood bark of Mezzettia Parviflora Becc, is a traditional medicine originated from Southeastern Sulawesi (Indonesia). It has been empirically known to have antitumor property. In this study, we examined the antiproliferative activity and obtained the antimitotic compound of ongkea cortex. Antimitotic activity was ultimately determined by the inhibition of cleavage-stage of newly fertilized sea urchin (Lytechinus variegatus) eggs. A bioassay-guided fractination was performed in order to find the bioactive substance of ongkea cortex. The IC50 values of methanolic extract, ethyl acetate-soluble part of metanolic extract and ethil acetat insoluble part of metanolic extract were 1221.68 µg/mL, 2.69 µg/mL, and 15.15 µg/mL, respectively. Ethyl acetate-soluble part of metanolic extract was further investigated. It was partitionated using vacuum liquid column chromatoghraphy with different solvent system by increasing their polarities. There were three different fractions obtained. Fraction III exerted the highest inhibition activity with IC50 value of 1.33 µg/mL. It was separated subsequently to result four groups of compounds. III-C group presented the most potent inhibition activity with IC50 value of 0.7147 µg/mL. It was then subjected to preparative TLC and yieldedsix groups of subfractions. III-C-3 subfraction was indicated as the most potent compound with IC50 value of 0.3378 µg/mL. It was ten times weaker compared with antimitotic activity of Vincristine with IC50 of 0.0351 µg/mL. As a conclusian, ongkea cortex might have antimitotic property with the highest rate inhibition activity exhibited by III-C-3 compound. Keywords: ongkea cortex, Mezzettia Parviflora Becc, sea urchin eggs, antimitotic compound, antiproliverative activity
Pengurangan Kadar CO2 Menggunakan Spirulina Platensis dalam Tubular Bioreactor Arifin, Zainal Syam
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.33 KB) | DOI: 10.25026/jtpc.v3i1.89

Abstract

Increasing the population impact on increasing energy demand. On the other hand, the energy generation industry has been blamed as one of the contributors of carbon dioxide about 25% of total CO2 emissions worldwide. Meanwhile, the production of biogas, which aims to address the increasing need of energy, produces carbon dioxide in the range of 25–50% by volume. To overcome this, a cheap method, optimum and efficient as well as environmentally friendly in reducing CO2 levels by using Spirulina platensis is needed. This research aims to created a mathematical models and found the optimum flow rate to reduced levels of CO2 by using Spirulina platensis. This study used a glass tubular bioreactor (D = 2.6 cm) at a temperature of 30°C and irradiated with a fluorescent lamp Philips TL 36 Watt, color temperature: 6,200K cool daylight, light output: 2,600 lm, 72 lm/W. Tubular reactor was placed in a box lined with silver foil walls on three sides. With mathematical models of tubular reactor, the reaction rate constants could be predicted. Based on calculations of data and graphs, optimum volumetric velocity could also be predicted. Variation of flowrate to observed the reduction rate of CO2 was 0.25 mL/sec, 0.35 mL/sec, 0.5 mL/sec, 0.75 mL/sec, 1 mL/sec. Carbon source was 99.99% CO2.Observations of Spirulina growth was made on the flow rate of 0.25 mL/sec at the initial levels of dry weight 2.1208 g/L. The results of this study indicated that the low flowratewas a more effective way to reduced carbon dioxide levels using Spirulina platensis (= 2.82×10-4 sec-1). The highest conversion was obtained at a volumetric flow rate of 0.25 mL/sec and optimum speeds in the range of 0.3 to 0.4 mL/sec. The rate of incoming CO2 flux should be less than 0.047 mL/cm2.detik. Specific Growth Rate (µ) of Spirulina platensis in this study was 2.56×10-2 minute-1. Keywords: Spirulina platensis, a vertical tubular bioreactor, CO2 reduction ABSTRAK Meningkatnya jumlah penduduk berdampak pada peningkatan kebutuhan energi. Di lain pihak, industri pembangkit energi dituding sebagai salah satu penyumbang karbon dioksida sekitar 25% dari total emisi CO2 di seluruh dunia. Disisi lain, produksi biogas yang bertujuan untuk mengatasi peningkatan kebutuhan energi justru menghasilkan karbon dioksida pada kisaran 25 – 50% volume. Untuk mengatasi hal ini, diperlukan metode yang murah, optimum dan efisien serta ramah lingkungan dalam mengurangi kadar CO2 dengan menggunakan spirulina platensis. Penelitian ini bertujuan membuat model matematik dan menemukan kecepatan aliran yang optimum untuk menurunkan kadar CO2 dengan menggunakan Spirulina Platensis. Penelitian ini menggunakan reaktor tubularterbuat dari kaca (D = 2,6 cm) pada suhu 30°C dan disinari dengan lampu TL Philips fluoresen 36 Watt, temperatur warna: 6.200K cool daylight, light output: 2.600 lm, 72 lm/W. Reaktor tubular ditempatkan dalam kotak yang dilapisi dinding dengan kertas perak pada ketiga sisinya. Dengan model matematik reaktor tubular, dapat diprediksi konstanta kecepatan reaksinya. Berdasarkan grafik hasil perhitungan data, kecepatan volumetrik optimumnya juga dapat diprediksi. Variasi flowrate yaitu 0,25 mL/detik, 0,35 mL/detik, 0,5 mL/detik, 0,75 mL/detik, 1 mL/detik. Sumber karbon adalah CO2 99,99%. Pengamatan pertumbuhan Spirulina dilakukan pada flow rate 0,25 mL/detik dengan kadar berat kering mula – mula 2,1208 g/L. Hasil penelitian ini menunjukkan bahwa aliran lambat (flowrate rendah) merupakan cara yang lebih efektif dalam mengurangi karbon dioksida menggunakan spirulina platensis (= 2,82×10-4 detik-1). Nilai konversi tertinggi diperoleh pada kecepatan aliran volumetrik 0,25 mL/detik dan kecepatan optimumnya pada kisaran 0,3 – 0,4 mL/detik. Laju flux CO2 masuk sebaiknya kurang dari 0,047 mL/cm2.detik. Nilai Specific Growth Rate (µ) Spirulina Platensis dalam penelitian ini yaitu 2,56×10-2 menit-1. Kata Kunci: Spirulina platensis, reaktor tubular vertikal, pengurangan kadar CO2
Aktivitas Antifungi Fraksi Etilasetat Akar Singawalang (Petiveria alliacea L.) terhadap Aspergillus niger Indriyanti, Niken
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.803 KB) | DOI: 10.25026/jtpc.v3i1.90

Abstract

Aspergillus niger is a mold that can infect respiratory tract in certain condition. Azoles are used to solve this infection. Drug development on antifungal drugs still continued, one of the resorce is from plant. A plant that widely studied as antifungi is singawalang (Petiveria alliacea L.). Activity of ethanol extract and fraction of singawalang roots on Aspergillus niger tested by microdilution broth method appropriate to Clinical and Laboratory Standard Institute (CLSI) standard. Microdilution test results showed that Singawalang roots extract has antifungal activity against Aspergillus niger with Minimum Inhibition Concentration (MIC) 32 μg/mL and Minimum Fungicidal Concentration (MFC) 1048 μg/mL. Fraction that has high activity against Aspergillus niger was ethylacetate fraction of Singawalang roots with MIC 128 µg/ml dan MFC 512 μg/mL. The higher activity of the extract than the fraction was predicted as the impact of multiple compounds that have synergic activity. The growth profile of Aspergillus niger showed unconstant result and tends to descend. However, further research needed to ensure this effect. Keywords: antifungal, microdilution, singawalang (Petiveria alliacea L.), Aspergillus niger ABSTRAK Aspergillus niger merupakan kapang penginfeksi saluran pernafasan pada kondisi tertentu. Obat-obat golongan azol biasa digunakan untuk mengatasi infeksi ini. Pengembangan obat antifungi saat ini terus dilakukan, termasuk dari tanaman. Salah satu tanaman yang telah banyak diteliti memiliki efek antifungi adalah tanaman singawalang (Petiveria alliacea L.). Pengujian dilakukan dengan Broth Microdilution sesuai standar Clinical and Laboratory Standard Institute (CLSI). Ekstrak akar singawalang menghambat pertumbuhan Aspergillus niger dan memiliki KHM 32 ppm dan KFM 1048 ppm. Hasil dan Fraksi Ekstrak Akar Singawalang Terhadap Aspergillus niger pada fraksi etilasetat ekstrak etanol akar singawalang adalah Konsentrasi Hambat Minimum (KHM) 128 μg/mL dan Konsentrasi Fungisidal Minimum (KFM) 512 μg/mL. KHM ekstrak yang lebih tinggi diduga karena senyawa yang bekerja sinergis. Profil pertumbuhan Aspergillus niger tidak konstan dan cenderung menurun mirip efek fungisida sehingga penelitian lanjutan diperlukan untuk memastikan efek tersebut. Kata Kunci: Antifungi, mikrodilusi, singawalang (Petiveria alliacea L.), Aspergillus niger
Isolasi dan Identifikasi Bakteri Lamun Enhalus Acoroides Di Perairan Pasarwajo Buton Gama, Sabaniah Indjar; Nafie, Nursiah La; Dali, Seniwati
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.411 KB) | DOI: 10.25026/jtpc.v3i1.91

Abstract

This research aims to isolation bacteria in segrass Enhalus acoroides 1) determination optimum growth factor of bacteria that symbiont in seagrass 2) identification kind of bacteria that isolated in seagrass. Base on the research that has done, the results show that bacteria symbiotically in seagrass grow in optimum temperature is 27 °C in 10-3 dilution. Identification characteristic, morphology and gram colouring bacteria that symbionts in seagrass is gram negatif bacteria that showed with result of PCR which species isolated in seagrass is enterobacter cloaceae. Keywords: symbiont bacteria, Pasar Wajo Buton, Enhalus acoroides ABSTRAK Lamun Enhalus acroides merupakan tanaman yang sangat penting bagi biota laut diperairan, salah satunya adalah bakteri karena lamun menyediakan tempat hidup serta nutrisi pada bakteri. Penelitian ini bertujuan untuk mengisolasi bakteri yang berada pada lamun Enhalus acoroides, menentukan pertumbuhan optimum bakteri yang bersimbion pada lamun dan menentukan jenis bakteri yang diisolasi pada lamun. Adapun tahapan-tahapan adalah isolasi, identfikasi bakteri dengan Uji fisiologis (pewarnaan), Uji Biokimia, dan PCR. Berdasarkan hasil penelitian bahwasanya bakteri yang bersimbion pada lamun Enhalus acoroides tumbuh pada suhu optimum 27 °C pada pengenceran 10-3. Sedangkan penentuan karakter morfologi dan pewarnaan gram bakteri simbion, dilakukan berdasarkan Microbiology Laboratory Manual dan menunjukkan bahwa morfologi sel bakteri yang berada pada lamun yaitu basill (batang), hasil perwarnaan gram pada lamun diperoleh gram negatif, begitu juga uji biokimia dan diperkuat dengan data hasil polymerase chain resction (PCR) bahwa bakteri yang bersimbion pada lamun adalah Enterobacter cloacae. Kata Kunci: bakteri simbion, Pasar Wajo Buton, Enhalus acoroides

Page 1 of 1 | Total Record : 10


Filter by Year

2015 2015


Filter By Issues
All Issue Vol. 5 No. 4 (2021): Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 1 (2020): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 6 (2019): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 5 (2019): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 4 (2018): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry Vol 4 No 3 (2018): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry Vol 4 No 2 (2017): Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 4 (2016): Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): Journal of Tropical Pharmacy and Chemistry Vol 3 No 4 (2016): Journal of Tropical Pharmacy and Chemistry Vol 3 No 3 (2016): Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry Vol 3 No 2 (2015): Journal of Tropical Pharmacy and Chemistry Vol 3 No 1 (2015): Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 5 (2014): Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 4 (2014): Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry Vol 2 No 4 (2014): Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 3 (2013): Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 2 (2013): Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 1 (2012): Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 3 (2011): Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 2 (2011): Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): Journal of Tropical Pharmacy and Chemistry More Issue