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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : -
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
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Articles 6 Documents
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Search results for , issue "Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry" : 6 Documents clear
Efektivitas Antihiperurisemia Ekstrak Etanol Daun Seledri (EEDS) pada Tikus Induksi Kalium Oksonat Rakanita, Yasinta; L, Hastuti; Tandi, Joni; Mulyani, Sri
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.027 KB) | DOI: 10.25026/jtpc.v4i1.124

Abstract

Seledri adalah tanaman yang memiliki kandungan kimia seperti alkaloid, flavonoid, saponin, dan tanin. Penelitian ini bertujuan untuk membuktikan efektivitas ekstrak etanol daun seledri dalam menurunkan kadar asam urat pada tikus putih jantan dan menentukan dosis ekstrak daun seledri yang efektif dalam menurunkan kadar asam urat pada tikus putih jantan. Ekstrak daun seledri dibuat secara maserasi dengan pelarut etanol 96%. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok. Data yang diperoleh dianalisis dengan mengunakan uji statistik Analisis Sidik Ragam pada taraf kepercayaan 95% yang mengunakan 30 ekor tikus putih jantan dibagi 6 kelompok perlakuan, tiap perlakuan terdiri dari 5 ekor. Model hewan dibuat hiperurisemia menggunakan penginduksi kalium oksonat dengan dosis 250 mg/kg BB. Kelompok I (normal) diberikan pakan standar, kelompok II (negatif) diberi suspensi Na CMC 0,5%, kelompok III (positif) diberi suspensi allopurinol 5,4 mg/kg BB, kelompok IV, V, dan VI diberi ekstrak etanol daun seledri masing-masing dengan dosis 50 mg/kg BB, 100 mg/kg BB, dan 200 mg/kg BB. Berdasarkan uji lanjut BNJ diperoleh hasil bahwa dosis ekstrak etanol daun seledri yang efektif adalah 50 mg/kg BB.
The Immunosuppressant Effect Comparation Between Ethyl Acetate and n-Butanol Fractions of Kalanchoe Pinnata (Lmk) Pers In 2,6,10,14 Tetramethylpentadecane-Treated Mice Indriyanti, Niken; Soeroso, Joewono; Khotib, Junaidi
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (786.305 KB) | DOI: 10.25026/jtpc.v4i1.126

Abstract

Immunosuppressant drugs are the main treatment of lupus patient. The ACR and SLICC treatment guidelines are able to increase the quality of life, but the outcome is not satisfying since the off-label therapy of corticosteroids and cytotoxic drugs give a lot of side effects. Many breakthrough efforts still develop in order to find the safe and effective drugs for lupus, such as finding immunosuppressant drugs from natural resources. One of the potential resources is Kalanchoe pinnata (Lmk) Pers, which have immunosuppressant, anti-inflammatory, antinociceptive, and antioxidant effects. Thus, in the previous study, we found the effect of the aqueous extract of Kalanchoe pinnata (Lmk) Pers is active to repair the lupus manifestation in 2,6,10,14 tetramethylpentadecane (TMPD)-treated mice. Then, this research was focused on the in vivo immunosuppressant effect of a flavonoid-rich fraction of the extract which was consisted of the ethyl acetate (FE) and n-butanol (FB) fractions. The induction method and the extraction procedure were the same as the previous study and then the fractionation was performed by using liquid-liquid extraction. After 2-week treatment of both fractions, we obtained the differences in the total leukocytes, organ indexes, and also the spleen, kidney, and joint structure parameters. The total leukocyte of the FE group was 3,600±264 cells/mm3, which was lower than that in the FB group. The spleen and kidney indexes increased after the administration of FB fraction, while the FE fraction was not. At last, despite the histology observation of spleen resembled mild structural changes differences, the clear differences between both treatment groups occurred in the kidney and joint histology. The differences led to a conclusion that the FE fraction has the better immunosuppressant effect in TMPD-treated mice.
Pemanfaatan Abu Sekam Padi menjadi Katalis Heterogen dalam Pembuatan Biodiesel dari Minyak Sawit Kusyanto, Kusyanto; Hasmara, Purwa Aditya
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.071 KB) | DOI: 10.25026/jtpc.v4i1.127

Abstract

Berdasarkan data BPS Kaltim (2014) jumlah produksi padi mencapai 432.612 ton/tahun. Produksi padi tersebut menghasilkan sekam padi rata-rata sebesar 20%. Sekam padi masih kurang dimanfaatkan dengan baik sehingga hanya menjadi tumpukan limbah pertanian. Abu sekam padi mengandung senyawa yang dapat digunakan sebagai support katalis yaitu diantaranya SiO2. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan abu sekam padi yang telah dikalsinasi dengan impregnasi KOH sebagai katalis pembuatan biodiesel dari minyak sawit secara konvensional. Sekam padi dikalsinasi pada suhu 500°C selama 3 jam lalu diimpregnasi dengan KOH 1,9 N. Kemudian dibilas dengan aquadest dan dioven hingga beratnya konstan. Transesterifikasi dilakukan pada minyak sawit dengan perbandingan massa terhadap volume minyak (10%, 15%, 20%, 25% v/b). Hasil yang didapatkan, semakin banyak massa katalis yang digunakan, konversi yield yang diperoleh semakin tinggi yaitu mencapai 67%. Viskositas dan densitas memenuhi standar biodiesel. Hasil uji surface area BET diperoleh surface area spesifik sebelum dan sesudah impregnasi berturut-turut adalah 89,937 m2/g dan 5,471 m2/g. Analisa produk dengan menggunakan GC-MS dilakukan untuk mendapatkan jenis methyl ester sterarate, palmitat, dan Linoleat.
Isolasi dan Karakterisasi Fungi Endofit Tanaman Tapak Dara (Catharanthus Roseus) Arifuddin, M.; Bone, Mahfuzun; Iswahyudi, Iswahyudi; Ibrahim, Arsyik; Rijai, Laode
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.682 KB) | DOI: 10.25026/jtpc.v4i1.128

Abstract

This study aims to determine the diversity of endophytic fungi Tread Dara (Catharanthus roseus) as one of the potential plants that can produce medicinal efficacious compounds. This study includes the isolation and identification of endophytic fungi on Tapak Dara plant using PDA medium. Based on the results obtained 6 endophytic fungal isolates originating from roots and leaves Tread Dara.
Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol Tandi, Joni; Roem, Moh.; Yuliet, Yuliet
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.913 KB) | DOI: 10.25026/jtpc.v4i1.129

Abstract

Nephroprotective compound is a compound that has the ability to protect the kidneys from kidney disorders caused by free radicals. This research aimed to determine the nephroprotective effect of the combination of Abelmoschus manihot leaves and Orthosiphon stamineus leaves extract as well as to know the effective extract dose combinations as nephroprotective. This research applied Group Random Design with 6 treatment groups consists of 5 tested animals. Group I was normal control. Group II was negative control. All extract groups was given 0,75% of ethylene glycol and 2% of ammonium chloride. Group III was given 100 mg/kg BW of Abelmoschus manihot leaves extract and 200 mg/kg BW of Orthosiphon stamineus leaves extract. Group IV was given 50 mg/kg BW of Abelmoschus manihot leaves extract and 100 mg/kg BW of Orthosiphon stamineus leaves extract. Group V was given 100 mg/kg BW of Abelmoschus manihot leaves extract. Group VI was given 200 mg/kg BW of Orthosiphon stamineus leaves extract. Treatment was given for 14 days and the levels of creatine and urea were measured on day 0, 8 and 15. The results show the nephroprotective effect in all the extract groups, but the most effective one was the group III.
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico Sastyarina, Yurika; Nafisah, Zuhrotun; Yusuf, Muhammad; Ramli, Martalena; Mutalib, Abdul; Soedjanaatmadja, Ukun
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2422.954 KB) | DOI: 10.25026/jtpc.v4i1.130

Abstract

Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Å

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