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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : -
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
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Articles 8 Documents
Search results for , issue "Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry" : 8 Documents clear
Pengaruh Merokok terhadap Keefektivitasan Terapi Hipertensi pada Penderita Hipertensi Perokok Di Empat Puskesmas Tahun 2017 Mardena, Dna Raras; Kusuma, Anjar Mahardian
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.975 KB) | DOI: 10.25026/jtpc.v4i2.133

Abstract

Hypertension is a chronic condition of the mesh where blood pressure rises above normalized blood pressure. This study aims to measure the effect of smoking on the effectiveness of hypertension therapy in patients with hypertension of smokers at Puskesmas I Sumbang, Puskesmas II Kembaran, Puskesmas Purwokerto Timur I, Puskesmas Purwokerto Selatan 2017. Type of study used prospective cohort, in terms of patient's blood pressure with drug consumption Single 1st, 10th day, 30th day to assess effectiveness. Data were analyzed univariat and bivariate through Chi-square test. The result showed that p> 0,05 that p = 0,361 showed that there was no significant difference in the effectiveness of hypertension therapy between group of non smoker hypertension and smoker hypertension. Does not affect the effectiveness of therapy statistically. Keywords: Hypertension, Effectiveness, Amlodipine, Smoking
Peran Homepharmacycare pada Pasien Diabetes Mellitus Tipe II Prolanis terhadap Tingkat Kepatuhan dan Keberhasilan Terapi Di BP Sentra Medika Lebaksiu Tegal Najiha, Mita Rodiyatun; Utaminingrum, Wahyu; Wibowo, Much Ilham Novalisa Aji
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.059 KB) | DOI: 10.25026/jtpc.v4i2.134

Abstract

Diabetes mellitus disease (DM) is chronic diseases due to the increase of glucose concentration in the body. The compliance and successful treatment of diabetes are needed to prevent complications. The patients’ compliance in using the medicine is an important factor of the successful therapy. One of the most comprehensive interventions for DM patients is Home Pharmacy Care. Objective: This study aims to determine the effect of Home Pharmacy Care role in patients with diabetes mellitus in increasing the compliance and successful therapy. Method: This research is pre experimental research conducted at Bp Sentra Medika Clinic and counseling at home respondents in Lebaksiu ,Tegal with using the method of one group pretest posttest design. Purposive sampling method is used in this research and got 35 respondents. Measurements were made using the MMAS-8 (pretest-postest) and pill count instrument to determine the patient's compliance level and the glucotest to measure the success of therapy characterized by blood sugar levels. Statistics test uses Wilcoxon and Mc Nemar to determine the effect of provision of Home Pharmacy Care intervention on compliace and successful therapy level. The results: showed that a total of 20 patients (57%) comliance to MMAS-8 and pill count scores and a total of 20 patients (57%) of successful treatment were achieved based on controlled blood glucose levels. Conslusion: The statistical test showed that there was a significant difference between before and after intervention marked with the value of p value of both tests was 0,000 so that there is an effect of giving Home Pharmacy Care toward the improvement of compliance and successful therapy. Keywords : diabetes mellitus, homepharmacycare, prolanis, compliance and successful therapy level
Studi Pendahuluan Fitokimia Tanaman Koleksi Arboretum Legok Pulus Garut Handayani, Retty; Rustamsyah, Ardi; Perdana, Farid; Ihsan, Setiady; Suwandi, Deden Winda
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.42 KB) | DOI: 10.25026/jtpc.v4i2.136

Abstract

Arboretrum is a botanical garden which is an open place where there are plants that have been labeled. The purpose of this research is the preliminary study on phytochemical content of secondary metabolite compounds on the leaves of the Legok Pulus Garut arboretum collection plant. the results of the study known twenty-two types of plants contained in Arboretum Garut contain various phytochemical compounds and can be used as collection and research base of medicinal plants. Keywords : arboretum, phytochemicals, secondary metabolites.
Pengaruh Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm f.)Alston) terhadap Glukosa Darah, Ureum dan Kreatinin Tikus Putih (Rattus norvegicus) Tandi, Joni
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.073 KB) | DOI: 10.25026/jtpc.v4i2.137

Abstract

Diabetes mellitus with complications of Diabetic Nephropathy become one of the most common cause of end-stage renal failure in the world. Impaired kidney function is measured by Glomerular Filtration Rate (GFR). Where the decline in GFR was followed by increased levels of blood glucose, urea and creatinine. This study aimed to determine whether there is the content of secondary metabolites in leaves of Sizygium aqueum leaf extract, at a dose of extract what impact the blood glucose, urea and creatinine levels of male rats and whether the water extract of guava leaves have an influence on the blood glucose, urea and creatinine white male rats. This study uses a randomized block design with six treatment groups consisting of five test animals. Group I was normal control (CMC Na suspension 0.5%). Group II negative control (streptozotocin 40 mg/kg). positive control group III (suspension glibenclamide). Group IV given guava leaf extract 100 mg/kg BW. V group awarded guava leaf extract 200 mg/kg BW. Group VI given guava leaf extract 300 mg/kg BW. Treatment was given for 28 days and measured levels of blood glucose urea and creatinine on days 0, 7, 14, 21 and 28. The results showed nefroprotektif effect on all groups and most effective extract are a group of guava leaf extract 100 mg/kg BW). Keywords: Diabetic nephropathy, urea, creatinine, Syzygium aqueum
Uji Aktivitas Trakeospasmolitik Ekstrak Etanol Centella asiatica (L.) Urb. pada Organ Terpisah Trakea Marmut untuk Melihat Efek Antiasma Bachtiar Moerad, Emil; Paramita, Swandari; Iskandar, Abdillah; Ismail, Sjarif; Pratiningrum, Moriko; Irawiraman, Hadi
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.429 KB) | DOI: 10.25026/jtpc.v4i2.139

Abstract

Asma merupakan penyakit inflamasi kronik saluran nafas yang ditandai dengan terjadinya hiperesponsif saluran nafas dan penyempitan saluran nafas secara reversibel. Asma hingga kini masih merupakan masalah kesehatan utama di dunia. Pemberian obat-obatan anti asma merupakan penatalaksanaan penyakit tersebut. Namun demikian terdapat masalah efek samping obat dan masalah biaya yang dikeluarkan untuk pembelian obat tersebut, apalagi asma merupakan penyakit kronis yang memerlukan pengobatan jangka panjang. Dengan demikian maka perlu pengembangan obat antiasma berbasis tumbuhan obat dengan biaya yang lebih terjangkau dan efek samping yang lebih sedikit. Penelitian ini dilakukan untuk menguji potensi ekstrak etanol Centella asiatica (L.) Urb. yang secara tradisional digunakan etnis Dayak sebagai obat batuk. Penelitian ini dilakukan untuk melihat aktivitas trakeospasmolitik ekstrak etanol C. asiatica pada organ terpisah trakea marmut untuk melihat efek antiasma. Hasil penelitian menunjukkan ekstrak C. asiatica memiliki aktivitas trakeospasmolitik yang signifikan jika dibandingkan dengan kontrol negatif. Meskipun nilai E maks C. asiatica lebih rendah daripada aminofilin, namun nilai EC50 tidak jauh berbeda dengan aminofilin sebagai kontrol positif. Kesimpulan penelitian ini adalah ekstrak etanol C. asiatica memiliki efek antiasma berdasarkan aktivitas trakeospasmolitiknya. Kata kunci: Centella asiatica, spasmolitik, organ terpisah trakea
Persepsi, Efektifitas, dan Keamanan Penggunaan Rokok Elektrik (E-Cigarette) oleh Perokok Aktif sebagai Terapi dalam Smoking Cessation: Mixed Methods dengan Pendekatan Studi Kuantitatif dan Kualitatif Lorensia, Amelia; Yudiarso, Ananta; Herwansyah, Findry Rafsanjani
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.237 KB) | DOI: 10.25026/jtpc.v4i2.142

Abstract

Rokok merupakan salah satu faktor penyebab gangguan kesehatan terbesar di dunia. Kerugian dalam hal kesehatan dan ekonomi tersebut maka program berhenti merokok (smoking cessation) menjadi pilihan utama pengobatan bagi perokok. Kini banyak perokok beralih menggunakan rokok elektrik (e-cigarette) yang meningkat pesat perkembangannya. Penelitian ini bertujuan untuk menggali lebih dalam mengenai persepsi, efektifitas dan keamanan penggunaan rokok elektrik oleh perokok aktif dalam usahanya untuk berhenti merokok. Desain penelitian ini menggunakan mix method, dengan tahap metode deskriptif dan tahap interpretatif phenomenologi analysis (IPA) dalam mengamati persepsi, efektifitas, dan keamanan. Responden yang terlibat sebanyak 47 orang, yaitu pengguna rokok elektrik yang sebelumnya pernah menggunakan rokok biasa (tembakau). Hasil penelitian menunjukkan partisipan menganggap rokok elektrik efektif membantu dalam proses smoking cessation. Rokok eletrik terbukti mengurangi frekuensi penggunaan rokok tembakau (25%) dan menyebabkan berhenti merokok (75%). Sedangkan sebagian besar responden tidak mengalami efek samping (66,66%), dan efek yang dilaporkan adalah tenggorokan terasa kering dan batuk (33,33%). Kesimpulannya rokok elektrik diyakini mampu membantu proses smoking cessation walaupun efektifitas dan keamanannya masih membutuhkan penelitian lebih lanjut. Kata Kunci: persepsi, efektifitas, keamanan, rokok elektrik, smoking cessation
Aktivitas Antioksidan Senyawa Kumarin Ter-O-Geranilasi dari Akar Limonia acidissima L. Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Tanjung, Mulyadi
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.906 KB) | DOI: 10.25026/jtpc.v4i2.143

Abstract

Five O-geranylated coumarins namely as auraptene (1), 7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2), 7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3), 6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated from the roots of Limonia accidissima L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210 and 234 µg/ml, respectively. Keywords: Limonia accidissima L., O-geranylated coumarins, antioxidant activity, DPPH
Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta Ismail, Sjarif; Kosala, Khemasili; Fikriah, Ika; Magdaleni, Agustina Rahayu
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.693 KB) | DOI: 10.25026/jtpc.v4i2.146

Abstract

Coptosapelta flavescens Korth. is a liana plant from the Rubiaceae family. In East Kalimantan, it is also known as “Akar Tambolekar” or “Merung”, it is called “akar” or root as its trunk spreads like a root. The plant’s stems are used by ethnic Dayak in East Kalimantan to overcome high blood pressure and it has been proven to induce vasorelaxation on blood vessels, but the its action mechanism in the endothelial or vascular smooth muscle cells (VSMC) are unknown. Vasorelaxation on the blood vessels could be mediated by endothelial or by the VSMC. This research aims to study in vitro which of them is the mechanism of action of Coptosapelta flavescens Stems (CFS) extract. CFS were taken from the secondary forest in Paser Regency, East Kalimantan Province. Its simplicia were macerated with methanol solvent for three days and twice repeated. Vasorelaxation activity of the blood vessels was tested with rats’ isolated thoracic aorta with endothelial and with the endothelial removed (endothelium-denuded). Both aorta of 3 mm length were soaked into Krebs-Henselheit solution at 37°C, pH 7.4 and aerated with carbogen gas. After they have acclimatized, both aortas were contracted with phenylephrine solution, after reaching peak contraction and plateau, the solution of extract or its solvent (Control) was administered in cumulatively increasing doses. The results show that CFS extracts induce vasorelaxation both in the endothelial-intact aorta and in the endothelial-denuded aorta. At high concentrations, the vasorelaxation activity in the endothelial-intact aorta was weaker than that on endothelial-denuded aorta. This study proves that action mechanism of blood vessels’ vasorelaxation induced by the methanol extract of CFS were more dominantly mediated by the blood vessels smooth muscle; and at high concentrations the endothelial actually weakened the VSMC vasorelaxation activity. Further study is necessary on the mechanism of action vasorelaxation through the modulation of intracellular or extracellular calcium ion channels of VSMC Keywords: Coptosapelta flavescens, vasorelaxation, extract, aorta, in vitro

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