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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : -
Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: 2087-7099, ISSN-e: 2407-6090), The journal had been established in 2010, and online publication was begun in 2014. Since 2018, the journal has been published in English by Faculty of Pharmacy, Universitas Mulawarman (UNMUL) Samarinda, Indonesia in and only receives manuscripts in English.
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Articles 17 Documents
Search results for , issue "Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry" : 17 Documents clear
WITHDRAWAL: Essential Oil Chemical Characterization and Antibacterial Activities of Lepidium sativum Seed Nigussie, Gashaw; Desta, Dinkayehu; Ashenafi, Sintayehu; Werede, Yemane
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.265

Abstract

Lepidium sativum plants are available abundantly in all part of Ethiopia and traditionally used for the treatment of various ailments. The work done on essential oil chemical characterization and biological activity of this plant are still insufficient reports in Ethiopia. Therefore the aim of the present study was to carry out essential oil chemical characterization and antibacterial activities of the seeds extracts and oils of L. sativum obtained from the local area Kersu Kebele, Goma Wereda, Jimma zone. The study was conducted by extraction of the seeds with organic solvents n-hexane, dichloromethane, ethyl acetate and methanol. The study performed on extraction of essential oil of the seed through hydrodistillation and investigation of phytochemical constituents of each solvent extract. The n-hexane extract (oil) and the essential oil of the seed extract were analyzed with GC-MS and 11 components were obtained from each types of oil. 7, 10, 13-hexadecatrienoic acid (64.42%) and Indol (63.78%) were the major components of n-hexane extracted and essential oil of the seeds respectively. Moreover both oils were held unsaturated fatty acid, saturated fatty acid and aromatic derivative compounds. The preliminary phytochemical test revealed the presence of alkaloids, flavonoids, glycosides, phenols, saponins, anthraqunnes, and tannins. Antibacterial activities of the essential oil were implemented by disc diffusion method against one Gram positive bacterium Stphylococus aureus and three Gram negative bacteria: E.coli, Proteus mirabilis and Klibsiella pneumoniae. The inhibition zones of the samples were compared with standard drug ceftriaxone. The essential oil showed antibacterial activities on all the tested bacteria.
Effect Analysis of Protein Intake of Pedicab Driver in Surabaya Lorensia, Amelia; Suryadinata, Rivan Virlando; Sidabutar, Bela C. M.
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.266

Abstract

Approximately 64 million people suffer from copd and 3 million people die from copd. No exception to pedicab rickshaw drivers, which is one job that has a high risk of copd. From workplace factors that are always exposed to vehicle fumes and dust pollution and also lifestyles such as smoking habits. Pedal rickshaw drivers are also classified as low economic groups, so their daily food intake is sometimes insufficient. Thus making daily protein intake also reduced, protein intake is very important in copd disease. Where protein can improve the performance of respiratory muscles and improve immune function. This study uses a 24-hour recall method by recording the respondent's food history in the last 24 hours to see how daily food protein intake. In this study lung function measurements were also performed using spirometry where the normal value is if fev1 / fvc> 70%. Obtained a total of 124 respondents with a total of 62 in the lung function disorder group and 62 non-impaired groups of respondents aged an average of 55-64 years with a history of working as a pedicab driver for approximately 5 years. In the different test the asymp sig has a result of 0.000 where the conclusions in this study are as follows: there is a significant difference between daily food protein intake in the pedicab rickshaw driver group with impaired pulmonary function and non pedestrian pedicab driver.
A Phytopharmacological Review on a Medicinal Plant: Cordia africana Lam. Nigussie, Gashaw; Ibrahim, Fozia; Neway, Sebsib
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.267

Abstract

The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Cordia africana Lam. (family- Boraginaceae) is a small to medium-sized evergreen tree, 4 to 15 (30) m high, heavily branched with a spreading, umbrella-shaped or rounded crown. Bole typically curved or crooked. Bark grayish-brown to dark brown, smooth in young trees, but soon becoming rough and longitudinally fissured with age; young branch lets with sparse long. Uses of C. africana: firewood, timber (furniture, beehives, boxes, mortars, church, drums), food (fruit), medicine (bark, roots), fodder (leaves), bee forage, mulch, soil conservation, ornamental, shade. Various phytoconstituents like flavonoids, alkaloids, tannins, terpenoids, saponins, steroids, anthraquinones, carbohydrates and protins having different activities were screened and isolated from different parts of Cordia africana. Various important Pharmacological properties including Antioxidant, Cytotoxicity, anti-inflammatory, anthelmintic, antimicrobial, anti-nociceptive, and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of Cordia africana to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of Cordia africana that can be followed for future research on this plant for human health benefits.
Leaf Extract Microencapsulation of Stevia rebaudiana Bert Using Inulin-Chitosan as Anti-Diabetes Diet Mutmainah, Mutmainah; Martono, Yohanes; Puspitaningrum, Ika; Kusmita, Lia
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.270

Abstract

Diabetes mellitus is a collection of symptoms that arise in someone who has increased blood glucose levels. The Stevia plant (Stevia rebaudiana Bert) contains a compound of diterpene glycosides as steviosida and rebaudiosida A. Purified extract of steviosida and rebaudiosida A is widely used as a sweetener for low calorie food and beverage products or as a sugar substitute for diabetics and has the effect of lowering blood sugar levels. This study aims to determine the antidiabetic effect of microencapsulated preparations of Stevia leaf extract (Stevia rebaudiana) with a combination of inulin chitosan encapsulation. Antidiabetic mellitus test was carried out in vivo using test animals of male white rats of Wistar strain. The inducing compound that can cause the condition of diabetes mellitus test animals is Aloxan with a dose of 150 mg / kg Body weight of rats. given intraperitoneally for one day, then the mice were allowed to stand for 3 days to reach a state of diabetes mellitus. Blood glucose levels of test animals were measured on days 1 (initial), 5 (induction) and 12 (treatment) to determine the initial blood glucose levels, after induction of alloxan and after administration of test compounds both CMC Na 0.5% , glibenclamide, and preparations microencapsulation of Stevia leaf extract at a dose of 100; 300; and 700 mg / kg body weight. The results were obtained after 7 days of treatment, it was seen that blood glucose levels in the CMC group remained high, while the Glibenclamid administration group, and the three dosages of microencapsulation preparations of Stevia leaf extract could reduce blood glucose levels. This can be seen from the statistical test that there is a significant difference (p
Overview of Nutritional Status of Pregnant Women with Preeclampsia: Case Study in Aru Islands Regency, Dobo City, Southeast Maluku Tampubolon, Rifatolistia; Probowati , Hapsari; Manutilaa, Judith Devi
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.272

Abstract

Background: Preeclampsia is a syndrome in terms of hypertension after 20-week pregnancy referring to a pregnant woman that previously had normal blood pressure, followed by having hypertension, proteinuria, edema and generally occurs in the third trimester of pregnancy. Preeclampsia is one of five main causes of maternal mortality up to 12% in the world as well. Objective: This study was conducted to describe nutritional status of pregnant women with preeclampsia in Aru Islands Regency, Dobo City, Southeast Maluku. Methodology: This study used mix methods, namely, quantitative and qualitative research with Case Study design. Qualitative research was to determine nutritional status of pregnant women with preeclampsia and quantitative research was to record nutrition intake of pregnant women and measure nutritional status of pregnant women with preeclampsia. Results & Discussion: Characteristics of participants with preeclampsia were more than 27 years old, worked as housewife that could be one of stress triggers and had some risk to increase preeclampsia cases because of stress that caused blood pressure increase. Preeclampsia was detected in pregnancy term of participants about 20-30 weeks according to Maternal and Child Health data. Preeclampsia risk was doubly by every increase in body weight (5-7 kg). Participants had body weight increase ranging from 8-25 kg which caused preeclampsia risk increase. Parameters of recommended dietary allowances of pregnant women including energy excess, protein deficit, fat excess, calcium and zinc deficiency were secondary factor of preeclampsia risk increase in Aru Islands Regency, Dobo City, Southeast Maluku.
Determination of 4,4-(propane-2,2-diyl) diphenol (Bisphenol A) Concentration in Canned Tomatoes Fabusola, G.P; Akpambang, V.O.E
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.273

Abstract

Bisphenol A (BPA) is a chemical used in the production of polycarbonate plastics and for lining metal cans, used in canned foods. BPA is a well-known endocrine disrupting chemical, it therefore, is very hazardous to human health. BPA levels were determined in three brands of canned tomatoes (Gino, Super Mama, Derica) as sold in Nigerian markets. The samples were analyzed using solvent extraction, separation and quantitation by gas chromatography- mass spectrometric method. The recovery value for BPA in the method was 89% with the relative standard deviations of 3%.The BPA concentration in the samples ranged from 0.124 to 0.141 (), which are higher than the European Food Safety Authority Specific Migration Limit (SML) of 0.05 mg/kg in food sample. The samples analyzed in this work may be, therefore, of a potential health concern to the consumers.
Phytochemical, Proximate, and Vitamin C Content in Morinda citrifolia (Noni) Saah, Selina Ama; Adu-Poku, David
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.274

Abstract

Morinda citrifolia, L commonly called noni, has a long history as a medicinal plant and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. Photochemical analyses of ethanol and hexane extracts of noni fruit revealed the presence of flavonoids, terpenoids, alkaloids and steroids. Proximate composition of the noni fruit revealed a moisture content of 54.21, crude protein 2.18, crude fat 3.25, crude fiber 4.49, ash 0.73 and carbohydrate 35.14%. The Vitamin C content was estimated using iodometric titration and found to be 134.10 mg/100g. This suggests that the noni fruit can if consumed can help promote good health.
Metformin Role in Diabetic Patients with Tuberculosis: a Review Wibisono , Esravila Ariya
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.275

Abstract

Tuberculosis (TB) epidemic is a global health challenge, and WHO estimated the incidence of the new cases reaching 11.1 million people in 2017. Indonesia is classified as a high TB burden country, with 8% of its population infected by TB and ranks third in the world. Type-2 diabetes mellitus (T2DM) is known comorbidity for TB patients. TB-T2DM patients have a higher chance of morbidity, mortality, relapse, bacterial resistance, treatment failure, and slower sputum conversion than TB patients without T2DM. Recent studies suggest that metformin may have a potential synergistic role for TB-T2DM patients. Metformin has immunomodulator properties that can improve the body's immune response and inflammatory response against TB in individuals with T2-DM.
Phytochemical Screening, Cytotoxicity and Antioxidant Activities of Leaves Extracts from Eucalyptus citriodora Idris, Musa Maikudi; Yelwa, Adamu Mohammed; Muhammad, Aminu
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.280

Abstract

The genus Eucalyptus has been used in African traditional medicine for the treatment of cardiovascular diseases and diabetes. In this work, chloroform and methanol extracts from the leaves of Eucalyptus citriodora was investigated for their phytochemicals, cytotoxicity and antioxidant potentials. Phytochemical screening of the extracts showed the presence of alkaloid, flavonoid, phenols, reducing sugar and steroids in the methanol extract. IR absorptions of the extract supported the presence of these phytochemicals by revealing the bands 3335 cm-1 (O-H), 1613, 1480 cm-1 (C=C) and 1721 cm-1 (C=O). Evaluation of the cytotoxicity of the methanol extract using brine shrimp assay, suggested that, the extract was not toxic with LC50 value of 1.64 mg/mL. Antioxidant potentials of both chloroform and methanol extracts were determined using phenolic content quantification and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Methanol extract (37.32 ?g TAE/mg) had higher phenolic content than the chloroform extract (12.09 ?g TAE/mg). The radical scavenging potentials of the extracts recorded inhibitory activities of IC50 values of 892.7 ?g/mL (chloroform extract) and 8.3 ?g/mL (methanol extracts) relative to the positive control values of 31.1 ?g/mL (butylated hydroxytoluene) and 3.5 ?g/mL (ascorbic acid). These results showed that E. citriodora might contain promising antioxidant agents.
The Effectiveness of Sea Urchin Extract (Echinometra matthaei) for Wound Healing on Deep Second-Degree in White Rats (Rattus norvegicus) Wistar Kresnamurti, Angelica; Nurlita R, Dita; Budiarti, Fitri
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.281

Abstract

Background: Burns is a form of tissue damage caused by high temperatures. Echinometra matthaei sea urchins have several secondary metabolites that can potentially help in the healing process of burns. In this study, 70% E. matthaei ethanol extract was formulated in the form of O / W (oil in water) type cream preparations which were applied topically. Objective: This study aims to determine the effectiveness of E. matthaei ethanol extract cream preparations on the healing of second-degree burns in Wistar strain rats. In this study preparations were made in 3 formulations, namely Formulation 1 (extract concentration of 1%), Formulation 2 (extract concentration of 3%), and Formulation 3 (extract concentration of 5%). This research was conducted for 7 days with the method used is the post-test only control group design. Experiments were given induction of burns using a hot plate with a diameter of 20 mm at a temperature of ± 200ºC for 15 seconds. Wound healing is observed periodically by observing macroscopically healing inflammation of the inflammatory phase and observing tissue growth in the proliferation phase. Results: The average percentage of inflammation healing showed improvement in the F2: 100%, F1: 80%, F3: 71% results were better than the wound group: 50% as evidenced by the value ? = 0.012 (

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