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Faisal Abdurahman
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JIMR - Journal of Islamic Medicine Research
Published by Universitas Islam Malang
ISSN : 25982974     EISSN : 2580927X     DOI : -
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology
Journal of Islamic Medicine Research contains information on the results of research activities, conceptual thinking and review of the field of medical science and medicine. This scientific journal is published by the Faculty of Medicine, Islamic University of Malang. This journal is published with the frequency of 2 times a year, ie in June and December. The editorial receives the writings of scientific research, both in the form of research and empirical research in fields related to health sciences and or medicine.
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Articles 21 Documents
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In Silico Studies on Bidara (Ziziphus mauritiana) Leaves Ethanol Extract Bioactive Ligands compared to Acarbose toward ?-glucosidase Enzyme Merlita Herbani; yoni Rina Bintari
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

ABSTRACTIntroduction : Diabetes mellitus has been widely concerned in human health. Diabetes mellitus has a huge amount of sufferers. Carbohydrate diet, which is needed for energy supply, contributes to uncontrolled postprandial blood glucose which worsens diabetes mellitus. ?-glucosidase is an enzyme that had been targeted to modify oligosaccharides, to decrease postprandial blood glucose. This study aims to predict the ability of the active compound contained in Z. mauritiana leaves to inhibit ?-glucosidase protein through an in silico study.Methods : Identified local Z. mauritiana leaves simplicial were extracted with 96% p.a ethanol solvent. The extract then analyzed with LCMS to confirm 6 active compound in the extract. Confirmed active compounds then undergo docking procedure, by downloading active compounds and acarbose molecular structure via PubChem, then converted to be 3D structure in pdb format by Pymol. Protein target ?-glucosidase molecular structure were obtained from Uniprot, and 3D structure built by Swissmodel. Docking process held by Pyrex by AutoDock Vina. Protein interaction ligands were visualized by Biovia Discovery Studio.Results : LCMS analysis revealed that there are apigenin, quercetin, routine, kaempferol, isovitexin and quercetin-3-rhamnoside in the extract. Molecular docking analysis explained that rutin has higher binding affinity than acarbose as the control. Rutin shared the same hydrogen bonding with acarbose in Arg 275 and Val 544.Conclusion : In conclusion, Z. mauritiana have potential as ?-glucosidase inhibitor.KEYWORDS : Ziziphus mauritiana ethanol extract Active Compound, Acarbose, in silico, ?-glucosidase

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