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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 260 Documents
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Pengaruh Wet Cupping terhadap Kadar Hemoglobin Darah Vena Orang Sehat Pranata, Lilik
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Wet cupping known as blood letting in western countries has long been done since the Hippocrates. Hijamah or cupping (other languages, coke, cupping, cupping) is a therapy that aims to cleanse the body of blood which contains toxic with thin slices or small punctures on the surface of the skin, Wet Cupping is developed as an alternative and complementary treatment, the purpose of the study is to determine the effect of wet cupping against healthy blood vein hemoglobin levels. This research method with experimental clinical test with pre and post intervention design without control group. The implementation of wet cupping is carried out at Puskesmas Palembang Campus and blood collection and blood tests at the Health Laboratory Center (BBLK) of South Sumatra Province. The sample of this study was 30 respondents with an age range of 18-22 years, the parameters seen were the value of hemoglobin levels, the treatment was carried out after 8 hours of intervention. To control confounding factors in this study, respondents before getting treatment were not allowed to exercise and heavy activities and still consume daily food without additional food. The results of the study showed a significant increase in hemoglobin levels, 8 hours after wet cupping was performed on healthy venous blood, the mean hemoglobin level was 15.08 ± 0.63, increasing to 15.45 ± 0.76. The conclusion that wet cupping affects healthy people's venous blood hemoglobin levels, it is hoped that wet cupping can be used in alternative and complementary therapies.
Hubungan Kadar Vitamin D Plasma dengan Indeks Mitosis pada Pasien Kanker Payudara Pratiwi, Astrid Siska; Siregar, Yahwardiah
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Breast cancer is the most common cancer suffered by women and one of the biggest causes of death for women worldwide. Later, nutrition became one of the risk factors in breast cancer outcome, one of them is vitamin D. Calcitriol is the active form of vitamin D as an anti-proliferation, and inhibits tumor growth. Uncontrolled proliferation is one of the characteristics of cancer cells. Tumor growth rates become prognostic markers that can be evaluated by correlating at cellular levels such as mitosis. The aimed of this study was to analyze the relationship between vitamin D levels and mitosis index in breast cancer patients. Research with cross sectional design gathered 50 breast cancer patients who were newly diagnosed and had never received chemotherapy. The study was conducted from January 2017 - August 2018 at the Department of Surgical Oncology, RSUPH. Adam Malik Medan. Examination of plasma vitamin D levels is done by ELISA technique at the Lab. Faculty of Medicine Universitas Sumatera Utara. The mitosis index data was obtained from the medical record of the research subjects reviewed by anatomical pathology specialists at the Lab. Anatomical Pathology of Faculty of Medicine Universitas Sumatera Utara. Statistical test uses Fisher Exact. The results of the study 48% of subjects had vitamin D sufficiency, 38% insufficiency and 14% had deficiency. The mean vitamin D levels in all of the study subjects were insufficiency (27.93ng / ml). In this study there was no significant relationship between plasma vitamin D levels and mitosis index in breast cancer patients p = 0.062. The insignificant relationship between vitamin D levels and mitotic index in this study shows that vitamin D not a single factors to influence the mitosis index in breast cancer patients.
Placental Factors Affecting Birth Weight of Late Onset Severe Preeclampsia Martadiansyah, A; Pangemanan, W T; Bernolian, N; Maulani, H; Theodorus, Theodorus
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Objective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisher’s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one.
Hubungan Lama Penyimpanan Sampel Arsip Jaringan Dalam Blok Parafin Terfiksasi Formalindengan Kualitas Hasil Ekstraksidna Mitokondria Jaringan Hafy, Zen; Larasati, Veny; Puspita, Riana Sari; S, Novizar; M, Haekal; A, Rafdi; R, Sentani
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Formalin-fixed paraffin-embedded (FFPE) archival tissue presents a readily available resource in molecular study nowadays. The quality of nucleid acid, especially mitoconhdrial DNA (mtDNA) extracted from FFPE tissue could be affected by the storage time. Thus, this study investigated if the FFPE tissue’s storage time had an effect on the quality of the extracted mtDNA at Department of Pathology RSUP Dr. Mohammad Hoesin Palembang. DNA was extracted from 16 randomly selected archival FFPE tissues in Laboratory of Pathology Anatomy, RSUP dr. Mohammad Hoesin Palembang. The samples were grouped based on their storage time (less than 1 year and 1 to 5 yrs.’ old). The isolated DNA from each group was amplified using PCR with two primer pairs specifically designto amplify mtDNA of 320 bp and 142bp length, respectively. The PCR products were visualized by electrophoresismethod. None of the samples from both groups could be amplified witht the 320bp primers. However, the PCR result of the 149 bp primers showed positive for all of the samples from each study group. The study indicated that the storage time does not affect the quality of mtDNA isolated from the FFPE samples archived in Department of Pathology RSUP Dr. Mohammad Hoesin Palembang. Furthermore, the study showed that the mtDNA extracted from FFPE tissue has been degraded, therefore, the samples are not suitable for genetic studies require a long mtDNA amplicon.
Perbedaan Skor Functional Independence Measure (FIM) pada Pasien Rawat Inap dengan Stroke Iskemik dan Stroke Hemoragik di Rumah Sakit di Kota Bengkulu Tahun 2018 Nugraha, Panji Harry Priya; Bantolo, Suryo; Kurniati, Annelin; Erlinawati, Noor Diah; Nasution, Ahmad Azmi
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Stroke is one of the most common causes of disability in the world. Patients with ischemic stroke have different functional improvements from patients with hemorrhagic stroke. The tool is the Functional Independence Measure (FIM) questionnaire. This study aims to determine the difference in FIM scores in hospitalized patients with ischemic stroke and hemorrhagic stroke at hospitals in Bengkulu City. This research is an observational analytic research with cross-sectional design. The study involved stroke patients who hospitalized at RS Bhayangkara Bengkulu City, RSUD Bengkulu City, and RSUD dr. M. Yunus Bengkulu City from January-April 2018 with total sample 22 ischemic stroke patients and 22 hemorrhagic stroke patients who met the inclusion criteria. FIM scores as independent variables, while the type of stroke as dependent variables. The difference between the two variables was analyzed by unpaired t test and Mann-Whitney test. Patients with ischemic stroke had admission FIM score higher than patients with hemorrhagic stroke (26 vs 13,5; p=0.006). There were no differences in discharge FIM score in patients in both types of stroke (1,67 vs 1,58; p=0,081). There was no difference in FIM score gain between patients with ischemic stroke and patients with hemorrhagic stroke (4,12 vs 4,36; p=0,444). Patients with ischemic stroke had higher admission FIM score compared to patients with hemorrhagic stroke, but there was no significant difference in FIM score gain during hospitalization between ischemic stroke and hemorrhagic stroke patients at hospitals in Bengkulu City.
Hubungan Pengetahuan Akseptor Kb terhadap Pemakaian Kontrasepsi Implan di Kota Palembang Tahun 2017 Yusnilasari, Yusnilasari; Ariani, Debby Utami Siska
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Data of Health Office of Palembang City Year 2014, from 16 sub districts in Palembang city, there are 4 districts which proportion of new KB 0% implant participants, ie District Ilir Barat II, Plaju, Kalidoni and Sematang Borang where from 4 Subdistricts have 6 Puskesmas with each of the proportion of participants of new KB Implants also 0% Sie Makrayu Health Center, Plaju, Bukit Sangkal, Kalidoni, Sei Selincah and Sematang Borang. This study aims to know the relation of knowledge of acceptor of KB to implant contraception usage in Palembang city year 2017. This research design is analytic survey with Cross sectional approach. The population used by the researcher is the family planning acceptors who are in the working area of ​​Makrayu Health Center, Plaju, Sarang Hill, Kalidoni, Sei Selincah and Sematang Borang City of Palembang in 2017 and the sample number is 30 respondents. Sampling technique using Simple Random Sampling approach. Bivariate analysis using chi square statistical test (α = 0,05). The instrument used for data collection is a questionnaire conducted at 6 health centers in Palembang city. The results obtained p value 0.002 <α (0.05), it shows that there is a relationship between the knowledge of respondents with the use of contraceptive implants in Palembang City Year 2017. Test results also obtained OR = 3,143. The conclusion of this research is that there is a correlation between the knowledge of respondents with the use of contraceptive implants in Palembang City in 2017. It is expected to build positive information about KB Implant by involving the role of health cadres through extension activities and dissemination of information about the success of Implant use.
Hubungan Profil Lipid dengan Kejadian Ulkus Kaki Diabetik pada Pasien Diabetes Melitus Tipe 2 RSUP dr. Mohammad Hoesin Palembang Sinulingga, Sadakata; Kohar, Evlin; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Diabetic foot ulcersare long-term complications of diabetes mellitus that may increase morbidity and mortality, also reduce the quality of life of the patients. One of the causes of diabetic foot ulcers is peripheral arterial disease due to dyslipidemia. This study was conducted to determine the relationships of lipid profile with diabetic foot ulcers in patients with type 2 diabetes mellitus. Analytical observational study with cross-sectional design was conducted in 69 diabetic patients. Data was retrieved secondarily by observing the medical records. Total cholesterol, triglycerides, LDL, HDL, and consumption of lipid-lowering drugs of the patients were all recorded. Documented variables were analyzed using Fisher Exact test if Chi-square test criterias were not fulfilled. There was a significant association between diabetic foot ulcers with total cholesterol (p=0,001) and HDL (p=0,015), while triglycerides (p=0,393) and LDL (p=0,176) did not have a significant association with diabetic foot ulcers.Multivariable logistic regression identified HDL (B=2,221, S.E.=1,131, Wald=3,855, p=0,050, exp(B)=9,220 IK95% 1,004–84,691)as the most influential lipid profile fraction to the incident diabetic foot ulcers. Total cholesterol and HDL had a significant association with diabetic foot ulcers. The most influential lipid profile fraction to the incident diabetic foot ulcers is HDL.
Hubungan Obesitas dengan Kadar Asam Urat Darah pada Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sriwijaya Soputra, Ezra Hans; Sinulingga, Sadakata; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Uric acid is the end product of purine catabolism which is sinthesized especially by the liver and excreted through urinary tract. Increased blood uric acid levels can cause many disease such as gout arthritis, hipertension, and renal disease. Individual with obesity often have lower renal excretion rate and may have increased production of uric acid. This study is conducted to determine the relationship of obesity and blood uric acid levels.This Study with cross-sectional design took a sample of 119 students of Medical Education Program Study at Medical Faculty of the Sriwijaya University by consecutive sampling. Body weight, body height, and uric acid levels then are taken using measurement tools appropriate, categorized, and processed according to research objectivesThe study found that 27,5% female and 10,3% male have hyperuricemia. A total of 39,3% obese students and 16,5% non-obese students have high level of uric acid. The result of bivariate analysis showed that there is a significant relationship between obesity and gender with blood uric acid levels (p=0,022 and 0,035 respectively). After multivariate analysis, factor that has relationship with uric acid level is obesity.Obesity have a significant relationship with uric acid levels.
Stabilisasi dan Transportasi Neonatus Kadir, Minerva Riani
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Approximately 10 percent of newborns will require some level assistance with breathing, and a few (<1 percent) will require resuscitation in the birthing room. After resuscitation, many of these newborns require acute transport to a different facility. Stabilisation prior to transport is essential and the principles of neonatal transportation are independent of distance. Hypothermia and hypoglycaemia should be prevented in neonates during transport as they adversely affect the outcome. This article provides an overview of principles from the STABLE Program, which guides clinicians in providing postresuscitation care and pretransport and during transport stabilization for compromised newborns.
Hubungan Polimorfisme Gen p53 Codon 72 dengan Kejadian Kanker Serviks di Rumah Sakit Dr. Mohammad Hoesin Palembang Hayati, Lusia; Delvia, Siska
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Di Indonesia angka kejadian kanker serviks diperkirakan sekitar 50 per 100.000 penduduk. Diperkirakan ada lebih dari 1 juta perempuan di seluruh dunia dengan kanker serviks dan sebagian besar dari mereka belum didiagnosis atau tidak memiliki akses untuk skrining dan perawatan. Polimorfisme pada gen p53 codon 72 dapat mempengaruhi risiko kanker serviks melalui regulasi proliferasi dan apoptosis sel. Tujuan untuk mengetahui hubungan polimorfisme gen p53 codon 72 dengan kejadian kanker serviks. Penelitian ini merupakan penelitian observasional analitik. Pelaksanaan penelitian dengan pemeriksaan di laboratorium Biologi Molekuler Fakultas Kedokteran Universitas Sriwijaya dengan pendekatan studi Kasus Kontrol (Case-Control). Terdapat 70 sampel yang dibagi 2 kelompok, yaitu 35 Kasus dan 35 Kontrol. Penentuan Genotip dan Alotip menggunakan teknik PCR-RFLP. Hasil penelitian menunjukkan ada perbedaan signifikan pada karakteristik responden yang diamati antar kelompok kasus dan kontrol. Hasil genotip gen p53 codon 72 pada kelompok kasus terdapat 7 subjek (20,0%) yang memiliki genotip Pro/Pro dan Arg/Arg 5 subjek (14,3%) dan ada 23 subjek (65,7%) yang memiliki memiliki genotip Pro/Arg. Pada kelompok kontrol terdapat 28 subjek (80,0%) yang memiliki genotip Pro/Pro dan Arg/Arg 0 subjek (0,0%) dan ada 7 subjek (20,0%) yang memiliki memiliki genotip Pro/Arg. Frekuensi alel Prolin pada kelompok kasus 37 alel (52,9%) dan alel Arginin 33 alel (47,1%) sedangkan pada kelompok kontrol alel Prolin 63 (90%) dan alel Arginin 7 alel (10%). Hasil uji chi square genotip didapatkan p value 0.000, OR 1,304 and CI 95% 1,071-5,891, sedangkan pada alel didapatkan ρ value 0,000; OR 8,027 ; CI 95% 3,228 - 19,962.Disimpulkan ada hubungan antara genotip dan alel polimorfisme gen p53 codon 72 dengan kejadian kanker serviks.

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