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Jurnal Respirologi Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
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Articles 8 Documents
Search results for , issue "Vol 38, No 1 (2018)" : 8 Documents clear
Effect of Low Dose Azithromycin Towards The Long Period of Clinical Improvement, Level of IL-8 And Sputum Neutrophil of Pneumonia Patients Leonardo H. Simandjuntak; Reviono Reviono; Harsini Harsini
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.138

Abstract

Backgrounds: Pneumonia is an acute inflammation of the lung parenchyma caused by microorganisms. Inflammation is an immune response that occurs when bacterial infection. The immune response that occurs will induce alveolar macrophages secrete IL-8 which mediates the movement of neutrophils into the alveolar to release reactive oxygen species (ROS) and protease. Low-dose azithromycin has anti-inflammatory effects that are used on a chronic inflammatory disease of the lung, so its use in pneumonia interesting to do. This study aimed to determine the effect of low-dose azithromycin towards the long period of clinical improvement, level of IL-8 and sputum neutrophil of pneumonia patients. Methode: This research is an experimental study with pretest and post-test design. Subjects were patients with pneumonia who were treated at the Hospital Dr. Moewardi Surakarta in July - August 2016. Samples were taken by consecutive sampling as many as 30 patients. treatment group (n = 15) received additional therapy of azithromycin 250 mg / day and the control group (n = 15) received additional placebo. Result: Supplementation of low-dose azithromycin was significantly reduced levels of IL-8 (reduction = -90.31 ± 89.30; P=0.002) and sputum neutrophil (reduction = -35.73 ± 25.25; P=0.0001) in pneumonia patients. There is a statistically significant difference (P=0.0001) of the long period of clinical improvement between treatment groups (3.87 + 0.64 days) and control (5,60+ 0.91 days). Conclusion: Supplementation 250 mg/day of azithromycin during hospitalization led to decreased levels of IL-8 serum, sputum neutrophil, and affect the long period of clinical improvement in pneumonia patients. (J Respir Indo 2018; 38(1): 39-47)
Respiratory Failure in Pneumonia with Diabetic Ketoacidosis (DKA) Novita Maulidiyah; Sri Indah Indriani; Prasenohadi Prasenohadi; Menaldi Rasmin
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.140

Abstract

The annual incidence rate of KAD is estimated to be between 4.6 and 8 per 1000 patients with diabetes. Based on the results of the physical examination, the patient was diagnosed as pneumonia with KAD. The mortality rate for community pneumonia on outpatients was 2%, inpatients was 5-20%, more so in patients in intensive care that was more than 50%. The problem in the patient is pneumonia. Resulting in pulmonary dysfunction which causes overload. Infections that can increase morbidity and mortality may be associated with Streptococcus infection (group B, S, pneumonia), Legionella and viral infections (influenza). The most common infections are pneumonia and urinary tract infections which account for between 30% and 50% of cases. Therefore, the choice of empiric antimicrobial therapy in diabetic patients with evidence of staphylococcal pneumonia (consistent with sputum smear results or associated soft tissue infection) should be guided by the prevalence of MRSA in the associated institutions. Respiratory failure is a complication of KAD and increases the mortality rate. and morbidity. Based on the high nasal carriage rate, there is an increased risk of staphylococcal pneumonia infection in diabetic patients. Community pneumonia is acute inflammation due to infection of the lung parenchyma acquired in the community. (J Respir Indo 2018; 38(1): 57-63)
Correlation of Hemostatic Parameter with Lung Tumor Marker in Non-Small Cell Lung Cancer Patient with Chemotherapy Ganda M. Leonard Samosir; Parluhutan Siagian; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.137

Abstract

Backgrounds: There is a subclinical activation of coagulation and fibrinolysis system in patient with lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In oncology practice, the use of tumor markers may be helpful in the diagnosis and pathologic classification of tumors. Tumor marker may reflect both, stage of the disease and prognosis. Aim of this research is to asses the correlation of this parameters in patient non-small cell lung cancer with chemotherapy. Methods: This research is an analytic observational with a cross sectional design. The research was conducted at RSUP Haji Adam Malik, Medan from January 1, 2015 to May 31, 2016. Blood test examination was performed to measure the hemostatic parameter (PT, INR, APTT, TT, D-dimer) and serum tumor marker (CEA, Cifra21-1, NSE) of 41 non-small cell lung cancer patients before first cycle of chemotherapy and after fourth or sixth cycles of chemotherapy. Results: The study comprised 41 patients of non-small cell lung cancer (31 adenocarcinoma, 10 squamous cell carcinoma), There were 35 men (85,4%) and 3 women (14,6%) with mean age of 56,7 years. For all patients, we give a platinum based therapy as first line chemotherapy (gemsitabine and carboplatin regimen in 27 patients, paclitaxel and carboplatin in 10 patients, vinorelbine and carboplatin in 4 patients). There is no significant difference of hemostatic parameter and serum tumors marker values before chemotherapy againts after chemotherapy values. And there is a weak negative correlation of hemostatic parameter againts serum tumor marker on non-small cell lung cancer patients with chemotherapy. Conclusion: There is a weak negative correlation of hemostatic parameter againts serum tumor marker in non-small cell lung cancer patients with chemotherapy. (J Respir Indo 2018; 38(1): 33-38)
Correlation Between Pleural Fluid GenXpert® and Histopathology Finding of Pleural Biopsy in Tuberculous Pleural Effusion Sheilla Matheos; Isnin Anang Marhana; Anny Setijo Rahaju
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.133

Abstract

Backgrounds: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB, but a definite diagnosis is still a challenge. Pleural biopsy has historically been the gold standard procedure for the diagnosis of pleural tuberculosis. GenXpert® is a computerize test based in nucleic acid amplification tahat automatically detect MTB and rifampicin resistance. This study aimed to prove the correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. Methods: This study used an observational analytic design with a cross-sectional design conducted in Dr. Soetomo Hospital, Surabaya in March-June 2017. Statistic analysis was using chi square test and contingensi coofisient. The pleural GenXpert® was tested in 23 patients with pleural effusion and their biopsy speciments underwent histopathological analysis. Results: Histopathological findings of pleural biopsy was positive in 4 subjects and pleural fluid GenXpert® resulted positive in 6 subjects. There was significant correlation between pleural fluid GenXpert® and histopathological findings of specimen pleural biopsy in patients with pleural tuberculosis (P=0.040) with moderate strenght (P=0.014). Sensitivity and specificity of pleural fluid GenXpert® were 75.0% dan 84.2% respectively. Conclusions: There was significant correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. (J Respir Indo 2018; 38(1): 1-6)
Effects of Green Tea to Absolute Neutrophil Count, MMP-9, %VEP1, and COPD Assessment Test Scores Stable COPD Patients Hendrastutik Apriningsih; Suradi Suradi; Yusup Subagio Sutanto
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.134

Abstract

Backgrounds: Chronic obstructive pulmonary disease is the leading cause morbidity and mortality worldwide. Cigarette smoke and noxious agent causing oxidative stress activated nuclear factor-κB then increase inflammatory genes releases. Epigallocatechin-3-gallate green tea have antiiinflammatory effect which can be use as addition therapy for stable COPD. Methods: This study aimed to analyze the effect of EGCG to absolute neutrophil count (ANC), serum MMP-9, %FEV1, and CAT score stable COPD patients. Clinical trials of experimental with pre-test and post-test design was conducted on 30 patients in Dr. Moewardi Hospital Surakarta from February-April 2017. Samples were taken by consecutive sampling divided into treatment group (n=15) received standard therapy and green tea capsule 2x500mg/day during 28 days and control group received only standard therapy (n=15). Decreased inflammation measured by ANC and serum MMP-9, improvement of obstruction measured by %FEV1, and clinic improvement measured by CAT score. Results: There were no significant differences (P=0.135) decrease ANC treatment group (-662.45±1446.80 µL) compared control (413.79±2292.90 µL), decrease serum MMP-9 (P=0.413) treatment group (-324.34±333.56 ng/ml) compared control (-181.21±577.52 ng/ml), %FEV1 (P=0.236) treatment group (2.56±10.77), compared control (-4.30±19.12), and significant difference (P=0.034) CAT score treatment group (-1.07±1.16) compared control (-0.20±1.08). Conclusions: The addition of green tea capsule 2x500 mg/day during 28 days was significantly lowered CAT score, decreasing ANC, serum MMP-9 and increasing %FEV1 but not significant. (J Respir Indo 2018; 38(1): 7-15)
Preliminary Study: Increased Profile of PAI-1 in Lung Cancer Patients Receiving Chemotherapy Ria Siska Myrnasari; Triwahju Astuti; Suryanti Dwi Pratiwi
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.139

Abstract

Background: Lung cancer has the highest mortality rate in the world. Lung cancer management requires biomarkers to evaluate the chemotherapy response. Levels of Plasminogen Activator Inhibitor-1 (PAI-1) in malignancy >14 ng/ml shows poor prognosis. Increased levels of PAI-1 are associated with stage, metastasis, and prognosis of lung cancer. The chemotherapy is thought to decrease PAI-1 levels. The aim this study is analyze the profile of PAI-1 levels before and after 3rd and 6th chemotherapy cycle and their changes by type of lung cancer and Response Evaluation Criteria in Solid Tumors (RECIST). Methods: This research was conducted from December 2016 to December 2017 at RSSA Malang. The study design was a cohort of 18 lung cancer patients. PAI-1 levels were measured by ELISA in 18 lung cancer stage III or IV patients before (PAI-1(1)) and after 3rd chemotherapy cycle (PAI-1(2)), and 9 patients after 6th chemotherapy cycle (PAI-1(3)). Average PAI-1 levels are presented in tables and graphs. Result: PAI-1(1) 2,151±0,564 ng/ml, PAI-1(2) 1,951±0,534 ng/ml, and PAI-1(3) 1,647±0,495 ng/ml. PAI-1 levels in non-small cell lung carcinoma (NSCLC) were 1.658±0.562 ng/ml and small cell lung carcinoma (SCLC) were 1.609±0.244 ng/ml. Levels of PAI-1(2) in partial response 1.784 ± 0.363 ng/ml, stable disease 1.980 ± 0.304 ng/ml, and progressive disease 2.020±0.635 ng/ml. Levels of PAI-1(3) in the partial response 1.427 ± 0.324 ng/ml and in progressive disease 2.085±0.532 ng/ml. Conclusions: PAI-1 levels in patients with stage III and IV lung cancer after chemotherapy were lower than before chemotherapy, and showed changes corresponding to the response according to RECIST. PAI-1 levels in NSCLC are higher than SCLC. (J Respir Indo 2018; 38(1): 48-56)
Effect of Inhaled Magnesium Sulphate on Bronchodilating Response, Levels of Substance P and Clinical Improvement of Acute Exacerbations COPD Patients Prima Karita Sari; Suradi Suradi; Jatu Aphridasari
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.135

Abstract

Background: Inhaled magnesium sulphate has a bronchodilator and antiinflammatory effect by block the calcium channels and inhibiting substance P. This study aimed to analyze the effect of magnesium sulfate inhalation on bronchodilator response, substance P levels, and clinical improvement on AECOPD patients. Methods: A quasi-experimental clinical trial, pre-test and post-test design with 34 acute exacerbation of COPD patients who are hospitalized in emergency room on Dr. Moewardi Hospital, Surakarta and Ario Wirawan Hospital, Salatiga on March-April 2017 used consecutive sampling. The independent variable is inhaled magnesium sulphate dose of 150 mg 3 times every 20 minutes when the patients was admitted in emergency room, while the dependent variables are peak expiratory flow rate, the plasma levels of substance P and CAT score acute exacerbation of COPD patients. Results: There was a significant difference (P=0.009) decrease of PEFR value of treatment group (111.76±12.37) compared to control group (141.18±24.21). There was a significant difference (P=0.0001) decrease in CAT score of treatment group (-14.88±1.75) compared to control group (-9.00±1.17). There was a significant difference (P=0.0001) treatment group (-1305.92±417.91) than control group (-355.95±206.25). Conclucions: The addition of MgSO4 inhalation of 150 mg during exacerbation increased PEFR, decreased the level of P substance, and decreased the CAT score with statistically significant results. (J Respir Indo 2018; 38(1): 16-23)
Effect of Vitamin C to The Plasma Level of Interleukin-6, Plasma MDA and Length of Hospitalization of COPD Exacerbation Patient Fadlia Yulistiana; Suradi Suradi; Reviono Reviono
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.136

Abstract

Background: Exacerbation is an acute condition characterized by worsening of symptoms that require a change in therapy. Increased inflammation of the airways and lungs during exacerbations causes an increase in plasma IL-6 and MDA levels and causes most patients needed treatment at the hospital. Vitamin C is an antioxidant vitamin that has anti-inflammatory and antioxidant effects so that it can be added to COPD exacerbations therapy. This study aims to determine the effect of vitamin C on plasma IL-6, plasma MDA levels and length of hospitalization of acute exacerbation of COPD patients. Methods: This research is an experimental study with pre-test and post-test design. Subjects consisted of 33 patients with exacerbation of COPD were treated at the Soehadi Pridjonegoro Hospital Sragen in October-November 2015 which were selected by purposive sampling. Subjects were divided into two groups, the treatment group (n=16) received vitamin C therapy 1x1000 mg/day and the control group (n=17) received 5 mL of NaCl 0.9%. Levels of IL-6 plasma and plasma MDA was measured on admission and at discharge criteria are met. Length of hospitalization is calculated based on the number of days’ patients in hospital. Results: There was no statistically significant difference to decreased of IL-6 plasma level (P=0.379), MDA plasma level (P=0.27) and length of hospitalization (P=0.24) between treatment and control group. Conclucions: The addition of vitamin C 1x1000 mg/day during hospitalization is not helpful to decreased in levels of plasma IL-6, plasma MDA and length of hospitalization in this study. (J Respir Indo 2018; 38(1): 24-32)

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