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Jurnal Respirologi Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
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Articles 10 Documents
Search results for , issue "Vol 41, No 1 (2021)" : 10 Documents clear
Differences of Interleukin-6 Serum Levels in Lung Cancer Patients and Healthy Individuals in Medan Dumasari Siagian; Noni Novisari Soeroso; Bintang Yinke Magdalena Sinaga; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.155

Abstract

Background: Interleukin-6 (IL-6) is a pro-inflammatory cytokines involved in the development of lung cancer. However, the association of IL-6 in lung cancer patients remains uncertain. The aim of this study was to analyze the difference of IL-6 serum levels in lung cancer patients and healthy individuals in Medan. Methods: This was a case-control study that included 42 lung cancer patients (case) and 42 healthy individuals (control) which was held in Haji Adam Malik General Hospital Medan. The examinations of IL-6 serum levels were conducted for all subjects using ELISA method. Differences of IL-6 serum levels in lung cancer patients and healthy individuals were analyzed using Spearman Correlation test. Results: The mean serum IL-6 levels in lung cancer patients was 45.99 pg/ml while in healthy individuals was 6.24 pg/ml. There was a significant difference of serum IL-6 levels in the lung cancer group compared to healthy individuals (P=0.0005;r=0.854). Conclusion: There was a statistically significant difference of IL-6 serum levels between lung cancer patients and healthy individuals.
The Depiction of Lung Function and Fractional-Exhaled Nitric Oxide (FeNO) among Asthmatic Outpatients: A Preliminary Study Mulkan Azhary; Ratnawati Ratnawati; Budhi Antariksa
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.152

Abstract

Background: Asthma is a heterogeneous disease manifested by airway inflammation and wheezing, dyspnea, breathlessness and cough which are varied in intensity and time accompanied with variably restricted expiratory airflow. Asthma patients experienced decreased lung function that occured during asthma attack accompanied by increased levels of fractional-exhaled nitric oxide (FeNO) caused by the pathophysiological process of asthma and the resulting ventilation problems. The study aimed to reveal the depiction of lung function using spirometry dan FeNO level among asthmatic outpatients. Methods: This was a cross sectional study involving 13 uncontrolled-moderate persistent asthmatic outpatients at Asthma Clinic of Persahabatan General Hospital during October 2019 – March2020. The involved respondents had to undergo the spirometry test and the measurement of FeNO level. Results: The uncontrolled-moderate persistent asthmatic patients were dominated by female with mean age of 48.38+12.494 years old. The mean predicted FEV1 was 70.38+20.230% of whom 61.54% patients showed moderate obstruction. The mean FEV1/FVC ratio was 72.85+12.681% of whom 53.85% patients showed obstruction inFEV1/FVC ratio. The mean FeNO level was 29.62+9.152 ppb of whom 76.92% patients had FeNO level ranging 25-50 ppb. Conclusion: The moderate persistent asthmatic patients showed a decreased lung function with reduction of FEV1, obstructive FEV1/FVC ratio as well as increasing FeNO level.
Clinical Characteristics of COVID-19 Patients in Dr. Saiful Anwar Hospital, Malang Magdalena Magdalena; Yani Jane Sugiri; Rezki Tantular; Aditya Listyoko
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.150

Abstract

Background: Coronavirus Disease (COVID-19) emerge as a new global health crisis. COVID-19 has a wide range of clinical feature, from mild cough to severe respiratory failure. This study aims to learn more about clinical feature of COVID-19. Methods: This cross sectional analytic descriptive study includes all COVID-19 patients that yield positive result through GeneXpert-SARS-CoV-2 or Polymerase Chain Reaction (PCR). All data was taken from inpatient form March 12th –June 30th 2020. Results: There were 103 patients with 58 men and 45 women. Patients with male sex tend to experience severe pneumonia than women. It was also found that patients exposed to cigarette smoke tended to experience severe pneumonia symptoms. Patients with more than 1 comorbid tend to develop severe pneumonia symptoms. The dominant clinical symptoms in the patient were cough (84.5%), fever / history of fever (70.9%), and shortness of breath (67.9%). Hematological parameters that correlate with the degree of severity are leucocytes, thrombocyts, lymphocytes, neutrophils, CRP, LDH, creatinine, procalcitonin, SGOT, and SOFA Score. The most common radiological picture obtained was bilateral infiltrate (78.2%). The most common complication was sepsis (38.9%). The mortality rate for COVID-19 patients treated at RSSA tends to be high (26.2%). Discussion: clinical characteristics such as gender, smoking history, comorbides, clinical symptoms (fever, shortness of breath and cough), laboratory (leukocytes, % lymphocytes, % neutrophils and neutrophil counts, CRP, LDH, procalcitonin, creatinine, SGOT, and SOFA scores) has a significant effect on the severity of Covid infection 19 Conclusion: The clinical characteristics of COVID-19 patients affects the severity of the disease.
The Association of Working Duration with Lung Function and Chest X-Ray Results in Ceramic Industry Workers of Company X, Mabar Medan Marini Puspita Sari; Amira P Tarigan; Nuryunita Nainggolan; Putri C Eyanoer; Agus Dwi Susanto; Erlangga Samoedro; Caecilia Marliana
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.158

Abstract

Background: Ceramics industry workers are often exposed to silica materials from ceramics. The aim of this study was to determine the association between silica exposure withlung function test and chest x-ray (CXR) results of the workers. Methods: This was an analytical study with cross-sectional design conducted in the Ceramic Industry X in Mabar, Medan City. The dust level in the work station was measured using Personal Dust Sampler. Lung function was measured by spirometry and CXR was evaluated using the ILO interpretations. Results: About 35 male workers were included as subjects, divided into 3 working stations namely precompression section of 11 subjects (31.4%), compression section of 13 subjects (37.1%) and 11 subjects (31.4%) in the sintering section. Dust levels in each work location are 24.8, 29.2, and 6.11 respectively. Of all subjects, 9 (25.7%) had respiratory symptoms, 21 (60%) had restriction in lung function and 8 (22.8%) had abnormal CXR (6 pneumoconiosis and 2 tuberculosis). There were no association between dust levels with lung function and CXR (P>0.05), but there was a significant correlation between duration of work with lung function. The FEV1 and FVC values of subjects working
The Role of Bronchoscopic Cryoablation in Management of Central Airway Obstruction Dicky Soehardiman; Rahma Ayu Indahati; Mia Elhidsi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.154

Abstract

Central airway obstruction is one of respiratory emergency manifested as dyspnea, stridor and obstructive pneumonia. Most of central airway obstruction cases were treated with resection and surgery. Bronchoscopy is an initial modality to diagnose, stabilize the airway obstruction and evaluate for palliative treatment. Cryoablation is an evolving therapeutic bronchoscopic methods. Through rapid freeze–thaw cycles, cryoablation causes cell death and tissue necrosis or tissue adherence that can be used via the flexible or rigid bronchoscope. Cryoablation can safely restore airway patency and improve symptoms in patients with central airways obstruction from exophytic tumours. It is also used in the treatment of granulation tissue and benign strictures. Clinical studies showed improvement of dyspnea, cough, and hemoptysis with non-significant complications.
Problems of Chronic Obstructive Pulmonary Disease (COPD) Among Workers Agus Dwi Susanto
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.148

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. Occupational exposure as a one of important risk factor that contribute for COPD on nonsmoker patients. Several studies at population consistent showed that COPD correlated with hazards exposure at work place. COPD among workers can decrease quality of life, increase of work impairment, work disability and hospitalitation also increase of abstinentia from work and decrease of work productivity. Prevention were major action to prevent incident and morbidity of COPD among workers. Prevention programs including primary, secondary and tertiary prevention.
Comparison Between The Effect of Clove, Filter and Biomass Cigarette Smoke to The Lung Function of COPD Patients at Harum Melati Pringsewu Clinic Lampung Province, Period January 2013-January 2020 Retno Ariza S Soemarwoto; Hetti Rusmini; Fransisca Sinaga; Agus Dwi Susanto; Arif Widiyantoro
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.153

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common disease characterized by respiratory symptoms and limited air flow associated with the airways and/or alveolar abnormalities triggered by a significant effect on substances or gases. COPD is the leading of death cause in the world. COPD can be caused by cigarette smoke and biomass. Method: This research is aquantitative method with descriptive analytic and retrospective approach. The samples were 203 COPD patients taken from medical records January 2013-January 2020 at Harum Melati Pringsewu Clinic Lampung Province with statistical test use Analysis Varians (ANOVA) technique. Results: From the characteristics based on type of COPD smoke exposure were clove smokers 127 people (62.6%), filter smokers 3 people (1.5%) and biomass users 73 people (36.0%). The mean lung function COPD patients based on type of smoke exposure were 127 people with clove smokers with average lung function value 55.03%, the lowest value 12.20% and the highest 121.50%. Filter smokers of 3 people with average lung function value 75.07%, the lowest value was 67.00% and the highest 81.41%. Biomass users 73 people with average lung function value 56.91%, the lowest value 19.50% and the highest 149.13%. Comparison the effect clove cigarettes smoke, filter cigarettes and biomass on the pulmonary function of COPD patients obtained P=0.319. Conclusion: There is a decrease lung function in clove smokers, filter smokers and biomass users in COPD patients but not statistically significant difference.
Profile of Adenosine Deaminase (ADA) Level in Active Pulmonary Tuberculosis Patients Sheila Gerhana Darmayanti; Soedarsono Soedarsono
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.149

Abstract

Background: Pulmonary tuberculosis (TB) has a risk of increasing the transmission of infection and death may occur if diagnosis is delayed due to limited testing. Faster, more accurate, inexpensive new methods with easy-to-obtain samples, such as serum levels of Adenosine deaminase (ADA), need to be applied. This study aims to compare serum ADA levels in new cases of pulmonary TB patients and in healthy individuals, and to examine the potential of serum ADA to diagnose pulmonary TB. Methods: This study was an observational analytic study conducted at the Outpatient Clinic of TB/TB-MDR-DOTS, Dr. Soetomo Hospital, Surabaya, Indonesia, from August to December 2019. The subjects were new cases of pulmonary TB patients and healthy individuals. Serum ADA levels were analyzed using the enzymatic colorimetric method, using Erba XL 600. Results: A total of 60 patients were divided into 34 new cases of pulmonary TB patients and 26 healthy individuals. Serum ADA levels in new cases of pulmonary TB patients were significantly higher compared to those in healthy individuals (P
Coal Workers' Pneumoconiosis at PT. A Sawahlunto and The Influencing Factors Ulfahimayati Ulfahimayati; Deddy Herman; Masrul Basyar; Fenty Anggrainyi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.157

Abstract

Background: Coal workers’s pneumoconiosis (black lung disease) is an interstitial lung disease caused by chronic inhalation of coal dust. The incidence of coal workers’s pneumoconiosis increased globally from the 1990s to the 2000s by 3.2%. Indonesia is the country which has many coal mining, but national prevalence of coal workers pneumoconiosis was not discovered. PT. A is one of mining companies in Sawahlunto. The aims of this study was to determine the incidence of coal workers’ pneumoconiosis at PT. A Sawahlunto and it’s influencing factors. Methods: This study is an analytic study with cross sectional design, conducted from November 2019 to April 2020. There were 90 coal miners participated in this study. All subjects were performed chest X-ray examination with ILO standard to asses the incidence of pneumoconiosis. Spirometr examination, dust level measurement with portable low volume air sampler, interview, and validated questionnare were performed to evaluate it’s influencing factors. Statistical analysis used Chi-square test and double logistic regression test. Results: This study found 12 workers (13.3%) had pneumoconiosis. From the statistical test results obtained age >50 years (P=0.035), duration of exposure (P=0.040), mask usage (P=0.029), restrictive lung function (P=0.004), and the mixed abnormality lung function (P=0.006) is associated with pneumoconiosis. The most dominant factor was mask usage (P=0.049) with OR=5.026 Conclusion: The most dominant factor that influence coal workers’ pneumoconiosis was mask usage. Others related factors were age, duration of exposure and abnormality lung function.
The Compability Level of Tuberculin Skin Test and T-SPOT.TB, Sensitivity and Spesifisity of T-SPOT.TB in Detecting Latent Tuberculosis in Hemodialysis Patients Astuti Setyawati; Reviono Reviono; Wachid Putranto
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.159

Abstract

Background: Controling Latent Tuberculosis Infection (LTBI) is important for the End TB Strategy program. The prevalence of LTBI and reactivation to active tuberculosis are increased in immunodeficiency conditions, such on hemodialialysis patients. Laten tuberculosis can be diagnosted by Tuberculin Skin Test (TST) and immunoglobulin release assay (IGRA). This diagnostic study aimed to determine the agreement level of TST and T-SPOT.TB, accurancy of T-SPOT.TB, and the correlation between T cluster of differentiation 4 (CD4+) cell counts with TST and T-SPOT.TB. Methods: This is a cross sectional study design was performed in hemodialysis patients of Dr. Moewardi Surakarta Hospital in May 2018. The study subject had TST and T-SPOT.TB examinations by using 2 Tuberkulin Unit (TU) of intradermal purified protein derivate (PPD) RT 23 (Biofarma, Bandung) and venous blood ELISPOT analysis, respectively. Statistical analysis used windows SPSS 21. Results: There were 30 study subjects. The prevalence of LTBI was 23.3%. The agreement level of TST and T-SPOT.TB was substantial (K=0.667;P

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