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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 331 Documents

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Correction to: Histochemical Changes Liver and Kidney of Mice Exposed to Mercury and Recovery with Nanogold. Molekul, (2016) 11(1), 80-91. - Editors
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

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Corrigendum to:In Abstract typed as: "The background of this research is the circulation cosmetic with mercury that occur today in society. The problem of the research is that occur histochemical’s damage liver and kidney after exposure to mercury, and is that nanogold can recovery that damage. The pre-clinical study needed 24 mice (Mus muscullus) were divided into 6 groups, the control is A group, B group was exposed to mercury, Groups C, D, E and F after being exposed to mercury, than recovery by nanogold with concentration each of 5, 10, 15 and 20 ppm. Exposure was performed 1 week and 4 weeks of recovery. Necropsy of mice doing after treatment, liver and kidneys are processed into preparations by blocking with paraffin embedding method. Histochemical staining of liver and kidney tissue with Hematoxylin eosin (HE) to determine changes of cell constituent and staining Van Geyson to determine the structure of collagen constituent. Statistics Manova showed different results between treatment groups. Tissue damage, lysis cell and destruction of collagen can be observed from histochemical techniques for mercury-exposed group compared to the control group. Tissue and collagen recovery process can be observed from group C, D, E and F. The conclusion that the effects of mercury one week exposed through skin give effect to collagen tissue damage at liver and kidneys of mice. 20 ppm of Nanogold can recovery damaged cells and collagen tissue from the liver and kidneys of mice after four weeks of recovery”. In the abstract, some English grammar should be corrected.Erratum:In Abstract section, some English grammars have been corrected. Therefore, the sentence in the Abstract was corrected to “Background study of this research is today phenomena of cosmetic with mercury circulation that occurs in society. This research focused on histochemical’s damage liver and kidney after exposure to mercury did occur or not, and nanogold can recovery that damage or not. The pre-clinical study needed 24 mice (Mus muscullus) which were divided into 6 groups, including A group as a control group, B group which was exposed to mercury, C, D, E and F groups which were exposed to mercury, then recovery by nanogold with concentration each of 5, 10, 15 and 20 ppm. The exposure was performed in 1 week and 4 weeks of recovery time. Necropsy of mice was done after liver and kidneys treatment were processed into preparats by blocking using paraffin embedding method. Histochemical staining of liver and kidney tissue were investigated using Hematoxylin eosin (HE) to determine changes of cell constituent, and staining Van Geyson was used to determine the structure of collagen constituent. Statistics Manova showed different results between treatment groups. Tissue damage, lysis cell and destruction of collagen can be observed from histochemical techniques for mercury-exposed group compared to the control group. Tissue and collagen recovery process can be observed from C, D, E and F group. Thus, it can be concluded that one week mercury exposured through skin gave effect on collagen tissue damage at liver and kidneys of mice. The nanogold concentration of 20 ppm can recovery the damaged cells and collagen tissue from the liver and kidneys of mice after four weeks of recovery time.”

KARAKTERISTIK ADSORPSI TEMBAGA (II) PADA HUMIN DALAM MEDIUM AIR TAWAR Roy Andreas; Narsito Narsito; Sri Noegrohati
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Although humic substances consist mosly of humin (65%), however its characteristic in Cu(II) odsorption is not yet clearly revealed. In this work, humin was isolated from peat soil of west Kalimantan, purified and then interacted with Cu(II). The purity of isolated humin was determined by its ash content. The funtional group in this purified humin was characterized qualitatively by FTIR and quantitatively by titration. Study on the solubility of Cu(II) in freshwater was carried out at pH from 2-12 in the presence and without purified humin. To obtain adsorption kinetic parameters of Cu(II) on humin in freshwater, study based on Langmuir-Hinshelwood was carried out, while for its thermodinamics parameters, a study based on Langmuir and Freundlich were employed.The ash content of purified humin was 1,58 % (w/w), it showed that the humin was in pure condition. The active fungtional group identified humin were –COOH (1700 cm-1) 115 cmol/kg and –OH fenolic (3421,5 cm-1) 562 cmol/kg. At 2<pH<5 was in Cu(II) and [Cu(H2O)4]2+ which soluble in water, at 6<pH<7 part of the soluble Cu(II) precipitated as Cu(OH)2 while at pH>7 all of Cu(II) was precipitated as Cu(OH)2. The rate constant for Cu(II) in freshwater medium were 2,7 x 10-3 S-1 and 0,6 x 10-3 S-1. The obtained curve fitting of langmuir and freundlich adsorption showed that Langmuir model fit better than Freundlich, indicated that the adsorption reaction are of monolayer. The adsorption capacities of Cu(II) on humin in freshwater was 3,033 x 10-4 mol/g

MODEL QSAR SENYAWA FLUOROKUINOLON BARU SEBAGAI ZAT ANTIBAKTERI Salmonella thypimurium Eva Vaulina, Ponco Iswanto Eva Vaulina; Ponco Iswanto
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Modelling of novel Fluoroquinolone derivates as antibacterial compund of Salmonella thypimurium was conducted. The research was done as an initial step in discovering some new Fluoroquinolone compounds which have higher activity to Salmonella thypimurium. There are 16 compunds that use as the material of the research and they already have antibacterial activity data that expressed in Minimal Inhibitory Concentration (MIC, mg/mL). Calculation was performed by semiempirical AM1 method. The QSAR model was determined by multilinear regression analysis, with Log MIC as dependent variable and the independent variables are atomic net charges of C5 (qC5) and C7 (qC7), dipole moment (m), polarizability (a), n-octanol-water coefficien partition (Log P), molecular weight (Mw), and surface area of van der Waals (AvdW). The relationship between Log MIC and the descriptors which performed by statistical analysis is:(Log MIC) = -2.119 + 34.541(qC5) – 19.748(qC7) – 0.919polar + 1.170logP + 0.111(Mw) – 0.003(Avdw), with n =16, r = 0.907, r2 = 0.822, SD = 0.288, F calc = 6.938, F table = 3.374 , F calc/F table = 2.056 and PRESS = 0.749. The research can obtain the new coumpounds that modified from compound number 16 (etil fluoroquinolone, MIC prediction = 0.0354 mg/mL), (etil fluoroquinlone fosfate, 2.84. 10-19mg/mL), and (isopropyl fluoroquinlone, 0.1085 mg/mL), and compound number 2 (m-nitro fluoroquinolone sulfonat, 1.32. 10-11mg/mL). This results can be suggested to synthesis step.

ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA SERTA UJI AKTIVITAS ANTICANDIDAISIS SERBUK DAUN SIRIH DUDUK (Piper sarmentosum Roxb. Ex Hunter) Suwandri Suwandri; Hartiwi Diastuti
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Sirih duduk or Piper sarmentosum Roxb. ex Hunter have been long used the people in Indonesia for traditional medicine to cure various diseases. One of them was used to treat fungoid diseases. This research was aimed to examine the anticandidaisis activity from extract of P. sarmentosum leaves and to isolate and identify the anticandidaisis compounds from P. sarmentosum leaves. The isolation bioactive compounds of P. sarmentosumleaves was performed by extraction the powder of P. sarmentosum leaves using methanol and the bioactivity tests were performed against Candida albicans. The methanol extracts was then fractionated using organic solvents such as n-hexane, benzene, chloroform, and ethyl acetate. Identification of the bioactive compounds was carried out using ultraviolet-visible spectrometry, fourier transform infra red spectrometry and gas chromatography-mass spectrometry. The result showed that the chloroform fraction of methanol extract of P. sarmentosum leaves have activity against C. albicans. The fractionation was performed by coloumn chromatography using n-hexane-ethyl acetate(1:1) eluent. A bioactive compound of sinamic acid derivative was 4-ethoxy-2-hidroxy-3,5-dimethoxy sinamic acid could be purely isolated.

SINTESIS NATRIUM PENTAGAMAVUNONAT DAN UJI STABILITASNYA MENGGUNAKAN SPEKTROFOTOMETER UV-Visible Ely Setiawan; Trisnowati Trisnowati; Dadan Hermawan
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

A research on the synthesis of sodium pentagamavunonat (Na-PGV-0) and its stability test using UV-Visible spectrophotometer were carried out. The synthesis of Na-PGV-0 carried out by reacting PGV-0 in tetrahydrofuran solvent refluxed with sodium ethoxide in mol comparison (1:2) for two hours. Structure elucidation by spectroscopic methods using UV-Visible, IR, 1H-NMR, 13C-NMR and stability test in water using UV-Visible spectrophotometer. The reaction yields 107,21 % (% w/w) products. A products was soluble in water and methanol. Structure elucidation results indicated that the formed compound where the OH phenolic of pentagamavunon-0 was replaced by sodium ions. Stability test shows that decreasing of sodium

FRAKSINASI EKSTRAK METANOL KULIT BATANG Rhizophora mucronata DAN UJI DAYA HAMBATNYA TERHADAP BAKTERI Escherichia coli Dian Riana Ningsih; Warsinah Warsinah; Suwandri Suwandri
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Rhizhophora mucronata is commonly found mangrove plant due to it’s wide distribution. The bark of this plant used for traditional medicine as slimming, antidiarrhea , anticonstipation. The chemical compounds of R. mucronata are tannins, alcaloide, flavanoids and saponin. In order to find out the effect of chemical activity of this plant, a research entitled Fractionation Metanol Extracts Bark of R. Mucronata and Inhibiting Capacity Assay againstEscherichia coli Bacteria has been carried out.The bark of R. mucronata was extracted by soxhlet with methanol solvent. Than methanol extract was fractionated with developing solvent kloroform : metanol (1:9) and producing five fractions that gave positive result on test for alcaloide compounds. The result of infrared spectroscopy that fraction 1-5 also contains of alcaloide. All fractions from coulomn chromatography tested on E. coli with dilution method which gave result that these fractions inhibit the growth of E. coli.

SINTESIS DAN UJI AKTIVITAS ANALGETIKA-ANTIINFLAMASI SENYAWA N-(4t-butilbenzoil)-p-aminofenol Sri Sutji Susilowati; Santi Nur Handayani
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

The synthesis of N-4t-butyl benzoil-p-aminophenol has been done by reacting p-aminophenol and N-4t-butyl benzoil chloride compounds, then the products were isolated and analyzed by TLC, melting point determination, UV/Vis Spectrofotometry, infra red spectrofotometry and mass spectrometry. The synthesis yield of N-4t-butylbenzoil-p-aminophenol was 33,52%, with the compound melting point between 192-194 oCThe determination of analgesic (ED50 of % analgesic activity ) and anti inflammatory activity (ED50 of edema inhibition) gave the ED50 of % analgesic activity was 144 mg/kg and ED50 of % edema inhibition was 43,24 mg/kg.

PENENTUAN WAKTU KONTAK DAN pH OPTIMUM PENYERAPAN METILEN BIRU MENGGUNAKAN ABU SEKAM PADI Anung Riapanitra; Tien Setyaningtyas; Kapti Riyani
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Dyes are widely used for colouring in textile industries, significant losses occur during the manufacture and processing of the product, and these lost chemical are discharged in surrounding effluent. Adsorption of dyes is an effective technology for treatment of wastewater contaminated by the mismanaged of different types of dyes. In this research, we investigated the potential of rice husk ash for removal of methylene blue dyeing agent in aqueous system. The aim of this research is to find out the optimum contact time and pH on the adsorption of methylene blue using rice husk ash. Batch kinetics studies were carried out under varying experimental condition of contact time and pH. An adsorption equilibrium condition was reached within 10 minutes and the optimum condition for adsorption was at pH 3. The adsorption of methylene blue was decreasing with decreasing the solution pH value.

PENENTUAN ASAM OKSALAT SECARA SPEKTROFOTOMETRI DENGAN METODE METILEN BIRU Irmanto Irmanto; Suyata Suyata
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

A spectrophotometric method for the determination of oxalic acid has been developed, based on its catalytic effect on the redox reaction between methylene blue and sulphide, measured at the maximum absorption wavelength of 664 nm. Under the optimum conditions of 3 mL of 31 % formaldehyde; 0.8 mL of 0,067 M EDTA - Triethanolamine; 1.2 mL of 0,010 M sulphide; 2 mL of 0,0010 % methylene blue at 20 oC for 1 minute a detection limit of 0,43 mg/mL for oxalic acid determination was obtained. This method can be applied to determination of trace level of oxalic acid.

PEMBUATAN SELULOSA ASETAT DARI PULP KENAF (Hibiscus cannabinus) Senny Widyaningsih; Cynthia Linaya Radiman
Molekul Vol 2, No 1 (2007)
Publisher : Universitas Jenderal Soedirman

Cellulose acetate (CA) is one of polymer which is usually used in industry. Kenaf (Hibiscus cannabinus) pulp is one of non wood cellulose sources which can be used for producing CA. CA was produced in three step i.e. initial, acetylation, and hydrolysis. The characterization of CA kenaf had been conducted with analyzing function groups and determining relative molecule mass, acetyl content, and structure of CA. The result of infrared spectroscopy analyze showed that specific peak of acetyl group at 1237.4 cm-1 with acetyl content 40.40% and the relative molecule mass of CA was 1.15.104 with amorf structure.

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
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Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA