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INDONESIA
JURNAL ILMU KEFARMASIAN INDONESIA
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmu Kefarmasian Indonesia memuat tulisan ilmiah baik berupa naskah hasil penelitian maupun naskah konsep di bidang Kefarmasian. Diterbitkan setiap 2 (dua) kali dalam setahun yaitu pada bulan April dan Oktober.
Arjuna Subject : -
Articles 603 Documents
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Mengungkap Potensi Kluwak (Pangium edule Reinw) Sebagai Antioksidan Alami dan Penghambat Senescence Ratih Kurnia Wardani; Yurananda Magnalia Putri; Dhella Angelina Nurjanah; Ratna Asmah Susidarti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.958

Abstract

Senescence is a condition that causes tissue dysfunction, causing problems such as premature senescence. Premature senescence is caused by oxidative stress that comes from reactions in the body and the environment (UV rays, X rays, and free radicals). Kluwak seeds (Pangium edule Reinw) contain a variety of powerful antioxidant compounds such as vitamin E, vitamin C, polyphenols, flavonoids (quercetin and catechins), quinine, and β carotene. This narrative review aims to uncover kluwak’s potential as a natural senescence-inhibiting agent for antioxidants. The literature search method with the Booelan technique is used by combining several keywords with the notation AND, OR, NOT from various literatures from national and international journals published from various databases. The results showed that the compounds in kluwak can prevent oxidative stress that causes senescence because they have antioxidant activity from phenolic groups and conjugated double bonds. The mechanisms possessed by kluwak seeds are: stabilizing ROS, increasing antioxidant enzymes in the body, inhibiting prooxidant enzymes, preventing lipid peroxidation, and inhibit markers of senescence (anti-SASP). Therefore, kluwak is used as an anti-senescence agent in the form of cosmetic preparations that have local effects, such as hydrogels which are easy and safe to use in the body.
Formulasi Sediaan Nanoemulsi Antiselulit Mengandung Kafein dan Minyak Biji Anggur (Vitis vinifera L.) Sani Ega Priani; Dinnanda Yussepina Wulansari; Fitrianti Darusman
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1009

Abstract

Caffeine is a methylxantin derivative that has anti-cellulite activity by increasing lipolysis. Grape seed oil containing oligoproanthocyanidin which can also act as an anti-cellulite. The nanoemulsion system is known could increase percutaneous penetration of lipophilic or hydrophilic compounds such as caffeine. This study aims to develop caffeine nanoemulsion containing grape seed oil and to determine the effect of nanoemulsion formulation on the percutaneous penetration of caffeine. Nanoemulsion preparations were made using grapeseed oil as the oil phase, tween 80 as a surfactant, glycerin as a cosurfactant, with various concentration of caffeine as the active substance (1;1,5;and 2%). The preparations were characterized by organoleptic, homogeneity, pH, viscosity, rheology, spreadability, %transmittance, globule size distribution, and physical stability testings. The percutaneous penetration test was carried out in vitro using franz diffusion cell. The results showed that the nanoemulsion preparation containing 1% caffeine with 5% of grapeseed oil had good physical characteristics with transparent and homogeneous appearance, Newtonian flow properties, percent transmittance value of 99.17 ± 0.06% and globule size of 101 ± 13 nm. Nanoemulsion was able to increase the penetration of caffeine based on in vitro testing compared to the gel dosage form which were statistically significant (p <0.05).
Pemberian Serbuk Kelopak Rosella Merah yang Diseduh Mampu Mencegah Penurunan HDL Pada Sprague dawley yang Dipapar Jelantah Arya Ulilalbab; Eni Maskanah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1158

Abstract

Lipid metabolism disorder is caused by waste cooking oil that is one of the source of exogenous free radicals. Publics know the utilization of red rosella calyx is used as a brew that contains antioxidants. Purpose of this research is to find out the effect of giving brewed red rosella calyx to rat lipid metabolism caused by waste cooking oil on High-density Lipoprotein (HDL) value. This research used 24 male rats which were selected by random sampling and divided into 4 groups: positive control (2 ml kg/BW waste cooking oil given), negative control (without treatment), treatment 1 (2 ml/kg BW waste cooking oil given and giving of 540 mg/kg BW brewed red rosella calyx), and treatment 2 (2 ml/kg BW waste cooking oil given and giving of 810 mg/kg BW brewed red rosella calyx). One-way Analysis of Variance (α = 0.01) and Tukey honestly significant difference test showed that HDL p-value = 0.00. All groups have a significant effect on HDL. The best value is giving of 810 mg/kg BW dose of brewed red rosella calyx (HDL of 57.47 mg/dl). Giving of brewed red rosella calyx dose of 540 mg/kg BW (EC50 = 407.52 bpj) and red rosella calyx dose 810 mg/kg BW (EC50 = 247.82 bpj) can prevent HDL decrease. Red rosella calyx can improve the lipid profile of waste cooking oil treated to Sprague Dawley rats (especially for HDL on this research).
Efektivitas Flukonazol dalam Mencegah Infeksi Jamur Invasif pada Bayi dengan Berat Lahir Sangat Rendah: Tinjauan Sistematis dan Meta-analisis Fonny Cokro; Lorensia Yolanda; Shelly Caroline
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1035

Abstract

Fungal infections in neonates, especially in Very Low Birth Weight (VLBW) infants, are mostly caused by Candida species and may lead to morbidity and mortality. A systematic review and a meta-analysis were conducted to determine the extent to which fluconazole, an antifungal prophylactic, was effective and safe to use in VLBW or premature infants in preventing Invasive Fungal Infection (IFI), by including Randomized Controlled Trials (RCTs) carried out worldwide. The investigation started with searching process through publication databases: MEDLINE, Cochrane, ScienceDirect, and Garuda, for Randomized Controlled Trials (RCTs) that compared the prophylactic effects of fluconazole and placebo on IFI in VLBW infants. The selected eight RCT studies indicated that, compared to placebo, fluconazole accounted for 68% risk reduction of overall fungal colonization (RR=0.32; 95% confidence interval [CI]=0.24-0.42, p=0.00001, I-square=0%) and 60% risk reduction of IFI (RR=0.40; 95%[CI]=0.22-0.72, I-square=56%, p=0.002). However, fluconazole did not significantly reduce mortality in VLBW infants (RR=0.79; 95%[CI]=0.60-1.03; p=0.08, I-square=0%). Also, regarding its safety, fluconazole prophylaxis did not result in significant elevations of SGOT/SGPT levels (RR=1.22; 95%[CI]=0.50-3.00, p=0.66, I-square=0%) nor cause intestinal perforation (RR=0.96; 95%[CI]=0.25-3.68, p=0.96, I-square=59%). Fluconazole is an effective prophylaxis agent against invasive fungal infection when given to preterm infants with birth weight <1500, but not proven in reducing the mortality incidence in VLBW infants.
Penetapan Kadar Vitamin E dalam Ekstrak n-Heksan Buah Kelapa Sawit (Elaeis guineensis Jacq) dan CPO (Crude Palm Oil) dengan Metode KCKT Mustika Furi; Rahma Dona; Vincent Tristan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.915

Abstract

Palm fruit (Elaeis guineensis Jacq) is a natural source of vitamin E (tocopherol). This study has determined vitamin E levels in n-hexane extracts of palm fruit (Elaeis guineensis Jacq) and CPO (Crude Palm Oil) using HPLC (High Performance Liquid Chromatography) method. The subject were palm fruit and CPO obtained from plantations and palm fruit mills PT X located in Kampar district, Riau. Extraction of palm fruit and CPO using ultrasonication and saponification method. Measurement using HPLC obtained optimum conditions using mobile phase acetonitrile: water (86:14), flow 1 mL/minute, UV-Vis detector at wavelength 284 nm and obtained retention time is 3,488 minutes. Determination of the calibration curve is obtained the regression equation y = 702,872x + 3273,26 and r2 = 0,9985. The result of the determination vitamin E levels in the palm fruit extract and CPO sequentially is (469,4008 ± 2,5879) µg/mg and for CPO is (262,5248 ± 6,3987) µg/mg.
Aktivitas Antioksidan Masker Peel-Off Kopi (Coffea arabica) dan Kunyit (Curcuma longa) Menggunakan Metode DPPH Regia Desty Rakhmayanti; Youstiana Dwi Rusita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1212

Abstract

Peel-Off face mask is one of the cosmetics that is used to treat skin from free radicals. Coffee (Coffea arabica) contains chlorogenic, ferulic, caffeic, and n-coumaric acids which can be useful as antioxidants. Turmeric (Curcuma longa) contains curcumin, which has anti-inflammatory and antioxidant properties. The purpose of this study is to evaluate the quality parameters and analyzed the antioxidant activity of peel-off masks containing coffee (Coffea arabica) and turmeric (Curcuma longa). This research has made 3 mask formulas, each of which contains coffee and turmeric. The formula made was a combination of coffee and turmeric with a ratio of each formula F1 (10:0), F2 (5:,5) and F3 (0:10). The result of organoleptic parameters for F1 was dark brown with coffee aroma and consistency like gel, F2 wasyellowish-brownn with spiced coffee aroma and consistency like gel and F3 was yellow with turmeric aroma and consistency like gel. The result of the homogeneity test of all formulasmula was homogeny. The result of the pH value of all formulasmula was 5. The resulspreadabilityd ability of F1, F2 and F3 were 26.877 cm2; 26.278 cm2; 26.875 cm2. The drying time of each formula was F1 27.36 min; F2 28.38 min; F3 28.54 min. The antioxidant activity is shown the by IC50 value. The value of IC50 for each formula F1 (37.277 ppm), F2 (34.757 ppm), and F3 (37.399 ppm). The test results showed that all formulas met the quality test requirements and had very strong antioxidant activity.
Optimalisasi Komposisi Koktail dan Pengembangan Proses Fermentasi Up-scale dari Empat Strain Bakteri Komensal Kulit Ahmad Baikuni; Meidy Richky Wanyodiharjo; Harry Ardiansyah; Fathan Luthfi Hawari; Amarila Malik
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1224

Abstract

Analyzing the actual microbial composition in the skin microbiome is riveting to create a potential sourceof active substances in skincare products. Our previous study isolated four bacterial strains from Javanese male and female skin samples, Staphylococcus hominis MBF12–19J, Staphylococcus warneri MBF02–19J, Bacillus subtilis MBF10–19J, and Micrococcus luteus MBF05–19J. This study aimed to determine the composition of those strains in a bacterial cocktail and optimize the condition for up-scale laboratory production of the cocktail. To assess the ability of bacteria to coexist and live in cocktail communities, simultaneous monitoring was performed using the Deferred Growth Inhibition Assay (DGIA) method and real-time PCR for DNA copy number measurement. Results showed the best composition based on even distribution and cell growth viability was at the ratio 1.5:1:0.5:0.5 of Micrococcus luteus MBF05-19J, Bacillus subtilis MBF10-19J, Staphylococcus warneri MBF02-19J, Staphylococcus hominis MBF12-19J, which is equivalent to DNA copy number/mL 1.209 x 1024 CFU : 2.484 x 1041 CFU : 2.645 x 1041 CFU : 9.041 x 1035 CFU, respectively. The optimum growth incubation time of individual bacterial cultures for an up-scale 2-L bio-fermentor mixture was as follows; Micrococcus luteus MBF05-19J = 21 hrs; Bacillus subtilis MBF10-19J = 7 hrs; Staphylococcus warneri MBF02-19J = 17 hrs; Staphylococcus hominis MBF12-19 = 15 hrs. For up-scale conditions, the fermentation incubation time was 3 hours at 37oC, agitation 50 RPM, and aeration 5% dissolved oxygen.
Efek Antibakteri Kombinasi Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Amoksisilin terhadap Staphylococcus aureus dan Escherichia coli secara In Vitro Setiadi Abdillah Pratama; Tri Widyawati; Muhammad Ichwan; Dian Dwi Wahyuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1174

Abstract

Staphylococcus aureus and Escherichia coli often infect humans and risky cause antibiotics resistance including amoxicillin. This encourages us finding alternative active ingredients: Moringa oleifera leaf. This study evaluated antibacterial activity of combination of Moringa leaf extract (KDK) and amoxicillin (KA) against S. aureus and E. coli in vitro. The research methods with true experimental research with post-test control group design. KDK obtained by maceration. Four concentrations of KDK test materials (20, 30, 40, 50%) and 1 concentration of KA (3 mg/mL). Disc diffusion test method taken and the parameter measured: the diameter of the disc inhibition zone. Data analyzed by One-way ANOVA and further Tukey’s test. KDK+KA against S. aureus (20.77±1.79 – 21.33±1.74 mm)>KDK (11.45±0.21 – 12.45±0.28 mm) or KA (14.50±0.42 mm). KDK+KA against E. coli (15.53±0.71 – 17.87±0.42 mm)>KDK (9.00±0.28 – 10.30±0.42 mm) or KA (13.45±0.35 mm). A significant (p<0.05) was obtained between the combination group (KDK+KA) versus a group (KDK or KA). The combination of Moringa leaf ethanol extract and amoxicillin synergistically effected as antibacterial against S. aureus and E. coli in vitro.
Uji Aktivitas Antioksidan Fraksi N-Heksan dari Ekstrak Metanol Daun Binjai Mangifera caesia Jack. Ex. Wall Menggunakan Metode DPPH Hafiz Ramadhan; Siti Purnama; Putri Indah Sayakti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1133

Abstract

Natural antioxidant compounds can be found in plants of the Mangifera genus, one of them is Mangifera caesia, Jack. ex. Wall or which was also known as binjai. This study aims to determine group compounds and the antioxidant activity of the n-hexane fraction from the binjai leaves methanol extract against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The binjai leaves powder extraction was carried out using the soxhlet apparatus with methanol and liquid-liquid fractionation using water and n-hexane. Phytochemical screening was done by adding specific reagents. The antioxidant activity assay qualitatively on TLC that being sprayed with DPPH and quantitative assay by measuring the absorbance of the fraction attenuation against DPPH radicals using a UV-Vis Spectrophotometer. The Phytochemicals screening results showed that the n-hexane fraction contained phenolic, flavonoid, and steroids. The qualitative test results showed some compounds had an antioxidant activity that appeared by changing the color of the spots to yellow on a purple background after spraying with DPPH solution. The n-hexane fraction resulted in an IC50 value of 34.0668 ppm with quercetin IC50 of 2.4469 ppm. Based on these results, it can be concluded that the n-hexane fraction of binjai leaves methanol extract contains phenolic and flavonoid compounds that played a role in producing very strong antioxidant activity.
Efektivitas Gel Ekstrak Tangkai Talas (Colocasia esculenta L.) untuk Penyembuhan Luka Bakar pada Tikus Putih Jantan Erni Rustiani; Nisa Najwa; Lulu Nurzillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1154

Abstract

The stalk of Colocasia esculenta (L.) plant contains flavonoids and saponins. Flavonoids presented effects in respect of the inflammatory process, re-epithelialization and oxidative stress. Saponin not only promotes re-epithelialization of the wound but also effectively inhibits inflammatory reactions during the early phase, and promotes matrix synthesis throughout the wound healing process. So that the content of metabolites in Colocasia stalks is thought to be able to play a role in the healing process of burns, especially wounds with complications of infection. One of the topical dosage forms to treat burns is a gel dosage form. This study aimed to make and determine the effectiveness of gel of Colocasia stalk extract in healing infected burns in white male rats. The test animals were divided into five groups, each consisting of 5 rats. The groups given the gel were F1 (1% w/w), F2 (3% w/w), F3 (5% w/w). While the positive control group was given (Bioplacenton®) and the negative control group (gel base). The gel was given once a day, and the method used was the Morton method. Observations included evaluation of gel quality, decrease in wound diameter, and epithelialization time. The results showed that gel of Colocasia stalk extract (1%, 3%, and 5% w/w) had a good quality and significantly wound infected burns (p<0.05). The decrease in wound diameter and epithelialization time had a value (p<0.05) compared to the negative control group. The healing effect of burns depends on the concentration of the dried extract of Colocasia stalk in the gel preparation. Extract concentration of 5% w/w (F3) has the most effective percentage of burn wound healing for 13 days.

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