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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 183 Documents
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Aktivitas Ekstrak Daun Bangle (zingiber purpureum roxb.) Terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa Fajrin Noviyanto; Siti Hodijah; Yusransyah Yusransyah
Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.373 KB) | DOI: 10.37311/jsscr.v2i1.2665

Abstract

The bacteria that cause infections that can lead to high morbidity and mortality, the bacterium Pseudomonas aeruginosa. Bangle has a pharmacological activity as antibacterial, laxative, pancreatic lipase inhibitor, and protect cells from damage caused by oxidative stress. The purpose of this study are: to know the chemical constituents present in the extract of leaves bangle (Zingiber purpureum Roxb.) Can be efficacious as an antibacterial and knowing Minimal Inhibitory concentration (MIC) of the extracts of leaves bangle against Pseudomonas aeruginosa. Tests on the leaf extracts for antibacterial activity against Pseudomonas aeruginosa bangle made by the method of Kirby Bauer and solvents used are DMSO. Test solution with a concentration of leaf extract bangle 200, 400, 600, 800 and 1,000 ppm, the positive control solution (ciprofoxacin) and the solution negative control (DMSO). The results showed that the chemical constituents present in the extract of leaves bangle (Zingiber purpureum Roxb.) Are flavonoids, saponins, tannins, alkaloids and steroids. Value Minimum Inhibitory Concentration (MIC) of ethanol extract of the leaf bangle S bacteria Pseudomonas aeruginosa is a concentration of 40 % with an average diameter of 5.44 mm inhibitory. MIC extract ethanol extract of leaf bangle belonging to the bacterial activity that is strong enough..
Uji Toksisitas Ekstrak Etanol Daun Ekor Kucing (Acalypha hispida Burm.f.) Dengan Metode Brine Shrimp Lethality Test (BSLT) Hadi Kurniawan; Meri Ropiqa
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11398

Abstract

Daun Ekor Kucing (Acalypha hispida Burm.f.) merupakan jenis tanaman hias yang telah dikenal masyarakat Indonesia untuk pengobatan, namun belum ada penelitian untuk meneliti toksisitas akut daun ekor kucing. Tanaman ini mengandung senyawa alkaloid dan flavonoid. Tujuan dari penelitian ini adalah untuk mengetahui potensi ketoksikan akut ekstrak etanol daun ekor kucing (A. hispida Burm.f.) terhadap larva Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT) yang ditunjukkan dengan nilai LC50. Penelitian eksperimental ini menggunakan 300 ekor larva udang (Artemia salina Leach) yang dibagi menjadi 5 kelompok kontrol negatif dan 5 kelompok seri konsentrasi ekstrak. Masing-masing kelompok terdiri dari 10 ekor larva dengan replikasi 3 kali untuk tiap kelompok perlakuan. Kelima kelompok perlakuan diberi suspensi sediaan uji ekstrak etanol daun ekor kucing dengan konsentrasi 100 ppm, 250 ppm, 500 ppm, 750 ppm, dan 1.000 ppm. Data kematian Artemia salina Leach dianalisis dengan analisis probit untuk mengetahui nilai LC50. Hasil penelitian ini menunjukkan harga LC50 dari ekstrak etanol daun ekor kucing adalah 220,005 ppm. Ekstrak etanol daun ekor kucing memiliki potensi toksisitas akut terhadap larva Artemia salina Leach menurut metode BSLT yang ditunjukkan dengan harga LC50 1.000 ppm.
Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri Feny Oktaviana; Puput Noviana
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11688

Abstract

Typhoid fever has the highest incidence in children. Treatment for typhoid fever uses antibiotics. Increasing bacterial resistance to antibiotics is a global problem. This study was conducted to determine the differences in the effectiveness of antibiotics in the treatment of typhoid fever on the heat-free time and the length of treatment for pediatric patients in the inpatient ward of the X Hospital, Kediri City. This research is a descriptive analysis research. A retrospective study was conducted using medical records in 2017. Data were collected by purposive sampling. Data were taken on pediatric patients with typhoid fever aged 5-11 years. The statistical test used to analyze the effectiveness of therapy in pediatric patients with typhoid fever was performed using the Kruskal-Wallis test. The sample used in this study were 38 pediatric patients. The antibiotics used were ciprofloxacin 52.63%, ceftriaxone 28.95%, cefuroxim 10.53%, and penicillin 7.89%. The results of the analysis of differences in the effectiveness of antibiotics against heat-free time obtained a sig value 0.05 (0.947) and a sig value 0.05 (0.329) for the length of treatment. There was no significant difference in heat-free time and length of treatment between ceftriaxone, cefuroxim, ciprofloxacin and penicillin.
FORMULASI EMULGEL DARI EKSTRAK DAUN KELOR (Moringa oleifera LAM) SERTA EVALUASI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Nurul Istiqomah; Juliyanti Akuba; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9874

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Analisis Kadar Metabolit Sekunder, Histokimia, dan Aktivitas Antioksidan Akar Acalypha indica L. Novia Agustina; Nurul Istiqomah
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11376

Abstract

Acalypha indica L. is a species of wild plant that has secondary metabolites are used as medicine, but the usage is not optimized yet. The objective of of this study was to determine secondary metabolites content, location and distribution of secondary metabolites, and also the capacity for antioxidant. Secondary metabolites content was determined included phenol, flavonoids, tannin of chloroform and methanol extracts from Acalypha indica L. root, using spectrophotometre. Histochemical test was done by making fresh sliced preparation which was reacted with reagent. Antioxidant activity was determined by using DPPH method. The result of this study showed that secondary metabolites content of chloroform extract, were phenol 9,89 ± 0,77 %GAE, flavonoids 5,87 ± 1,40 %QE, and tannin 3,33 ± 1,21 %GAE, while methanol extract were phenol 45,11 ± 4,86 %GAE, flavonoids 19,87 ± 0,61 %QE, and tannin 6,76 ± 0,31 %GAE. Histochemical test showed that phenol, flavonoids, tannin, and alkaloids were found in Acalypha indica L. root. Antioxidant activity showed the IC50 value was 161,81 ± 7,88 μg/mL for chloroform extract and 92,81 ± 4,33 μg/mL for methanol extract.
FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α) Parawansah Parawansah; Nuralifah Nuralifah; Yulfa Yulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13484

Abstract

Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.
Analisis Cemaran Bakteri Coliform Pada Minuman Jajanan Dengan Metode MPN (Most Probable Number) Ervina Surnianingsi Jufri; Ismail Rahman
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13595

Abstract

Coliform bacteria contamination of food and beverages may result from various causes, one of which is faecal contamination, leading to serious health issues. Drinking water contamination of coliform bacteria 50/100 mL has been found to be responsible for diarrhea episode. Local regulation has determined the cut-off point of its contamination within commercial beverages not to exceed 3/mL. No such study has ever been conducted in Ternate. To determine the exact value of coliform bacteria within street beverages sold in various city parks in Ternate. This descriptive was carried out through laboratory testing of street beverages obtained from various city parks in Ternate. The most probable number test for coliform bacteria was carried out at the Technical Implementation Unit, Basic and Integrated Laboratory, North Maluku from December 2021-January 2022. The presumption test and the affirmation test were conducted accordingly. From 22 instant powdered ice drinks samples obtained from Toboko, Falajawa 1, Nukila, Landmark, and Film Benteng parks, 90,9% contained coliform bacteria exceeding the cut-off value. Coliform bacteria contamination in the city parks within Ternate has exceeded the quality standard threshold based on Indonesian National Standard 7388 of 2009. Further research is needed to confirm this.
Hubungan Kepatuhan Konsumsi Tablet Zat Besi dengan Kejadian Anemia Ibu Hamil Ginanjar Zukhruf Saputri; Ana Hidayati; Susan Fitria Candradewi; Sulfah Sulfah
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13540

Abstract

Anemic in Pregnancy is still a health problem in Indonesia. Iron supplementation is a preventive measure carried out by the government in primary health services. However, the average coverage of national Fe tablets is still not maximal (85.1%). Research related to adherence to iron supplement consumption is still limited, therefore this study aims to determine the relationship between adherence level with anemia of pregnant women. The study used an analytic observational method with a cross sectional approach, conducted in the period August-November 2019 at Jetis I Bantul, primary health service Yogyakarta. A total of 39 respondents who met the inclusion criteria and agreed to informed consent were recruited in this study. Data on the level of compliance were taken through interviewing respondents using quistionnaire and pill count, at least on the 7th day after consuming iron tablets, while Hb levels were taken from medical records and examination of respondents. Statistical analysis was performed using chi square. Results showed that 61.5% of pregnant women complied with the consumption of iron tablets, while the measurement of the pill count showed 59.0% has complience. There was a significant correlation between the consumption of iron tablets and the incidence of pregnancy anemia, both adherence to the questionnaire measurement p = 0.000; OR = 0.050; (CI: 0.010-0.263), or the measurement of pill count p = 0.003; OR = 0.126 (CI: 0.030-0.538). A total of 15.4% of pregnant women have anemia in the 2nd trimester of gestation, and 25.6% in the 3rd trimester. Based on this study, it is concluded that there is a correlation between the level of adherence  of  Iron tablet consumption towards the incidence of anemia in pregnant women.
Uji Efektivitas Mukolitik Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb) Robiatun Rambe; Zulmai Rani; Nur Ain Thomas
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.7041

Abstract

Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%.  Mucolytic effectiveness was better than positive controls (acetylcysteine).
Formulasi dan Uji Stabilitas Hand Body Lotion dari Ekstrak Etanol Rumput Laut (Eucheuma cottonii) Yusnita Usman
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13519

Abstract

Research  has been carried out on formulation and stability test of hand body lotion from ethanolic extract of seaweed (Euchema cottonii). This study aims to obtain a hand body lotion formulation from seaweed extract (Eucheuma cottonii) that meets the requirements for the physical quality of the lotion, where the formula made consists of 4 formulas with extract concentrations of 5%, 10%, 15% and formulas without extracts. The evaluation of lotion preparations included organoleptic tests, pH tests, homogeneity tests and dispersibility tests. Data analysis was carried out by testing the physical quality of each formula compared to the quality standard of lotion preparations according to theory. From the research that has been done, it shows that the composition of the 4 formulas shows homogeneous results. The pH values of the formulas with extract concentrations of 5%, 10% and 5% and formulas without extracts were 5,8;5,3;5,1 and 6.6 (quality requirements 4,5 -6.6). Meanwhile, the pH distribution of the formula with 5%, 10% and 5% extract concentrations and the formula without extract was 5.2, respectively; 4.8; 4,4 and 5 (quality requirements 5-7). Based on the results obtained, it can be concluded that the formula with an extract concentration of 5% has the most physical stability that meets the requirements for the quality of lotion preparations.

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