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Scientia Psychiatrica
Published by HM Publisher
ISSN : -     EISSN : 27159736     DOI : https://doi.org/10.37275/scipsy
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience Public Health
Scientia Psychiatrica covers the latest developments in various fields of psychiatric : biological psychiatry, neuropsychiatry, child psychiatry, psychiatry of community, psychotherapy, drugs-related mental illness, psychiatry of geriatric, psychosomatics medicine, psychology, cultural psychiatry, military psychiatry, forensic psychiatry, consultation liaison psychiatry and all medicine fields related psychiatry. Genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact of psychiatry.
Arjuna Subject : Kedokteran - Psikiatri dan Kesehatan Mental
Articles 79 Documents
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Haloperidol and Risperidone Induce Apoptosis Neuronal Cell: In vivo Study Ester G Panserga; Cecep S Kristanto; Budi Pratiti; Patricia Wulandari
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.205 KB) | DOI: 10.37275/scipsy.v1i1.5

Abstract

Introduction: Antipsychotics are drugs that are widely prescribed for mental disorders, such as schizophrenia and psychosis. Recent in vitro studies show antipsychotics play a role in the initiation of neuronal cell apoptosis. This study aims to determine the effect of haloperidol and risperidone on neuronal cell apoptosis in Wistar white rats. Methods: Male Wistar rats aged 8 weeks (n = 30) were used in this study. Wistar rats were randomized into 6 groups. Group A: 5 Wistar rats as the control without induced schizophrenia, aquadest, and drugs. Group B: 5 Wistar-induced psychotic mice (using 30 mg / kgBB ketamine, intraperitoneal injection for 5 days) and aquadest. Group C: 5 rats were induced psychotic and were given haloperidol or 0.05 mg / kgBB orally, for 28 days. Group D: 5 mice were induced psychotic and were given haloperidol 0.1 mg/kg orally, for 28 days. Group E: 5 mice were induced psychotic and were given risperidone 0.05 mg / kgBB orally, for 28 days. Group F: 5 mice were induced psychotic and given risperidone 0.1 mg / kgBB orally, for 28 days. Apoptosis of neuronal cells in the ventral tegmental area was assessed by caspase-3 immunohistochemistry. The colored area will be calculated as a total percentage using the ImageJ program. Results: Risperidone and haloperidol increase caspase-3 activity, but haloperidol increases caspase- 3 activity more than risperidone. Conclusion: Risperidone and haloperidol induce apoptosis of neuronal cells and tardive dyskinesia in Wistar rats with psychotic models.
Video Game Increases Depression in Students Edith Humries; Budi Pratiti; Patricia Wulandari; Rachmat Hidayat
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.035 KB) | DOI: 10.37275/scipsy.v1i1.3

Abstract

Introduction: The effects of exposure to violence in newspaper and electronic media to children and adolescents were being an awareness various parties, namely, researchers, health practitioners and policy makers. Depression is a mental problem that is always found due to exposure to video games. Methods: This study was an observational study with a cross-sectional research design. The subjects of the study were teenagers aged 15-18 years, students of Vocational School Yogyakarta, Indonesia. Data analysis was performed with IBM SPSS 16. Data analysis to assess the relationship between length and video game content with depression levels (Children’s Depression Inventory -2) used Independent student T-test analysis and linear regression analysis. Results: The study subjects consisted of 4.3% men and 95.7% women. There were no significant differences between subjects with male and female sex related to CDI-2 score, p> 0.05. The sexes of men and women have CDI-2 scores of 26.92 ± 5.02 and 26, 42 ± 3.32, respectively. There is a significant relationship between the intensity of playing video games with a CDI-2 score. Research subjects who had the intensity of playing video games for more than 2 hours a day had a higher mean CDI-2 score (28.62 ± 2.62, p <0.05) when compared to research subjects who played video games for less than 2 hours per day (26.13 ± 3.38, p <0.05). There was a significant relationship between video game content and the average CDI-2 score. Research subjects who played violent video games had higher CDI-2 scores (29.91 ± 2.07, p <0.05) when compared to groups who played video games with non-violent game themes (26, 29 ± 3.37 , p <0.05). Based on linear regression analysis, there is a relationship between the intensity of playing video games with the average CDI- 2 score (β = 1.87, SE = 0.72, p = 0.01). Meanwhile, for video game content there is no relationship between video game content containing violence and the average CDI-2 score (β = 1.91, SE = 1.21, p = 0.11). Conclusion: There is a relationship between the intensity of playing video games with the average CDI-2 score.
Co-occurring Toxoplasma Infection and Psychotic Symptoms: Case Report Carla R Marchira; Andrian F Kusumadewi; Patricia Wulandari
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (41.958 KB) | DOI: 10.37275/scipsy.v1i1.4

Abstract

Introduction: Schizophrenia is a neuropsychiatric disease that is global and is experienced by 1% of the population in the United States and Europe. This study raises awareness of the role of infectious agents in the initiation of psychotic symptoms in schizophrenia. Case presentation: A 20-year-old man is taken by the family to the emergency department because he has decreased consciousness, and the body suddenly stiffens. Patients begin to experience changes in behavior in the form of difficulty sleeping, when invited to talk quietly, laughing alone, and whispering without the other person. TORCH examination found an increase in anti-toxoplasma IgM and IgG. This patient is then given basic life support in the form of ABC (airway, breathing, circulation support) and seizure management. Also given risperidone 2 mg / 12 hours, pyrimethamine 1-II (1x200 mg), pyrimethamine day III-XXI (1x 25 mg), intravenous Cefotaxime 2g / 8 hours, Clindamycin 500 mg / 8 hours. The patient experienced improvement after the second week of treatment. Conclusion: Toxoplasmosis causes lesions in the brain that cause changes in brain neurotransmitter pathways, which lead to changes in patient behavior.
Comorbid of Obsessive-Compulsive Disorder and Schizophrenia: A Case Report Budi Pratiti; Jimmi Aritonang
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.855 KB) | DOI: 10.37275/scipsy.v1i1.1

Abstract

Introduction: Schizophrenia was a chronic mental disorder that is marked by abnormal social and impairment in reality testing ability. A person diagnosed with schizophrenia may experience a number of symptoms including hallucinations, delusions, disorganized thinking, bizarre speech, and behavior. Obsessive-compulsive disorder is well known as a comorbid of schizophrenia. Comorbid OCD will affect the treatment of schizophrenia and other mental disorder. Case presentation: A 14-year-old student Muslim boy from a rural household in Central Java, Indonesia who had 8 years of formal education and live with his parent was brought to the emergency department of a mental hospital by his parents who reported a one-year history of excessive washing of his body, soaking his body for hours in the bathtub and sleep in the bathroom. The patient first fell in January 2019; over a six-month period, he became progressively deteriorated, lost interest in his hobby, stopped going to school, and reduced his food intake. After one week treatment of with venlafaxine and risperidone, He became more cooperative and interactive with the examiner. At that time, the patient reported delusional beliefs about contamination and paranoid delusion, and there were several indications of formal thought disorder, including derailment, neologisms, concrete thinking, circumstantiality, and illogicality. An intelligence test revealed average intelligence (IQ=100). The total score of the Brief Psychiatric Rating Scale (BPRS) 3 dropped from 42 to 24, the score on the Yates-Brown Obsessive-Compulsive Symptoms (YBOCS)4 scale dropped from 24 to 18, and the score on the Global Assessment of Functioning scale (GAF)5 increased from 25 to 55. After discharge, the patient adhered to his medication regimen, and three months after discharge, his clinical improvement persisted; he was able to maintain his personal hygiene and take care of his daily needs, but he remained socially isolated and was unable to return to school. Conclusion: Obsessive-compulsive disorder and schizophrenia could happen together in one individual. The treatment should consider the underlying condition and cognitive function, especially if the patient is of productive age.
Evidence-Based Electroconvulsive Therapy for Major Depression Disorder Zahra D Khan; Carla Raymondalexas Marchira; Patricia Wulandari
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.242 KB) | DOI: 10.37275/scipsy.v1i1.2

Abstract

Electroconvulsive Therapy (ECT) is a treatment that steals medical attention and the public. Memory disturbance after ECT is a special consideration for the Food and Drugs Administration (FDA) of the United States to classify ECT, whether it belongs to class III (high risk). Psychiatrists or anesthesiologists (who are experienced with ECT) tend to change this classification, while neurologists, psychologists, biostatistics experts, and public representatives agree to maintain ECT status in class III. Contrary to unexpected effects, ECT can induce a transition in severe melancholic patients and suicide to normal functioning humans, after other treatments have failed. With the aim of balancing effectiveness and safety, this paper provides modern evidence of the benefits and risks of ECT.
Psychotic Symptoms Related Anti NMDA Receptor in Ovarian Teratoma Cecep Sugeng Kristianto
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.6

Abstract

Psychotic symptoms related ovarian teratoma are uncommon but has been well known in previous medical literature. Psychotic problems experienced by patients are often mistaken for psychological causes without organic causes, because commonly patients do not show symptoms associated with teratomas. Diagnosis of teratoma-related psychotic illnesses is often delayed due to the nature of the symptoms, that is leading to delayed treatment and worsen long-term neurological outcomes. Neuropsychiatric symptoms in teratoma can occur if it contains brain tissue inside and antibody anti-NMDA (N-methyl-D-Aspartate) receptor. The occurrence of psychotic symptoms in ovarian teratomas is based on cellular mechanisms. Antibodies bind to the NMDA receptor, which leads to the internalization of the cell surface and the relative state of the NMDA receptor hypofunction. While the impact of specific regions and circuit circuits of anti-NMDA receptor antibodies remains to be explored, the mechanism of anti-NMDA receptor encephalitis strengthens the hypothesis that NMDA receptor hypofunction may have a role in schizophrenia and psychosis.
Profile of Personality and Psychopathology Dimensions of Indonesian Medical Students who Failed in Medical Doctor Competency Exams (UKMPPD) Patricia Wulandari; Rachmat Hidayat; Carla R Marchira
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.7

Abstract

Introduction: Medical doctor competency exams (UKMPPD) in Indonesia is a final test that should be followed by medical student before being declared worthy of a medical doctor’s degree. This exam is certainly intended with good intentions, in order to improve the standards and quality of graduates of Indonesian doctors. However, each policy turns out to have two opposite sides of the situation, on the one hand it is profitable but on the other it often creates new problems. Students’ fear of the competency test often causes new psychological problems for students. No doubt the failure of the competency exam causes students to experience prolonged disappointment and sadness, which in turn will cause depression. This research is the first research that aim to present a description of personality and psychopathology dimension data from UKMPPD participants who failed the test. Method: This study was an exploratory descriptive study by presenting narratives of personality and psychopathology dimensions of unsuccessful UKMPPD participants. This research was conducted at the Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia. Each participant was assessed personality and psychopathology dimensions using MMPI-2 (Minnesota Multiaxial Personality Inventory-2). The results of analysis with MMPI-2 present data in the form of clinical psychic conditions, the work capacity, interpersonal relationships, the work abilities and the ability to change the self potential of the research subjects. Result: The research subjects were UKMPPD participants who did not successfully pass the first exam. From 7research subjects, there were 2 subjects who successfully passed the second exam (28.5%) and there were 3 people who successfully passed after the third exam (43%). Meanwhile, 2 research subjects have not successfully passed the UKMPPD exam until the fifth exam (28.5%). The results are quite surprising that of the 7 participants who failed to pass the UKMPPD exam, all of them felt depression. Conclusion: Medical students who experienced UKMPPD failures have an inability to develop their own potential which result in depression due to failure of the exam
Neuronal Cell Death Induces Depressive Disorder in Rats Depression-Like Behaviors Caused by Chronic Stress Rachmat Hidayat; Mgs Irsan Saleh; Nita Parisa
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.8

Abstract

Introduction: Depression is believed to be a disorder in which an increase in serotonin activity in the brain. This has implications for the development of various antidepressant drugs that work to increase serotonin levels, by inhibiting serotonin reuptake. However, management with antidepressants is still believed to be not optimal, there are still various problems that have not been able to be solved only by increasing serotonin levels in the brain. Therefore, it is necessary to do further exploration to find out other possible pathophysiology of depressive disorders. This study intended to explore the role of apoptosis of neuronal cells in the prefrontal cortex to answer the hypothesis that depression was not only caused by increased serotonin levels but also there was a role of dead neuronal cells in the prefrontal cortex which will trigger the body's homeostatic efforts to compensate by increasing serotonin levels. Methods: A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). Experimental animals were placed in cages under controlled conditions (12 hours of light / dark cycles with temperatures of 22 ± 1˚C and humidity of 40-60%), fed and drank ad libitum. Experimental animals with depression model were induced using Chronic Mild Stress (CMS). CMS procedures were performed with mild stressors such as repeated cold stress (4 ° C), space reduction in the homecage, changed cages and social interaction with other animals of the CMS group. To assess wether animal were being depression or not, the animal were tested using Forced Swimming Test (FST). After induction, rats were randomly divided into two groups which each contained 15 animals: the normal control group (not induced CMS) and the CMS group (negative control). Furthermore, the animal model was performed perfusion to maintain organ when evacuation was done, cell damage did not occur. To evaluate cell organ, immunohistochemistry examination and ELISA examination was performed. All data are presented as mean ± standard deviation and all statistical analyzes are performed with the SPSS 25 (IBM) program. Result: This research showed that CMS animal model has a greater duration of immobility than the normal group and serotonin level in CMS animal models decreased almost threefold compared to the normal group. In addition, there were increased expression of caspase-3 indicates that more neuronal cells suffered from apoptosis. So, in this research, it was clearly stated that in depressive disorder, there were elevation of neuronal cell apoptosis in the prefrontal cortex. Conclusion: Neuronal cell apoptosis in the prefrontal cortex plays a role in the pathophysiology of depression through activation of negative feedback on serotonin production.
Depression and Anxiety in Irritable Bowel Syndrome: A Literature Review A. Deza Farista
Scientia Psychiatrica Vol. 3 No. 3 (2022): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v3i3.50

Abstract

Irritable bowel syndrome (IBS) is a common and potential disabling functional gastrointestinal disorder. Studies have revealed a possible association between IBS and psychological problems, such as anxiety and depression. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. This review confirms the higher levels of anxiety and depression in patients with IBS; however, no specific subtype has been identified to be associated with higher psychiatric comorbidities compared to the others. The Best Management therapy for reduce anxiety and depression are Low-dose antidepressants and Psychotherapy.
Panic Disorder with Choking Phobia: A Case Report Patricia Wulandari
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.11

Abstract

Panic disorder is a form of anxiety disorder characterized by repeated panic attacks and preoccupied with worrying that a panic attack will occur. Panic attacks are characterized by fears of a disaster or loss of self-control even though there is really nothing to worry about. Other symptoms experienced during a panic attack are heart palpitations (similar to a heart attack), shortness of breath, feelings of suffocation, and the body feels weak. If this disorder is not detected early, it will affect the daily life of the patient. This case report presents the case of a 34-year-old woman who experiences symptoms of panic disorder with choking phobia that is managed with antidepressants and cognitive behavior therapy. In addition, there is discussion of differential diagnosis and the role of cognitive behavior therapy in handling this case.

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