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Scientia Psychiatrica
Published by HM Publisher
ISSN : -     EISSN : 27159736     DOI : https://doi.org/10.37275/scipsy
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience Public Health
Scientia Psychiatrica covers the latest developments in various fields of psychiatric : biological psychiatry, neuropsychiatry, child psychiatry, psychiatry of community, psychotherapy, drugs-related mental illness, psychiatry of geriatric, psychosomatics medicine, psychology, cultural psychiatry, military psychiatry, forensic psychiatry, consultation liaison psychiatry and all medicine fields related psychiatry. Genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact of psychiatry.
Arjuna Subject : Kedokteran - Psikiatri dan Kesehatan Mental
Articles 5 Documents
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Search results for , issue "Vol. 1 No. 1 (2020): Scientia Psychiatrica" : 5 Documents clear
Haloperidol and Risperidone Induce Apoptosis Neuronal Cell : Invivo Study Panserga, Ester G; Kristanto, Cecep S; Pratiti, Budi; Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.205 KB) | DOI: 10.37275/scipsy.v1i1.5

Abstract

Abstract Introduction Antipsychotics are drugs that are widely prescribed for mental disorders, such as schizophrenia and psychosis. Recent in vitro studies show antipsychotics play a role in the initiation of neuronal cell apoptosis. This study aims to determine the effect of haloperidol and risperidone on neuronal cell apoptosis in Wistar white rats. Methods Male wistar rats aged 8 weeks (n = 30) were used in this study. Wistar rats were randomized into 6 groups. Group A: 5 wistar rats as a control without induced schizophrenia, aquades and drugs. Group B: 5 Wistar-induced psychotic mice (using 30 mg / kgBB ketamine, intraperitoneal injection for 5 days) and aquadest. Group C: 5 rats were induced psychotic and were given haloperidol or 0.05 mg / kgBB orally, for 28 days. Group D: 5 mice were induced psychotic and were given haloperidol 0.1 mg / kg orally, for 28 days. Group E: 5 mice were induced psychotic and were given risperidone 0.05 mg / kgBB orally, for 28 days. Group F: 5 mice were induced psychotic and given risperidone 0.1 mg / kgBB orally, for 28 days. Apoptosis of neuronal cells in the ventral tegmental area was assessed by caspase-3 immunohistochemistry. The colored area will be calculated as a total percentage using the imageJ program. Results Risperidone and haloperidol increase caspase-3 activity, but haloperidol increases caspase-3 activity more than risperidone. Conclussion Risperidone and haloperidol induce apoptosis of neuronal cells and tardive dyskinesia in Wistar rats with psychotic models.
Video Game Increases Depression in Students Humries, Edith; Pratiti, Budi; Wulandari, Patricia; Hidayat, Rachmat
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.035 KB) | DOI: 10.37275/scipsy.v1i1.3

Abstract

Abstract Introduction The effects of exposure to violence in newspaper and electronic media to children and adolescents were being an awareness various parties, namely, researchers, health practitioners and policy makers. Depression is a mental problem that is always found due to exposure to video games. Method This study was an observational study with a cross-sectional research design. The subjects of the study were teenagers aged 15-18 years, students of Vocational School Yogyakarta, Indonesia. Data analysis was performed with IBM SPSS 16. Data analysis to assess the relationship between length and video game content with depression levels (Children’s Depression Inventory -2) used Independent student T-test analysis and linear regression analysis. Results The study subjects consisted of 4.3% men and 95.7% women. There were no significant differences between subjects with male and female sex related to CDI-2 score, p> 0.05. The sexes of men and women have CDI-2 scores of 26.92 ± 5.02 and 26, 42 ± 3.32, respectively. There is a significant relationship between the intensity of playing video games with a CDI-2 score. Research subjects who had the intensity of playing video games for more than 2 hours a day had a higher mean CDI-2 score (28.62 ± 2.62, p <0.05) when compared to research subjects who played video games for less than 2 hours per day (26.13 ± 3.38, p <0.05). There was a significant relationship between video game content and the average CDI-2 score. Research subjects who played violent video games had higher CDI-2 scores (29.91 ± 2.07, p <0.05) when compared to groups who played video games with non-violent game themes (26, 29 ± 3.37 , p <0.05). Based on linear regression analysis, there is a relationship between the intensity of playing video games with the average CDI-2 score (β = 1.87, SE = 0.72, p = 0.01). Meanwhile, for video game content there is no relationship between video game content containing violence and the average CDI-2 score (β = 1.91, SE = 1.21, p = 0.11). Conclusion There is a relationship between the intensity of playing video games with the average CDI-2 score.
Co-occuring Toxoplasma Infection and Psychotic Symptoms : Case Report Marchira, Carla R; Kusumadewi, Andrian F; Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (41.958 KB) | DOI: 10.37275/scipsy.v1i1.4

Abstract

Abstract Introduction Schizophrenia is a neuropsychiatric disease that is global and is experienced by 1% of the population in the United States and Europe. This study raises awareness of the role of infectious agents in the initiation of psychotic symptoms in schizophrenia. Case Presentation A 20-year-old man is taken by the family to the emergency department because he has decreased consciousness, and the body suddenly stiffens. Patients begin to experience changes in behavior in the form of difficulty sleeping, when invited to talk quietly, laughing alone and whispering without the other person. TORCH examination found an increase in anti-toxoplasma IgM and IgG. This patient is then given basic life support in the form of ABC (airway, breathing, circulation support) and seizure management. Also given risperidone 2 mg / 12 hours, pyrimethamine 1-II (1x200 mg), pyrimethamine day III-XXI (1x 25 mg), intravenous Cefotaxim 2g / 8 hours, Clindamycin 500 mg / 8 hours. The patient experienced improvement after the second week of treatment. Conclusion Toxoplasmosis causes lesions in the brain that cause changes in brain neurotransmitter pathways, which lead to changes in patient behavior.
Comorbid of Obsessive Compulsive Disorder and Schizophrenia: A Case Report Pratiti, Budi; Aritonang, Jimmi
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.855 KB) | DOI: 10.37275/scipsy.v1i1.1

Abstract

Abstract Introduction Schizophrenia was a chronic mental disorder that marked by abnormal social and impairment in reality testing ability. A person diagnosed with schizophrenia may experience amount of symptoms including hallucinations, delusions, and disorganized thinking, bizzare speech and behaviour. Obsessive compulsive disorder are well known as a comorbid of schizophrenia. Comorbid OCD will affect treatment of schizophrenia and others mental disorder. Case Presentation A 14-year-old student Muslim boy from a rural household in Central Java, Indonesia who had 8 years of formal education and live with his parent was brought to emergency department of mental hospital by his parents who reported a one year history of excessive washing of his body, soaking his body for hours in bathtub and sleep in bathroom. The patient first fell in January 2019; over a six-month period he became progressively deteriorated, lost interest in his hobby, stopped going to school and reduced his food intake. After one week treatment of venlafaxine and risperidone, He became more cooperative and interactive to the examiner. At that time, the patient reported delusional beliefs about contamination, paranoid delusion and there were several indications of formal thought disorder, including derailment, neologisms, concrete thinking, circumstantiality, and illogicality. An intelligence test revealed average intelligence (IQ=100). The total score of the Brief Psychiatric Rating Scale (BPRS) 3 dropped from 42 to 24, the score on the Yates-Brown Obsessive Compulsive Symptoms (YBOCS)4 scale dropped from 24 to 18, and the score on the Global Assessment of Functioning scale (GAF)5 increased from 25 to 55. After discharge the patient adhered to his medication regimen and at three months after discharge his clinical improvement persisted; he was able to maintain is his personal hygiene and take care of his daily needs, but he remained socially isolated and was unable to return to school. Conclusion Obsessive compulsive disorder and schizophrenia could happen together in one individual. The treatment should consider underlying condition and cognitive function, especially if patient in productive age.
Evidence-Based Electroconvulsive Therapy for Major Depression Disorder Khan, Zahra D; Wulandari, Patricia; Marchira, Carla Raymondalexas
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.242 KB) | DOI: 10.37275/scipsy.v1i1.2

Abstract

Abstract Electroconvulsive Therapy (ECT) is a treatment that steals medical attention and the public. Memory disturbance after ECT is a special consideration for the Food and Drugs Administration (FDA) of the United States to classify ECT, whether it belongs to class III (high risk). Psychiatrists or anesthesiologists (who are experienced with ECT) tend to change this classification, while neurologists, psychologists, biostatistics experts, and public representatives agree to maintain ECT status in class III. Contrary to unexpected effects, ECT can induce a transition in severe melancholic patients and suicide to normal functioning humans, after other treatments have failed. With the aim of balancing effectiveness and safety, this paper provides modern evidence of the benefits and risks of ECT.

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