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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 83 Documents
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Formulation and Antibacterial Activity of Citrus limon Peel Essential Oil and Eucalyptus globulus Essential Oil Combination as Gel Hand Sanitizer with The Simplex Lattice Design Method Muhammad Fariez Kurniawan; Rika Dwiaprinia
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.23539

Abstract

          Citrus limon peel essential oil (CLEO) and Eucalyptus globulus essential oil (EGEO) contain active compound limonene (CLEO) and 1,8-cineole (EGEO) which can act as an antibacterial agent. This study was conducted to determine the physical properties and the inhibition zone of combination formulas of CLEO and EGEO as hand sanitizer gel against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. The results of physical properties and antibacterial power obtained were tested by Simplex Lattice Design (SLD) method to formulate an optimal formula. The results of the physical properties showed that the formulas were in gel form, white ivory, the scent of F1 smell CLEO, the scent of F2 smell EGEO, and the scent of F3 smell the combination of CLEO and EGEO, visually homogeneous but under the microscope magnification 40x and 100x, it showed coarse grains, the values of pH were 5.07, 5.14, and 5.01, the values of spreadability were 5.81 cm, 6.12 cm, and 5.54 cm, the values of adhesion were 7.3 minutes, and 6.9 minutes, and 8.1 minutes, and the values of the viscosity were 171 dPa.s, 170 dPa.s, and 171.3 dPa.s. Antibacterial power tested by disc paper method, the results of antibacterial activity showed that the formula tested, showed that F1 100% CLEO, F2 100% EGEO, and F3 50% CLEO: 50% EGEO had antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. The inhibition zones of each formula in a row were: inhibition zones of F1 were 9.77 mm, 11.22 mm, and 11.77 mm, inhibition zones of F2 were 10.55 mm, 12.77, and 11.88 mm, and inhibition zones of F3 were 11.66 mm, 11.55 mm, and 10.55 mm. Based on the SLD, the optimal formula of hand sanitizer gel was 20% Citrus limon essential oil and 80% Eucalyptus globulus essential oil, with the pH value was 5.50 and adhesion value was 7.20 minutes, the zones of inhibition against S. aureus, E. coli, and P. aeruginosa were 19.99 mm, 12.22 mm, and 11.44 mm
ATR-FTIR Method for Detection of Cassava Impurities in Indonesian Commercial White Pepper (Piper nigrum L.) Based on Principal Component Analysis Aiyi Asnawi; Ajeng Fitriani; Ellin Febrina; Emma Emawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.24664

Abstract

White pepper (Piper nigrum L.) is one of the most popular flavourings targeted for adulteration, i.e., cassava, resulting in quality loss and infringement on consumer rights and interests. Because it is easy and quick cleanup, minimal sample preparation, and excellent performance with strongly or thickly absorbed samples, the Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) spectrum signal is widely used to measure commercial herbal products. Manipulation of the spectrum signal can be used to quantify a sample as well as reduce its dimensionality. As a result, there is a lot of interest in developing methods for detecting cassava in commercial white pepper (Piper nigrum L.). The aim of the research was to get an ATR-FTIR spectroscopic technique combined with chemometrics to detect cassava as an adulterant in commercial white pepper (Piper nigrum L.). The chemical profiles of white pepper (Piper nigrum L.) and cassava were compared using principal component analysis (PCA). Bangka, Sudu, and Pontianak were used to collect white pepper (Piper nigrum L.)  and cassava. White pepper (Piper nigrum L.) and cassava were macerated in 96 percent ethanol for 3×24 hours before being concentrated with a rotary evaporator until thick. Each extract's IR spectral was measured using ATR-FTIR spectroscopy in the 4000-650 cm-1range. In addition, the IR spectral was clustered using PCA in the R program. To obtain the appropriate PCA model, we applied two IR spectral manipulation procedures (normal and derivative IR spectra) of the pure material. The PCA chosen was of the normal IR spectral type, with PC1 and PC2 values of 82.3 percent and 7.5 percent, respectively.. The projection of three commercial samples from the markets revealed that samples A and B were negative for cassava adulterant, while Sample C was suspected to be positive. Finally, the ATR-FTIR spectroscopic method tandem PCA was successful in clustering the presence or absence of cassava content in the commercial of Indonesian White Pepper
Isolation and Identification of New Pigment From Monascus purpureus Anna Yuliana; Lina Rahmawati; Salsabila Adlina
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.24689

Abstract

This research was aimed to isolate and identify the new pigment from the main pigments of Monascus purpureus, which derive from five different isolates and through with solid fermentation used IR-64 rice as substrate. The measurement of pigment was done by extracting t samples using methanol in the 14th day of fermentation process. The absorbance of main pigment was measured by a UV-Visible spectrophotometer at the wavelengths of 364, 365, 375, 400, 480 and 500 nm. The results showed that the absorbance of each pigments isolate varied within ranges from 0.219 to 0.559. Result followed of Thin Layer Chromatography (TLC) method with chloroform: acetone (9: 1). TLC results were followed by isolating IPB-B samples using Thin Layer Chromatography- Preparative (TLC-P), whereas the band obtained was identified by using Liquid Chromatography-Mass Spectrum (LC-MS) instrument. The isolated and identified IPB-B samples showed that there was found a new compound of Molecular Weight (MW), which was Monaphilol A with Molecular Weight (MW) of 384.47.
Hair Growth Activity Test of Hair Tonic that Contain Combination of Green Tea Leaf Extract and Celery Leaf Extract Nursiyah Nursiyah; Romadhiyana Kisno Saputri; Akhmad Al-Bari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25003

Abstract

Hair loss is an abnormality where the amount of hair is less or more than normal with or without visible thinning. Excessive hair loss can lead to baldness. The prevalence of hair loss in women aged 14-28 years in Jakarta is 50%, and in Surabaya, it occurs in 53.3% of hijab users. One of the formulations that could be used to prevent hair loss is hair tonic formulations. Hair tonic is a cosmetic formulation that functions to stimulate hair growths, both in normal hair and in hair loss and baldness. Hair tonic can be developed from natural ingredients such as green tea leaves, celery leaves, or a combination of both. Green tea leaves contain epigallocatechin-3-gallate and flavonoids which have hair growth activity, while celery leaf (Apium graveolens L.) contain apigenin compounds that have hair growth activity. This research aims to formulation and evaluation of hair tonic contain ethanol extract of green tea leaves (Camellia Sinensis L.), celery leaf (Apium grave lens L.), and a combination of ethanol extract of green tea leaves (Camellia Sinensis L.) and celery leaf (Apium grave lens L.) in guinea pigs. This study is an experimental type of quantitative research with a true experimental design. laboratory and Completely Randomized Design (CRD). Hair tonic formulations were made with 6 formulations given to 6 groups of guinea pigs with a total of 4 guinea pigs in each group. The formulations used were negative control, positive control of celery leaf extract, positive control of green tea leaf extract, formulation of 1 green tea leaf 7,5% and celery leaf extract 2,5%, formulation of 2 green tea leaf 5% and celery leaf extract 5%, formulation 3 green tea leaf extract 2,5% and celery leaf extract 7,5%. Evaluation of hair tonic formulations was carried out by physical evaluation with organoleptic tests and pH tests. Evaluation of hair growths activity observed the hair growth of guinea pigs every 7 days for 28 days and measured it with a caliper. The results of the organoleptic test of organoleptically stable hair tonic formulations were assessed from the color, smell, and texture that did not change. The results of the pH test met the requirements for the skin's pH value of 4.5-6.5. The results of the hair growth test on hair tonic formulations showed that all formulations could grow hair in guinea pigs. Green tea leaves (Camellia sinensis L) extract, celery leaves (Apium grave lens L), and the combination of green tea leaves (Camellia sinensis L) extract and celery leaves (Apium grave lens L) extract can be formulated and used as hair growth in guinea pigs. The best grow hair fast formulation is a combination of green tea leaves extract: celery leaves extract is 2,5%:7,5%.
Histopathological Study of Streptozotocin Induced Liver Regeneration of Wistar Mice after Administration of Pumpkin Leaf Ethanol Extract Niluh Puspita Dewi; Windi Olivia Kawanga; Debora Rislianti Lakiu
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25115

Abstract

This study aims to prove that the ethanol extract of pumpkin leaf can improve the liver histological structure of Wistar rats streptozotocin and find out the effective dose in regenerating the liver cells of Wistar rats. Wistar rats were divided into six groups so that each group has five replications. The control group was not given the extract, and the treatment group was administered the extract with three doses of 125 mg/kg BW, 150 mg/kg BW, and 175 mg/kg BW which were carried out for three weeks. Rats were then sacrificed and the liver organs were taken for the histopathology preparations with Hematoxylin-Eosin staining (HE). The results showed fatty degeneration and necrosis of the livers. The results of the Mann-Withney test analysis showed that there was a significant difference in liver histopathology scoring from each treatment group. Ethanol extract  of pumpkin leaves at a dose of 150 mg/kg BW gave an effect on the  regeneration of liver cells of Wistar rats with a damage score of 1.4 and had no effective dose
Formulation of Film Soap Ethanol Extract Mesocarp of Red Watermelon (Citrullus lanatus) and Antioxidant Activity Test Noni Rahayu Putri; Tisa Mandala Sari; Rizki Aulia Wulandari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25172

Abstract

Film soap is soap in the form of a thin layer having a thickness of 100 - 500 µm made of foaming film and plasticizer. The advantages of paper soap preparations are convenient in use, hygienic, practical, and easy to carry anywhere. Mesocarp red watermelon is a part of watermelon that contains flavonoid compounds that have antioxidant activity. The purpose of this study was to formulate the film soap of red watermelon mesocarp extract and to determine its antioxidant activity. In this study, the formulation was carried out by making four formulas with varying concentrations of ethanol extract mesocarp of red watermelon F0 = 0%; F1 = 1.5%; F2 = 2% and F3 = 3%. The evaluation was carried out in the form of organoleptic examination, pH, foam power, weight uniformity, moisture content, thickness, irritation test, stability and antioxidant activity tests. The evaluation results of the film soap from the four formulas were pH 9.29 - 9.12; weight uniformity 0.125 - 0.134 grams, water content 16.80 - 16.30%; thickness 0.14 - 0.15 mm and physically stable. The antioxidant activity of each formula was seen from the value, namely  IC50F0 = 76.42µg / mL; F1 = 70.36 µg / mL; F2 = 65.14µg / mL; F3 = 62.14 µg / mL. From the research results, it can be concluded that the ethanol extract of red watermelon mesocarp can be formulated into film soap and has antioxidant activity which is included in the strong group.
Potential of Modified Cassava Starch as a Tablet Binder in Direct Compression Method Wira Noviana Suhery; Anita Lukman; Afriyanti Afriyanti
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25212

Abstract

Research on the potential of modified cassava starch as a binder for the direct compression method has been carried out. The use of modified cassava starch as a binder using six formulas with the drug model ibuprofen. Variations in the concentration of modified cassava starch were modified cassava starch 48 and modified cassava starch 72 were 15%, 17.5%, and 20%, respectively. The formula with a modified starch 72 concentration (15%) is the best formula that produced optimal tablets. The value of hardness was 5.3 kg/cm2, friability of 0.90%, and disintegration time of 2.06 minutes which are the main parameters of the binder
AKTIVITAS EKSTRAK HIBISCUS ROSA-SINENSIS L. DAN BACCAUREA RACEMOSA TERHADAP PERTUMBUHAN RAMBUT PADA ALOPECIA YANG DIINDUKSI STRESS Putu Indrayoni; Anak Agung Istri Mas Padmiswari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.27645

Abstract

Alopecia is the loss of excess hair that causes baldness, either temporarily or permanently. Physical and emotional stress are the most common causes. This study aims to determine the activity of H. rosa-sinensis L. and B. racemosa extracts on stress-induced hair growth in alopecia. Stress induction in male Wistar albino rats was obtained using the tail suspension test (TST) method. The results of the chemical content test were the total phenol content test (4,223.06 mg/100 g), total flavonoid (10,383.12 mg/100 g) and DPPH free radical reduction of B. racemosa (EB) extracts (1,593.17 mg/L GAEAC) were greater than those of the H. rosa-sinensis L. (EH) extract. The longest hair and highest hair density were obtained in the Minoxidil 2% group. While the most hair follicles were found in the group given the combination of EH and EB = 1: 1. The content of phenolic and flavonoid substances affects the hair growth activity. KEYWORDS: alopecia, stress, hibiscus, baccaurea, DPPH
Formulation Of Talas Leaf (Colocasia Esculenta) Emulgel As A Candidate Of Antibacterial Causes Of Bulbs: Formulation Of Talas Leaf (Colocasia Esculenta) Emulgel As A Candidate Of Antibacterial Causes Of Bulbs Maria ulfa; Radhia Reski; Muthiah Ridhayanah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.28964

Abstract

One of the plants that are used as a boil medicine by the community, especially the people of Papua, is taro leaves (Colocasia esculenta). Taro leaves have antibacterial activity against bacteria that cause boils (S. aureus) with a concentration of 5%. This research aims to obtain a taro leaf emulgel preparation that is physically and determine the effectiveness of taro leaf emulgel against bacteria that cause boils. Taro leaf extract with a concentration of 5% was made into an emulgel preparation using gelling agent carbopol 940. gelling agent carbopol 940 with various concentrations of 1%, 1.5%, and 2%. Then each formula was tested for its antibacterial effectiveness by the good diffusion method against boil-causing bacteria with a positive control of gentamicin cream. Data analysis was carried out by calculating the average of the inhibition zones for each concentration. Taro leaf emulgel formula (Colocasia esculenta) is stable physically and is FII using 1.5% gelling agent. Effectiveness test of taro leaf emulgel formula against boil causing bacteria (S. aureus), namely FI, FII, and FIII, with a resistance of 18.24, 18.99, and 17.58 in the strong category.
Solvent Optimization for Extraction Mesua ferrea L. Leaves As An Antioxidant Using Simplex Lattice Design Method Handa Muliasari; Luh Putu Intan Paramitha Sari; Aliefman Hakim
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29302

Abstract

Mesua ferrea L. leaves methanol extract has the highest antioxidant activity than the other part of the plant. However methanol is toxic solvent, so the using of methanol for extraction may harmful for health and environment. The purpose of this study was to optimize the solvent combination of ethanol and water for extraction of Mesua ferrea L. leaves by using Simplex Lattice Design (SLD) method. The samples were extracted by Ultrasonic Assisted Extraction (UAE) using variation of solvents ethanol 96%, ethanol 50% and water. The solvent combination was optimized by using SLD method based on the Total Phenolic Content of all crude extract. The result showed that the TPC of ethanol 96%, ethanol 50% and water crude extracts were 574.7±66.97 mgGAE/g, 657.8±37.02 mgGAE/g and 524.23±14.48 mgGAE/g respectively. SLD was calculated and the optimal solvent obtained was ethanol 55% with TPC of 626.235± 23 mgGAE/g. The ethanol 55% extract of Mesua ferrea L. leaves has strong antioxidant activity (IC50 57.77) ppm using DPPH method.

Page 6 of 9 | Total Record : 83

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