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Lalu Rudyat Telly Savalas
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telly@unram.ac.id
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INDONESIA
Acta Chimica Asiana
Published by Universitas Mataram
ISSN : 2550049x     EISSN : 25500503     DOI : -
Acta Chimica Asiana (online ISSN 2550-0503, print ISSN 2550-049x) is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles and short communication in all areas of Chemistry, including Chemical Education and Chemical Engineering. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal is published by the Himpunan Kimia Indonesia Cabang Nusa Tenggara (Indonesian Chemical Society, Nusa Tenggara Division). All papers published free of charge
Articles 5 Documents
Search results for , issue "Vol. 4 No. 2 (2021)" : 5 Documents clear
Physical Characteristics, Total Phenolic, and Flavonoid Content of Coccinia grandis (L.) Voigt Leaves Extract I Made Wisnu Adhi Putra; I Gusti Ayu Wita Kusumawati; Ni Luh Utari Sumadewi
Acta Chimica Asiana Vol. 4 No. 2 (2021)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v4i2.66

Abstract

Coccinia grandis (L.) Voigt is an herbal plant that has been widely used for the treatment of various types of diseases. The phenolic and flavonoid content of plant extracts largely determine their pharmacological activity. The aim of this study was to determine the total phenolic and flavonoid contents of the ethanol extract of C. grandis leaves. Leaf samples in this study were obtained in the area of ​​Dalung, North Kuta, Badung, Bali. The powdered C. grandis leaf was extracted by maceration method using 70% ethanol followed by evaporation using an oven at 45oC to obtain a thick extract. The non-specific parameters of the extract were then determined, such as moisture content, ash content, and acid insoluble ash. Total phenolic content was determined using the follin-ciocalteu method and total flavonoid content was determined using the aluminum chloride method. Based on the research results, the yield of C. grandis leaf extract was 19.36%. C. grandis leaf extract has a description of a thick and sticky extract, blackish brown color, distinctive aroma, and a bitter sour taste. The water content of the ethanolic extract of C. grandis leaves was 9.93±0.03% (g/g). The total ash value of the simplicia and ethanolic extract of C. grandis leaves were 20.76±0.15% (g/g) and 27.38±0.19% (g/g), respectively. The acid insoluble ash content of the extract was 4.05±0.30% (g/g). The total phenolic and total flavonoid contents of the extract were 111.92±0.49 µg GAE/mg dry extract and 73.60±3.53 µg QE/mg dry extract, respectively.
Molecular Study of Antiviral Compound of Indonesian Herbal Medicine as 3CLpro and PLpro Inhibitor in SARS-COV-2 Baiq Ressa Puspita Rizma; Yek Zen Mubarok; Dian Fathita Dwi Lestari; Agus Dwi Ananto
Acta Chimica Asiana Vol. 4 No. 2 (2021)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v4i2.74

Abstract

Rapid transmission of COVID-19 disease and the fatal effects of the disease lead researchers to use various way to find potential anti-COVID-19 compounds, including using modern approaches. Molecular docking is one of the methods that can be used to analyse antiviral compounds and its molecular target from Indonesian herbs that are believed to have properties as anti-COVID-19. This study aims to analyse antiviral compounds from 5 herbs that have the potential as inhibitors of PLpro and 3CLpro, which both are a non-structural protein in SARS-CoV-2 by molecular docking approach using PLANTS. Remdesivir triphosphate, the active metabolite of remdesivir, was used as the comparison compound in studies. The results showed docking scores obtained from interactions between natural ligands, remdesivir trifospat, curcumin, demetoksikurkumin, bisdemetoksikurkumin, luteolin, apigenin, kuersetin, kaempferol, formononrtin-7-O-glucoronide, androgafolide, and neoandrogafolide with PLpro are as follows -111,441, -103,827, -103,609, -102,363, -100,27,-79,6655, -78.6901, -80.9337, -79.4686, -82.1124, -79.1789, and -97.2452.Combination between quercetin, neoandrographolide, bisdemethoxycurcumin, demetoxycurcumin, and curcumin showed a synergy effect by reduce its docking score. Meanwhile its interaction with the protein 3CLpro showed docking score for those compounds as follows 64.0074, -86.1811, -81.428, -87.1625, -78.2899, -73.4345,-70,3368, -71.5539, -68.4321, -72.0154, -75.9777 and -93.7746.Combination between andrographolide, neoandrographolide, bisdemethoxycurcumin, demetoxycurcumin and curcumin, also shows synegy effect in 3CLpro allow them to reduce the docking score.This study concludes that curcumin was known as the most potent compound that act as a PLpro inhibitor based on a docking score of -103,609, while in 3CLpro all the compound have a potential to inhibit 3CLpro with demethosxycurcumin and  neoandrogafolide as the most potent compound with a docking score -87,126 and -93.7746.
The Microemulsion Stability of Virgin Coconut Oil Based on Tradition of Melala Sumbawa's Society Devi Ayu Septiani; Jono Irawan; Hermansyah Hermansyah; Yayuk Andayani
Acta Chimica Asiana Vol. 4 No. 2 (2021)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v4i2.75

Abstract

The Melala is a tradition of the Sumbawa people who use coconut milk to obtain Sumbawa oil for traditional medicine. Coconut milk is a colloidal system of stable oil in water (O/W) microemulsion. Within a particular time, the emulsion will split to produce oil (VCO), protein, and water due to the colloid equilibrium on the stability of the coconut milk emulsion. The purpose of this study was to compare the microemulsion stability of the coconut milk colloid system. The VCO was isolated by heating, enzymatically, acidifying, and adding whiting methods for comparison. The physical stability of the O/W microemulsion was measured by the volume of VCO produced from various isolation methods in simple laboratory experiments. The results showed that the physical stability of the O/W microemulsion on VCO isolation by enzymatic method using papain enzyme was the least.
Kinetic Study of Gas Formation in Styrofoam Pyrolysis Process I Dewe Ketut Anom
Acta Chimica Asiana Vol. 4 No. 2 (2021)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v4i2.76

Abstract

This research aims to study the reaction kinetics of gas formation in the pyrolysis of styrofoam waste. Pyrolysis of styrofoam waste without a catalyst takes place at a constant temperature of 180°C. In contrast, the pyrolysis of styrofoam waste by adding a zeolite catalyst took place at a constant temperature of 170°C. The amount of styrofoam waste used in this research sample is 200 grams, and the natural zeolite catalyst is 5 grams. Pyrolysis of styrofoam waste without using a catalyst form a gas at a constant temperature of 180°C, the kinetics of the reaction takes place on the zero-order. This result follows the Arrhenius equation K = Ae10617/RT with an activation energy value (Ea) of 1.27x103 kJ.mol-1. Pyrolysis of styrofoam waste by adding a zeolite catalyst to gas formation at a constant temperature of 170°C also takes place on the zero-order. The equation follows Arrhenius K= Ae4711,5/RT and the activation energy value (Ea) is 5.66x102 kJ.mol-1.
Environmental chemistry course assisted problem-based learning in developing students’ higher-order thinking skills and characters. Wildan Wildan; Supriadi Supriadi; Dwi Laksmiwati; Rizki Nur Analita
Acta Chimica Asiana Vol. 4 No. 2 (2021)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v4i2.54

Abstract

Character development and higher-order thinking abilities are crucial in environmental chemistry courses because they can motivate students to care about the environment. Environmental chemistry courses can benefit from a problem-based learning approach. Students learn to think critically and analytically, as well as locate and use relevant learning resources, through problem-based learning. This was a quasi-experimental study that used a pre-test post-test design. The goal of this study was to describe how problem-based learning was implemented in environmental chemistry classes and how it influenced the development of higher-order thinking abilities and student personalities. Data was gathered through an essay test that required higher-order thinking skills, and students' personalities were determined through an inventory. ANOVA statistics were used to evaluate the data. The stages of concept presentation, presentation of factual problems in various forms, group discussions, and class discussions were used to implement problem-based learning in the Environmental Chemistry course; (2) problem-based learning can significantly improve students' higher-order thinking skills and characters; and (3) high-order thinking skills contribute significantly to character development.  

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