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JURNAL PENELITIAN FARMASI & HERBAL
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 124 Documents
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EFEKTIVITAS EKSTRAK ETANOL DAUN EFEKTIVITAS EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS JANTAN GALUR WISTAR HIPERURISEMIA Bunga Rimta Barus
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.315

Abstract

Sidaguri leaves (Sida rhombifolia L.) Have been shown to contain flavonoid compounds, where they are efficacious as hyperuricemia. This study aims to determine effectiveness ethanol extract of sidaguri leaves as antihyperuricemia in white rats. The study was conducted using the method of potassium oxanate induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of sidaguri leaves 50 mg / kg body weight, group II ethanol extract of sidaguri leaves 100 mg / kg body weight, group III ethanol extract of sidaguri leaves 200 mg / kg body weight for 5 hours. Examination of antihyperuricemia effects is done by comparing the uric acid levels value of the rats before and after treatment. The results of this study indicate that the three dose ethanol extract of sidaguri leaves provide an antihyperuricemia effect and based on one-way Anova, Tuckey and LSD data analysis, shows that the dose of 50 mg / kg body weight is effective as antihyperuricemia and does not have a significant difference (p> 0.05). The conclusion of this study is that the dose is the most effective in decreases uric acid levels in white rats, which is a dose of 200 mg / kg body weight because it mostly decreased uric acid levels.
FORMULASI OBAT KUMUR GAMBIR DAN UJI EFEKTIVITAS TERHADAP BAKTERI Staphylococcus aureus Zola Efa Harnis
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.316

Abstract

Oral hygiene and dental health are very important, there are various kinds of patogen bacteria in the oral cavity, including the bacteria that cause thrush, Staphylococcus aureus. Gambir is the result of extraction containing polyphenol compounds. The main components contained in gambir consist of alkaloids, flavonoids, tannins and saponins. The use of gambir as a mouthwash preparation is an alternative to replace mouthwash preparations which generally contain an antiseptic in the form of alcohol which can trigger oral cancer. This research is to formulate gambir as a mouthwash and determine the differences in the effectiveness of antibacterial on the growth of Staphylococcus aureus with variations in the concentration of 5%, 10%, 15%. Antibacterial activity test using NA media with agar diffusion method. Physical requirements tests include organoleptic tests, pH tests and viscosity testsshowed that the preparation of 5%, 10% and 15% gambir mouthwash had a pH outside the optimum bacterial growth range of 5. Viscosity of mouthwash preparations of 1.30-5.10 Cp. The antibacterial activity of Staphylococcus aureus in F1 did not produce inhibitory zones, F2 was 5.46 mm, F3 was 9.60 mm and F4 was 10.76 mm while in f5 the positive control was 12.10 mm. Conclusio of this study is gambier mouthwash concentration of 5%, 10% and 15% can inhibit the growth of staphylococcus aureus bacteria.
EFEKTIVITAS SALEP KOMBINASI EKSTRAK DAUN BANGUN – BANGUN (Coleus amboinicus Lour.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI OBAT LUKA SAYAT Rika Puspita Sari
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.317

Abstract

Bangun-bangun leaves and palm leaves contain various secondary metabolites such as tannins, alkaloids and flavonoids which can healing wound. The aim of this study was to determine the effect of ointment combination of ethanol extract of leaves of bangun- bangun (Coleus amboinicus Lour.) And ethanol extract of palm leaves (Elaeis guineensis Jacq.) In healing wound. The bangun- bangun leaves and the palm leaves are separated from the petiole and then dried in a drying cupboard so that it becomes a simplisia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. Thick extracts from the leaves of bangun- bangun and palm leaves are then formulated into ointment preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Next mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using surgical scissors that have been sterilized first with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 23 experienced changes in wound diameter. The combination ointment of ethanol extract of leaves wake-up (EEDB) 10% and ethanol extract of palm oil leaves (EEDKS) 10% have a more effective effect in wound healing than single dose.
EFEK PENYEMBUHAN LUKA BAKAR GEL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia Amygdalina) DAN EKSTRAKETANOLDAUNBANGUN–BANGUN(ColeusamboinicusLour) Nina Irmayanti Harahap
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.318

Abstract

african leaves ( Vernonia Amygdalina )and wake-up leaves (Coleus amboinicus Lour)are plants traditional plants that are used as medicine. Leaves african which is contain flavonoid, saponin, tanin and leaves wake up which is contain flavonoid, tanin, saponin and steroid. This study to find aims out as effect healing of burns.Method : Sample in this study was african leaves and wake-up leaves which were taken purposively without comparing sampel from other regions, then extrated by maceration using ethanol 96 %. Result : Testing of rhe healing effects of burns can be divided in five treatment, positive group using biolacenton , negatif group using basis gel and the last group using the extract ethanol gel EEDA and EEDB concentrations of 4%+2,5%,8%+5%,16%+10%. Given burns to the back of rabbits length with of 2cm, and the gel is applied twice a day for 11 day and diameter measured of the wound. Conclusion : The combination of EEDA and EEDA the ethanol extract the concentration of 16% + 10% was the effective control for healing burns. When compared bioplacenton gel as a healing wound in rabbit.
UJI EFEKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN BANGUN-BANGUN (Coleus amboinicus L.) DAN DAUN KELAPA SAWIT (Elaeis guieensis Jacq) SEBAGAI OBAT LUKA BAKAR TAHUN 2020 Evi Depiana Gultom
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.320

Abstract

Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain various secondary metabolites such as saponins, tannins, alkaloids and flavonoids that function in wound healing. The purpose of this study was to determine the healing effect of burns using a gel preparation combination of ethanolic extract of Coleus amboinicus L. (EECAL) And ethanolic extract of Elaeis guineensis Jacq. (EEEGJ) In healing burns. Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain are separated from the petiole and then dried in a drying cupboard so that it becomes a simplicia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. EECAL and EEEGJ are then formulated into gel preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Then mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using a hot iron plate that has been sterilized beforehand with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 20 experienced changes in wound diameter. EECAL 15% and EEEGJ 10% have a more effective effect in healing of burn than in their single form.
EFEKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN EKSTRAK ETANOL DAUN KELAPA SAWIT(Elaeis guineensis Jacq.)TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH Rani Ardiani
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.321

Abstract

African leaves (Gymnanthemum amygdalinum Del.) And palm oil leaves (Elaeis guineensis Jacq.) Have been shown to contain flavonoid compounds, where they are efficacious as antidiabetic. This study aims to determine the combined effectivenessof ethanol extract of African leaves and palm oil leaves as antidiabetic in white rats.The study was conducted using the method of alloxan induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of african leaves and oil palm leaves 25 + 25 mg/kg weight, group II combination of ethanol extract of african leaves and palm oil leaves of 50 + 50 mg/kg weight, group III combination of ethanol extract of African leaves and leaves of oil palm 100 + 100 mg/kg weight for 15 days. Examination of antidiabetic effects is done by comparing the KGD value of the rats before and after treatment. The results of this study indicate that the three doses have antidiabetic effects. Data on the differences in the KGD of rats were carried out statistically using the Shapiro Wilk normality test and the Levene homogeneity test and continued with the ANOVA test. The conclusion of this study is that the dose is the most effective in reducing blood glucose levels in rats, which is a dose of 100 + 100 mg/dl because it mostly decreases blood glucose levels.
PEMBUATAN SEDIAAN BALSEM STICK DARI SEREH (Cymbopogon citratus (DC.) Stapf) SEBAGAI AROMATERAPI okto purba
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.326

Abstract

Introduction: Lemongrass plants contain essential oils that can be used as aromatherapy. In the context of efforts to improve public health services in Indonesia, traditional medicine has the opportunity as one of the potential alternative treatments. Society uses traditional medicine in the form of herbal medicine, stew, juice or by rubbing directly on the affected part. Method: Sample in this study was African leaves and palm leaveswhich were taken purposively without comparing samples from other regions, To get the essential oil of lemongrass done by distillation. Result: Aromatherapy balm from essential oil is formulated with some concentrations of 0%, 15%, 20% and 25% of the evaluation of balm which has been done to 3 qualified balm formulas and has good physical quality. Concludes: Citronella essential oil can be made into a supply of balm stick with various concentrations, namely 15%, 20% and 25%. Stick balm made from essential oils of lemongrass can give an aromatherapy effect which is characterized by a refreshing aroma when inhaling the balm preparations and can provide a warm sensation. The best concentration as an aromatherapy stick balm preparation is 25% because it gives the highest aroma and test preferences.
PERBANDINGAN EFEK PENYEMBUHAN LUKA BAKAR ANTARA GEL EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.)DENGAN GEL EKSTRAK ETANOL DAUN KELAPA SAWIT ( Elaeis guineensis Jacq.) SERTA KOMBINASINYA PADA KELINCI TAHUN 2019 Suventi Syafrina Ginting
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.327

Abstract

African leaves (Gymnanthemum amygdalinum Del.) And palm leaves (Elaeis guineensis Jacq.) Have secondary metabolites, namely alkaloids, steroids / terpenoids, flavonoids, tannins, and saponins in this study aimed to determine the effectiveness of healing burns. The extract was made by maceration method using 96% ethanol. This test used 3 rabbits, each of which had been burnt into 6 wound areas on the back of the rabbit. First group (positive control), second group (without treatment), third group gel with Arfika leaf ethanol extract concentration of 5%, fourth group gel with palm ethanol extract concentration of 7.5%, fifth group of groups gel with a combination of Arfika leaf ethanol extract concentration of 5% and 7.5% palm oil leaf ethanol extract The burns that have been made are smeared with as much test preparation as possible once a day. The next day the diameter of the wound was measured, then smeared with an adequate amount of gel. This is done until the diameter of the wound is equal to zero or the wound has been covered by new tissue. The results of testing the effectiveness of healing burns showed that all treatment groups had a faster recovery day compared to negative controls. The conclusion of this study is the combination of 5% arfika ethanol extract gel and 7.5% oil palm leaf ethanol extract is the group with the fastest fastest day on the 19th day.
PERBANDINGAN EFEKTIVITAS EKSTRAK DAN JUS BUAH BIT (Beta vulgaris L.) TERHADAP PENURUNAN KOLESTEROL TIKUS PUTIH Linda Margata; Dewi Sartika Br Haloho; Parhan Parhan
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.330

Abstract

Kandungan pada buah bit diketahui mampu menurunkan kolesterol dengan cara menghambat pembentukan asam glutarat. Penelitian ini bertujuan untuk membandingkan efek penurunan kolesterol ekstrak dan jus buah bit pada tikus putih. Penelitian ini menggunakan 24 ekor tikus yang dibagi menjadi empat kelompok. Pada penelitian ini tikus diinduksi dengan propiltiourasil (PTU) selama 10 hari lalu masing-masing kelompok diberikan: CMC Na, simvastatin, ekstrak buah bit, dan jus buah bit selama 15 hari. Data penelitian diolah dengan program SPSS menggunakan ANAVA satu-jalur dengan signifikansi 0,05. Kolesterol total sebelum perlakuan pada jus buah bit yaitu 306 mg/dl dan pada ekstrak 311 mg/dl. Kadar kolesterol total setelah perlakuan yaitu 103 mg/dl pada jus dan 148 mg/dl pada ekstrak. Pemberian ekstrak buah bit dan jus buah bit secara signifikan berpengaruh terhadap penurunan kadar kolesterol total. Pemberian ekstrak dan jus buah bit dapat menurunkan kadar kolesterol tikus putih.
UJI EFEKTIVITAS ANTIDEPRESAN EKSTRAK BATANG SERAI (Cymbopogon nardus (L.) Rendle) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) Delisma Simorangkir
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.331

Abstract

Depression is a mood disorder that is characterized by profound and sustained sadness and sadness until the loss of life passion. Lemongrass which contains eugenol is thought to have the potential as an antidepressant that works by inhibiting the Mono Amine Oxidase enzyme. This study aims to determine the effectiveness of antidepressant citronella extract (Cymbopogon nardus (L.) Rendle) on male white mice. This study used 5 treatment groups namely CMC Na 0.5%, amitriptilyn, lemongrass extract dose 1.5 mg/kgBB, 15 mg/kgBB and 150 mg/kgBB. Antidepressant testing was determined based on immobility time using the forsed swim test method. Data analysis using statistics was tested for normality and continued with the One Way Anova method with a 95% confidence level. The results showed that the most effective treatment group as an antidepressant was amitriptilyn followed by lemongrass extract dose 150 mg/kgBB. The conclusion of this study is that lemongrass extract dose 150 mg/kgBB has the effectiveness as an antidepressant but is no more effective than the comparison of amitrip

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