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Indonesian Journal of Pharmacology and Therapy

JPT
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Published by Universitas Gadjah Mada

ISSN : - EISSN : 2745455X DOI : https://doi.org/10.22146/ijpther.4468

Core Subject : Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Neuroscience

Indonesian Journal of Pharmacology and Therapy (IJPTher ) is a scientific journal which managed by Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada. IJPTher is an open-access, and double-blind peer-reviewed journal published twice Issues a year. IJPTher aims to communicate high-quality articles in the fields of pharmacology. IJPTher publishes original articles, review articles, case reports and book reviews in the fields of pharmacology including basic pharmacology, clinical pharmacology, pharmacotherapy, pharmacoepidemiology, pharmacogenetics, pharmacogenomics, pharmacoeconomic, toxicology and toxicogenomics.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 58 Documents

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Drug-related problems (DRPs) on antibiotic therapy in pediatric patients: a review Arina Titami; Juniarto Mende; Nurfina Dian K.
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Drug-related problems (DRPs) is event that can interfere with the outcome of therapy. It can occur in various patient populations and ages. The DRPs in pediatric patients is found to be significantly frequent due to their vulnerable features. Many factors such as age, weight, body surface area should be considered during drug therapy in pediatric patients. The organs development continues for many years and the organs responsible for drug metabolism and elimination have not yet full capacity in pediatric patients. Antibiotics are often prescribed to pediatric patients. Several studies concerning DRPs on antibiotic therapy have been conducted in some countries. This review summarizes types, factors and impacts to the occurrence of DRPs on antibiotic therapy in pediatric patients.

Drug-related problems (DRPs) in geriatric patients with type 2 diabetes mellitus (T2DM): a review Lathifa Nabila; Sundas Ejaz; Shalahuddin Al Madury
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Asthma is an inflammatory airway disease characterized by bronchial hyper-responsiveness, reversible airflow limitation, and respiratory symptoms. Asthma affects 300 million people in developed countries. More than 10% of asthma complaints in children occur at school age. Asthma therapy in children using pharmacological agents is still the main choice until now. However, the response of pediatric patients to asthma treatment varies. In addition to age, organ function, and drug interactions, genetic factors are often associated with drug response variability. This variability can occur due to single nucleotide polymorphisms (SNP) in protein-coding genes that play a role in bioavailability and drug response. Understanding of pharmacogenomics as the basis of individualized medicine aims to avoid adverse drug reactions and maximize drug effectiveness. The existence of genetic variation allows the drug response between individuals to be different. Pharmacogenomics provides important information in individual-based medicine so that it can predict the existence of a population that can respond well to certain drugs and a population that has a higher risk of adverse drug reactions. Implementation of individual treatment can optimize treatment in patients because the dose of treatment and therapeutic options have been adjusted based on individual genetic characteristics.

Anticoagulant use to treat VTE (venous thromboembolism) in pregnancy: a review Ayuningtyas Galuh Purwandityo; Muhammad S. Finnegan; Mukarromah D. Putri; Muya Saroh; Nindita Rachmania; Riandita G. Putri
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a medical condition that occurs when a blood clot forms in a deep vein that major cause of pregnancy-related maternal death. As pregnancy progresses, the risk of hypercoagulability increases, fibrinogen, factors VII, VIII, X and VWF (Von Willebrand Factor), plasminogen activator inhibitor-1, plasminogen activator inhibitor-2 are increases and 40-60% protein S decreases. Therefore, anticoagulant drugs are the mainstay of therapy for patients with VTE. The review aimed to select the best anticoagulant for pregnancy women with VTE. A scoping review was used. The type of articles reviewed were original articles obtained from four electronic journal databases published within 2012-2021. The main therapeutic agent recommended for use in the prevention and treatment of VTE in pregnancy is low molecular weight heparin (LMWH). LMWH has better bioavailability than other anticoagulants, has a lower risk of maternal bleeding, thromboembolic, thrombocytopenia and osteoporosis. The use of LMWH is actually better, more comfortable and safety for patients.

Antibacterial activity of ethanolic extract of Averrhoa bilimbi L. fruit against Salmonella typhi Ni Made Riris Divayani Aristyantari; Ni Ketut Ayu Juliasih; Ni Luh Gede Sudaryati; I Nyoman Arsana
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Averrhoa bilimbi L. fruit has been used in Bali traditional medicine to treat typhoid fever. The fruit contains flavonoids and triterpenoids which are considered to have antibacterial activity. This study aimed to investigate antibacterial activity of ethanolic extract of A. bilimbi L. fruit. The ethanolic extract was prepared by maceration and antibacterial activity was determined by the disc diffusion method against Salmonella typhi cultured on Mueller hinton agar (MHA). Ciprofloxacin was used as positive control and sterile distilled water as negative control. The results showed that the ethanolic extract of A. bilimbi L. fruit at various concentrations of 25; 50; 75 and 100% have an inhibition zone diameter of 0 ± 0; 13.000 ± 1.414; 18.750 ± 1.500 and 20.250 ± 1.707 mm, respectively. In addition, ciprofloxacin at concentration of 1 mg/L has an inhibition zone diameter of 34.250 ± 1.892 mm. In conclusion, the ethanolic extract of A. bilimbi L. fruit has strong antibacterial activity against S. typhi.

Knowledge of hypertension and its therapy in lay people Abraham Simatupang; Fransiska Sitompul; Linggom Kurniaty; Mulyadi Djojosaputro; Romauli Lumbantobing; Hertina Silaban
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Hypertension is one of the non-communicable diseases that is becoming a global health problem. Hypertension can be identified by systolic blood pressure of 140 mmHg and diastolic 90 mmHg . Uncontrolled hypertension can lead to complications such as stroke, ischemic heart disease, heart attack, heart failure, kidney failure, blindness, etc. According to Basic Health Research 2018 ( Ris et Kesehatan Dasar 2018/Ris kesdas 2018) the prevalence of hypertension for >18 years old wa s 8.4%, and through measurements taken in health care facilities by 34.1%. Prevalence in the city was 34.4%, in the village was 33.7%, while according to gender 31.3% f or male and 36.9% for female. The study aimed to find out the knowledge and awareness of laypeople on hypertension and its therapy. This was a cross-sectional online study with 11 questions. Respondents were recruited from social media groups. The results showed 5 00 respondents (62.8 % female and 37.2 % male) involved in this study . The most common age range was 21-40 years (36.2 %), followed by 41-55 years (38.2%) , and the least was 56-65 years old (18.4%). Seventy-two percent of respondents did not have hypertension, and 9% said they did not know. Fifty-three percent of respondents knew about the value of high blood pressure, and 89% of the respondents said hypertension should be treated regularly. The most hypertension complications answered by respondents were stroke (40%), heart attack (26%) , and heart failure (16%). Amlodipine was the most mentioned by the respondents, and the second was ACE-inhibitor. However, omeprazole and omega-3 were also mentioned as anti-hypertension. Genetic s and a high salt diet were risk factors that many respondents chose. In conclusi on, the r espondents have a good understanding of hypertension. Information related to behaviour is needed to discontinue the increasing prevalence.

The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report Sjarif Ismail; Ika Fikriah; Nataniel Tandirogang; Khemasili Kosala
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

The hepatitis B virus (HBV) causes acute and chronic liver infections which can be treated by using interferon and antiviral. However, the treatment is relatively expensive. We reported here a case of a patient with chronic hepatitis B who had negative seroconversion without interferon (IFN) and antiviral treatment after herbal consumption. A retrospective investigation showed that the patient consumed Curcuma xanthorrhiza rhizome and Camelia sinensis green tea. These herbs were widely both in vitro and in vivo studied for their effects against HBV infection, although the clinical studies are limited. This case reported the effect of C. xanthorrhiza rhizome and C. sinensis green tea consumption in a patient with chronic hepatitis B. A female patient with chronic hepatisis B infection at the age of 32 y.o. had been taking neuro vitamins regularly for a year before infection detected. She was an asymptomatic patient with normal limits liver function, positive HBsAg and negative anti-Hbs. At the age of 45, she started taking C. xanthorrhiza rhizome simplicia equivalent to 5mg of curcumin twice daily and drinking C. sinensis green tea regularly. Six years later, HBsAg was not detected and her liver function remained within normal limits and Anti-HBs were detected 5 years later. In conclusion, the consumption of C. xanthorrhiza rhizome and C. sinensis green tea can against chronic hepatisis B infection by eliminate HBV dan induce anti-HBs.

Current Update of Pharmacogenomic in Drug Discovery and Development : A narrative review Elvia Rahmi Marga Putri; Istifarwati; Isvina Unai Zahroya
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Pharmacogenomics currently has an essential role in drug discovery and development. Research related to pharmacogenomics has increased rapidly since the human genome project was completed in the early 20th century, increasing awareness of the importance of personalized medicine, which is expected to be safer and more beneficial for human health. Therefore, this article aims to review recent developments regarding pharmacogenomics in drug discovery and development. In addition, this article will also discuss the challenges that still exist in the implementation of pharmacogenomics in drug development and clinical practice. It is hoped that these challenges can be overcome in the future with collaboration between researchers, practitioners, and the government so that precision and personalized therapy can be realized for each individual. Keywords: drug discovery, drug development, pharmacogenetic, pharmacogenomic

Total flavonoid content and analgesic activity of ethyl acetate fraction of Indian jujube (Ziziphus mauritiana lamk) leaves Priska Ernestina Tenda; Fatmawati Blegur; Lely A.V Kapitan
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Indian jujube leaves (Ziziphus mauritiana Lamk) have various potential biological activity. Previous studies have proven that ethanol extracted from Indian jujube (Z. mauritiana Lamk) leaves had analgesic activity. This study aimed to determine the total flavonoid content and analgesic activity of the ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves ethanol extract. Tested fraction was prepared by maceration using ethanol as solvent followed by fractionation using ethyl acetate. Identification of active compounds was performed using color reaction, and determination of total flavonoids by colorimetric method. Ethyl acetate fraction was further tested for its analgesic activity using the writhing method. Swiss-Webster white male mice were divided into 5 treatment groups consisting of negative control contained sodium-CMC, positive control contained sodium diclofenac, while groups 3-5 were given ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves with doses of 50, 150, and 200 mg/kg BW. All interventions were administered as a single oral dose. 0.7% (w/v) acetic acid was used as a pain inducer. Analgesic activity was measured by calculating the percentage of writhing protection as a measure of the analgesic effect produced by each intervention. The data were analyzed using one-way Anova to compare analgesic activity between treatment groups. Results showed that ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves at doses of 50, 150, and 200 mg/kg BW gave an effect that was not significantly different from sodium diclofenac as positive control. The ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves ethanol extract contained flavonoids, saponin, and tannins with total flavonoid content of 22.41 ± 1.16% w/w. It can be concluded that the ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves have analgesic activity in mice.

Safety profile between fluoxetine and sertraline as antidepressants for pregnant women with depression disorder Dewa Ayu Sri Handani; Maria Sri Ayu Mustikawati; Ni Putu Parwatininghati; Zulkarnaen; Jusnita Akuba
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Depression disorders are common in women of productive age, especially during pregnancy and peripartum period. Making a decision on the choosing of antidepressants is associated to the biggest concern about the risk of birth defects and major anomalies of their exposure. Decisions of antidepressant use not only involve considering the risks of medications exposure, but also the risks of untreated depression during pregnancy. Evaluation of the safety profile of selective reuptake inhibitors (SSRIs) which are commonly prescribed during pregnancy therefore urgently needed. This review aimed to compare two widely used SSRIs i.e. fluoxentine and sertraline as antidepressants for pregnant women with depression disorder. It is found that sertraline has more positive effects and more safe. Sertraline is well tolerated in pregnant women and breastfeeding mothers with depression disorder.

Asthma in pregnant woman and its management : a review Farni Yuliana Pratiwi; Hadiatussalamah; Intan Adevia Rosnarita; Yuda Anzas Mara; Novia Ariani Dewi
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Asthma is the most common comorbidity in pregnant women and gives 30% of exacerbation experience. The other 30% will see improvement of their symptoms, and the rest will not see the changes. Exacerbations have become a major clinical concern in pregnant women. Medical concerns for the mother and the childbirth included low birth weight, preeclampsia, and preterm delivery. The major goal is to keep asthma under control to ensure mother's health and well-being, as well as fetal growth. Controlling asthma and preventing exacerbations are the main goals of asthma treatment during pregnancy. Treatment for asthma should ideally begin before conception. This is to avoid day-time and night-time symptoms, as well as to keep lung function. Furthermore, fetal oxygenation is a crucial factor during the pregnancy. With a few exceptions, asthma drugs are basically the same in pregnancy as they are in non-pregnant people. Inhaled corticosteroids (ICS) are often used as a controlling treatment. Budesonide is the recommended ICS. Short-acting β-agonist (SABA) preferable as reliever in acute asthma and to relieve exacerbation. As an add-on therapy for medium to high dose ICS, long-acting β-gonists (LABA) is often used. Virus infections and ICS nonadherence are the two most common causes of asthma exacerbations during pregnancy.

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Home Page

OAI Link

Editorial Team

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Contact Name Nurhadiyahya

Contact Email nurhadiyahya@ugm.ac.id

Phone +6289672800034

Journal Mail Official ijpther@ugm.ac.id

Editorial Address Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

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Abstract

Contact Name
Nurhadiyahya

Contact Email
nurhadiyahya@ugm.ac.id

Phone
+6289672800034

Journal Mail Official
ijpther@ugm.ac.id

Editorial Address
Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA