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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 124 Documents
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Pengaruh Konsentrasi Asam Stearat Terhadap Mutu Fisik Losion Ekstrak Daun Nangka (Arthocarpus heterophyllus) Sebagai Antioksidan Natasya Sava Agasta; Siti Aisiyah; Mamik Ponco Rahayu
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.173

Abstract

Jackfruit leaf extract was developed into a lotion preparation to increase skin moisture and prevent the skin from being exposed to free radicals.  The purpose of this study was to determine the effect of variations in stearic acid base on physical quality, differences in antioxidant activity in jackfruit leaf extract and preparations, best formula that can provide antioxidant activity.Jackfruit leaf extract was obtained by maceration using 70% ethanol and then formulated with a concentration of 6% jackfruit leaf extract and variations in stearic acid base 2%, 3%, and 4%. This study used the DPPH method to determine antioxidant activity and ANOVA for statistical analysis.  This study obtained the IC50 value of jackfruit leaf extract of 64.5616 ppm. Variations of stearic acid have an effect on the physical quality and value of antioxidant activity. The IC50 value of jackfruit leaf extract and lotion was different due to the presence of additional ingredients in the lotion.  The best formula from this research, formula has the best physical quality value, with the IC50 value of the extract in the formula 70.6862 ppm and the IC50 value of the base in the formula 1179.3357 ppm. 
SINTESIS OKTIL SINAMAT DENGAN METODE SONOKIMIA DAN POTENSINYA SEBAGAI ANTIKOLESTEROL Erlita Verdia Mutiara; Achmad Wildan; Yustisia Dian Advistasari; Erwin Indriyanti
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.178

Abstract

Derivat asam sinamat memainkan peran yang sangat penting dalam sintesis senyawa-senyawa penting lainnya dan sebagai prekursor untuk sintesis ester sinamat. Ester sinamat  memiliki bioaktivitas yang beragam. Golongan ini memiliki aktivitas antioksidan, hepatoprotektif, antiinflamasi, anxiolitik, penolak serangga, antidiabetik dan antikolesterol. Oktilsinamat merupakan derivat asam sinamat diduga berkhasiat sebagai penurun kadar kolesterol. Kolesterol telah dikenal sebagai penyebab utama terjadinya proses aterosklerosis, yaitu proses pengapuran dan pengerasan pembuluh darah. Akibat proses ini saluran pembuluh darah, khususnya pembuluh darah koroner menjadi sempit dan menghalangi aliran darah.. Oktilsinamat telah berhasil disintesis dari reaksi esterifikasi antara asam sinamat dan n-oktanol dengan katalis asam sulfat pekat. Metode sonokimia merupakan salah satu metode yang dikembangkan dalam proses sintesis ini karena sangat mudah dilakukan, efisien, dengan rendemen yang tinggi, waktu yang singkat dan ramah lingkungan. Dari hasil sintesis dilakukan identifikasi senyawa melalui titik leleh dan spektrofotometri FTIR.  Berdasarkan hasil interpretasi data dari FTIR bahwa hasil sintesis adalah n-oktil sinamat.Sintesis dilakukan padai suhu 600C dengan lama waktu sonikasi 7 jam. Aktivitas antikolesterol  dari senyawa n-oktil sinamat hasil sintesis yang optimal pada konsentrasi 5 ppm adalah sebesar 55,42%.
The Relationship Between Characteristics and Knowledge Of Pharmaceutical Engineering Personnel In Reconstitution Of Antibiotic Injection At RS UNS Inpatients Septiyani Dwi Utari
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.194

Abstract

Reconstitution is the process of mixing the solvent medium into a dry powder mass to produce suspended or dissolved substances. Mixing injection drugs, including reconstitution of antibiotic injections, should be formulated by pharmacists, in fact all of them are still made by non-pharmaceutical health workers, apart from lack of correlation, it also gives the impression that the hospital is violating the rules. To prevent errors in compounding, pharmaceutical staff attend aseptic technique training to minimize contamination during compounding. The purpose of this study was to examine the relationship between characteristics and knowledge of pharmaceutical technicians in reconstitution of antibiotic injections at UNS Hospital inpatients. Descriptive research with correlation studies the relationship between two or more variables. Data collection is done.total.sampling. Retrieval of data used a questionnaire and processed with SPSS 21.0 For.Windows application. The results of this study indicate that the characteristics include gender, p value = 0.014, at = 0.05 (p<α), education p value = 0.961, at = 0.05 (p>α), length of work p value = 0.719, at =0.05 (p>α). The conclusion obtained is that there is no significant relationship between education and length of work. There is a significant relationship between gender in the knowledge of pharmaceutical technicians in reconstitution of antibiotic injections at UNS Hospital inpatients.
FORMULATION AND TEST OF ANTIBACTERIAL Staphylococcus aureus PAPERSOAP SOURSOP’S LEAVES EXTRACT (Annona muricata L.) WITH VARIATIONS OF GLYCERIN AS PLASTICIZER Vivin Nopiyanti; Din Samsudin; Anita Nilawati
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.208

Abstract

Papersoap is a thin printed solid soap product as a unique innovation because it resembles paper. Soursop leaves contain flavonoid compounds, tannins, alkaloids and saponins that are useful as antibacterial. preparations papersoap with soursop leaf extract require glycerin as a plasticizer is believed to produce good physicochemical properties. This study aims to determine the physical quality of papersoap from the effect of soursop leaf extract and variations of glycerin and to test the antibacterial activity of the Papersoap against Staphylococcus aureus ATCC 25923.Soursop leaf extract was obtained by maceration method with 96% ethanol as solvent. The concentration of soursop leaf extract 5% was formulated into papersoap with three variations of glycerin formula, namely 10%, 15%, and 20%.preparation papersoap includes organoleptic, pH, homogeneity, foam stability, water content, and free alkali tests which have passed the curing for two weeks as the preparation evaluation stage. Antibacterial activity test against Staphylococcus aureus ATCC 25923 using well diffusion method. The data obtained were processed using Shapiro-wilk, one way ANOVA/Kruskal.The results showed that the formula of the papersoap preparation of soursop leaf ethanol extract (Annona muricata L.) with glycerin variations can provide differences in the physical quality of papersoap preparations and have an inhibitory diameter against Staphylococcus aureus bacteria ATCC 25923 successively 25.26; 24,67; 23.47 mm
Identification of Drug Interactions on Prescribing Patients with Type 2 Diabetes Mellitus at Puskesmas X khotimatul khusna
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.209

Abstract

Indonesia occupies the top ten countries with the highest population of people with Diabetes Mellitus in the world, which is ranked 5th with a range of 19.5 million people, and it is estimated that in 2045 it will increase to 28.6 million. Diabetes Mellitus is a chronic disease that is often accompanied by complications. This can lead to drug interactions. Drug interactions can affect the body's response to treatment. The purpose of this study was to determine the percentage of drug interactions on prescriptions received by patients with Type 2 Diabetes Mellitus at a health center in Surakarta. This research is a descriptive observational study. Data collection was carried out retrospectively through tracking records of drug use by patients with Diabetes Mellitus Type 2 at Puskesmas X. The sample in this study was all prescriptions for patients with Diabetes Mellitus Type 2 in April-December 2018. The results showed that the most prescribed antihyperglycemic drugs were 38, 89%, analgesics 16.20%, vitamins 14.2%, and antihypertensives 12.19%. The types of drugs that were most widely used in prescriptions were metformin at 18.98%, amlodipine at 11.57%, and paracetamol at 8.64%. The potential incidence of drug interactions is 62.5% of prescriptions. The conclusion of this study showed that the potential for pharmacokinetic drug interactions was 1.36%, the potential for pharmacodynamic drug interactions was 46.94%, and the incidence of unknown drug interactions was 51.70%.
OPTIMASI SEDIAAN GUMMY CANDY PARASETAMOL DENGAN VARIASI KONSENTRASI GELATIN DAN GLISERIN MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN Siti Aisiyah
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.211

Abstract

Gummy candy parasetamol adalah permen kenyal yang tersusun atas campuran pemanis dan komponen hidrokoloid yang mengandung parasetamol dan didesain untuk hancur dan lumer di lidah. Penelitian ini bertujuan untuk melihat pengaruh variasi konsentrasi gelatin dan gliserin terhadap kualitas fisik sediaan parasetamol gummy candy, serta mengetahui konsentrasi gelatin dan gliserin yang terbaik untuk mendapatkan sediaan parasetamol gummy candy dengan sifat fisi k optimum.Pembuatan sediaan menggunakan metode cetak tuang dan menggunakan 8 rancangan formula dari Design Expert Simplex Lattice Design dengan perbandingan konsentrasi gelatin dan gliserin. Hasil uji mutu fisik dengan parameter kritis kekenyalan dan kadar air, dianalisis dengan metode Simplex Lattice Design. Metode ini dapat digunakan untuk optimasi formula sediaan pada berbagai variasi jumlah komposisi bahan, sehingga menghasilkan formula optimum dengan karakteristik fisik yang diharapkan.Hasil penelitian menunjukkan bahwa gelatin lebih berpengaruh pada kekenyalan dan gliserin lebih berpengaruh pada kadar air gummy candy parasetamol. Proporsi gelatin 998,723 mg dan gliserin 51,277 mg menghasilkan formula optimum dengan kekenyalan dan kadar air gummy candy parasetamol terbaik.  
Kesesuaian Aseptik Dispensing Injeksi Antibiotik Pada Pasien Anak Rumah Sakit Umum Daerah dr. Soediran Mangun Sumarso Wonogiri eny rusmiyati
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.175

Abstract

The use of injection preparations in hospitalized patients has a high prevalence rate so that dispensing injections needs attention because there are many risks that can arise during the mixing process. The purpose of the study was to determine the suitability of the aseptic procedure for dispensing antibiotics in pediatric patients with standard operating procedures applicable at the dr. Sudirman Mangun Sumarso Wonogiri. This study used a retrospective method with descriptive analysis of the data for August – October 2021. Conformity was measured using a checklist form and the percentage of conformity was calculated. The results showed that from 106 antibiotic mixtures consisting of Cefotaxim inj (46%), Ceftriaxon inj (12%), Chloramphenicol inj (3%), and Gentamicin inj (39%) obtained 85.71% according to standard operating procedures. Compliance that has met the standard includes reviewing prescriptions, doing 5 correct, calculating dosage suitability, choosing solvents, calculating solvent volumes, making delivery forms and those that are not appropriate, namely checking the condition of the drug when it is received. Examination of the condition of the drug when it is received should be carried out accompanied by a form so that there is a record that can be used for tracing when a medication error occurs.
GAMBARAN TINGKAT PENGETAHUAN TENAGA TEKNIS KEFARMASIAN TENTANG TINDAKAN ASEPTIC DISPENSING DI RS UMUM DAERAH DR. MOEWARDI Ina Damayanti
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.191

Abstract

Safe handling of parenteral preparations needs to be done in a disciplined and careful manner to prevent unwanted risks, Human resources are a very important part in the implementation of sterile preparations dispensing services, it is necessary to understand aseptic actions in the mixing process with applicable procedures to avoid the dangers of pyrogens and contaminants as well as prevent medication errors. This study aims to determine pharmaceutical technician knowledge about aseptic dispensing at RSUD Dr. Morwardi. This research is a non experimental research with a descriptive survey design. The sampling technique in this research is total sampling. The sample in this study amounted to 50 people. Respondent’s knowledge data was collected using a questionnaire with a total of 10 questions that had been tested for validity with Pearson’s correlation and reliability test with Cronbach’s Alpha which was then analized using SPSS 25. The results showed that knowledge about standard precautions was good, as many as 44 people (88%). Respondents with sufficient knowledge were 4 people (8%), and with poor knowledge were 2 people (4%). The conclusion of this study is that the level of knowledge of pharmaceutical technician about aseptic dispensing at RSUD Dr. Moewardi is good.
Anti-Inflammatory Test of Topical Cream Preparations from Ethyl Acetate Fraction of Johar Leaves (Cassia siamea L.) in White Mice Audri Nandia Apriyanti; Diah Pratimasari; Eka Wisnu Kusuma
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 1 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i1.223

Abstract

Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n-hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti-inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage
Kajian Etnofarmasi Penggunaan Tumbuhan Obat Sebagai Alternatif Pengobatan Diare Oleh Masyarakat Suku Osing Dusun Krajan Amira Septa Sanjaya; Hartono Hartono; Truly Dian Anggraini
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 1 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i1.203

Abstract

Diarrhea is a disease whose existence is still a global health problem, including Indonesia. Diarrhea is in the top 10 diseases that still occur frequently and is ranked 5th in the Osing Tribe. For the treatment of diarrhea, the Osing tribe still uses plants as medicinal plants that are used for generations. This study was conducted to examine how ethnopharmacy in the Osing tribe is intended as a preliminary study for the development of traditional medicine carried out by the Osing tribe as traditional medicine/phytopharmaca. This research is a descriptive study using qualitative methods with sampling techniques using snowball sampling through open-ended interviews by filling out informant information sheets and involving 22 informants from the Osing Tribe, Krajan hamlet, Kemiren, Glagah, Banyuwangi, East Java. The results of the ethnopharmaceutical research in the Osing Tribe showed that there were 8 types of plants and an analysis was carried out using ICF (Informant Consensus Factor) with the results of 0.6 being interpreted as being trusted and used as a hereditary treatment, PPV (Plant Part Value) to calculate the plant part used. with a yield of 50% leaves, 23% fruit, 27% rhizome and FL (Fidelity Level) to determine the types of plants most often used in treating diarrhea with the highest yield of 100%, including Psidium guajava L and Manihot esculenta.

Page 12 of 13 | Total Record : 124

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